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Endothelin-converting enzyme 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
PhosphoramidonIC50800.0 [1]
ThiorphanIC508.0 [1], 100000.0 [2]
ThiorphanKi10000.0 [1]
(S)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)ethylaminomethyl phosphonic acidIC50410.0 [1]
(2S)-3-Dibenzofuran-3-yl-2-(phosphonomethylamino)propanoic acidIC5022.0 [1]
3-Biphenyl-4-yl-2-{[1-(2-mercapto-pentanoylamino)-cyclopentanecarbonyl]-amino}-propionic acidIC5011.0 [1]
[3-Naphthalen-1-yl-1-[[(1S)-2-(4-phenylphenyl)-1-(2H-tetrazol-5-yl)ethyl]amino]propyl]phosphonic acidIC5017.0 [1]
[3-Naphthalen-1-yl-1-[[(1S)-2-(4-phenylphenyl)-1-(2H-tetrazol-5-yl)ethyl]amino]propyl]phosphonic acidKi10.8 [1]
(2S)-2-[[1-[[[(1R)-1-[[(2S)-6-Amino-2-(methanesulfonamido)hexanoyl]amino]-2-phenylethyl]-hydroxyphosphoryl]methyl]cyclopentanecarbonyl]amino]-3-(1H-indol-3-yl)propanoic acidIC5070.0 [1], 80.0 [2]
2-(4-Morpholinyl)-4H-1-benzopyran-4-oneIC5012.0 [1], 67.0 [2]
(2S)-2-[[1-[[(2S)-3-Methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]-3-(4-phenylphenyl)propanoic acidIC5077.0 [1]
[[(S)-1-(2H-Tetrazole-5-yl)-4-(2-fluorophenyl)-3-butynyl]amino]methylphosphonic acidIC50150.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-5-(2,4-Difluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-4-methylpentanoyl]amino]propanoic acidIC508.0 [1]
2-[5-(2,4-Difluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoic acidIC5051.0 [1]
(2S)-2-[[(2R)-2-[(1R)-2,3-Dihydro-1H-inden-1-yl]-3-sulfanylpropanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi26.0 [1]
2-(2-Indan-1-yl-3-mercapto-propionylamino)-3-(1H-indol-3-yl)-propionic acidKi100.0 [1]
(2S)-3-(1H-Indol-3-yl)-2-[[(2R)-2-[(1S)-5-methoxy-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanoyl]amino]propanoic acidKi10.0 [1], 180.0 [2]
2-[[1-[[(2S)-3-Methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]-3-(4-pyrimidin-5-ylphenyl)propanoic acidIC50120.0 [1]
2,3-Dihydro-1,4-benzodioxin-5-yl (2S,4R)-4-acetylsulfanyl-2-[(2,4,5-trifluorophenyl)methoxymethyl]pyrrolidine-1-carboxylateIC506.9 [1], 76.5 [2]
2-[[1-[[(2S)-3-Methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acidIC5029.99 [1], 30.0 [2]
2,3-Dihydro-1,4-benzodioxin-5-yl (2S,4R)-4-benzoylsulfanyl-2-[(2,4,5-trifluorophenyl)methoxymethyl]pyrrolidine-1-carboxylateIC5049.7 [1], 480.5 [2]
2-[[1-[[(2R)-2-Sulfanylhexanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acidIC5055.98 [1], 56.0 [2]
2-[[1-[[(2S)-2-Sulfanylhexanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acidIC5023.99 [1], 24.0 [2]
2-[[1-[[(2S)-2-Sulfanylpentanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acidIC5026.98 [1], 27.0 [2]
2-[[1-[[(2R)-2-Sulfanylpentanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acidIC5082.0 [1], 82.04 [2]
3-[6-(3-Acetamidophenyl)pyridin-3-yl]-2-[[1-[[(2S)-3-methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]propanoic acidIC50130.0 [1], 130.02 [2]
2-[[1-[[(2S)-4-Methyl-2-sulfanylpentanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acidIC509.79 [1], 9.8 [2]
2-[[1-[[(2S)-3-Cyclohexyl-2-sulfanylpropanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acidIC5023.0 [1], 23.01 [2]
3-[6-(2-Methoxyphenyl)pyridin-3-yl]-2-[[1-[[(2S)-3-methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]propanoic acidIC50699.84 [1], 700.0 [2]
2-[[1-[[(2S)-3-Methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-pyridin-3-ylpyridin-3-yl)propanoic acidIC5041.0 [1], 41.02 [2]
2-[[1-[[(2S)-3-Methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-phenylpyridin-3-yl)propanoic acidIC5076.91 [1], 77.0 [2]
