EML4-ALK Inhibitors (IC50, Ki)

Name: EML4-ALK Inhibitors (IC50, Ki)
Creator: AAT Bioquest
License: https://www.aatbio.com/tou.html

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Crizotinib	IC50	605.0 ^[1]
	Lorlatinib	IC50	9.0 ^[1]
	(16R)-19-Amino-13-fluoro-3,5,8,16-tetramethyl-17-oxa-4,8,20-triaza-5-azoniatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaen-9-one	IC50	0.7 ^[1], 14.0 ^[2]
	Alectinib	IC50	2.0 ^[1]
	Ceritinib	IC50	41.0 ^[1]
	Alk-IN-1	IC50	5.0 ^[1]
	Entrectinib	IC50	28.0 ^[1]
	JH-VIII-157-02	IC50	2.0 ^[1]
	9-Ethyl-6,6-dimethyl-8-[1-(oxan-4-yl)pyrazol-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	78.0 ^[1]
	9-Ethyl-6,6-dimethyl-11-oxo-8-(1-piperidin-4-ylpyrazol-4-yl)-5H-benzo[b]carbazole-3-carbonitrile	IC50	40.0 ^[1]
	8-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	2.0 ^[1]
	8-[1-[3-(Dimethylamino)propyl]pyrazol-4-yl]-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	14.0 ^[1]
	2-[4-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)pyrazol-1-yl]-N,N,2-trimethylpropanamide	IC50	6.0 ^[1]
	4-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethylpyrazole-1-carboxamide	IC50	56.0 ^[1]
	9-Ethyl-6,6-dimethyl-11-oxo-8-(2H-triazol-4-yl)-5H-benzo[b]carbazole-3-carbonitrile	IC50	115.0 ^[1]
	8-[4-(Dimethylamino)piperidin-1-yl]-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	2.0 ^[1]
	9-Ethyl-6,6-dimethyl-11-oxo-8-(1H-pyrazol-5-yl)-5H-benzo[b]carbazole-3-carbonitrile	IC50	50.0 ^[1]
	9-Ethyl-6,6-dimethyl-8-(1-methylpyrazol-4-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	61.0 ^[1]
	9-Ethyl-6,6-dimethyl-11-oxo-8-(1H-pyrazol-4-yl)-5H-benzo[b]carbazole-3-carbonitrile	IC50	64.0 ^[1]
	9-Ethyl-6,6-dimethyl-8-(1,2-oxazol-4-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	59.0 ^[1]
	9-Ethyl-6,6-dimethyl-8-(4-methylpiperazin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	2.0 ^[1]

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References

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MLA	"Quest Database™ EML4-ALK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/eml4-alk-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ EML4-ALK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/eml4-alk-inhibitors-ic50-ki.
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EML4-ALK Inhibitors (IC50, Ki)

References

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