Eukaryotic initiation factor 4A-III Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-Chloro-7-fluoro-6-propan-2-yl-1H-indole-2-carboxylic acid	IC50	360.0 [1], 970.0 [2]
	4-Chloro-7-fluoro-6-propan-2-yl-1H-indole-2-carboxylic acid	Ki	430.0 [1]
	Eif4A3-IN-2	IC50	110.0 [1], 200.0 [2]
	Hippuristanol	IC50	40000.0 [1]
	6-Methyl-1H-indole-2-carboxylic acid	IC50	100000.0 [1]
	6-Chloro-1H-indole-2-carboxylic acid	IC50	100000.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanone	IC50	2200.0 [1]
	(4-Bromophenyl)-[(2R)-4-(6-bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]methanone	IC50	60000.0 [1]
	6-Benzyl-3-[3-(1,3-thiazol-5-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione	IC50	100000.0 [1]
	(3S,3'R,5'S)-5-Fluoro-3'-methyl-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one	IC50	100000.0 [1]
	(3S,3'R,5'S)-1'-(1-Benzylimidazole-4-carbonyl)-5-fluoro-3'-methyl-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one	IC50	100000.0 [1]
	6-Benzyl-3-(3-phenylmethoxyphenyl)-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione	IC50	100000.0 [1]
	3-Fluoro-6-propan-2-yl-1H-indole-2-carboxylic acid	IC50	20000.0 [1]
	(3-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanone	IC50	100000.0 [1]
	4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)-1-[(2-phenyl-1,3-oxazol-5-yl)methyl]piperazin-2-one	IC50	100000.0 [1]
	(2-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanone	IC50	100000.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(1-phenylpyrazole-3-carbonyl)piperazin-1-yl]methanone	IC50	100000.0 [1]
	7-Fluoro-6-propan-2-yl-1H-indole-2-carboxylic acid	IC50	6900.0 [1]
	(4-Bromophenyl)-[4-(6-bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]methanone	IC50	420.0 [1]
	[4-(5-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(4-chlorophenyl)methanone	IC50	830.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(5-phenyl-1,3-oxazole-2-carbonyl)piperazin-1-yl]methanone	IC50	100000.0 [1]
	(4-Bromophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanone	IC50	660.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)-1,4-diazepan-1-yl]methanone	IC50	100000.0 [1]
	Eif4A3-IN-1	IC50	260.0 [1]
	(3R,3'S,5'R)-1'-(1-Benzylimidazole-4-carbonyl)-5-fluoro-3'-methyl-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one	IC50	100000.0 [1]
	[4-(4-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(4-chlorophenyl)methanone	IC50	8900.0 [1]
	3-[5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]benzonitrile	IC50	600.0 [1]
	7-Chloro-6-propan-2-yl-1H-indole-2-carboxylic acid	IC50	100000.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(1H-indole-3-carbonyl)piperazin-1-yl]methanone	IC50	2300.0 [1]
	[2-(4-Chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]-phenylmethanone	IC50	11000.0 [1]
	(4-Bromophenyl)-[2-(4-chlorophenyl)-4-(6-methoxypyrazolo[1,5-a]pyridine-3-carbonyl)piperazin-1-yl]methanone	IC50	920.0 [1]
	4-Fluoro-6-propan-2-yl-1H-indole-2-carboxylic acid	IC50	5000.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(1-phenylpyrazole-4-carbonyl)piperazin-1-yl]methanone	IC50	2400.0 [1]
	(4-Chlorophenyl)-[2-cyclohexyl-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanone	IC50	100000.0 [1]
	6-Benzyl-3-[2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione	IC50	100000.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(pyrazolo[1,5-a]pyridine-3-carbonyl)piperazin-1-yl]methanone	IC50	1100.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-[(2-phenyl-1,3-oxazol-5-yl)methyl]piperazin-1-yl]methanone	IC50	100000.0 [1]
	(4-Chlorophenyl)-[2-(3-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanone	IC50	100000.0 [1]
	6-Propan-2-yl-1H-indole-2-carboxamide	IC50	100000.0 [1]
	2-[5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]benzonitrile	IC50	2100.0 [1]
	5-Fluoro-6-propan-2-yl-1H-indole-2-carboxylic acid	IC50	30000.0 [1]
	2-[5-[4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]pyridine-4-carbonitrile	IC50	390.0 [1]
	4-[5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]benzonitrile	IC50	8400.0 [1]
