Fibroblast growth factor receptor 4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Azd4547	IC50	103.0 [1]
	N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamide	IC50	14.0 [1]
	Infigratinib	IC50	0.82 [1], 60.0 [2], 62.0 [3], 64.0 [4], 71.0 [5]
	2-Formyl-N-[5-(trifluoromethyl)pyridin-2-yl]quinoline-8-carboxamide	IC50	57.0 [1]
	(1S,2S,3R,4R)-3-[[5-Cyano-2-[4-[4-(dimethylamino)piperidin-1-yl]-2-(2-methylpropoxy)anilino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide	IC50	6.9 [1]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2-(prop-2-enoylamino)benzamide	IC50	0.8 [1], 1.5 [2], 3.6 [3], 443.0 [4]
	6-Chloro-N-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-3-nitropyridin-2-amine	IC50	21.0 [1], 32.0 [2], 53.0 [3], 10000.0 [4]
	Nvp-tae 684	IC50	16.0 [1], 20.0 [2], 1920.0 [3]
	N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide	IC50	189.0 [1], 261.0 [2], 261.3 [3]
	N-(5-Cyano-4-methoxypyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	6.3 [1], 72.0 [2]
	N-[5-Cyano-4-(2-methoxyethoxy)pyridin-2-yl]-2-formyl-5,6,7,8-tetrahydropyrido[2,3-b]azepine-9-carboxamide	IC50	175.0 [1], 741.0 [2]
	N-(5-Chloropyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	21.0 [1], 916.0 [2]
	N-[5-Cyano-4-[2-(dimethylamino)ethoxy]pyridin-2-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	10.6 [1], 11.0 [2], 588.0 [3]
	N-(5-Cyanopyrimidin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	45.0 [1], 131.0 [2]
	N-(5-Cyanopyridin-2-yl)-2-formyl-5,6,7,8-tetrahydropyrido[2,3-b]azepine-9-carboxamide	IC50	660.0 [1], 3000.0 [2]
	6-Formyl-N-[5-(trifluoromethyl)pyridin-2-yl]-2,3-dihydropyrido[3,2-b][1,4]oxazine-4-carboxamide	IC50	42.0 [1], 531.0 [2]
	N-(5-Cyano-4-morpholin-4-ylpyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	27.0 [1], 224.0 [2]
	N-[5-Cyano-4-(4-hydroxy-4-methylpiperidin-1-yl)pyridin-2-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	1.2 [1], 24.0 [2]
	N-[5-Cyano-4-(2-methoxyethoxy)pyridin-2-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	1.3 [1], 18.0 [2]
	N-(5-Cyano-4-propan-2-yloxypyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	0.7 [1], 29.0 [2]
	N-(5-Cyanopyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	15.8 [1], 16.0 [2], 108.0 [3]
	7-Formyl-N-(6-methoxypyrimidin-4-yl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	140.0 [1], 3000.0 [2]
	N-(5-Cyano-4-propan-2-yloxypyridin-2-yl)-6-formyl-2,3-dihydropyrrolo[2,3-b]pyridine-1-carboxamide	IC50	1.1 [1], 55.0 [2]
	N-[5-Cyano-4-(oxan-4-yl)pyridin-2-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	17.0 [1], 150.0 [2]
	B-Cell Immunosuppressant	IC50	10000.0 [1]
	8-[[5-(Trifluoromethyl)pyridin-2-yl]carbamoyl]quinoline-2-carboxylic acid	IC50	10000.0 [1]
	2-(Hydroxymethyl)-N-[5-(trifluoromethyl)pyridin-2-yl]quinoline-8-carboxamide	IC50	10000.0 [1]
	2-Formyl-N-[4-(trifluoromethyl)phenyl]quinoline-8-carboxamide	IC50	10000.0 [1]
	Debio-1347	IC50	290.0 [1]
	H3B-6527	IC50	0.2 [1], 1.0 [2]
	N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamide	IC50	4.0 [1], 11.1 [2]
	7-Formyl-N-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	13.0 [1], 13.3 [2]
	7-Formyl-N-pyridin-2-yl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	300.0 [1]
	N-(5-Cyanopyrazin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	33.0 [1]
	2-[4-[6-Chloro-2-[4-(4-methylpiperazin-1-yl)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide	IC50	20.0 [1], 130.0 [2]
	3-[5-Cyano-4-(2-methoxyethylamino)pyridin-2-yl]-1-(6-formylpyridin-2-yl)-1-methylurea	IC50	6.5 [1], 41.0 [2]
	3-[5-Cyano-4-(2-methoxyethylamino)pyridin-2-yl]-1-(6-formylpyridin-2-yl)-1-(2-methoxyethyl)urea	IC50	7.4 [1], 91.0 [2]
	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	23.0 [1], 2800.0 [2]
	7-Formyl-N-(5-methyl-1H-pyrazol-3-yl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide	IC50	790.0 [1], 3000.0 [2]
	N-(5-Cyano-4-propan-2-yloxypyridin-2-yl)-6-formylpyrrolo[2,3-b]pyridine-1-carboxamide	IC50	3.2 [1], 750.0 [2]
	Infigratinib phosphate	IC50	60.0 [1], 168.0 [2]
	4-N-(3,5-Dimethoxyphenyl)-4-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-1-N-propan-2-ylcyclohexane-1,4-diamine	IC50	6.76 [1], 25.12 [2]
	Staurosporine	IC50	148.3 [1]
	Acrylamide	IC50	938.0 [1]
	Nintedanib	IC50	610.0 [1]
	Nintedanib esylate	IC50	610.0 [1]
	Ponatinib	IC50	7.1 [1]
	Ceritinib	IC50	950.0 [1]
	Doramapimod	IC50	7000.0 [1]
	Nvp-aew541	IC50	5000.0 [1]
	Erdafitinib	IC50	6.61 [1]
