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Estrogen receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
EstradiolIC500.01 [1], 0.7 [2], 1.5 [3]
EstradiolKi0.11 [1], 0.12 [2], 0.14 [3], 0.18 [4], 0.38 [5]
TamoxifenIC50580.0 [1]
TamoxifenKi11.9 [1], 34.4 [2], 157.0 [3]
RaloxifeneIC500.34 [1]
AcolbifeneIC500.14 [1], 0.55 [2]
AcolbifeneKi0.04 [1], 0.05 [2], 0.07 [3], 0.08 [4]
FulvestrantIC500.21 [1], 4.0 [2], 5.0 [3]
FulvestrantKi0.67 [1], 0.76 [2], 7.63 [3]
AfimoxifeneIC500.5 [1], 2.6 [2], 3.0 [3], 7.0 [4]
AfimoxifeneKi0.25 [1], 0.35 [2]
Unii-xcr716lecpIC500.14 [1], 1.3 [2]
Unii-xcr716lecpKi0.02 [1], 4.71 [2], 11.14 [3]
ProgesteroneIC501000.0 [1], 10000.0 [2]
ProgesteroneKi10000.0 [1]
MifepristoneIC501000.0 [1], 2244.0 [2], 10000.0 [3]
MifepristoneKi10000.0 [1]
(Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)-phenyl)-2-phenylbut-1-en-1-yl)phenolIC501.58 [1], 2.6 [2], 10.0 [3], 510.0 [4]
N-n-Butyl-N-methyl-11-(3,17beta-dihydroxyestra-1,3,5(10)-trien-7alpha-yl)undecanamideKi1.53 [1], 1.76 [2], 2.33 [3], 4.6 [4]
(2S,3R)-3-(4-Hydroxyphenyl)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-olIC502.8 [1], 3.0 [2], 9.6 [3]
(2R)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-olIC508.4 [1], 15.0 [2]
(2R)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-olKi1.89 [1], 2.09 [2]
OnapristoneIC501000.0 [1]
OnapristoneKi20.0 [1]
[4-[(2R)-7-(2,2-Dimethylpropanoyloxy)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-3-yl]phenyl] 2,2-dimethylpropanoateIC5036.2 [1]
[4-[(2R)-7-(2,2-Dimethylpropanoyloxy)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-3-yl]phenyl] 2,2-dimethylpropanoateKi4.22 [1], 270.0 [2]
2-(4-Hydroxyphenyl)-3-methyl-1-(10-pentylsulfonyldecyl)-5-indololIC501.4 [1], 20.0 [2], 50.0 [3]
4-[(E)-4-(4-Hydroxyphenyl)-10-[methyl-[3-(4,4,5,5,5-pentafluoropentylsulfanyl)propyl]amino]dec-3-en-3-yl]phenolIC500.22 [1], 7.0 [2], 10.0 [3]
3-[(E)-3-(4-Hydroxyphenyl)-14-pentylsulfonyltetradec-3-en-4-yl]phenolIC5049.0 [1], 270.0 [2], 370.0 [3]
4-[(E)-4-(4-Hydroxyphenyl)-14-pentylsulfonyltetradec-3-en-3-yl]phenolIC505.1 [1], 100.0 [2], 130.0 [3]
3-[(E)-4-(4-Hydroxyphenyl)-14-pentylsulfonyltetradec-3-en-3-yl]phenolIC506.1 [1], 50.0 [2], 110.0 [3]
4-[(E)-4-(4-Hydroxyphenyl)-10-[methyl(3-pentylsulfanylpropyl)amino]dec-3-en-3-yl]phenolIC500.75 [1], 10.0 [2]
DiethylstilbestrolKi0.13 [1]
Medroxyprogesterone acetateIC50924.0 [1]
Raloxifene hydrochlorideIC500.37 [1], 4.32 [2]
LasofoxifeneIC500.1 [1], 2.3 [2]
E-GuggulsteroneIC505000.0 [1]
E-GuggulsteroneKi5000.0 [1]
GuggulsteroneIC505000.0 [1]
GuggulsteroneKi5000.0 [1]
MoxestrolIC502.5 [1], 2.9 [2]
Unii-IS4M82C29XIC509.5 [1]
[(5R)-2-(2,2-Dimethylpropanoyloxy)-5-[4-(2-piperidin-1-ylethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromen-8-yl] 2,2-dimethylpropanoateIC50175.0 [1], 510.0 [2]
Rac-AcolbifeneIC500.24 [1]
Rac-AcolbifeneKi0.03 [1]