3-[6-(Furan-2-yl)pyridin-3-yl]-2-[[1-[[(2S)-3-methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]propanoic acidIC5042.95 [1], 43.0 [2]
2-[[1-[[(2S)-3-Methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]-3-[6-(3-nitrophenyl)pyridin-3-yl]propanoic acidIC5098.0 [1], 98.17 [2]
2-[[1-[[(2S)-4-Methylsulfanyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acidIC5054.95 [1], 55.0 [2]
2-[[1-[[(2S)-3-Methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-2-ylpyridin-3-yl)propanoic acidIC5048.98 [1], 49.0 [2]
Methyl 2-[[2-[methyl-[(4R)-1-naphthalen-2-ylsulfonyl-4-sulfanylpyrrolidine-2-carbonyl]amino]acetyl]amino]benzoateIC5080.8 [1], 10890.0 [2]
(4R)-N'-Methyl-N'-(4-methylphenyl)sulfonyl-1-naphthalen-2-ylsulfonyl-4-sulfanylpyrrolidine-2-carbohydrazideIC5061.3 [1], 2530.0 [2]
Propan-2-yl (4R)-2-[[(2,5-difluorophenyl)methylamino]methyl]-4-sulfanylpyrrolidine-1-carboxylateIC5016.0 [1], 1090.0 [2]
(3R)-5-[[(2,5-Difluorophenyl)methylamino]methyl]-1-(5-propylpyrimidin-2-yl)pyrrolidine-3-thiolIC5010.4 [1], 72.9 [2]
[2-Naphthalen-2-yl-1-[[(1S)-2-(4-phenylphenyl)-1-(2H-tetrazol-5-yl)ethyl]amino]ethyl]phosphonic acidIC5045.0 [1], 20000.0 [2]
CaptoprilKi10000.0 [1]
ActinoninIC504000.0 [1]
KelatorphanIC508.0 [1]
SampatrilatIC501500.0 [1]
Unii-cdl03A411TIC501000.0 [1]
D-Tryptophan, N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-IC501000.0 [1]
(2R)-2-[[1-[(5-Ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]pentanoic acidIC503000.0 [1]
N-[(2r)-2-(Hydroxycarbamoyl)-4-Methylpentanoyl]-L-AlanylglycinamideIC5011.0 [1]
(Inverted exclamation markA)-WS75624BIC501300.0 [1]
(2S)-3-(4-Hydroxyphenyl)-2-[[(2R)-2-[[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]methyl]-3-(3-phenyl-1,2-oxazol-5-yl)propanoyl]amino]propanoic acidKi14.0 [1]
(2S)-2-[[(2R)-2-[(1S)-5-Bromo-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi90.0 [1]
2-[3-Dibenzofuran-3-yl-2-(phosphonomethyl-amino)-propionylamino]-3-phenyl-propionic acidIC5023.0 [1]
2-(3-Mercapto-5-methylhexanamido)-3-phenylpropanoic acidIC5010000.0 [1]
(2S)-2-[[2-Benzyl-3-[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi1.2 [1]
N-PhosphorylleucyltryptophanIC501500.0 [1]
(R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylamino]-3-(1H-indol-3-yl)-propionic acidIC501000.0 [1]
3-(2-Hydroxycarbamoylmethyl-3-methyl-butyrylamino)-propionic acidIC50190.0 [1]
(2S)-2-[[(2S)-2-[[Cyclohexylmethyl(hydroxy)phosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC504800.0 [1]
(2S)-2-[[(2S)-2-[[Hydroxy(propyl)phosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC502000.0 [1]
(2S)-2-[[(2S)-2-[[Hydroxy(phenoxy)phosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC5037000.0 [1]
3-[(4-Amino-4-oxo-2-propan-2-ylbutanoyl)amino]propanoic acidIC506500.0 [1]
(6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[11.3.1]heptadeca-1(16),13(17),14-triene-6-carboxylic acidIC50620.0 [1]
(2S)-2-[[(2S)-2-[[Hydroxy(propyl)phosphoryl]methyl]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC50100000.0 [1]
(S)-2-((1-((5-Ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cyclopentyl)methyl)pentanoic acidIC503000.0 [1]
3-(1H-Indol-3-yl)-2-[3-mercapto-2-(5-methoxy-indan-1-yl)-propionylamino]-propionic acidKi22.0 [1]
2-[2-(5-Bromo-indan-1-yl)-3-mercapto-propionylamino]-3-(1H-indol-3-yl)-propionic acidKi31.0 [1]
3-(1H-Indol-3-yl)-2-[3-mercapto-2-(5-methylsulfanyl-indan-1-yl)-propionylamino]-propionic acidKi35.0 [1]
5-[(3,3-Dimethylbutanoyl)amino]-1-(2-fluorobenzyl)-N~2~-phenyl-1H-indole-2-carboxamideIC50220.0 [1]
2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-succinamic acidIC503.0 [1]
