Epidermal growth factor receptor and ErbB2 (HER1 and HER2) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amine	IC50	12.0 [1], 110.0 [2]
	4-[4-[(1-Benzylindazol-5-yl)amino]quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amine	IC50	12.0 [1], 89.0 [2]
	4-[4-(3-Chloro-4-phenylmethoxyanilino)quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amine	IC50	11.0 [1], 290.0 [2]
	4-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amine	IC50	54.0 [1], 2450.0 [2]
	N-(2-Methylsulfonylethyl)-4-[4-(4-phenylmethoxyanilino)quinazolin-6-yl]-1,3-thiazol-2-amine	IC50	28.0 [1], 1320.0 [2]
	N-(2-Methylsulfonylethyl)-4-[4-[4-[[3-(trifluoromethyl)phenyl]methoxy]anilino]quinazolin-6-yl]-1,3-thiazol-2-amine	IC50	320.0 [1], 7400.0 [2]
	N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	70.0 [1]
	Tyrphostin AG 825	IC50	350.0 [1]
	4-(3-Bromoanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	190.0 [1]
	4-(3,4-Dimethoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	50490.0 [1]
	4-(3-Chloro-4-fluoroanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	540.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 20	IC50	13850.0 [1]
	6,7-Dialkoxyquinoline deriv. 53	IC50	34220.0 [1]
	2-Cyano-3-(4-hydroxy-3-methoxy-5-((phenylthio)methyl)phenyl)-2-propenamide	IC50	130.0 [1]
	4-[4-(4-Fluorophenyl)-2-(1-methylpiperidin-4-yl)-1,3-thiazol-5-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amine	IC50	280.0 [1]
	3-[3-(2-Chloro-benzylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide	IC50	250.0 [1]
	(3-Chloro-4-fluoro-phenyl)-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine	IC50	602000.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 55	IC50	350.0 [1]
	(E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide	IC50	2000.0 [1]
	2-[5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-benzoic acid	IC50	8000.0 [1]
	2-Cyano-3-[4-hydroxy-3-methoxy-5-(pyridin-2-ylsulfanylmethyl)-phenyl]-acrylamide	IC50	700.0 [1]
	2-Cyano-3-[4-hydroxy-3-[[(2-carboxyphenyl)thio]methyl]-5-methoxyphenyl]propenamide	IC50	450.0 [1]
	2-[3-Methyl-4-hydroxy-5-methoxybenzylidene]propanedinitrile	IC50	112000.0 [1]
	2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl)-benzylidene]-malononitrile	IC50	17400.0 [1]
	3-[3-(5-Chloro-benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide	IC50	15000.0 [1]
	2-Cyano-3-[4-hydroxy-3-[(benzylthio)methyl]-5-methoxyphenyl]propenamide	IC50	200.0 [1]
	3-(3-Benzylsulfanylmethyl-4,5-dihydroxy-phenyl)-2-cyano-acrylamide	IC50	1020.0 [1]
	3-[3-(2-Acetylamino-phenylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide	IC50	3300.0 [1]
	2-(4-Hydroxy-3-methoxy-5-phenylsulfanylmethyl-benzylidene)-malononitrile	IC50	2500.0 [1]
	3-[3-(1H-Benzoimidazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide	IC50	6100.0 [1]
	3-[3-(Benzooxazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide	IC50	1500.0 [1]
	2-Cyano-3-(4-hydroxy-3-methoxy-5-p-tolylsulfanylmethyl-phenyl)-acrylamide	IC50	1650.0 [1]
	4-(3-Bromoanilino)-6,7-diethoxyquinoline-3-carbonitrile	IC50	420.0 [1]
	4-(3-Chloro-4-fluoroanilino)-6,7-diethoxyquinoline-3-carbonitrile	IC50	980.0 [1]
	4-(3-Chloroanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	180.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 10	IC50	1450.0 [1]
	4-(3-Fluoroanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	740.0 [1]
	4-(3-Cyanoanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	14180.0 [1]
	4-[(4-Fluorophenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile	IC50	47940.0 [1]
	4-(3-Acetylanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	7380.0 [1]
	4-(3-Aminoanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	820.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 18	IC50	870.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 21	IC50	6360.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 22	IC50	2730.0 [1]
	3-[(3-Cyano-6,7-dimethoxyquinolin-4-yl)amino]benzamide	IC50	7690.0 [1]
	4-(3-Bromo-4-methylanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	1790.0 [1]
	4-(3-Chloro-4-hydroxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	9040.0 [1]
	4-(3,5-Dichloro-4-hydroxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	3150.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 27	IC50	17020.0 [1]
	4-(3-Chloro-4-methylanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	1480.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 31	IC50	230.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 32	IC50	360.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 33	IC50	62320.0 [1]
