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Focal adhesion kinase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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8-(4-Ethylphenyl)-5-Methyl-2,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-DioxideIC504200.0 [1]
1-Ethyl-8-(4-Ethylphenyl)-5-Methyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-DioxideIC503200.0 [1]
StaurosporineIC5055.0 [1]
CID 11612883IC5030.0 [1]
2-({5-Chloro-2-[(2-Methoxy-4-Morpholin-4-Ylphenyl)amino]pyrimidin-4-Yl}amino)-N-MethylbenzamideIC506.79 [1]
PF-00562271 free baseIC501.0 [1], 1.5 [2]
N-(4-Tert-Butylbenzyl)-1,5-Dimethyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazin-8-Amine 4,4-DioxideIC50640.0 [1], 2200.0 [2], 7100.0 [3]
CID 11598628IC501.0 [1], 1.5 [2]
(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamideIC5025.0 [1], 133.0 [2], 944.0 [3]
4-[[4-[[(1R,2R)-2-(Dimethylamino)cyclopentyl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-N-methylbenzenesulfonamideIC503800.0 [1], 4500.0 [2]
2-[2-[2-[2-(1,2,3,4-Tetrahydroisoquinolin-6-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC502.4 [1], 25.0 [2], 113.0 [3]
2-[2-[2-[2-[4-(4-Methylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC501.1 [1], 1.9 [2], 80.0 [3]
2-[2-[2-[2-[4-(1-Methylpiperidin-3-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC509.6 [1], 48.0 [2], 240.0 [3]
2-[2-[2-[2-(4-Piperidin-2-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC504.8 [1], 6.1 [2], 127.0 [3]
2-[2-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC502.5 [1], 3.0 [2], 67.0 [3]
2-[2-[2-[2-[3-(4-Methylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC503.4 [1], 31.0 [2], 44.0 [3]
2-(2-(2-((4-(Morpholin-2-yl)phenyl)-amino)-5-(trifluoromethyl)pyrimidin-4-yl-ethyl)phenyl)acetamideIC502.8 [1], 15.0 [2], 30.0 [3]
2-[2-[2-[2-[4-(Piperazin-1-ylmethyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC503.0 [1], 14.0 [2], 66.0 [3]
2-[4-[2-[2-[4-(1-Methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyrimidin-5-yl]acetamideIC507.0 [1], 11.0 [2], 658.0 [3]
2-[2-[2-[2-[4-(1-Methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyridin-3-yl]acetamideIC506.2 [1], 16.0 [2], 81.0 [3]
2-[2-[2-[2-[4-[(4-Methylpiperazin-1-yl)methyl]anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC502.3 [1], 16.0 [2], 169.0 [3]
2-[2-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]propanamideIC506.3 [1], 12.0 [2], 81.0 [3]
2-[2-[2-[2-[4-(4-Aminopiperidin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC500.81 [1], 5.0 [2], 30.0 [3]
2-[2-[2-[2-[4-(1-Methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC502.0 [1], 11.0 [2], 36.0 [3]
2-[2-[2-[2-[4-(1-Ethylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC503.6 [1], 12.0 [2], 67.0 [3]
2-[2-[2-[2-[4-(4-Acetylpiperidin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC500.77 [1], 3.9 [2], 71.0 [3]
Bms-536924IC50150.0 [1]
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dioneIC50650.0 [1], 970.0 [2]
Cep-37440IC502.0 [1], 80.0 [2]
7-Pyridin-2-Yl-N-(3,4,5-Trimethoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-2-AmineIC50200.0 [1], 212.0 [2]
N-Methyl-2-[[4-[(3,4,5-Trimethoxyphenyl)amino]-1,3,5-Triazin-2-Yl]amino]benzamideIC50400.0 [1]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-(4-methylsulfonylphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamineIC501300.0 [1]
1-[4-(6-Amino-9h-Purin-9-Yl)phenyl]-3-[3-Tert-Butyl-1-(4-Methylphenyl)-1h-Pyrazol-5-Yl]ureaIC50266.0 [1], 750.0 [2]
