Fibroblast growth factor receptor 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Azd4547	IC50	2.5 [1]
	Staurosporine	IC50	1.77 [1], 3.36 [2], 5.8 [3], 34.0 [4]
	Debio-1347	IC50	7.6 [1]
	N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide	IC50	2.29 [1], 2.3 [2], 6.2 [3]
	7-(1,3,4,6,7,8,9,9a-Octahydropyrido[1,2-a]pyrazin-2-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]quinazolin-4-amine	IC50	0.2 [1], 0.4 [2], 0.8 [3]
	4-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	1.6 [1], 24.8 [2], 155.7 [3]
	Infigratinib phosphate	IC50	1.4 [1], 2.0 [2], 4.9 [3]
	Infigratinib	IC50	1.0 [1], 1.2 [2]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	1.0 [1], 10.0 [2]
	Lucitanib	IC50	82.5 [1]
	3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide	IC50	3.08 [1], 8.79 [2]
	N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamide	IC50	246.9 [1], 1700.0 [2]
	2-[2-[4-[4-(4-Tert-butylanilino)phenoxy]-6-methoxyquinolin-7-yl]oxyethylamino]ethanol	IC50	69.0 [1], 88.0 [2]
	3-[[5-[6-[(3-Chlorophenyl)amino]pyrazinyl]-3-pyridinyl]amino]-1-propanol	IC50	210.0 [1]
	N-[4-[[3-(3,5-Dimethoxyphenyl)-7-[4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide	IC50	4.0 [1], 58.0 [2]
	6,6-Dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	360.0 [1]
	2-[4-[6-Chloro-2-[4-(4-methylpiperazin-1-yl)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide	IC50	20.0 [1], 63.0 [2]
	4-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-ethylpiperazin-1-yl)-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]quinazoline-2,4-diamine	IC50	10.0 [1], 100.0 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-5-methoxyquinazolin-4-amine	IC50	100.9 [1], 200.0 [2]
	8-Chloro-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]quinazolin-4-amine	IC50	4.8 [1], 200.0 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-8-methoxyquinazolin-4-amine	IC50	3.9 [1], 200.0 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-8-(4-ethylpiperazin-1-yl)quinazolin-4-amine	IC50	4.3 [1], 13.8 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-ethylpiperazin-1-yl)quinazolin-4-amine	IC50	0.8 [1], 1.2 [2]
	N-[5-[2-(2,6-Dichloro-3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-ethylpiperazin-1-yl)quinazolin-4-amine	IC50	0.3 [1], 1.4 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-methylpiperazin-1-yl)quinazolin-4-amine	IC50	0.7 [1], 1.0 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-propan-2-ylpiperazin-1-yl)quinazolin-4-amine	IC50	0.1 [1], 0.6 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-[3-(dimethylamino)pyrrolidin-1-yl]quinazolin-4-amine	IC50	0.4 [1], 10.0 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]quinazolin-4-amine	IC50	0.1 [1], 0.2 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine	IC50	0.7 [1], 10.8 [2]
	2-Chloro-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-ethylpiperazin-1-yl)quinazolin-4-amine	IC50	0.6 [1], 108.2 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-ethylpiperazin-1-yl)isoquinolin-1-amine	IC50	1.2 [1], 1.8 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-[4-(dimethylamino)piperidin-1-yl]quinazolin-4-amine	IC50	0.3 [1], 17.5 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	0.8 [1], 9.0 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]quinazolin-4-amine	IC50	3.2 [1], 200.0 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-morpholin-4-ylquinazolin-4-amine	IC50	0.4 [1], 3.9 [2]
	4-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-N-(2-morpholin-4-ylethyl)quinazoline-4,7-diamine	IC50	1.3 [1], 13.2 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-ethylpiperazin-1-yl)-2-methylquinazolin-4-amine	IC50	0.6 [1], 105.7 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2-ethyl-7-(4-ethylpiperazin-1-yl)quinazolin-4-amine	IC50	0.5 [1], 24.7 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-(4-ethylpiperazin-1-yl)-2-propylquinazolin-4-amine	IC50	0.7 [1], 90.0 [2]
	5-Chloro-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]quinazolin-4-amine	IC50	16.9 [1], 200.0 [2]
	4-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-N-(2-methoxyethyl)quinazoline-4,7-diamine	IC50	2.7 [1], 10.3 [2]