	4-(4-Bromoanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	6650.0 [1]
	4-(2-Bromoanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	4180.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 37	IC50	840.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 38	IC50	620.0 [1]
	4-(3-Azidoanilino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	2210.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 40	IC50	69400.0 [1]
	4-(3-Bromophenylamino)-6-ethoxy-7-methoxyquinoline-3-carbonitrile	IC50	21190.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 49	IC50	33020.0 [1]
	4-(3-Bromoanilino)-6,7-dimethoxyquinoline-3-carbaldehyde	IC50	3370.0 [1]
	6,7-Dialkoxyquinoline deriv. 54	IC50	15170.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 56	IC50	6750.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 57	IC50	1100.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 58	IC50	6790.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 59	IC50	5150.0 [1]
	6,7-Dimethoxyisoquinoline-4-carbonitrile deriv. 62	IC50	88290.0 [1]
	6-Alkoxy-4-anilinoquinazoline 8f	IC50	540.0 [1]
	2-(3,4-Dihydroxy-5-methylbenzylidene)malononitrile	IC50	59000.0 [1]
	4-[1-[2-(Cyclopentylamino)pyrimidin-4-yl]-2-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-1-methylpiperidin-4-ol	IC50	10000.0 [1]
	2-Methyl-5-(6-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol	IC50	644000.0 [1]
	2-Methyl-5-(7-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol	IC50	101000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	2500000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-6-methylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	509000.0 [1]
	N-(3-Chloro-4-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	345000.0 [1]
	3-(3-Benzylsulfanylmethyl-4-hydroxy-5-methoxy-phenyl)-2-(3,4-dihydroxy-benzoyl)-acrylonitrile	IC50	6200.0 [1]
	3-[3-(Benzothiazol-2-ylsulfanylmethyl)-4,5-dihydroxy-phenyl]-2-cyano-acrylamide	IC50	8100.0 [1]
	4-[[5-[(E)-3-Amino-2-cyano-3-oxoprop-1-enyl]-2-hydroxy-3-methoxyphenyl]methylsulfanyl]butanoic acid	IC50	16000.0 [1]
	2-Cyano-3-[4-hydroxy-3-(4-hydroxy-phenylsulfanylmethyl)-5-methoxy-phenyl]-acrylamide	IC50	1600.0 [1]
	3-[3-(4-Chloro-benzylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide	IC50	3000.0 [1]
	2-Cyano-3-[4-hydroxy-3-methoxy-5-(naphthalen-2-ylsulfanylmethyl)-phenyl]-acrylamide	IC50	4600.0 [1]
	[5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-acetic acid	IC50	91000.0 [1]
	4-[5-[2-(Cyclohexylamino)pyridin-4-yl]-4-(4-fluorophenyl)-1,3-oxazol-2-yl]piperidin-4-ol	IC50	1100.0 [1]
	6,7-Dimethoxy-4-(3-methylsulfanylanilino)quinoline-3-carbonitrile;hydrochloride	IC50	760.0 [1]
	4-[3-(Dimethylamino)anilino]-6,7-dimethoxyquinoline-3-carbonitrile;hydrochloride	IC50	850.0 [1]
	1-(3-Bromoanilino)-6,7-dimethoxyisoquinoline-4-carbonitrile;hydrochloride	IC50	70840.0 [1]
	4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinoline-3-carbonitrile;hydrochloride	IC50	91200.0 [1]
	4-[4-Fluoro-3-(trifluoromethyl)anilino]-6,7-dimethoxyquinoline-3-carbonitrile;hydrochloride	IC50	160.0 [1]
	4-Anilino-6,7-dialkoxyquinoline deriv. 5	IC50	81300.0 [1]
	6,7-Dialkoxyquinoline-3-carbonitrile deriv. 50	IC50	104700.0 [1]
	6,7-Dialkoxyquinoline deriv. 51	IC50	102200.0 [1]
	N-Cyclopentyl-4-[2-(4-fluorophenyl)-5-(4-methylpiperazin-1-yl)imidazo[4,5-b]pyridin-1-yl]pyrimidin-2-amine	IC50	10000.0 [1]
	2-Methyl-5-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol	IC50	270000.0 [1]
	5-O-(4-Fluorophenyl) 1-O-[4-[(E)-2-nitroethenyl]phenyl] pentanedioate	IC50	10000.0 [1]
	Pentanedioic acid 4-((E)-2-nitro-vinyl)-phenyl ester phenyl ester	IC50	420.0 [1]
	[4-[(E)-2-Nitroethenyl]phenyl] 5-anilino-5-oxopentanoate	IC50	10000.0 [1]
	1-O-Benzyl 5-O-[4-[(E)-2-nitroethenyl]phenyl] pentanedioate	IC50	10000.0 [1]
	Pentanedioic acid 4-methoxy-phenyl ester 4-((E)-2-nitro-vinyl)-phenyl ester	IC50	1000.0 [1]
	Pentanedioic acid furan-2-ylmethyl ester 4-((E)-2-nitro-vinyl)-phenyl ester	IC50	290.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Epidermal growth factor receptor and ErbB2 (HER1 and HER2) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/epidermal-growth-factor-receptor-and-erbb2-her1-and-her2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Epidermal growth factor receptor and ErbB2 (HER1 and HER2) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/epidermal-growth-factor-receptor-and-erbb2-her1-and-her2-inhibitors-ic50-ki.
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