3-[[4-[[(1R,2R)-2-(Dimethylamino)cyclopentyl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-N,N-dimethylbenzamideIC503900.0 [1], 4000.0 [2]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-pyridin-4-yl-5-(trifluoromethyl)pyrimidine-2,4-diamineIC504100.0 [1], 6900.0 [2]
2-[4-[4-[[5-Chloro-7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC505.0 [1], 420.0 [2]
2-[4-[4-[[7-[2-[Methyl(methylsulfonyl)amino]pyridin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5014.0 [1], 750.0 [2]
2-[4-[4-[[7-[2-[Methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5014.0 [1], 610.0 [2]
2-[4-[4-[[7-(4-Methylsulfonylphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC50114.0 [1], 10000.0 [2]
2-[4-[4-[[7-(3-Methylsulfonylphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5025.0 [1], 1010.0 [2]
2-[4-[4-[[7-(3-Methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC502040.0 [1], 10000.0 [2]
2-[4-[4-[[7-[3-(Methanesulfonamido)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5021.0 [1], 660.0 [2]
2-[4-[4-[[7-(6-Methoxypyridin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5039.0 [1], 1190.0 [2]
2-[4-[4-[[7-[3-[Methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5048.0 [1], 10000.0 [2]
2-[4-[4-[[7-[3-(Tert-butylsulfamoyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC505.7 [1], 1340.0 [2]
2-[4-[4-[[7-[3-(Hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5033.0 [1], 1390.0 [2]
2-[4-[4-[[7-(2-Methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5055.0 [1], 690.0 [2]
2-[4-[4-[[5-Methyl-7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5011.0 [1], 1230.0 [2]
N-Methyl-2-[[2-(6-morpholin-4-ylpyridin-3-yl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]benzamideIC5045.0 [1], 107.0 [2]
N-[3-[[[5-Cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC50177.0 [1], 1300.0 [2]
N-[3-[[(5-Cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC50195.0 [1], 1100.0 [2]
N-[3-[[[5-Cyano-2-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC50220.0 [1], 6500.0 [2]
N-[3-[[(5-Cyano-1H-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC502400.0 [1], 10000.0 [2]
N-Methyl-N-[3-[[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl]pyridin-2-yl]methanesulfonamideIC508800.0 [1], 10000.0 [2]
2-[[2-(4-Fluorophenyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]-N-methylbenzamideIC5051.0 [1], 552.0 [2]
N-[3-[[[6-Bromo-2-(4-fluorophenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC504500.0 [1], 10000.0 [2]
2-[[6-Bromo-2-(4-fluorophenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]-N-methylbenzamideIC50170.0 [1], 10000.0 [2]
N-[3-[[[2-(4-Fluorophenyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC5037.0 [1], 2015.0 [2]
N-Methyl-2-[[2-(4-morpholin-4-ylphenyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]benzamideIC5045.0 [1], 83.0 [2]
N-[3-[[[2-(4-Fluorophenyl)-6-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC50130.0 [1], 10000.0 [2]
N-[3-[[[2-(4-Fluorophenyl)-5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC50910.0 [1], 10000.0 [2]
N-[3-[[[2-(4-Fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC504800.0 [1], 10000.0 [2]
N-[3-[[[2-(4-Bromophenyl)-6-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamideIC50700.0 [1], 10000.0 [2]
8-(4-Ethylphenyl)-1,5-dimethylpyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxideIC5077.0 [1], 420.0 [2]
N-(4-Fluorophenyl)-1,5-dimethyl-4,4-dioxopyrazolo[4,3-c][2,1]benzothiazin-8-amineIC504300.0 [1], 30000.0 [2]
N-[(4-Fluorophenyl)methyl]-1,5-dimethyl-4,4-dioxopyrazolo[4,3-c][2,1]benzothiazin-8-amineIC50320.0 [1], 19000.0 [2]
