Equilibrative nucleoside transporter 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-Nitrobenzylthioinosine	IC50	0.3 [1], 8.51 [2]
	4-Nitrobenzylthioinosine	Ki	0.43 [1], 0.71 [2]
	(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol	IC50	1698.24 [1]
	(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol	Ki	19.95 [1], 53.0 [2]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(5-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diol	IC50	3019.95 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(5-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diol	Ki	250.0 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(8-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diol	IC50	3630.78 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(8-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diol	Ki	300.0 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(6-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diol	IC50	181.97 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(6-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diol	Ki	15.0 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(7-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diol	IC50	5.5 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(7-nitro-3,4-dihydro-1H-isoquinolin-2-yl)purin-9-yl]oxolane-3,4-diol	Ki	0.45 [1]
	Dipyridamole	Ki	8.18 [1], 8.79 [2]
	Nbtgr	IC50	21.38 [1]
	Nbtgr	Ki	1.1 [1]
	6-S-((4-Chlorophenyl)methyl)-6-thioinosine	Ki	14.23 [1], 14.79 [2]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(2-methylphenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol	IC50	6309.57 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(2-methylphenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol	Ki	67.61 [1]
	(2R,3R,4S,5R)-2-[6-[(2-Chlorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	99.49 [1], 117.49 [2]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(m-tolylmethylsulfanyl)purin-9-yl]tetrahydrofuran-3,4-diol	IC50	12022.64 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(m-tolylmethylsulfanyl)purin-9-yl]tetrahydrofuran-3,4-diol	Ki	16.22 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(p-tolylmethylsulfanyl)purin-9-yl]tetrahydrofuran-3,4-diol	IC50	457.09 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(p-tolylmethylsulfanyl)purin-9-yl]tetrahydrofuran-3,4-diol	Ki	15.14 [1]
	(2R,3R,4S,5R)-2-[6-[(4-Bromophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	9.98 [1], 11.48 [2]
	(2R,3R,4S,5R)-2-[6-[(4-Fluorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	9.02 [1], 9.12 [2]
	(2R,3R,4S,5R)-2-[6-[(2-Fluorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	19.87 [1], 23.99 [2]
	9-Benzyl-6-(4-nitro-benzylsulfanyl)-9H-purine	Ki	135.0 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(4-iodophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol	Ki	3.8 [1], 3.88 [2]
	(2R,3R,4S,5R)-2-[6-(3,4-Dihydro-1H-isoquinolin-2-yl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	IC50	1819.7 [1]
	(2R,3R,4S,5R)-2-[6-(3,4-Dihydro-1H-isoquinolin-2-yl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	150.0 [1]
	(2R,3R,4S,5R)-2-[6-[(3-Fluorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	11.21 [1], 12.88 [2]
	(2R,3R,4S,5R)-2-[6-[(3-Chlorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	15.96 [1], 18.2 [2]
	(2R,3R,4S,5R)-2-[6-[(2-Bromophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	134.23 [1], 151.36 [2]
	(2R,3R,4S,5R)-2-[6-[(3-Bromophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	20.54 [1], 20.89 [2]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(2-iodophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol	Ki	16.13 [1], 19.5 [2]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(3-iodophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol	Ki	13.79 [1], 13.8 [2]
	(1R,13R,14S,15R)-7-(7-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol	IC50	331.13 [1]
	(1R,13R,14S,15R)-7-(7-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol	Ki	18.89 [1]
	(1R,13R,14S,15R)-7-(8-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol	IC50	1737800.83 [1]
	(1R,13R,14S,15R)-7-(8-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol	Ki	1000.0 [1]
	(1R,13R,14S,15R)-7-(5-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol	IC50	7413102.41 [1]
	(1R,13R,14S,15R)-7-(5-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol	Ki	1000.0 [1]
	(1R,13R,14S,15R)-7-(6-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol	IC50	245470.89 [1]
	(1R,13R,14S,15R)-7-(6-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol	Ki	1000.0 [1]
	Adenosine	IC50	17000.0 [1]
	Uridine	IC50	52000.0 [1]
	Phlorizin	Ki	1000000.0 [1]
	N6-Cyclopentyladenosine	Ki	1100.0 [1]
	Dilazep	IC50	17.5 [1]
	Lidoflazine	Ki	279.9 [1]
	5-Iodotubercidin	IC50	229086.77 [1]
	6-Methylmercaptopurine riboside	IC50	229086.77 [1]