	[4-(6-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(4-chlorophenyl)methanone	IC50	720.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(5-methyl-1-phenylpyrazole-4-carbonyl)piperazin-1-yl]methanone	IC50	1600.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(2-phenyl-1,3-oxazole-4-carbonyl)piperazin-1-yl]methanone	IC50	69000.0 [1]
	(4-Chlorophenyl)-[2-(2-chlorophenyl)-4-(2-phenyl-1,3-oxazole-5-carbonyl)piperazin-1-yl]methanone	IC50	100000.0 [1]
	3-[5-[4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]benzonitrile	IC50	360.0 [1]
	6-Propan-2-yl-2-(2H-tetrazol-5-yl)-1H-indole	IC50	30000.0 [1]
	4-Chloro-6-propan-2-yl-1H-indole-2-carboxylic acid	IC50	1900.0 [1]
	[4-(7-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(4-chlorophenyl)methanone	IC50	1900.0 [1]
	(4-Chlorophenyl)-[2-(4-chlorophenyl)-4-(1H-indazole-3-carbonyl)piperazin-1-yl]methanone	IC50	62000.0 [1]
	[3-(4-Chlorophenyl)-4-[(4-chlorophenyl)methyl]piperazin-1-yl]-(2-phenyl-1,3-oxazol-5-yl)methanone	IC50	100000.0 [1]
	(3R,3'S,5'R)-5-Fluoro-3'-methyl-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one	IC50	100000.0 [1]
	6-Benzyl-3-[3-(pyridin-3-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione	IC50	100000.0 [1]
	3-[4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]pyrazolo[1,5-a]pyridine-6-carbonitrile	IC50	9000.0 [1]
	3-[4-[(3R)-4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-5-methylpyrazol-1-yl]benzonitrile	IC50	100000.0 [1]
	3-[4-[4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-5-methylpyrazol-1-yl]benzonitrile	IC50	580.0 [1]
	5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1-phenyl-3-[3-(trifluoromethyl)phenyl]pyridin-2-one	IC50	140.0 [1]
	4-[(3S)-4-(4-Bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-2H-isoquinolin-1-one	IC50	290.0 [1]
	5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-(3-chlorophenyl)-1H-pyridin-2-one	IC50	290.0 [1]
	[(2S)-4-(6-Bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]-(5-bromopyridin-2-yl)methanone	IC50	280.0 [1]
	5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-(4-chlorophenyl)-1H-pyridin-2-one	IC50	1100.0 [1]
	3-[5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1-methyl-2-oxopyridin-3-yl]benzonitrile	IC50	100.0 [1]
	5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-[3-(trifluoromethyl)phenyl]-1H-pyridin-2-one	IC50	700.0 [1]
	5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-phenyl-1H-pyridin-2-one	IC50	410.0 [1]
	5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1-methyl-3-[3-(trifluoromethyl)phenyl]pyridin-2-one	IC50	750.0 [1]
	5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-(2-chlorophenyl)-1H-pyridin-2-one	IC50	420.0 [1]
	3-[5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-2-oxo-1H-pyridin-3-yl]benzonitrile	IC50	50.0 [1]
	(4-Bromophenyl)-[(2S)-2-(4-chlorophenyl)-4-(isoquinoline-4-carbonyl)piperazin-1-yl]methanone	IC50	1600.0 [1]
	3-[5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-2-oxo-1H-pyridin-3-yl]benzonitrile	IC50	190.0 [1]
	5-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-3-(3-methylsulfonylphenyl)-1H-pyridin-2-one	IC50	490.0 [1]
	(4-Bromophenyl)-[(2S)-2-(4-chlorophenyl)-4-(quinoline-4-carbonyl)piperazin-1-yl]methanone	IC50	2700.0 [1]
	4-[4-(4-Chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-2H-isoquinolin-1-one	IC50	1300.0 [1]
	6-Isopropyl-1H-indole-2-carboxylic acid	IC50	27000.0 [1]
	6-Ethyl-1H-indole-2-carboxylic Acid	IC50	100000.0 [1]
	7-Isopropyl-1H-indole-2-carboxylic acid	IC50	100000.0 [1]
	Methyl 6-isopropyl-1H-indole-2-carboxylate	IC50	100000.0 [1]
	5-Isopropyl-1H-indole-2-carboxylic acid	IC50	100000.0 [1]
	3-[5-[(Z)-(2-Cyclohexyl-5-imino-7-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-ylidene)methyl]furan-2-yl]benzoic acid	IC50	32000.0 [1]
	1-Methyl-6-(1-methylethyl)-1H-indole-2-carboxylic Acid	IC50	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 81 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Eukaryotic initiation factor 4A-III Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/eukaryotic-initiation-factor-4a-iii-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Eukaryotic initiation factor 4A-III Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/eukaryotic-initiation-factor-4a-iii-inhibitors-ic50-ki.
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