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Fatty acid synthase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
OrlistatIC504630.0 [1], 203000.0 [2]
OrlistatKi280.0 [1]
LansoprazoleIC5093000.0 [1], 124000.0 [2]
LansoprazoleKi5300.0 [1]
CeruleninIC505800.0 [1], 13000.0 [2], 21860.0 [3]
4-[1-[2,4-Dimethyl-5-(6-pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrileIC5012.0 [1], 17.0 [2], 22.0 [3]
ThiolactomycinIC50100000.0 [1], 380000.0 [2]
C75 transIC5032430.0 [1], 59000.0 [2]
(5E)-1-(3,5-Dimethylphenyl)-5-[(5-phenylfuran-2-yl)methylidene]-1,3-diazinane-2,4,6-trioneKi380.0 [1]
3-[[(3R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-5,5-dimethyl-2-(4-quinolin-7-ylphenyl)imidazol-4-oneIC5056.23 [1]
3-[[(3R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-2-[4-(1H-indol-5-yl)phenyl]-5,5-dimethylimidazol-4-oneIC5047.86 [1], 138.04 [2]
3-[[1-(Cyclopropanecarbonyl)azetidin-3-yl]methyl]-2-[4-(8-fluoronaphthalen-2-yl)phenyl]-5,5-dimethylimidazol-4-oneIC50177.83 [1], 346.74 [2]
3-[[(3R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-2-[2-fluoro-4-(1-methylindazol-5-yl)phenyl]-5,5-dimethylimidazol-4-oneIC5093.33 [1], 323.59 [2]
Benzyl (2S)-5-[[(2R,3S)-3-hexyl-4-oxooxetane-2-carbonyl]amino]-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoateIC50160.0 [1], 4350.0 [2]
4-[1-[2,4-Dimethyl-5-[6-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl]benzoyl]piperidin-4-yl]benzonitrileIC50430.0 [1], 990.0 [2]
4-[1-[2,4-Dimethyl-5-(6-morpholin-4-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrileIC5040.0 [1], 73.0 [2]
4-[1-[2,4-Dimethyl-5-(6-methylsulfonyl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrileIC5085.0 [1]
4-[1-[5-[5-(Azetidin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl]-2,4-dimethylbenzoyl]piperidin-4-yl]benzonitrileIC5070.0 [1]
4-[1-[3-(1H-Benzimidazol-2-yl)-4-methylbenzoyl]piperidin-4-yl]benzonitrileIC50980.0 [1]
4-[1-[3-(3H-Imidazo[4,5-c]pyridin-2-yl)-4-methylbenzoyl]piperidin-4-yl]benzonitrileIC50490.0 [1], 590.0 [2]
4-[1-[3-(6-Pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrileIC50130.0 [1]
5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methyl-N-(6-pyrrolidin-1-ylpyridin-3-yl)benzamideIC5035.0 [1]
4-[1-[4-Methyl-3-(6-pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrileIC50107.0 [1]
4-[1-[2-Methyl-5-(6-pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrileIC5060.0 [1]
4-[1-[5-[6-[2-Methoxyethyl(methyl)amino]-3H-imidazo[4,5-c]pyridin-2-yl]-2,4-dimethylbenzoyl]piperidin-4-yl]benzonitrileIC5058.0 [1], 60.0 [2]
4-[1-[2,4-Dimethyl-5-(6-methylsulfonyl-1H-imidazo[4,5-b]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrileIC5070.0 [1]
4-[1-[2,4-Dimethyl-5-(6-piperazin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrileIC50870.0 [1]
4-[1-[3-[6-(3-Hydroxyazetidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylbenzoyl]piperidin-4-yl]benzonitrileIC50300.0 [1]
4-[1-[5-[4-(Azetidin-1-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-2,4-dimethylbenzoyl]piperidin-4-yl]benzonitrileIC50480.0 [1]
4-[1-[4-Methyl-3-[6-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl]benzoyl]piperidin-4-yl]benzonitrileIC50520.0 [1], 990.0 [2]
Chembl4125752IC5028.0 [1], 54.0 [2]
4-[1-[3-[2-(4-Methoxycyclohexyl)-5-(trifluoromethyl)-1H-imidazol-4-yl]-4-methylbenzoyl]azetidin-3-yl]benzonitrileIC509.0 [1], 13.0 [2]
4-[1-[4-(3-Methoxycyclobutyl)-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrileIC50190.0 [1], 270.0 [2]
4-[1-[4-(3-Hydroxycyclobutyl)-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrileIC5070.0 [1], 240.0 [2]
4-[1-[4-(3-Fluorocyclobutyl)-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrileIC502250.0 [1], 5580.0 [2]
MethionineKi150000000.0 [1]
OmeprazoleKi3400.0 [1]
(-)-EpicatechinIC50100000.0 [1]
(-)-Epigallocatechin gallateIC5051970.0 [1]
