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Endothelial lipase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
2-[(3S)-3-(Pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50110.0 [1], 237.0 [2], 250.0 [3]
2-(2-Phenylethyl)-3-(trifluoromethyl)-9-oxa-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraeneIC5039.0 [1]
p-Tolylboronic acidIC5017000.0 [1], 22000.0 [2]
4-Nonylphenylboronic acidIC50100.0 [1], 1000.0 [2]
4-Ethylphenylboronic acidIC5011000.0 [1], 19000.0 [2]
2-([1,1'-Biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneIC501000.0 [1]
4-Undecylphenylboronic AcidIC50200.0 [1], 2000.0 [2]
2-[4-(Fur-2-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneIC501300.0 [1], 1900.0 [2]
4-Propylphenylboronic acidIC502000.0 [1], 4000.0 [2]
(4-Heptylphenyl)boronic AcidIC50320.0 [1], 1700.0 [2]
(4-Pentylphenyl)boronic AcidIC50470.0 [1], 1000.0 [2]
4,4,5,5-Tetramethyl-2-(4-(naphthalen-2-yl)phenyl)-1,3,2-dioxaborolaneIC501700.0 [1], 2000.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-4-hydroxy-1-methyl-5-oxo-2H-pyrrole-3-carboxamideIC5041.0 [1], 1760.0 [2]
2-[4-(Furan-3-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneIC502800.0 [1], 2900.0 [2]
4,4,5,5-Tetramethyl-2-(4-nonylphenyl)-1,3,2-dioxaborolaneIC501000.0 [1], 2500.0 [2]
3-Pentylphenylboronic AcidIC5012800.0 [1], 22000.0 [2]
2-(4-Heptylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneIC501100.0 [1], 3500.0 [2]
3-Nonylphenylboronic AcidIC502800.0 [1], 5000.0 [2]
4,4,5,5-Tetramethyl-2-(4-pentylphenyl)-1,3,2-dioxaborolaneIC501100.0 [1], 2600.0 [2]
2-[4-(4-Fluorophenyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneIC501100.0 [1], 1600.0 [2]
4,4,5,5-Tetramethyl-2-(4-undecylphenyl)-1,3,2-dioxaborolaneIC501400.0 [1], 4500.0 [2]
4,4,5,5-Tetramethyl-2-(4-propylphenyl)-1,3,2-dioxaborolaneIC505000.0 [1], 6000.0 [2]
4,4,5,5-Tetramethyl-2-(4-thiophen-3-ylphenyl)-1,3,2-dioxaborolaneIC501300.0 [1], 3100.0 [2]
2-Nonylphenylboronic AcidIC5011000.0 [1], 50000.0 [2]
3-[3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]phenyl]propanoic acidIC5095000.0 [1], 300000.0 [2]
4,4,5,5-Tetramethyl-2-(3-pentylphenyl)-1,3,2-dioxaborolaneIC504200.0 [1], 35000.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-4-hydroxy-5-oxo-1-(2-phenoxyethyl)-2H-pyrrole-3-carboxamideIC505.4 [1], 826.0 [2]
6-Methoxy-2-(2-phenylethyl)-3-(trifluoromethyl)-1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraeneIC5014.0 [1]
2-[(3S)-3-[(5-Fluoropyridin-2-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50130.0 [1], 219.0 [2]
2-[(3S)-3-[(3-Fluoropyridin-2-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50120.0 [1], 252.0 [2]
2-[(3S)-3-[(5-Fluoropyridin-3-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50214.0 [1], 330.0 [2]
2-(3-Phenylpropyl)-3-(trifluoromethyl)-9-thia-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraeneIC5033335.0 [1]
N-[4-(3,4-Dichlorophenyl)butan-2-yl]-1-ethyl-4-hydroxy-5-oxo-2H-pyrrole-3-carboxamideIC50835.0 [1], 910.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-2-(2,2-dimethylpropyl)-4-hydroxy-1-methyl-5-oxo-2H-pyrrole-3-carboxamideIC5029.0 [1], 1770.0 [2]
2-Cyclopropyl-N-[3-(3,4-dichlorophenyl)propyl]-4-hydroxy-1-methyl-5-oxo-2H-pyrrole-3-carboxamideIC5088.0 [1], 5290.0 [2]
2-(2-Chlorophenyl)-N-[3-(3,4-dichlorophenyl)propyl]-4-hydroxy-1-methyl-5-oxo-2H-pyrrole-3-carboxamideIC5059.0 [1], 5750.0 [2]
