Endothelial PAS domain-containing protein 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-[[(1S)-2,2-Difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile	IC50	12.0 [1]
	3-[[(1S)-7-(Difluoromethylsulfonyl)-2,2-difluoro-1-hydroxy-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile	IC50	5.0 [1]
	N-(3-Chloro-5-Fluorophenyl)-4-Nitro-2,1,3-Benzoxadiazol-5-Amine	IC50	490.0 [1]
	2-(3-Chloro-5-fluorophenoxy)-5-(trifluoromethylsulfonyl)benzoic acid	IC50	44400.0 [1]
	2-Bromo-1-(3-chloro-5-fluorophenoxy)-4-methylsulfonylbenzene	IC50	4400.0 [1]
	2-Bromo-1-(3-chloro-5-fluorophenoxy)-4-(trifluoromethylsulfonyl)benzene	IC50	170.0 [1]
	2-Chloro-1-(3-chloro-5-fluorophenoxy)-4-(difluoromethylsulfonyl)-3-(methoxymethyl)benzene	IC50	4200.0 [1]
	4-(3-Chloro-5-fluorophenoxy)-7-(difluoromethylsulfonyl)-2,3-dihydro-1H-inden-1-ol	IC50	5.0 [1]
	N-[[2-Bromo-3-(3-chloro-5-fluorophenoxy)-6-(difluoromethylsulfonyl)phenyl]methyl]acetamide	IC50	18200.0 [1]
	[2-(3-Chloro-5-fluorophenoxy)-5-(trifluoromethylsulfonyl)phenyl]methanol	IC50	1200.0 [1]
	Methyl 2-(3-chloro-5-fluorophenoxy)-5-(trifluoromethylsulfonyl)benzoate	IC50	52900.0 [1]
	[2-Bromo-3-(3-chloro-5-fluorophenoxy)-6-(difluoromethylsulfonyl)phenyl]methanamine	IC50	700.0 [1]
	2-Bromo-1-(3-chloro-5-fluorophenoxy)-4-(difluoromethylsulfonyl)benzene	IC50	180.0 [1]
	3-[[(1S)-7-Ethylsulfonyl-2,2-difluoro-1-hydroxy-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile	IC50	31.0 [1]
	[2-Chloro-3-(3-chloro-5-fluorophenoxy)-6-(difluoromethylsulfonyl)phenyl]methanol	IC50	46.0 [1]
	2-(3-Chloro-5-fluorophenoxy)-5-(trifluoromethylsulfonyl)benzamide	IC50	22600.0 [1]
	2-Chloro-1-(3-chloro-5-fluorophenoxy)-4-(trifluoromethylsulfonyl)benzene	IC50	140.0 [1]
	(1S)-4-(5-Chloropyridin-3-yl)oxy-7-(difluoromethylsulfonyl)-2,2-difluoro-1,3-dihydroinden-1-ol	IC50	60.0 [1]
	3-Fluoro-5-[[(1S,2S)-2-fluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl]oxy]benzonitrile	IC50	350.0 [1]
	3-[[(1S)-2,2-Difluoro-7-(fluoromethylsulfonyl)-1-hydroxy-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile	IC50	5.0 [1]
	3-[(6,6-Difluoro-5-hydroxy-4-methylsulfonyl-7,8-dihydro-5H-naphthalen-1-yl)oxy]-5-fluorobenzonitrile	IC50	3600.0 [1]
	(Rac)-PT2399	IC50	10.0 [1]
	3-[[(1S)-2,2-Difluoro-1-hydroxy-7-(trifluoromethylsulfonyl)-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile	IC50	5.0 [1]
	4-(3-Chloro-5-fluorophenoxy)-7-(difluoromethylsulfonyl)-2,2-difluoro-1,3-dihydroinden-1-ol	IC50	5.0 [1]
	2-(3-Chloro-5-fluorophenoxy)-5-(trifluoromethylsulfonyl)benzonitrile	IC50	34.0 [1]
	3-Fluoro-5-[[(1S,2R)-2-fluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl]oxy]benzonitrile	IC50	41.0 [1]
	4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2-difluoro-1,1-dioxo-3H-1-benzothiophen-3-ol	IC50	11.0 [1]
	5-(3-Chloro-5-fluorophenoxy)-2,2-difluoro-4-methyl-1,1-dioxo-3H-1-benzothiophen-3-ol	IC50	20.0 [1]
	5-(3-Chloro-5-fluorophenoxy)-4-(difluoromethyl)-2,2-difluoro-1,1-dioxo-3H-1-benzothiophen-3-ol	IC50	5.0 [1]
	4-Bromo-5-(3-chloro-5-fluorophenoxy)-1,1-dioxo-2,3-dihydro-1-benzothiophen-3-ol	IC50	2400.0 [1]
	5-(5-Chloropyridin-3-yl)oxy-4-(difluoromethyl)-2,2-difluoro-1,1-dioxo-3H-1-benzothiophen-3-ol	IC50	350.0 [1]
	4-Bromo-5-(3-chloro-5-fluorophenoxy)-2,2-difluoro-1,1-dioxo-3H-1-benzothiophen-3-ol	IC50	5.0 [1]
	5-(3-Chloro-5-fluorophenoxy)-2,2-difluoro-1,1-dioxo-3H-1-benzothiophen-3-ol	IC50	1100.0 [1]
	5-(3-Chloro-5-fluorophenoxy)-2,2-difluoro-3-hydroxy-1,1-dioxo-3H-1-benzothiophene-4-carbonitrile	IC50	49.0 [1]
	5-[[4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-3H-1-benzothiophen-5-yl]oxy]pyridine-3-carbonitrile	IC50	140.0 [1]
	3-[[4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-3H-1-benzothiophen-5-yl]oxy]-5-fluorobenzonitrile	IC50	14.0 [1]
	4-Bromo-5-(3-chloro-5-fluorophenoxy)-2,2-dimethyl-1,1-dioxo-3H-1-benzothiophen-3-ol	IC50	19600.0 [1]
