 | 8-Butyl-1-methyl-7-phenyl-1H-imidazo(2,1-f)purine-2,4(3H,8H)-dione | IC50 | 538.0 [1], 1500.0 [2], 1900.0 [3], 8300.0 [4] |
 | CID 44478401 | IC50 | 1.6 [1], 5.0 [2], 130.0 [3] |
 | N'-(5-Chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | IC50 | 25.0 [1], 90.0 [2], 187.0 [3], 190.0 [4] |
 | Sorafenib | IC50 | 0.2 [1], 4.46 [2], 4.62 [3], 1900.0 [4] |
 | 7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine | IC50 | 40.0 [1] |
| 7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine | Ki | 63.8 [1] |
 | N4-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-N2-(3,5-dimorpholinophenyl)pyrimidine-2,4-diamine | IC50 | 2.0 [1], 4.0 [2], 14.0 [3], 17.0 [4] |
 | 6-(2-Methoxyphenyl)-4-methyl-7-phenylpurino[7,8-a]imidazole-1,3-dione | IC50 | 3300.0 [1], 4350.0 [2] |
 | 8-(4-Hydroxybutyl)-1-methyl-7-phenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione | IC50 | 1600.0 [1], 5680.0 [2], 6800.0 [3], 7000.0 [4] |
 | 3-({4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide | IC50 | 40.0 [1], 172.0 [2] |
 | 8-Butyl-1-Methyl-7-(2-Methylphenyl)-1h-Imidazo[2,1-F]purine-2,4(3h,8h)-Dione | IC50 | 50.0 [1], 56.0 [2], 82.0 [3] |
 | 1-Amino-5-(5-Hydroxy-2-Methylphenyl)-7,8,9,10-Tetrahydropyrimido[4,5-C]isoquinolin-6(5h)-One | IC50 | 160.0 [1], 300.0 [2], 930.0 [3] |
 | 6-Butyl-7-(4-fluoro-2-methylphenyl)-4-methylpurino[7,8-a]imidazole-1,3-dione | IC50 | 68.0 [1], 91.0 [2], 139.0 [3] |
 | 6-Butyl-7-[5-(1H-indazol-4-yl)-2-methylphenyl]-4-methylpurino[7,8-a]imidazole-1,3-dione | IC50 | 14.0 [1], 133.0 [2], 150.0 [3] |
 | Staurosporine | IC50 | 126.4 [1], 233.0 [2] |
 | Nvp-aew541 | IC50 | 10000.0 [1] |
 | 3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione | IC50 | 5100.0 [1], 16000.0 [2] |
 | 4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol | IC50 | 15.9 [1] |
 | 3-(4-Amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)benzenesulfonamide | IC50 | 19.0 [1], 21.0 [2] |
 | 7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine | IC50 | 49.0 [1], 64.0 [2] |
 | 7-(2-Chlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine | IC50 | 58.0 [1] |
 | cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol | IC50 | 5.0 [1] |
 | 7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 2700.0 [1] |
 | 4-[[7-(2-Chloro-5-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamide | IC50 | 30.8 [1] |
 | 5-Methyl-7-phenyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine | IC50 | 391.0 [1] |
 | N'-(5-Chloro-1,3-Benzodioxol-4-Yl)-N-(3-Morpholin-4-Ylphenyl)pyrimidine-2,4-Diamine | IC50 | 580.0 [1] |
 | [4-Methyl-3-[methyl-[2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanol | IC50 | 3.0 [1], 11.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 1.3 [1], 9.0 [2] |
 | 3-(3-Chloro-4-fluorophenyl)-7-(pyridin-3-yl)thieno[3,2-c]pyridin-4-amine | IC50 | 29.0 [1], 51.0 [2] |
 | 3-(3-Chloro-4-fluorophenyl)-7-(3-(methylsulfonyl)phenyl)thieno[3,2-c]pyridin-4-amine | IC50 | 18.0 [1], 59.0 [2] |
 | 1-[2-Methoxy-5-(trifluoromethyl)phenyl]-3-[3-[8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]urea | IC50 | 37.0 [1], 50.0 [2] |
 | 1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-[8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]urea | IC50 | 49.0 [1], 400.0 [2] |
 | N-[3-[[4-(1H-Indazol-4-ylamino)pyrimidin-2-yl]amino]phenyl]methanesulfonamide | IC50 | 84.0 [1], 8420.0 [2] |
 | N^4^-1H-Indazol-4-YL-N^2^-[3-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine | IC50 | 61.0 [1], 2530.0 [2] |
 | 4-[[7-(2,6-Dimethylphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamide | IC50 | 73.7 [1] |
 | 4-N-(1H-Indazol-4-yl)-4-N-methyl-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | IC50 | 36.0 [1], 51.0 [2] |
 | 1-Amino-5-(3-methoxyphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5H)-one | IC50 | 5200.0 [1], 9400.0 [2] |