LuteolinIC5062500.0 [1]
S-Adenosyl-L-homocysteineKi150000.0 [1]
RabeprazoleIC5052000.0 [1]
3-HydroxyflavoneIC50100000.0 [1]
5'-Deoxy-5'-methylthioadenosineKi1500000.0 [1]
alpha-MangostinIC505540.0 [1]
(10E,12Z)-Octadeca-10,12-dienoic acidIC50100000.0 [1]
(5S)-4-Hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]thiophen-2-oneIC50208000.0 [1]
gamma-MangostinIC501240.0 [1]
NorathyriolIC5017850.0 [1]
GentiseinIC5040980.0 [1]
Garcinone EIC503300.0 [1]
(+)-EpicatechinIC501000000.0 [1]
EgonolIC5091070.0 [1]
9-HydroxycalabaxanthoneIC5040640.0 [1]
beta-MangostinIC5024830.0 [1]
1,3-Bis[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]ureaIC5015.8 [1]
7-Chloro-4-hydroxy-3-[3-(2-methoxyphenyl)phenyl]-2-oxo-1H-quinoline-6-carbonitrileIC5019.0 [1]
CID 67376285IC5010.0 [1]
Methylthioadenosine sulfoxideKi500000.0 [1]
(5S)-4-Hydroxy-5-methyl-5-[(1E)-2-methylbuta-1,3-dienyl]thiophen-2-oneIC5096800.0 [1]
[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-dimethylsulfanium;iodideKi2500000.0 [1]
Fas-IN-1IC5010.0 [1]
2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acidKi30000.0 [1]
4-[(2,6-Dihydroxy-3,3-dimethyl-4-oxo-5-propanoylcyclohexa-1,5-dien-1-yl)methyl]-3,5-dihydroxy-6,6-dimethyl-2-propanoylcyclohexa-2,4-dien-1-oneIC5060200.0 [1]
2,4,6,3',5'-PentahydroxybenzophenoneIC508590.0 [1]
3,4,5,3'-TetrahydroxybenzophenoneIC5014760.0 [1]
(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfinyl]butanoic acidKi150000.0 [1]
Benzyl (2S)-5-[[(2R,3S)-4-oxo-3-propyloxetane-2-carbonyl]amino]-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoateIC50160.0 [1]
(3R,4S)-3-Benzyl-4-(2-phenylethyl)oxetan-2-oneKi2500.0 [1]
Chembl4130264IC50360.0 [1]
Chembl4126662IC50300.0 [1]
Chembl4129199IC50160.0 [1]
Chembl4127363IC50460.0 [1]
Chembl4126535IC501100.0 [1]
Chembl4125794IC508510.0 [1]
Chembl4128608IC5033100.0 [1]
Chembl4130300IC50250.0 [1]
Chembl4127681IC50590.0 [1]
Chembl4128858IC50460.0 [1]
Chembl4127223IC508710.0 [1]
Chembl4125982IC50790.0 [1]
Chembl4126572IC50120.0 [1]
Chembl4128202IC508910.0 [1]
Chembl4128043IC50130.0 [1]
Chembl4129240IC5083.0 [1]
6-[[(3R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-5-[4-(1-methylindazol-5-yl)phenyl]-4,6-diazaspiro[2.4]hept-4-en-7-oneIC5030.0 [1]
Chembl4126247IC5020.0 [1]
Chembl4126126IC5042.0 [1]
Chembl4129046IC5050.0 [1]
Chembl4129812IC50200.0 [1]
Chembl4127623IC5020.0 [1]
Chembl4127845IC5010000.0 [1]
Chembl4126387IC50300.0 [1]
2-[4-(1H-Benzimidazol-2-yl)phenyl]-3-[[(3R)-1-(cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-5,5-dimethylimidazol-4-oneIC505888.44 [1]
3-[[(3R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-5-(methoxymethyl)-5-methyl-2-[4-(1-methylindazol-5-yl)phenyl]imidazol-4-oneIC50490.0 [1]
3-[[(3R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-5-methyl-2-[4-(1-methylindazol-5-yl)phenyl]-5-phenylimidazol-4-oneIC50160.0 [1]
3-[[(3R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-2-[4-(1H-indol-3-yl)phenyl]-5,5-dimethylimidazol-4-oneIC5041.0 [1]
3-[[(3R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-5,5-dimethyl-2-[4-(1-methylindazol-5-yl)phenyl]imidazol-4-oneIC50140.0 [1]
2-[2-Fluoro-4-[4-(1-methylpyrazol-4-yl)phenyl]phenyl]-3-[[(3R)-1-(1-hydroxycyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-5,5-dimethylimidazol-4-oneIC5030.2 [1]
6-Chloro-N-[2-methyl-5-[4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)piperidine-1-carbonyl]phenyl]pyridine-3-carboxamideIC5093.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Fatty acid synthase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/fatty-acid-synthase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Fatty acid synthase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/fatty-acid-synthase-inhibitors-ic50-ki.
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