GABA A receptor alpha-4/beta-3/gamma-2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Ethyl 8-ethynyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	5.3 [1], 53.0 [2]
	CID 5255267	Ki	1550.0 [1]
	CID 9971547	Ki	38.8 [1], 300.0 [2]
	Tert-Butyl beta-carboline-3-carboxylate	Ki	1000.0 [1]
	Ethyl 4-methyl-5-(1-methylethoxy)-9H-pyrido(3,4-b)indole-3-carboxylate	Ki	137.0 [1]
	3-Propoxy-9H-pyrido[3,4-b]indole	Ki	1000.0 [1]
	3-[3-Tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole	Ki	395.0 [1]
	Tert-butyl 5-methyl-6-oxo-8-(2-trimethylsilylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	7.8 [1]
	5-Methyl-8-chloro-3-acetyl-4H-imidazo[1,5-a][1,4]benzodiazepine-6(5H)-one	Ki	2610.0 [1]
	Ethyl 5-methyl-6-oxo-8-(2-trimethylsilylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	159.0 [1]
	8-Chloro-2-(4-methoxy-phenyl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Ki	10000.0 [1]
	5-Methyl-3-(6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)isoxazole	Ki	244.0 [1]
	Ethyl 8-ethynyl-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	1504.0 [1]
	Methyl(4-piperidinyl)phosphinic acid	Ki	340000.0 [1]
	(4-Hydroxy-piperidin-4-yl)-phosphinic acid	Ki	2100000.0 [1]
	(Piperidin-4-yl)phosphonic acid	Ki	3100000.0 [1]
	6-Iodo-9H-beta-carboline-3-carboxylic acid t-butyl ester	Ki	4000.0 [1]
	Tert-butyl 6-[2-[3-[(2-methylpropan-2-yl)oxycarbonyl]-9H-pyrido[3,4-b]indol-6-yl]ethynyl]-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	300.0 [1]
	Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	1000.0 [1]
	3-(8-Ethynyl-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbonyl)oxypropyl 8-ethynyl-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	5000.0 [1]
	Tert-butyl 5-methyl-6-oxo-8-(2-trimethylsilylethynyl)-3a,4-dihydro-1H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	Ki	2.61 [1]
	2-(7-Ethynyl-4-methyl-5-oxoimidazo[1,5-a]quinazoline-3-carbonyl)oxyethyl 7-ethynyl-4-methyl-5-oxoimidazo[1,5-a]quinazoline-3-carboxylate	Ki	1500.0 [1]
	Tert-butyl 6-ethynyl-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	2000.0 [1]
	2,2,2-Trifluoroethyl 6-thiophen-2-yl-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	2000.0 [1]
	2,2,2-Trifluoroethyl 9H-pyrido[3,4-b]indole-3-carboxylate	Ki	500.0 [1]
	[(2S)-1,1,1-Trifluoropropan-2-yl] 9H-pyrido[3,4-b]indole-3-carboxylate	Ki	3000.0 [1]
	2,2,2-Trifluoroethyl 6-phenyl-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	2000.0 [1]
	2,4,5-Trifluorophenyl 9H-pyrido[3,4-b]indole-3-carboxylate	Ki	3000.0 [1]
	1-Phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate	Ki	1000.0 [1]
	CID 52943345	Ki	1000.0 [1]
	Tert-butyl 6-fluoro-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	1000.0 [1]
	Ethyl 6-((trimethylsilyl)ethynyl)-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	2000.0 [1]
	2,2,2-Trifluoroethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	2000.0 [1]
	2,2,2-Trichloroethyl 9H-pyrido[3,4-b]indole-3-carboxylate	Ki	1000.0 [1]
	Tert-butyl 6-tert-butyl-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	1000.0 [1]
	2,2,2-Trifluoroethyl 6-(2-trimethylsilylethynyl)-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	200.0 [1]
	Tert-butyl 6-[4-[3-[(2-methylpropan-2-yl)oxycarbonyl]-9H-pyrido[3,4-b]indol-6-yl]buta-1,3-diynyl]-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	5000.0 [1]
	1,1,1-Trichloropropan-2-yl 9H-pyrido[3,4-b]indole-3-carboxylate	Ki	3000.0 [1]
	[(2R)-1,1,1-Trifluoropropan-2-yl] 9H-pyrido[3,4-b]indole-3-carboxylate	Ki	3000.0 [1]
	2,2,2-Trifluoroethyl 6-ethynyl-9H-pyrido[3,4-b]indole-3-carboxylate	Ki	2000.0 [1]
	CID 52950189	Ki	3000.0 [1]
	CID 52950202	Ki	3000.0 [1]
	Tert-butyl (7S)-15-ethenyl-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	26.0 [1]
	2,2,2-Trifluoroethyl (7S)-15-ethynyl-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	345.0 [1]
	2,2,2-Trifluoroethyl (7S)-15-(furan-2-yl)-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	51.0 [1]
	2,2,2-Trifluoroethyl (7S)-15-ethenyl-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	175.0 [1]
	2,2,2-Trifluoroethyl (7S)-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	333.0 [1]
	Tert-butyl (7S)-12-oxo-15-phenyl-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	114.0 [1]
	Tert-butyl (7S)-15-bromo-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	29.0 [1]
	2,2,2-Trifluoroethyl (7S)-12-oxo-15-(2-trimethylsilylethynyl)-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	333.0 [1]
	Tert-butyl (7S)-12-oxo-15-(2-trimethylsilylethynyl)-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	175.0 [1]
	2,2,2-Trifluoroethyl (7S)-15-bromo-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	291.0 [1]
	Tert-butyl (7S)-15-(furan-2-yl)-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	11.6 [1]
	2,2,2-Trifluoroethyl (7S)-12-oxo-15-phenyl-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	333.0 [1]
	Tert-butyl (7S)-12-oxo-15-thiophen-2-yl-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	119.0 [1]
	Tert-butyl (7S)-15-ethynyl-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate	Ki	213.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ GABA A receptor alpha-4/beta-3/gamma-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/gaba-a-receptor-alpha-4-beta-3-gamma-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ GABA A receptor alpha-4/beta-3/gamma-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/gaba-a-receptor-alpha-4-beta-3-gamma-2-inhibitors-ic50-ki.
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