Excitatory amino acid transporter 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-YL)-5-oxo-4H-chromene-3-carbonitrile	IC50	123.03 [1], 660.0 [2], 660.69 [3]
	(3s)-3-(Benzyloxy)-L-Aspartic Acid	IC50	1621.81 [1], 2089.3 [2], 817000.0 [3]
	2-Amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile	IC50	9120.11 [1], 9200.0 [2]
	(2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid	IC50	300000.0 [1], 3162277.66 [2]
	(2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid	Ki	3162277.66 [1]
	2-Amino-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	300000.0 [1], 316227.77 [2]
	Glutamic acid	IC50	11481.54 [1]
	Glutamic acid	Ki	31622.78 [1]
	N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine	IC50	851.14 [1], 5000.0 [2]
	2-Amino-3-phenylmethoxybutanedioic acid	IC50	3162.28 [1], 48000.0 [2]
	(2S,4R)-4-(3-Amino-3-oxopropyl)glutamic acid	IC50	3162277.66 [1]
	(2S,4R)-4-(3-Amino-3-oxopropyl)glutamic acid	Ki	3162277.66 [1]
	(4r)-4-[3-(Methylamino)-3-Oxopropyl]-L-Glutamic Acid	IC50	1000000.0 [1]
	(4r)-4-[3-(Methylamino)-3-Oxopropyl]-L-Glutamic Acid	Ki	3162277.66 [1]
	1,2,4-Butanetricarboxylic acid, 4-amino-, (2S,4S)-	IC50	3162277.66 [1]
	1,2,4-Butanetricarboxylic acid, 4-amino-, (2S,4S)-	Ki	3162277.66 [1]
	(2s,4r)-4-(3-Methoxy-3-Oxopropyl) Glutamic Acid	IC50	1000000.0 [1]
	(2s,4r)-4-(3-Methoxy-3-Oxopropyl) Glutamic Acid	Ki	3162277.66 [1]
	2-Amino-4-(2-fluorophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromen-3-yl cyanide	IC50	4786.3 [1]
	2-Amino-4-(2-fluorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile	IC50	316227.77 [1]
	(RS)-2-amino-3-(1-hydroxy-1,2,3-triazol-5-yl)propionate	IC50	100000.0 [1]
	2-Amino-5-oxo-4,7-diphenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	3900.0 [1], 6309.57 [2]
	(2S,4R)-4-(3-Benzylamino-3-oxopropyl)glutamic acid	IC50	1000000.0 [1]
	(2S,4R)-4-(3-Benzylamino-3-oxopropyl)glutamic acid	Ki	1000000.0 [1]
	(2S,4R)-4-(2,2-Diphenylethylamino-3-oxopropyl)glutamic acid	IC50	1000000.0 [1]
	(2S,4R)-4-(2,2-Diphenylethylamino-3-oxopropyl)glutamic acid	Ki	3162277.66 [1]
	(2S,4S)-4-(Hydroxymethyl)glutamic Acid	IC50	3162277.66 [1]
	(2S,4S)-4-(Hydroxymethyl)glutamic Acid	Ki	3162277.66 [1]
	(2S,4S)-4-(Benzyloxymethyl)glutamic Acid	IC50	1000000.0 [1]
	(2S,4S)-4-(Benzyloxymethyl)glutamic Acid	Ki	501187.23 [1]
	2-Amino-4-methyl-7-naphthalen-1-yl-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	338.84 [1], 420.0 [2]
	2-Amino-4-(1,3-benzodioxol-5-yl)-7-methyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile	IC50	316227.77 [1]
	2-Amino-7-benzyl-4-(4-methoxyphenyl)-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	4786.3 [1], 5100.0 [2]
	(2S,4R)-4-(3-Propylamino-3-oxopropyl)glutamic acid	IC50	3162277.66 [1]
