Geranylgeranyl pyrophosphate synthetase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Digeranyl bisphosphonate	IC50	200.0 [1]
	Zoledronic acid	IC50	97000.0 [1], 100000.0 [2]
	Zoledronic acid	Ki	2700.0 [1]
	Minodronic acid	IC50	670.0 [1], 65000.0 [2], 100000.0 [3]
	Minodronic acid	Ki	1800.0 [1]
	3-(Decyloxy)-1-(2,2-Diphosphonoethyl)pyridinium	IC50	251.19 [1], 280.0 [2], 250000.0 [3]
	Risedronic acid	IC50	100000.0 [1], 350000.0 [2], 300000000.0 [3]
	(1-Hydroxy-1-Phosphono-2-[1,1';3',1'']Terphenyl-3-Yl-Ethyl)-Phosphonic Acid	IC50	1995.26 [1], 2100.0 [2]
	(1-Hydroxy-1-Phosphono-2-[1,1';3',1'']Terphenyl-3-Yl-Ethyl)-Phosphonic Acid	Ki	60.0 [1]
	[2-(3-Dibenzofuran-4-yl-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid	IC50	3981.07 [1], 4000.0 [2]
	[2-(3-Dibenzofuran-4-yl-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid	Ki	110.0 [1]
	(1-Hydroxy-1-phosphono-2-[1,1';4',1'']terphenyl-3-yl-ethyl)-phosphonic acid	IC50	720.0 [1], 794.33 [2]
	(1-Hydroxy-1-phosphono-2-[1,1';4',1'']terphenyl-3-yl-ethyl)-phosphonic acid	Ki	20.0 [1]
	CID 16122555	IC50	2511.89 [1], 2600.0 [2]
	CID 16122555	Ki	70.0 [1]
	[1-Hydroxy-2-(1,1':3',1''-Terphenyl-3-Yloxy)Ethane-1,1-Diyl]Bis(Phosphonic Acid)	IC50	3981.07 [1], 4100.0 [2]
	[1-Hydroxy-2-(1,1':3',1''-Terphenyl-3-Yloxy)Ethane-1,1-Diyl]Bis(Phosphonic Acid)	Ki	110.0 [1]
	3-Biphenyl-3-Yl-1-(2-Hydroxy-2,2-Diphosphonoethyl)pyridinium	IC50	8200.0 [1], 10000.0 [2]
	3-Biphenyl-3-Yl-1-(2-Hydroxy-2,2-Diphosphonoethyl)pyridinium	Ki	230.0 [1]
	[2-[1-[(3E)-4,8-Dimethylnona-3,7-dienyl]triazol-4-yl]-1-phosphonoethyl]phosphonic acid	IC50	45.0 [1], 170.0 [2]
	Alendronic acid	IC50	398107.17 [1], 440000.0 [2]
	Pamidronic acid	IC50	180000.0 [1], 199526.23 [2]
	Ibandronic Acid	IC50	79432.82 [1], 83000.0 [2]
	(1-Hydroxy-1-phosphonodecyl)phosphonic acid	IC50	630.96 [1], 720.0 [2]
	(1-Hydroxyheptane-1,1-Diyl)bis(Phosphonic Acid)	IC50	10000.0 [1], 11000.0 [2]
	Lauryl alcohol diphosphonic acid	IC50	920.0 [1], 2511.89 [2]
	(2E, 6E)-Farnesylbisphosphonate	IC50	100.0 [1]
	[(7Z)-2,8,12-Trimethyl-5-phosphonotrideca-2,7,11-trien-5-yl]phosphonic acid	IC50	3000.0 [1], 60000.0 [2]
	(2,8-Dimethyl-5-phosphononona-2,7-dien-5-yl)phosphonic acid	IC50	100000.0 [1]
	[2-[1-[(2E)-3,7-Dimethylocta-2,6-dienyl]triazol-4-yl]-1-phosphonoethyl]phosphonic acid	IC50	17000.0 [1]
	Neridronic acid	IC50	690000.0 [1]