2-[4-(2-Piperidinoethoxy)phenyl]-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-olIC504.6 [1]
2-[4-(2-Piperidinoethoxy)phenyl]-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-olKi0.53 [1]
(R)-5-Bromo-2-((2,2-dimethyl-6-methylenecyclohexyl)methyl)-4-methoxyphenolIC5010000.0 [1]
(R)-5-Bromo-2-((2,2-dimethyl-6-methylenecyclohexyl)methyl)-4-methoxyphenolKi10000.0 [1]
5-[4-(2-Piperidin-1-ylethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene-2,8-diolIC5012.0 [1], 110.0 [2]
(5S)-5-[4-(2-Piperidin-1-ylethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene-2,8-diolIC5017.1 [1], 416.0 [2]
(5R)-5-[4-(2-Piperidin-1-ylethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene-2,8-diolIC5043.3 [1], 599.0 [2]
[(5S)-2-(2,2-Dimethylpropanoyloxy)-5-[4-(2-piperidin-1-ylethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromen-8-yl] 2,2-dimethylpropanoateIC5099.0 [1], 670.0 [2]
12-[4-(2-Piperidin-1-ylethoxy)phenyl]-7,12-dihydrobenzo[a]anthracene-3,11-diolIC5068.0 [1], 580.0 [2]
[2-(4-Ethynylphenyl)-6-hydroxy-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanoneIC500.8 [1]
1-Nitro-4-[(2-methylene-4,6,6-trimethyl-3-cyclohexenyl)methyl]benzeneIC5010000.0 [1]
1-Nitro-4-[(2-methylene-4,6,6-trimethyl-3-cyclohexenyl)methyl]benzeneKi10000.0 [1]
12-[4-(2-Piperidin-1-ylethoxy)phenyl]-7,12-dihydrobenzo[a]anthracene-3,10-diolIC506.6 [1], 130.0 [2]
12-[4-(2-Piperidin-1-ylethoxy)phenyl]-7,12-dihydrobenzo[a]anthracene-3,8-diolIC502.9 [1], 50.0 [2]
4-[6-Hydroxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]benzoic acidIC50325.0 [1]
Ethyl 4-[6-hydroxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]benzoateIC5050.0 [1]
1-[4-[6-Hydroxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]phenyl]ethanoneIC5032.0 [1]
[2-(4-Diethoxyphosphorylphenyl)-6-hydroxy-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanoneIC50210.0 [1]
4-[6-Hydroxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]benzamideIC50200.0 [1]
4-[6-Hydroxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]-N,N-dimethylbenzamideIC5020.0 [1]
1-[2-(4-Hydroxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-6-yl]ethanoneIC5060.0 [1]
Methyl 4-[6-hydroxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]benzoateIC5050.0 [1]
3-[(E)-4-(4-Hydroxyphenyl)-14-pentylsulfanyltetradec-3-en-3-yl]phenolIC50200.0 [1], 590.0 [2]
N,N-Dimethyl-2-[4-(4-phenyl-2,3-dihydro-1-benzoxepin-5-yl)phenoxy]ethanamineIC5016200.0 [1]
N,N-Dimethyl-2-[4-(4-phenyl-2,3-dihydro-1-benzoxepin-5-yl)phenoxy]ethanamineKi3200.0 [1]
N,N-Dimethyl-2-[4-[4-(4-methylphenyl)-2,3-dihydro-1-benzoxepin-5-yl]phenoxy]ethanamineIC5015700.0 [1]
N,N-Dimethyl-2-[4-[4-(4-methylphenyl)-2,3-dihydro-1-benzoxepin-5-yl]phenoxy]ethanamineKi828000.0 [1]
3-[(E)-3-(4-Hydroxyphenyl)-14-pentylsulfanyltetradec-3-en-4-yl]phenolIC501200.0 [1], 2100.0 [2]