	(2S,4R)-4-(3-Propylamino-3-oxopropyl)glutamic acid	Ki	3162277.66 [1]
	Aspartic acid	IC50	9332.54 [1]
	alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID	IC50	1000000.0 [1]
	Dihydrokainic acid	IC50	3162277.66 [1]
	DL-Threo-beta-Hydroxyaspartic acid	IC50	3890.45 [1]
	Hinokinin	IC50	500000.0 [1]
	L-Serine O-sulfate	IC50	100000.0 [1]
	Tfb-tboa	IC50	3.55 [1]
	L-beta-Threo-benzyl-aspartate	IC50	51286.14 [1]
	2-Amino-4-(1,3-benzodioxol-5-yl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile	IC50	3981.07 [1]
	2-Amino-5-oxo-7-phenyl-4-(3-pyridinyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile	IC50	31622.78 [1]
	2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid	IC50	270000.0 [1]
	(2S)-2-Amino-4-(9H-fluoren-2-ylamino)-4-oxobutanoic acid	IC50	300.0 [1]
	(1R,4S,5R,6S)-3-Azabicyclo[3.3.0]octane-4,6-dicarboxylic acid	Ki	127000.0 [1]
	(2S,4R)-4-Propylglutamic acid	Ki	10232.93 [1]
	(1s,2r)-2-[(S)-Amino(Carboxy)methyl]cyclobutanecarboxylic Acid	Ki	200000.0 [1]
	(2S,4R)-4-Pentylglutamic acid	Ki	117489.76 [1]
	(3S)-3-(1-Naphthylmethoxy)-L-aspartic acid	IC50	15000.0 [1]
	(3S)-3-(2-Naphthylmethoxy)-L-aspartic acid	IC50	16000.0 [1]
	2-Amino-4-(4-methoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	2290.87 [1]
	2-Amino-4-[4-(methylsulfanyl)phenyl]-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile	IC50	2754.23 [1]
	2-Amino-4-(4-nitrophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromen-3-yl cyanide	IC50	3630.78 [1]
	2-Amino-4-(1H-indol-3-yl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	100000.0 [1]
	2-Amino-5-oxo-7-phenyl-4-thiophen-2-yl-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	14125.38 [1]
	2-Amino-5-oxo-7-phenyl-4-(4-phenylphenyl)-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	2137.96 [1]
	2-Amino-4-(4-bromothiophen-2-yl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	4677.35 [1]
	2-Amino-4-(2,3-dimethoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	50118.72 [1]
	2-Amino-7-(2-chlorophenyl)-4-(4-methoxyphenyl)-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile	IC50	3235.94 [1]
	(4r)-4-{3-[Hydroxy(Methyl)amino]-3-Oxopropyl}-L-Glutamic Acid	IC50	3000000.0 [1]
	(2S,4R)-2-Amino-4-(2-cyanoethyl)pentanedioic acid	IC50	200000.0 [1]
	(2S,4R)-2-Amino-4-[3-(hydroxyamino)-3-oxopropyl]pentanedioic acid	IC50	1000000.0 [1]
	(2S,4R)-2-Amino-4-(2-aminoethyl)pentanedioic acid	IC50	1000000.0 [1]
	(2S,4R)-2-Amino-4-(3-aminopropyl)pentanedioic acid	IC50	1000000.0 [1]
	(1R,2S)-2-[(S)-Amino(carboxy)methyl]-2-methylcyclobutane-1-carboxylic acid	Ki	200000.0 [1]
	(2S,4R)-4-Ethylglutamic acid	Ki	22908.68 [1]
	5-Methyl-3-hydroxy-alpha-amino-3H-1,2,3-triazole-4-propionic acid	IC50	1000000.0 [1]
	(3S,5S)-2-Aza-bicyclo[2.2.1]heptane-3,5-dicarboxylic acid	Ki	400000.0 [1]