	N6-Benzyladenosine	IC50	10715.19 [1]
	Kinetin riboside	IC50	36307.81 [1]
	Tecadenoson	IC50	12000.0 [1]
	N6-Phenyladenosine	IC50	32359.37 [1]
	S-(2-Hydroxy-5-nitrobenzyl)-6-thioguanosine	IC50	2.75 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(propan-2-ylamino)purin-9-yl]oxolane-3,4-diol	IC50	257039.58 [1]
	2-(4-Chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol	IC50	77624.71 [1]
	7H-Pyrrolo[2,3-d]pyrimidine-4-thiol, 7-beta-D-ribofuranosyl-	IC50	389045.14 [1]
	N-[(4-Aminophenyl)methyl]adenosine	IC50	4168.69 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[[3-(trifluoromethyl)phenyl]methylsulfanyl]purin-9-yl]oxolane-3,4-diol	Ki	19.05 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(3-nitrophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol	Ki	1.78 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]purin-9-yl]oxolane-3,4-diol	Ki	7.08 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(4-methoxyphenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol	Ki	34.67 [1]
	(2R,3R,4S,5R)-2-[6-[(4-Tert-butylphenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	10000.0 [1]
	Methyl 4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]sulfanylmethyl]benzoate	Ki	46.77 [1]
	4-[[9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]sulfanylmethyl]benzonitrile	Ki	4.57 [1]
	(2R,3R,4S,5R)-2-[6-[(2,4-Dichlorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	4.37 [1]
	(2R,3R,4S,5R)-2-[6-[(2-Chloro-6-fluorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	87.1 [1]
	(2R,3R,4S,5R)-2-[6-[(3,4-Dichlorophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	12.59 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(4-methoxypyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol	IC50	338844.16 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(pentylamino)purin-9-yl]oxolane-3,4-diol	IC50	13489.63 [1]
	9h-Purin-2-amine, 9-propyl-6-[(2-pyridinylmethyl)thio]-	IC50	91201.08 [1]
	9-Butyl-6-(pyridin-2-ylmethylsulfanyl)purin-2-amine	IC50	52480.75 [1]
	2-Hydroxymethyl-5-[6-(2,4,6-trimethyl-benzylsulfanyl)-purin-9-yl]-tetrahydro-furan-3,4-diol	Ki	1905.46 [1]
	(2R,3R,4S,5R)-2-(2-Amino-6-methylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol	IC50	204173.79 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(4-piperidin-1-ylpyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol	IC50	194984.46 [1]
	(2R,3R,4S,5R)-2-(5-Bromo-4-methylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol	IC50	114815.36 [1]
	(2R,3R,4S,5R)-2-[6-(Cyclopentylamino)-8-(propylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Ki	97.0 [1]
	6-[(4-Nitrophenyl)methylsulfanyl]-9-[[2-[4-(trifluoromethyl)phenyl]phenyl]methyl]purine	Ki	39.0 [1]
	2-[6-(4-Nitro-benzylsulfanyl)-purin-9-ylmethyl]-phenol	Ki	39.0 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(3-methoxyphenyl)methylamino]purin-9-yl]oxolane-3,4-diol	IC50	114815.36 [1]
	2-{[6-(2-Hydroxyethoxy)-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl]oxy}ethan-1-ol	Ki	325.2 [1]
	(2R,3R,4S,5R)-2-[2-Amino-6-(3-methyl-5-nitroimidazol-4-yl)sulfanylpurin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	IC50	575439.94 [1]
	(2R,3R,4S,5R)-2-(4-Benzylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol	IC50	5248.07 [1]
	CID 25195323	Ki	1000000.0 [1]
	N-(3-Methylbutyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	234422.88 [1]
	(2R,3R,4S,5R)-2-[2-Amino-6-(pyridin-2-ylmethylsulfanyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	IC50	34673.69 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-phenylmethoxypurin-9-yl)oxolane-3,4-diol	IC50	2089.3 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(thiophen-2-ylmethylamino)purin-9-yl]oxolane-3,4-diol	IC50	17782.79 [1]
	3-[4-[3-(3,4,5-Trimethoxybenzoyl)oxypropyl]piperazin-1-yl]propyl 3,4,5-trimethoxybenzoate	IC50	66.1 [1]
	6-Ethylthioinosine	IC50	57543.99 [1]
	2-N,2-N,6-N,6-N-Tetrakis(2-methoxyethyl)-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diamine	Ki	91.6 [1]
	9-(2,5-Difluoro-benzyl)-6-(4-nitro-benzylsulfanyl)-9H-purine	Ki	1637.0 [1]
	9-(2,4-Difluoro-benzyl)-6-(4-nitro-benzylsulfanyl)-9H-purine	Ki	4877.0 [1]
	6-(4-Nitro-benzylsulfanyl)-9-phenethyl-9H-purine	Ki	2200.0 [1]
	2-[6-(4-Nitro-benzylsulfanyl)-purin-9-ylmethyl]-phenylamine	Ki	124.0 [1]
	9-(2-Methoxy-benzyl)-6-(4-nitro-benzylsulfanyl)-9H-purine	Ki	110.0 [1]
	9-(3-Methoxy-benzyl)-6-(4-nitro-benzylsulfanyl)-9H-purine	Ki	264.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Equilibrative nucleoside transporter 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/equilibrative-nucleoside-transporter-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Equilibrative nucleoside transporter 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/equilibrative-nucleoside-transporter-1-inhibitors-ic50-ki.
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