	7-(4-Cyclobutylpiperazin-1-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]quinazolin-4-amine	IC50	0.1 [1], 0.6 [2]
	4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-isoquinolin-6-ylpyridin-2-yl]phenol	IC50	2.0 [1], 249.0 [2]
	4,5-Difluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	2.8 [1], 288.6 [2]
	2-[5-[[(1R)-2-Hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	3.0 [1], 57.5 [2]
	(2R)-2-[[5-(3-Methyl-2H-indazol-5-yl)-6-phenylpyridin-3-yl]amino]-2-phenylethanol	IC50	26.3 [1], 677.7 [2]
	4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-2-yl]phenol	IC50	6.6 [1], 2281.3 [2]
	2,4-Difluoro-6-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	3.4 [1], 280.1 [2]
	5-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	4.7 [1], 313.3 [2]
	2-Fluoro-6-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	2.5 [1], 293.5 [2]
	4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	8.6 [1], 24.8 [2]
	3-[5-[[(1R)-2-Hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	21.4 [1], 36.2 [2]
	[5-Amino-1-(2-ethyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone	IC50	65.0 [1]
	[5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(6-bromo-1H-indol-2-yl)methanone	IC50	8.9 [1], 19.0 [2]
	[5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-[6-(morpholin-4-ylmethyl)-1H-indol-2-yl]methanone	IC50	3.4 [1], 3.6 [2]
	[5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(6-phenyl-1H-indol-2-yl)methanone	IC50	26.0 [1], 41.0 [2]
	[5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(6-methylsulfonyl-1H-indol-2-yl)methanone	IC50	21.0 [1]
	[5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-[6-[(4,4-difluoropiperidin-1-yl)methyl]-1H-indol-2-yl]methanone	IC50	9.4 [1]
	N-[4-[[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide	IC50	1.0 [1], 64.0 [2]
	4-N-(3,5-Dimethoxyphenyl)-4-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-1-N-propan-2-ylcyclohexane-1,4-diamine	IC50	1.78 [1], 2.4 [2]
	Ibrutinib	IC50	280.0 [1]
	Nintedanib	IC50	37.0 [1]
	Nintedanib esylate	IC50	37.0 [1]
	Ponatinib	IC50	1.3 [1]
	Ceritinib	IC50	260.0 [1]
	PD173074	IC50	5.0 [1]
	Doramapimod	IC50	24000.0 [1]
	Nvp-aew541	IC50	2700.0 [1]
	Pyridone 6	IC50	940.0 [1]
	4-({5-Amino-1-[(2,6-Difluorophenyl)carbonyl]-1h-1,2,4-Triazol-3-Yl}amino)benzenesulfonamide	IC50	220.0 [1]
	Erdafitinib	IC50	4.47 [1]
	Cudc-101	IC50	3430.0 [1]
	1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)urea	IC50	170.0 [1]
	MK-2461	IC50	39.0 [1]
	7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine	Ki	493.0 [1]
	Pyrimidone, 22	IC50	1000.0 [1]
	CID 53246941	IC50	320.0 [1]
	2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one	IC50	140.0 [1]
	CID 59604787	IC50	10000.0 [1]
	N-(4-Chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	IC50	55.0 [1]
	1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	IC50	130.0 [1]
	H3B-6527	IC50	1980.0 [1]
	CID 118295624	IC50	1.3 [1]
	CID 44814409	IC50	10000.0 [1]
	CID 91827382	IC50	4.0 [1]
	6H-Purin-6-one, 2-amino-1,7-dihydro-8-phenyl-	IC50	13460.0 [1]
	4-[(2-Morpholin-4-yl-7H-purin-6-yl)amino]benzenesulfonamide	IC50	10000.0 [1]
	9-Ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	50000.0 [1]
	(4-t-Butylphenyl){4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}methanone	IC50	190.0 [1]
	N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamide	IC50	10000.0 [1]
	4-(1H-Indazol-6-yl)phenol	IC50	3000.0 [1]
	(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione	IC50	1000.0 [1]
	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	IC50	50000.0 [1]
	CID 46864270	IC50	1.5 [1]
	(6s)-6-Phenyl-5,6-Dihydrobenzo[h]quinazolin-2-Amine	IC50	1230.0 [1]
	Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate	IC50	10000.0 [1]
	Pyrazine-Pyridine Biheteroaryl 39	IC50	2360.0 [1]
	Pyrazine-Pyridine Biheteroaryl 41	IC50	1400.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Fibroblast growth factor receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/fibroblast-growth-factor-receptor-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Fibroblast growth factor receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/fibroblast-growth-factor-receptor-2-inhibitors-ic50-ki.
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