	5-Methyl-1-hydroxy-alpha-amino-1H-imidazole-2-propionic acid	IC50	1000000.0 [1]
	4-Methyl-2-hydroxy-alpha-amino-2H-pyrazole-3-propionic acid	IC50	1000000.0 [1]
	2-Amino-3-(2-hydroxy-2H-pyrazol-3-yl)-propionic acid	IC50	1000000.0 [1]
	2-Methyl-3-hydroxy-alpha-amino-3H-imidazole-4-propionic acid	IC50	1000000.0 [1]
	2-Amino-3-(1-hydroxy-1H-imidazol-2-yl)-propionic acid	IC50	1000000.0 [1]
	2-Amino-3-(3-hydroxy-3H-imidazol-4-yl)-propionic acid	IC50	1000000.0 [1]
	5-Methyl-3-hydroxy-alpha-amino-3H-imidazole-4-propionic acid	IC50	1000000.0 [1]
	(2S,4R)-4-Isobutylglutamic acid	Ki	55000.0 [1]
	(2S)-2-Amino-4-[4-(2-methylphenyl)anilino]-4-oxobutanoic acid	IC50	2000.0 [1]
	(2S,4R)-4-Isopentylglutamic acid	Ki	28840.32 [1]
	(2S,4R)-4-Butylglutamic acid	Ki	50000.0 [1]
	(2S)-2-Amino-4-oxo-4-[[7-(trifluoromethyl)-9H-fluoren-2-yl]amino]butanoic acid	IC50	3800.0 [1]
	(3S)-3-Methoxyaspartic acid	IC50	69000.0 [1]
	(1R,2S)-1-[(2S)-2-Amino-2-carboxyethyl]cyclopropane-1,2-dicarboxylic acid	IC50	300000.0 [1]
	(1S,2S)-1-[(2S)-2-Amino-2-carboxyethyl]cyclopropane-1,2-dicarboxylic acid	IC50	300000.0 [1]
	(1R,2R)-1-[(2S)-2-Amino-2-carboxyethyl]cyclopropane-1,2-dicarboxylic acid	IC50	300000.0 [1]
	(1S,2R)-1-[(2S)-2-Amino-2-carboxyethyl]cyclopropane-1,2-dicarboxylic acid	IC50	300000.0 [1]
	(2S,3S)-2-Amino-3-[[3-[[2-(trifluoromethyl)benzoyl]amino]phenyl]methoxy]butanedioic acid	IC50	30.9 [1]
	(2S)-2-Amino-3-[[4-(trifluoromethyl)phenyl]sulfonylamino]butanedioic acid	IC50	31622.78 [1]
	(2S)-2-Amino-3-[(3,4-difluorophenyl)sulfonylamino]butanedioic acid	IC50	794.33 [1]
	(2S,3R)-2-Amino-3-(benzenesulfonamido)butanedioic acid	IC50	200000.0 [1]
	(2S)-2-Amino-3-(thiophen-2-ylsulfonylamino)butanedioic acid	IC50	9332.54 [1]
	(2S)-2-Amino-3-(phenoxycarbonylamino)butanedioic acid	IC50	79432.82 [1]
	(2S)-2-Amino-3-[(4-methoxyphenyl)sulfonylamino]butanedioic acid	IC50	4073.8 [1]
	(2S)-2-Amino-3-[(4-tert-butylphenyl)sulfonylamino]butanedioic acid	IC50	300000.0 [1]
	(2S)-2-Amino-3-(benzylsulfonylamino)butanedioic acid	IC50	48977.88 [1]
	(2S)-2-Amino-3-[[3-(trifluoromethyl)phenyl]sulfonylamino]butanedioic acid	IC50	100000.0 [1]
	(2S)-2-Amino-3-[(4-nitrophenyl)sulfonylamino]butanedioic acid	IC50	12882.5 [1]
	(2S)-2-Amino-3-[(2-chlorophenyl)sulfonylamino]butanedioic acid	IC50	1700.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Excitatory amino acid transporter 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/excitatory-amino-acid-transporter-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Excitatory amino acid transporter 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/excitatory-amino-acid-transporter-1-inhibitors-ic50-ki.
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