	4-Chloro-5-(3-chloro-5-fluorophenoxy)-2,2-difluoro-1,1-dioxo-3H-1-benzothiophen-3-ol	IC50	20.0 [1]
	5-(3-Chloro-5-fluorophenoxy)-2,2-difluoro-1,1-dioxo-4-(trifluoromethyl)-3H-1-benzothiophen-3-ol	IC50	5.0 [1]
	3-[[(3S)-4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-3H-1-benzothiophen-5-yl]oxy]-5-fluorobenzonitrile	IC50	1700.0 [1]
	5-(Difluoromethyl)-6-(3,5-difluorophenoxy)-1,1-dioxo-3,4-dihydro-2H-thiochromen-4-ol	IC50	3200.0 [1]
	(1R)-4-(3-Chloro-5-fluorophenoxy)-7-(difluoromethylsulfonyl)-2,3-dihydro-1H-inden-1-ol	IC50	5.0 [1]
	{2-Bromo-3-(3-chloro-5-fluorophenoxy)-6-[(difluoromethyl)sulfonyl]phenyl}methanol	IC50	55.0 [1]
	1-(3-Chloro-5-fluorophenoxy)-2-(difluoromethyl)-4-(trifluoromethylsulfonyl)benzene	IC50	220.0 [1]
	(1S)-4-(3-Chloro-5-fluorophenoxy)-7-(difluoromethylsulfonyl)-2,3-dihydro-1H-inden-1-ol	IC50	460.0 [1]
	(5S,7R)-5-(3-Bromophenyl)-7-phenyl-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	248.0 [1]
	(5R,7S)-5-(3-Bromophenyl)-7-phenyl-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	30000.0 [1]
	N-(3-Chloro-5-fluorophenyl)-2-nitro-4-[(trifluoromethyl)sulfonyl]aniline	IC50	5.0 [1]
	(5s,7r)-5,7-Bis(3-Bromophenyl)-4,5,6,7-Tetrahydrotetrazolo[1,5-A]pyrimidine	IC50	112.0 [1]
	(5S,7R)-5-(3-Bromo-5-fluorophenyl)-7-(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	43.0 [1]
	CID 136268871	IC50	195.0 [1]
	(5S,7R)-7-(2-Bromophenyl)-5-(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	314.0 [1]
	(5S,7R)-5-(3-Bromo-5-fluorophenyl)-7-phenyl-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	97.0 [1]
	(5S,7R)-7-(5-Bromo-2-chlorophenyl)-5-(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	87.0 [1]
	(5S,7R)-7-(3-Bromo-2,6-difluorophenyl)-5-(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	32.0 [1]
	CID 137036807	IC50	1000.0 [1]
	(5R,7S)-5-(3-Iodophenyl)-7-phenyl-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	30000.0 [1]
	(5R,7S)-7-(2-Bromophenyl)-5-(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	28300.0 [1]
	(5R,7S)-5-(3-Bromophenyl)-7-(2-chlorophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	30000.0 [1]
	(5R,7S)-5,7-Bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	30000.0 [1]
	CID 137036812	IC50	108.0 [1]
	(5R,7S)-5-(3-Bromophenyl)-7-(3-iodophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	30000.0 [1]
	(5R,7S)-7-(5-Bromo-2-chlorophenyl)-5-(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	30000.0 [1]
	(5R,7S)-7-(3-Bromo-2,6-difluorophenyl)-5-(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	22300.0 [1]
	(5R,7S)-5-(3-Bromo-5-fluorophenyl)-7-phenyl-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	30000.0 [1]
	(5R,7S)-5-(3-Bromo-5-fluorophenyl)-7-(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine	IC50	30000.0 [1]
	N-(3-Chloro-5-fluorophenyl)-2-nitro-4-(trifluoromethyl)aniline	IC50	280.0 [1]
	N-(3-Chloro-5-fluorophenyl)-4-(fluoromethylsulfonyl)-2-nitroaniline	IC50	280.0 [1]
	1-(3-Chloro-5-fluorophenoxy)-2-nitro-4-(trifluoromethylsulfonyl)benzene	IC50	32.0 [1]
	1-[4-(3-Chloro-5-fluoroanilino)-3-nitrophenyl]ethanol	IC50	12700.0 [1]
	3-(3-Cyano-5-fluorophenoxy)-2-(difluoromethyl)-6-(difluoromethylsulfonyl)benzoic acid	IC50	100000.0 [1]
	4-(3-Chloro-5-fluoroanilino)-N-methyl-3-nitrobenzenesulfonamide	IC50	4200.0 [1]
	N-(3-Chloro-5-fluorophenyl)-4-(difluoromethylsulfonyl)-2-nitroaniline	IC50	16.0 [1]
	Hif-2|A-IN-1	IC50	5.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 74 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Endothelial PAS domain-containing protein 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/endothelial-pas-domain-containing-protein-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Endothelial PAS domain-containing protein 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/endothelial-pas-domain-containing-protein-1-inhibitors-ic50-ki.
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