3-(2-Hydroxycarbamoyl-acetylamino)-propionic acidIC503000.0 [1]
(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-acetic acidIC506.8 [1]
(2S)-2-[[(2S)-2-[[Ethoxy(hydroxy)phosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC50109000.0 [1]
(2S)-2-[[(2S)-2-[[Benzyl(hydroxy)phosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC5061000.0 [1]
3-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-propionic acidIC500.01 [1]
(2S)-2-[[(2S)-2-[Hydroxy(propyl)phosphoryl]oxy-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC50100000.0 [1]
(2S)-2-[[(2S)-2-[Ethoxy(hydroxy)phosphoryl]oxy-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC50100000.0 [1]
(2S)-3-(1H-Indol-3-yl)-2-[[(2R)-2-[(1R)-5-methoxy-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanoyl]amino]propanoic acidKi10.0 [1]
(2S)-2-[[(2S)-2-[[Cyclohexyloxy(hydroxy)phosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC5048000.0 [1]
5-Chloro-2-oxo-1,2,3,4-tetrahydroquinazoline-3-acetohydroxamic acidIC5010000.0 [1]
(3R)-3-(Benzenesulfonyl)-N-hydroxyheptanamideIC50100000.0 [1]
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-3-methyl-butyric acidIC50110.0 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-oxo-1-[2-(4-phenylphenyl)ethylamino]pent-4-yn-2-yl]amino]methylphosphonic acidIC5028.0 [1]
(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoic acidIC50240.0 [1]
[[(2S)-1-[2-(4-Bromophenyl)ethylamino]-5-(2-fluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC50110.0 [1]
3-Cyclohexanesulfonyl-heptanoic acid hydroxyamideIC5078000.0 [1]
(2S)-2-[[(2S)-5-(2-Chlorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-4-methylpentanoic acidIC504300.0 [1]
(3S)-3-(Benzenesulfonyl)-N-hydroxyheptanamideIC50100000.0 [1]
[[2-(9-Methylcarbazol-2-yl)-1-(2H-tetrazol-5-yl)ethyl]amino]methylphosphonic acidIC504000.0 [1]
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-3-phenyl-propionic acidIC5056.0 [1]
[[(2S)-5-(2-Fluorophenyl)-1-(2-naphthalen-1-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC50130.0 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-(2-naphthalen-1-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC5034.0 [1]
(2S)-5-(2-Fluorophenyl)-2-[[(2S)-5-(2-fluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]pent-4-ynoic acidIC5028.0 [1]
3-Dibenzofuran-3-yl-2-[3-dibenzofuran-3-yl-2-(phosphonomethyl-amino)-propionylamino]-propionic acidIC506.4 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-oxo-1-(2-pyridin-2-ylethylamino)pent-4-yn-2-yl]amino]methylphosphonic acidIC50310.0 [1]
{[(S)-4-(2,4-Difluoro-phenyl)-1-(3-methyl-butylcarbamoyl)-but-3-ynylamino]-methyl}-phosphonic acidIC50140.0 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-oxo-1-(3-phenylpropylamino)pent-4-yn-2-yl]amino]methylphosphonic acidIC50150.0 [1]
[[(2S)-1-[2-(4-Bromophenyl)ethylamino]-5-(2,4-difluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC5043.0 [1]
{[(S)-1-Benzylcarbamoyl-4-(2-fluoro-phenyl)-but-3-ynylamino]-methyl}-phosphonic acidIC50250.0 [1]
[[(2S)-5-(2-Fluorophenyl)-1-oxo-1-[2-(4-phenylphenyl)ethylamino]pent-4-yn-2-yl]amino]methylphosphonic acidIC5033.0 [1]
2-(5-Chloro-2,2-dioxo-1,4-dihydro-2lambda6,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamideIC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Endothelin-converting enzyme 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/endothelin-converting-enzyme-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Endothelin-converting enzyme 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/endothelin-converting-enzyme-1-inhibitors-ic50-ki.
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