N-[(4-Bromophenyl)methyl]-1,5-dimethyl-4,4-dioxopyrazolo[4,3-c][2,1]benzothiazin-8-amineIC501400.0 [1], 30000.0 [2]
2-[[5-Cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]-N-methylbenzamideIC5037.0 [1], 365.0 [2]
1-[3-Tert-Butyl-1-(4-Methylphenyl)-1h-Pyrazol-5-Yl]-3-[4-(Pyridin-3-Yl)phenyl]ureaIC507000.0 [1], 10000.0 [2]
N-Methyl-2-[[2-pyridin-3-yl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]benzamideIC5057.0 [1], 10000.0 [2]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(4-methylimidazol-1-yl)phenyl]ureaIC507700.0 [1], 10000.0 [2]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-(4-imidazol-1-ylphenyl)ureaIC509100.0 [1], 10000.0 [2]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(4,5-dichloroimidazol-1-yl)phenyl]ureaIC508400.0 [1], 10000.0 [2]
2-[2-[2-[2-(4-Piperazin-1-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC502.1 [1], 10.0 [2]
3-(2-(2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamideIC502.5 [1], 120.0 [2]
2-[2-[2-[2-(4-Piperidin-3-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC501.5 [1], 4.0 [2]
2-[2-[2-[2-[4-(4-Ethylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC502.9 [1], 4.0 [2]
N-Methyl-2-[2-[2-[2-(4-piperazin-1-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC5018.0 [1], 37.0 [2]
2-Methyl-5-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamideIC507.7 [1], 37.0 [2]
2-[3-[2-[2-[4-(1-Methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyrazin-2-yl]acetamideIC507.2 [1], 30.0 [2]
2-[2-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyridin-3-yl]acetamideIC503.5 [1], 5.1 [2]
2-[2-[2-[2-(4-Piperidin-3-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyridin-3-yl]acetamideIC5014.0 [1], 23.0 [2]
2-[3-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyrazin-2-yl]acetamideIC5020.0 [1], 51.0 [2]
2-[2-[2-[2-(4-Pyrrolidin-3-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC507.7 [1], 53.0 [2]
2-[4-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyrimidin-5-yl]acetamideIC5011.0 [1], 68.0 [2]
3-(2-(2-((4-(Piperazin-1-ylmethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamideIC5015.0 [1], 254.0 [2]
2-[2-[2-[4-(1-Methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyridine-4-carboxamideIC505.7 [1], 184.0 [2]
3-(2-(2-((3-(4-Methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamideIC504.2 [1], 52.0 [2]
2-[2-[2-[2-[4-(1-Ethylpiperidin-3-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyridin-3-yl]acetamideIC5046.0 [1], 51.0 [2]
N-Methyl-2-[2-[2-[2-[3-(4-methylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC5013.0 [1], 664.0 [2]
2-[2-[2-[2-[4-(1-Ethylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]pyridin-3-yl]acetamideIC5023.0 [1]
2-[2-[2-[2-[4-(1-Acetylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC500.39 [1], 12.0 [2]
2-[2-[2-[2-[4-(1-Methylpiperidin-2-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC502.5 [1], 7.0 [2]
2-[2-[2-[2-[(2-Methyl-3,4-dihydro-1H-isoquinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC500.3 [1], 10.0 [2]
2-[2-[2-[2-[4-(4-Acetylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamideIC500.6 [1], 70.0 [2]
QuercetinIC501200.0 [1]
ErlotinibIC507400.0 [1]
Sorafenib tosylateIC5010000.0 [1]
SunitinibIC501600.0 [1]
DasatinibIC5050000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Focal adhesion kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/focal-adhesion-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Focal adhesion kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/focal-adhesion-kinase-1-inhibitors-ic50-ki.
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