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GABA-A receptor; anion channel Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DiazepamIC5012.0 [1]
DiazepamKi10.0 [1]
4-Butyl-3-[(3-chlorophenyl)methyl]-1H-1,2,4-triazole-5-thioneIC50370.0 [1], 467.0 [2], 567.0 [3]
4-Butyl-3-[(3-chlorophenyl)methyl]-1H-1,2,4-triazole-5-thioneKi88.0 [1], 93.3 [2], 113.0 [3]
3-[(3-Chlorophenyl)methyl]-4-hexyl-1H-1,2,4-triazole-5-thioneIC50361.0 [1], 535.0 [2], 626.0 [3]
3-[(3-Chlorophenyl)methyl]-4-hexyl-1H-1,2,4-triazole-5-thioneKi116.7 [1], 126.0 [2], 149.0 [3]
MuscimolIC502.0 [1], 16.0 [2], 135.0 [3]
MuscimolKi6.0 [1], 11.0 [2]
(4S)-4-Amino-2-pentenoic acidIC502500.0 [1], 2600.0 [2], 3500.0 [3], 4100.0 [4], 21000.0 [5]
(E,4R)-4-Aminopent-2-enoic acidIC5084000.0 [1], 88000.0 [2], 145000.0 [3], 148000.0 [4], 670000.0 [5]
5-[(R)-1-Aminoethyl]isoxazol-3-olIC508200.0 [1], 8900.0 [2], 9500.0 [3], 19000.0 [4], 83000.0 [5]
5-[(S)-1-Aminoethyl]isoxazol-3-olIC50510.0 [1], 640.0 [2], 740.0 [3], 1600.0 [4], 5800.0 [5]
(R)-4-Aminopentanoic acidIC502500.0 [1], 4300.0 [2], 5000.0 [3], 6100.0 [4], 21000.0 [5]
(S)-4-Aminovaleric acidIC502500.0 [1], 2900.0 [2], 4700.0 [3], 5200.0 [4], 24000.0 [5]
gamma-Aminobutyric acidIC5025.0 [1], 1450.0 [2]
gamma-Aminobutyric acidKi33.0 [1], 200.0 [2]
BicucullineIC506200.0 [1], 15000.0 [2], 44000.0 [3]
OlanzapineKi10000.0 [1]
FlumazenilKi0.9 [1]
ClonazepamIC50555904257.3 [1]
ClonazepamKi0.85 [1]
FlavoneKi17.0 [1], 1000.0 [2]
GabazineIC508.0 [1], 140.0 [2]
AmentoflavoneKi6.0 [1]
DelorazepamIC502.8 [1], 555904257.3 [2]
N-DesmethylolanzapineKi10000.0 [1]
7-Chloro-5-(2,6-dichlorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-oneIC507.0 [1], 181970085.9 [2]
7-Chloro-5-(2,6-dichlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-oneIC505.5 [1], 142889395.9 [2]
2-Hydroxymethyl OlanzapineKi1000.0 [1], 10000.0 [2]
5-[[3-(1,3-Benzodioxol-5-yl)-6-iminopyridazin-1-yl]methyl]-1,2-thiazol-3-one;hydrobromideIC500.76 [1], 17.0 [2]
(5Ar,7R,9aS,11aS)-2-amino-7-hydroxy-9a,11a-dimethyl-3,3a,3b,4,5,5a,6,7,8,9,9b,11-dodecahydronaphtho[2,1-e]indol-10-oneIC503.0 [1], 43.0 [2]
5-[(6-Imino-3-methyl-5-phenylpyridazin-1-yl)methyl]-1,2-thiazol-3-one;hydrobromideIC501000.0 [1], 6600.0 [2]
5-[[6-(4-Chlorophenyl)-3-iminopyridazin-2(3H)-yl]methyl]isoxazol-3-olIC5080.0 [1], 1200.0 [2]
5-[[4-Phenyl-1-iminophthalazin-2(1H)-yl]methyl]isoxazol-3-olIC50120.0 [1], 190.0 [2]
5-[[6-(4-Chlorophenyl)-3-iminopyridazin-2(3H)-yl]methyl]isothiazol-3-olIC5029.0 [1], 150.0 [2]
5-[[4-Phenyl-1-iminophthalazin-2(1H)-yl]methyl]isothiazol-3-olIC5025.0 [1], 160.0 [2]
[2-(5-Imidazo[4,5-b]pyridin-3-yl-1H-indol-3-yl)-ethyl]-dimethyl-amineIC5089.0 [1]
Olanzapine N-OxideKi10000.0 [1]
4-Amino-2,9-dimethyl-9H-pyrido[2,3-b]indole-3-carboxylic acid methyl esterIC502000.0 [1], 14600.0 [2]
Propyl 4-amino-2,9-dimethylpyrido[2,3-b]indole-3-carboxylateIC502000.0 [1], 2200.0 [2]