 | 3-({4-[(5-Chloro-1,3-benzodioxol-4-YL)amino]pyrimidin-2-YL}amino)benzamide | IC50 | 220.0 [1], 900.0 [2] |
 | (3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol | IC50 | 4.0 [1], 12.0 [2] |
 | N-[3-[[4-[(5-Chloro-1,3-benzodioxol-4-YL)amino]pyrimidin-2-YL]amino]phenyl]methanesulfonamide | IC50 | 741.0 [1], 794.0 [2] |
 | (3-((2-(3-Methoxy-5-morpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol | IC50 | 5.0 [1], 32.0 [2] |
 | [3-[[2-[3-(2-Methoxyethoxy)-5-morpholin-4-ylanilino]pyrimidin-4-yl]-methylamino]-4-methylphenyl]methanol | IC50 | 8.0 [1], 35.0 [2] |
 | [4-Methyl-3-[[2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]-propan-2-ylamino]phenyl]methanol | IC50 | 2.0 [1], 7.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(3-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 2.0 [1], 10.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-methyl-4-N-phenylpyrimidine-2,4-diamine | IC50 | 17.0 [1], 84.0 [2] |
 | 4-N-(3-Chlorophenyl)-2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 6.0 [1], 12.0 [2] |
 | (3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanol | IC50 | 10.0 [1], 114.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-methyl-4-N-(3-methylphenyl)pyrimidine-2,4-diamine | IC50 | 8.0 [1], 28.0 [2] |
 | 4-N-(2,5-Dimethylphenyl)-2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 19.0 [1], 38.0 [2] |
 | (2-Chloro-5-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanol | IC50 | 2.0 [1], 13.0 [2] |
 | (3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-5-methoxyphenyl)methanol | IC50 | 2.0 [1], 7.0 [2] |
 | 1-(3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)ethanol | IC50 | 35.0 [1], 180.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(5-methoxy-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 10.0 [1], 21.0 [2] |
 | [4-Methyl-3-[methyl-[2-[3-morpholin-4-yl-5-(oxan-4-yloxy)anilino]pyrimidin-4-yl]amino]phenyl]methanol | IC50 | 8.0 [1], 23.0 [2] |
 | [3-[[4-[5-(Hydroxymethyl)-N,2-dimethylanilino]pyrimidin-2-yl]amino]-5-morpholin-4-ylphenyl]-morpholin-4-ylmethanone | IC50 | 17.0 [1], 459.0 [2] |
 | (3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol | IC50 | 12.0 [1] |
 | [4-Methyl-3-[methyl-[2-[3-morpholin-4-yl-5-(1,4-oxazepan-4-yl)anilino]pyrimidin-4-yl]amino]phenyl]methanol | IC50 | 9.0 [1], 28.0 [2] |
 | [4-Methyl-3-[methyl-[2-[3-(4-methylpiperazin-1-yl)-5-morpholin-4-ylanilino]pyrimidin-4-yl]amino]phenyl]methanol | IC50 | 4.0 [1], 32.0 [2] |
 | [4-Methyl-3-[methyl-[2-(3-morpholin-4-yl-5-pyrrolidin-1-ylanilino)pyrimidin-4-yl]amino]phenyl]methanol | IC50 | 16.0 [1], 27.0 [2] |
 | [4-Methyl-3-[methyl-[2-(3-morpholin-4-yl-5-piperidin-1-ylanilino)pyrimidin-4-yl]amino]phenyl]methanol | IC50 | 10.0 [1], 11.0 [2] |
 | [4-Methyl-3-[methyl-[2-[3-morpholin-4-yl-5-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]phenyl]methanol | IC50 | 6.0 [1], 25.0 [2] |
 | (3-((2-(2,6-Dimorpholinopyridin-4-ylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol | IC50 | 8.0 [1], 14.0 [2] |
 | (3-((2-(2,6-Dimorpholinopyrimidin-4-ylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol | IC50 | 15.0 [1], 106.0 [2] |
 | 2-N-(2,6-Dimorpholin-4-ylpyridin-4-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 0.9 [1], 5.0 [2] |
 | 2-N-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 2.6 [1], 24.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(4-methoxypyridin-2-yl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 13.0 [1], 41.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(6-methoxypyridin-2-yl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 6.0 [1], 28.0 [2] |
 | 2-N-(4,6-Dimorpholin-4-ylpyrimidin-2-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 432.0 [1], 12000.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(5-methoxypyridin-3-yl)-4-N-methylpyrimidine-2,4-diamine | IC50 | 2.0 [1], 30.0 [2] |