1-Benzyl-N-[3-(3,4-dichlorophenyl)propyl]-4-hydroxy-5-oxo-2H-pyrrole-3-carboxamideIC503.6 [1], 3.65 [2]
4-Hydroxy-1-methyl-5-oxo-N-(2-phenylethyl)-2H-pyrrole-3-carboxamideIC502947.0 [1], 2950.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-1-ethyl-4-hydroxy-5-oxo-2H-pyrrole-3-carboxamideIC5030.0 [1], 3520.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-1-ethyl-4-(methylamino)-5-oxo-2H-pyrrole-3-carboxamideIC5010.0 [1], 3020.0 [2]
4-Hydroxy-1-methyl-5-oxo-N-(3-phenylpropyl)-2H-pyrrole-3-carboxamideIC505830.0 [1], 6445.0 [2]
N-[2-(3,4-Dichlorophenyl)ethyl]-4-hydroxy-1-methyl-5-oxo-2H-pyrrole-3-carboxamideIC50296.0 [1], 527.8 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-1-ethyl-5-oxo-4-(2-propan-2-yloxyethylamino)-2H-pyrrole-3-carboxamideIC5019.0 [1], 945.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-1-ethyl-5-oxo-4-(2-pyridin-4-ylethylamino)-2H-pyrrole-3-carboxamideIC5059.0 [1], 5990.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-4-hydroxy-1-[3-(methanesulfonamido)-3-oxopropyl]-5-oxo-2H-pyrrole-3-carboxamideIC5095.0 [1], 1050.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-4-hydroxy-5-oxo-1-[3-(2-oxopyrrolidin-1-yl)propyl]-2H-pyrrole-3-carboxamideIC5019.0 [1], 2440.0 [2]
N-[3-(3,4-Dichlorophenyl)propyl]-1-ethyl-5-oxo-4-(3-piperidin-1-ylpropylamino)-2H-pyrrole-3-carboxamideIC5025.0 [1], 4210.0 [2]
4,4,5,5-Tetramethyl-2-(4-(thiophen-2-yl)phenyl)-1,3,2-dioxaborolaneIC501600.0 [1], 1900.0 [2]
2-[(6-Phenyl-1,3-benzothiazol-2-yl)methyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazoleIC505.0 [1], 10.0 [2]
2-[1-[6-(6-Fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]ethyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazoleIC506518.0 [1]
2-[1-[6-(6-Fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-1-hydroxyethyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazoleIC5014880.0 [1]
3-[2-Methyl-5-(piperidine-1-sulfonyl)furan-3-yl]-1-phenylureaIC50130.0 [1]
N-(4-Chlorophenyl)-N'-[2-methyl-5-(piperidinosulfonyl)-3-furyl]ureaIC50200.0 [1]
2-Methyl-N-phenyl-5-(piperidin-1-ylsulfonyl)furan-3-carboxamideIC5050000.0 [1]
1-(2-Methyl-5-(morpholinosulfonyl)furan-3-yl)-3-phenylureaIC50130.0 [1]
1-(4-Methoxyphenyl)-3-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)ureaIC50130.0 [1]
1-Benzhydryl-3-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)ureaIC50160.0 [1]
1-(2,4-Dimethyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)-3-phenylureaIC5050000.0 [1]
1-Phenyl-3-(5-(piperidin-1-ylsulfonyl)furan-3-yl)ureaIC502500.0 [1]
1-(2-Methyl-5-piperidin-1-ylsulfonyl-1H-pyrrol-3-yl)-3-phenylureaIC5050000.0 [1]
1-(1,2-Dimethyl-5-piperidin-1-ylsulfonylpyrrol-3-yl)-3-phenylureaIC5050000.0 [1]
1-(1-Methyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-5-yl)-3-phenylureaIC5050000.0 [1]
1-(2-Methyl-4-(morpholinosulfonyl)phenyl)-3-phenylureaIC5050000.0 [1]
1-(2-Methyl-6-(piperidin-1-ylsulfonyl)pyridin-3-yl)-3-phenylureaIC5050000.0 [1]
1-(2-Chlorophenyl)-3-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)ureaIC50130.0 [1]
1-Benzyl-3-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)ureaIC5050000.0 [1]
1-(2-Methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-3-[(1S)-1-phenylethyl]ureaIC5060.0 [1]
1-Methyl-3-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-1-phenylureaIC5050000.0 [1]
1-(4-Chlorophenyl)-1-methyl-3-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)ureaIC5050000.0 [1]