	3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide	IC50	500.0 [1]
	CID 59604787	IC50	10000.0 [1]
	1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	IC50	560.0 [1]
	CID 118295624	IC50	19.3 [1]
	CID 44814409	IC50	10000.0 [1]
	Roblitinib	IC50	1.9 [1]
	6H-Purin-6-one, 2-amino-1,7-dihydro-8-phenyl-	IC50	20000.0 [1]
	cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol	IC50	2800.0 [1]
	7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine	IC50	10000.0 [1]
	N-[4-[[3-(3,5-Dimethoxyphenyl)-7-[4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide	IC50	32.0 [1]
	6-[2-[(E)-2-[4-(Morpholin-4-ylmethyl)phenyl]ethenyl]pyridin-4-yl]-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one	IC50	10000.0 [1]
	CID 46864270	IC50	34.0 [1]
	Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate	IC50	10000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile	IC50	10000.0 [1]
	N-(3-Imidazo[1,2-b]pyridazin-6-yloxyphenyl)-3-(trifluoromethyl)benzamide	IC50	10000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	2-[3-[[4-[(2,2-Difluoro-3-oxo-4H-1,4-benzoxazin-6-yl)amino]-5-fluoropyrimidin-2-yl]amino]phenoxy]-N-methylacetamide	Ki	217.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	1-[3-[8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	50000.0 [1]
	4-[6-(Benzylamino)imidazo[1,2-B]pyridazin-3-Yl]benzonitrile	IC50	5900.0 [1]
	6-[(2r)-2-(3-Fluorophenyl)pyrrolidin-1-Yl]-3-(Pyridin-2-Yl)imidazo[1,2-B]pyridazine	IC50	9200.0 [1]
	2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid	IC50	5300.0 [1]
	1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol	IC50	4400.0 [1]
	N-[(3R,4S)-4-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]oxolan-3-yl]prop-2-enamide	IC50	13.0 [1]
	N-[2-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamide	IC50	3.0 [1]
	N-[2-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-5-(4-ethylpiperazin-1-yl)-3-methylphenyl]prop-2-enamide	IC50	4.0 [1]
	N-[2-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]phenyl]prop-2-enamide	IC50	8.0 [1]
	4-Chloro-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(5-morpholin-4-ylpyridin-3-yl)ethynyl]benzamide	IC50	5.5 [1]
	7-(1,3,4,6,7,8,9,9a-Octahydropyrido[1,2-a]pyrazin-2-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]quinazolin-4-amine	IC50	52.7 [1]
	Clk1-IN-1	IC50	10000.0 [1]
	[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-(3-methylphenyl)methanone	IC50	4100.0 [1]
	5-[5-Amino-4-(1H-indole-2-carbonyl)pyrazol-1-yl]-1,3-dihydrobenzimidazol-2-one	IC50	50000.0 [1]
	[5-Amino-1-(2-chlorophenyl)pyrazol-4-yl]-(1H-indol-2-yl)methanone	IC50	3100.0 [1]
	[5-Amino-1-(1H-indol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone	IC50	110.0 [1]
	[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-quinolin-6-ylmethanone	IC50	740.0 [1]
	[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-(1H-indol-2-yl)methanone	IC50	200.0 [1]
	[5-Amino-1-(2-methyl-1H-indol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone	IC50	85.0 [1]
	[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]methanone	IC50	160.0 [1]
	[5-Amino-1-(2-chloro-5-hydroxyphenyl)pyrazol-4-yl]-(1-benzofuran-2-yl)methanone	IC50	730.0 [1]
	N-[2-[[5-[(3,5-Dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamide	IC50	188.0 [1]
	N-[3-Chloro-2-[[5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]phenyl]prop-2-enamide	IC50	3.8 [1]
	N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-(trifluoromethyl)phenyl]prop-2-enamide	IC50	24.9 [1]
	N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methoxyphenyl]prop-2-enamide	IC50	4.8 [1]
	N-[3,5-Dichloro-2-[[5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]phenyl]prop-2-enamide	IC50	8.5 [1]
	N-[3-Chloro-2-[[5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-5-fluorophenyl]prop-2-enamide	IC50	2.6 [1]
	N-[2-[[5-[(2,6-Dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-fluorophenyl]prop-2-enamide	IC50	5.3 [1]
	N-[2-[[5-[1-(2,6-Dichloro-3,5-dimethoxyphenyl)ethoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamide	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Fibroblast growth factor receptor 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/fibroblast-growth-factor-receptor-4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Fibroblast growth factor receptor 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/fibroblast-growth-factor-receptor-4-inhibitors-ic50-ki.
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