 | 2-(3-(4-Amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)phenyl)acetamide | IC50 | 20.0 [1], 44.0 [2] |
 | 6-(2-Methoxyphenyl)-4-methyl-7-(2-methylphenyl)purino[7,8-a]imidazole-1,3-dione | IC50 | 47.0 [1], 180.0 [2] |
 | 7-(3-Hydroxyphenyl)-6-(2-methoxyphenyl)-4-methylpurino[7,8-a]imidazole-1,3-dione | IC50 | 213.0 [1], 368.0 [2] |
 | 2-N-[3,5-Bis(methylsulfonyl)phenyl]-4-N-(5-chloro-1,3-benzodioxol-4-yl)pyrimidine-2,4-diamine | IC50 | 114.0 [1], 209.0 [2] |
 | N-[3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-methylsulfonylphenyl]methanesulfonamide | IC50 | 12.0 [1], 2054.0 [2] |
 | 3-(4-(5-Chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-(methylsulfonyl)benzamide | IC50 | 23.0 [1], 22200.0 [2] |
 | 4-N-(5-Chloro-1,3-benzodioxol-4-yl)-2-N-(3-methylsulfonyl-5-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | IC50 | 2.0 [1], 32.0 [2] |
 | 3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-(methanesulfonamido)benzenesulfonamide | IC50 | 1.0 [1], 14117.0 [2] |
 | N-[3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-morpholin-4-ylphenyl]methanesulfonamide | IC50 | 2.0 [1], 170.0 [2] |
 | N-[3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-(methanesulfonamido)phenyl]methanesulfonamide | IC50 | 15.0 [1], 7175.0 [2] |
 | 3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-(methanesulfonamido)benzamide | IC50 | 370.0 [1], 30000.0 [2] |
 | 3-(4-(5-Chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-morpholinobenzamide | IC50 | 13.0 [1], 887.0 [2] |
 | 5-(4-(5-Chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)isophthalamide | IC50 | 77.0 [1], 30000.0 [2] |
 | 1-(5-Bromo-2-methoxyphenyl)-3-[3-[8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]urea | IC50 | 26.0 [1], 50.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(1H-indazol-7-yl)pyrimidine-2,4-diamine | IC50 | 89.0 [1], 3500.0 [2] |
 | (3-(4-((1H-Indazol-4-yl)(methyl)amino)pyrimidin-2-ylamino)phenyl)methanol | IC50 | 21.0 [1], 232.0 [2] |
 | 2-((5-Chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methylsulfonyl)phenylamino)pyrimidin-4-yl)amino)ethanol | IC50 | 121.0 [1], 187.0 [2] |
 | 4-N-(2H-Benzotriazol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamine | IC50 | 115.0 [1], 8600.0 [2] |
 | 3-[[4-[1H-Indazol-4-yl(methyl)amino]pyrimidin-2-yl]amino]-N,N-dimethylbenzamide | IC50 | 29.0 [1], 453.0 [2] |
 | 4-N-(1,3-Benzoxazol-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | IC50 | 219.0 [1], 1350.0 [2] |
 | 4-N-(6-Chloro-1-benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | IC50 | 300.0 [1], 897.0 [2] |
 | (3-(4-(1H-Indazol-4-ylamino)pyrimidin-2-ylamino)phenyl)methanol | IC50 | 204.0 [1], 4400.0 [2] |
 | 4-N-(1,3-Benzoxazol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | IC50 | 549.0 [1], 1760.0 [2] |
 | 4-N-(3-Chloro-2H-indazol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamine | IC50 | 55.0 [1], 227.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(1H-indol-4-yl)pyrimidine-2,4-diamine | IC50 | 117.0 [1], 856.0 [2] |
 | 4-N-(1-Benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | IC50 | 205.0 [1], 460.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)pyrimidine-2,4-diamine | IC50 | 11.0 [1], 302.0 [2] |
 | 2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(3-methyl-2H-indazol-4-yl)pyrimidine-2,4-diamine | IC50 | 67.0 [1], 513.0 [2] |
 | 3-[[4-(1H-Indazol-4-ylamino)pyrimidin-2-yl]amino]-N,N-dimethylbenzamide | IC50 | 246.0 [1], 10400.0 [2] |
 | 4-N-(1,3-Benzodioxol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | IC50 | 34.0 [1], 186.0 [2] |
 | 4-N-(5-Chloro-1,3-benzodioxol-4-yl)-4-N-methyl-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | IC50 | 36.0 [1], 42.0 [2] |
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