1-Methyl-1-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-3-phenylureaIC5025000.0 [1]
1-(2-Methyl-5-(4-methylpiperazin-1-ylsulfonyl)furan-3-yl)-3-phenylureaIC501300.0 [1]
1-[5-[2-Methoxyethyl(methyl)sulfamoyl]-2-methylfuran-3-yl]-3-phenylureaIC50250.0 [1]
1-[2-Methyl-5-(phenylsulfamoyl)furan-3-yl]-3-phenylureaIC501000.0 [1]
1-[5-(Dimethylsulfamoyl)-2-methylfuran-3-yl]-3-phenylureaIC50300.0 [1]
2-(Cyclopropylmethylamino)-5-(trifluoromethyl)benzoic acidIC501010.0 [1]
2-[4-(4-Fluorophenoxy)piperidin-1-yl]-5-(trifluoromethyl)benzoic acidIC5010000.0 [1]
2-[3-(4-Fluorophenoxy)azetidin-1-yl]-5-(trifluoromethyl)benzoic acidIC501960.0 [1]
2-[(3S)-3-(4-Fluorophenoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50184.0 [1]
2-[(3R)-3-(4-Fluorophenoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50259.0 [1]
2-[3-[(4-Fluorophenyl)methyl]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC5025.0 [1]
5-(Trifluoromethyl)-2-[(3S)-3-[5-(trifluoromethyl)pyridin-2-yl]oxypyrrolidin-1-yl]benzoic acidIC50372.0 [1]
2-[(3S)-3-(6-Chloropyridin-3-yl)oxypyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50236.0 [1]
2-[(3S)-3-[(4-Fluorophenyl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50131.0 [1]
2-[(3S)-3-(Cyclopropylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50236.0 [1]
2-[(3S)-3-(2-Cyclopropylethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50156.0 [1]
2-[(3S)-3-Butoxypyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50366.0 [1]
2-[(3S)-3-(2-Phenylmethoxyethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC5088.0 [1]
2-[(3S)-3-(2-Hydroxyethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50570.0 [1]
2-[(3S)-3-(2-Ethoxyethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50499.0 [1]
2-[(3S)-3-[2-(2-Methoxyethoxy)ethoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50551.0 [1]
2-[(3S)-3-(2-Morpholin-4-ylethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC50659.0 [1]
5-[2-[(3S)-3-(4-Fluorophenoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)phenyl]-2H-tetrazoleIC50209.0 [1]
2-[(3S)-3-(4-Fluorophenoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzenesulfonamideIC5010000.0 [1]
N-[2-[(3S)-3-(4-Fluorophenoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)phenyl]sulfonylacetamideIC5010000.0 [1]
1-[2-[(3S)-3-(4-Fluorophenoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)phenyl]ethanolIC501946.0 [1]
S-[(5-Phenyl-1,3,4-oxadiazol-2-yl)methyl] N-[5-(3,5-difluorophenoxy)pentyl]carbamothioateIC5023.0 [1]
2-(3-Phenylpropyl)-3-(trifluoromethyl)-1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-6-amineIC504.0 [1]
N-[3-(3,4-Dichlorophenyl)propyl]-4-hydroxy-1-(2-morpholin-4-ylethyl)-5-oxo-2H-pyrrole-3-carboxamideIC50190.0 [1]
N-[3-(3,4-Dichlorophenyl)propyl]-3-hydroxy-1-methyl-2-oxopyridine-4-carboxamideIC5061.0 [1]
N-[[5-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]-1,3,4-oxadiazol-2-yl]-[6-(6-fluoropyridin-3-yl)-1,3-benzoxazol-2-yl]methyl]acetamideIC5010.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Endothelial lipase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/endothelial-lipase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Endothelial lipase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/endothelial-lipase-inhibitors-ic50-ki.
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