4-[(E)-4-(4-Hydroxyphenyl)-14-pentylsulfanyltetradec-3-en-3-yl]phenolIC50790.0 [1], 1400.0 [2]
5-[4-(2-Pyrrolidin-1-ylethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene-2,8-diolIC5080.0 [1], 150.0 [2]
5-[4-[2-(Dimethylamino)ethoxy]phenyl]-5,11-dihydrochromeno[4,3-c]chromene-2,8-diolIC50180.0 [1], 220.0 [2]
5-[4-(2-Morpholin-4-ylethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene-2,8-diolIC50410.0 [1], 1400.0 [2]
5-[4-[2-(Azepan-1-yl)ethoxy]phenyl]-5,11-dihydrochromeno[4,3-c]chromene-2,8-diolIC5013.0 [1], 660.0 [2]
6-(4-Fluorophenyl)-5-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}naphthalen-2-olIC500.34 [1], 3.18 [2]
2-(4-Hydroxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophene-6-carboxamideIC5030.0 [1], 1000.0 [2]
11-[4-(1-Hydroxy-3-piperidin-1-ylpropyl)phenyl]-6,11-dihydronaphtho[2,3-b][1]benzothiole-3,9-diolIC500.9 [1], 53.0 [2]
11-[4-(1-Hydroxy-3-piperidin-1-ylpropyl)phenyl]-6,11-dihydronaphtho[6,7-b][1]benzothiole-3,10-diolIC5042.0 [1], 680.0 [2]
11-[4-(1-Hydroxy-3-piperidin-1-ylpropyl)phenyl]-6,11-dihydronaphtho[2,3-b][1]benzothiol-3-olIC5017.0 [1], 710.0 [2]
11-[4-(1-Hydroxy-3-piperidin-1-ylpropyl)phenyl]-6,11-dihydronaphtho[3,2-b][1]benzothiole-3,8-diolIC500.7 [1], 45.0 [2]
12-[4-(2-Piperidin-1-ylethoxy)phenyl]benzo[a]anthracene-3,10-diolIC5057.0 [1], 820.0 [2]
11-[4-(1-Hydroxy-3-piperidin-1-ylpropyl)phenyl]naphtho[2,3-b][1]benzothiole-3,9-diolIC501.0 [1], 690.0 [2]
(E)-7,8-Bis(4-hydroxyphenyl)-N-methyl-N-[3-(4,4,5,5,5-pentafluoropentylsulfanyl)propyl]dec-7-enamideIC50310.0 [1], 700.0 [2]
(E)-7,8-Bis(4-hydroxyphenyl)-N-methyl-N-(3-pentylsulfanylpropyl)dec-7-enamideIC50600.0 [1], 19000.0 [2]
12-[4-(2-Piperidin-1-ylethoxy)phenyl]-7,12-dihydrobenzo[a]anthracene-3,9-diolIC501.9 [1], 31.0 [2]
[6-Ethynyl-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanoneIC5020.0 [1]
[6-Diethoxyphosphoryl-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanoneIC50200.0 [1]
6-(4-Methanesulfonyl-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol HydrochlorideIC500.86 [1], 10.7 [2]
6-(4-Hydroxyphenyl)-5-[[4-(2-piperidin-1-ylethoxy)phenyl]methyl]naphthalen-2-ol;hydrochlorideIC500.2 [1], 1.14 [2]
[2-(4-Ethenylphenyl)-6-hydroxy-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanoneIC507.0 [1]
6-(4-Methylsulfonylphenyl)-5-[[4-(2-piperidin-1-ylethoxy)phenyl]methyl]naphthalen-2-olIC503.4 [1], 4.78 [2]
PrednisoloneKi1000.0 [1]
GenisteinIC50990.0 [1]
ApigeninIC5014000.0 [1]
Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-IC507.0 [1]
StallimycinIC5020.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Estrogen receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/estrogen-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Estrogen receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/estrogen-receptor-inhibitors-ic50-ki.
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