4-Amino-2,9-dimethyl-9H-pyrido[2,3-b]indole-3-carboxylic acid, ethyl esterIC502000.0 [1], 4600.0 [2]
1-[3-[[(2R)-1-Methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]benzimidazole-5-carbonitrileIC502.8 [1], 3.3 [2]
5-[[6-(1,3-Benzodioxol-5-yl)-3-iminopyridazin-2(3H)-yl]methyl]isoxazol-3-olIC506.0 [1], 75.0 [2]
CocaineIC50127000.0 [1]
LiothyronineIC5023000.0 [1]
PhenytoinKi100000.0 [1]
Sodium valproateKi100000.0 [1]
Tubocurarine chlorideIC5058000.0 [1]
ApigeninKi3019.95 [1]
FlunitrazepamIC50263026799.2 [1]
BaicaleinKi5623.41 [1]
AllopregnanoloneIC5022.0 [1]
BaicalinKi77624.71 [1]
FipronilIC502.3 [1]
ChrysinKi3019.95 [1]
NitrazepamIC50100000000.0 [1]
TemazepamIC5062517269.28 [1]
ZafirlukastIC5010000.0 [1]
WogoninKi2041.74 [1]
9H-Pyrido[3,4-B]indoleIC501621.81 [1]
HarmanIC5012302.69 [1]
NordazepamIC50106414301.8 [1]
IsoguvacineKi55.0 [1]
Ethyl beta-carboline-3-carboxylateIC505.01 [1]
ProgabideKi40000.0 [1]
ScutellareinKi12022.64 [1]
beta-Carboline-3-carboxylic acid methyl esterIC505.01 [1]
HispidulinKi1000.0 [1]
GanaxoloneIC5042.0 [1]
(3-Aminopropyl)(n-butyl)phosphinic acidIC50508000.0 [1]
Bis(7)-TacrineIC506000.0 [1]
Tert-Butyl beta-carboline-3-carboxylateIC5010.0 [1]
HalazepamIC5010864256.24 [1]
Isonipecotic acidKi510.0 [1]
7-AminoflunitrazepamIC5015381546.4 [1]
MeclonazepamIC50833681184.6 [1]
2,5-Dihydro-2-(4-methoxyphenyl)-3H-pyrazolo(4,3-c)quinolin-3-oneIC500.1 [1]
NorfludiazepamIC50500034535.0 [1]
7-AminoclonazepamIC5013335214.32 [1]
CtepKi3160.0 [1]
Sodium N-(alpha-(4-chlorophenyl)-5-fluoro-2-hydroxy-benzylidene)-4-aminobutyrateKi680.0 [1]
BasimglurantKi3160.0 [1]
3-Propoxy-9H-pyrido[3,4-b]indoleIC5010.96 [1]
2-Phenyl-3aH-pyrazolo[4,3-c]quinolin-3-oneIC500.4 [1]
2-Aminonicotinic acidKi100000.0 [1]
2-(4-Chlorophenyl)-3aH-pyrazolo[4,3-c]quinolin-3-oneIC500.6 [1]
6-BromoflavoneKi70.79 [1]
NaluzotanKi2000.0 [1]
NorflunitrazepamIC50666806769.2 [1]
1-Ethyl-9H-pyrido[3,4-b]indoleIC50251188.64 [1]
(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-methyl-3H-1,4-benzodiazepin-2-oneIC50100000.0 [1]
1,3-Dihydro-5-phenyl-2H-1,4-benzodiazepin-2-oneIC502857590.54 [1]
7-AminonitrazepamIC502588212.92 [1]
5-(2-Chlorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-oneIC50454988060.2 [1]
3-Ethoxy-beta-carbolineIC5023.99 [1]
PitrazepinIC50240.0 [1]
6-Aminonicotinic acidKi4400.0 [1]
4'-FluoroflavoneKi3630.78 [1]
N-Benzyl-2-(1H-indol-3-yl)-2-oxoacetamideKi120.23 [1]
3-(N-Methylpyrrolidin-2-ylmethyl)-5-(3-nitropyrid-2-ylamino)-1H-indoleIC509600.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ GABA-A receptor; anion channel Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/gaba-a-receptor-anion-channel-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ GABA-A receptor; anion channel Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/gaba-a-receptor-anion-channel-inhibitors-ic50-ki.
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