	N-Geranyl-N'-(2-adamantyl)ethane-1,2-diamine	IC50	4500.0 [1]
	(1-Hydroxy-2-phenyl-1-phosphonoethyl)phosphonic acid	IC50	220000.0 [1]
	[1-Hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid)	IC50	410000.0 [1]
	{[(3-Methylpyridin-2-Yl)amino]methanediyl}bis(Phosphonic Acid)	IC50	220000.0 [1]
	1-Hydroxy-2-(4-aminophenyl)ethane-1,1-diphosphonic acid	IC50	180000.0 [1]
	1,1-Diphosphono-2-(1H-imidazole-4-yl)ethanol	IC50	220000.0 [1]
	Phosphonic acid, (1-hydroxybutylidene)di-	IC50	620000.0 [1]
	1-Hydroxypentane-1,1-bisphosphonate	IC50	200000.0 [1]
	2-[(Bis-phosphono-methyl)-amino]-4-methyl-pyridinium	IC50	260000.0 [1]
	(1-Hydroxyoctane-1,1-diyl)diphosphonic acid	IC50	4300.0 [1]
	(3-Amino-1-hydroxy-1-phosphono-butyl)-phosphonic acid	IC50	330000.0 [1]
	(1-Hydroxy-1-phosphono-hexyl)-phosphonic acid	IC50	53000.0 [1]
	Deoxy Risedronic Acid	IC50	316227.77 [1]
	4-(2-Hydroxy-2,2-bis-phosphono-ethylsulfanyl)-pyridinium	IC50	550000.0 [1]
	1,1-Diphosphono-1-undecanol	IC50	1400.0 [1]
	{1-Hydroxy-3-[methyl(4-phenylbutyl)amino]propane-1,1-diyl}bis(phosphonic acid)	IC50	3981.07 [1]
	2-Hydroxy-2-phosphono-3-(imidazo[1,2-a]pyridine-3-yl)propanoic acid	IC50	1000000.0 [1]
	[(Octylamino)-phosphonomethyl]phosphonic acid	IC50	2200.0 [1]
	3-Azageranylgeranyl diphosphate	IC50	140.0 [1]
	[(Hexylamino)-phosphonomethyl]phosphonic acid	IC50	19000.0 [1]
	Geranyl biphosphonate	IC50	10000.0 [1]
	Hydroxy-(1-hydroxy-1-phosphono-2-pyridin-1-ium-1-ylethyl)phosphinate	IC50	125892.54 [1]
	1-(2-Hydroxy-2,2-Diphosphonoethyl)-3-Phenylpyridinium	IC50	12589.25 [1]
	Hydroxy-(1-phosphono-2-pyridin-1-ium-1-ylethyl)phosphinate	IC50	158489.32 [1]
	Hydroxy-[2-(3-methylpyridin-1-ium-1-yl)-1-phosphonoethyl]phosphinate	IC50	50118.72 [1]
	[2-(3-Bromopyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate	IC50	100000.0 [1]
	Hydroxy-[2-(3-phenylpyridin-1-ium-1-yl)-1-phosphonoethyl]phosphinate	IC50	10000.0 [1]
	(2-Dimethylsulfonio-1-hydroxy-1-phosphonoethyl)-hydroxyphosphinate	IC50	63095.73 [1]
	Bisphosphonate, 9	IC50	100.0 [1]
	{2-[Dodecyl(methyl)amino]-1-phosphonoethyl}phosphonic acid	IC50	316.23 [1]
	{2-[3-(Decyloxy)phenyl]-1-hydroxy-1-phosphonoethyl}phosphonic acid	IC50	630.96 [1]
	{2-[5-(Decyloxy)pyridin-3-Yl]ethane-1,1-Diyl}bis(Phosphonic Acid)	IC50	5011.87 [1]
	[1,3-Bis(2,4-dichlorophenyl)-2-phosphonopropan-2-yl]phosphonic acid	IC50	25118.86 [1]
	(2-Carbamimidamido-1-hydroxy-1-phosphonoethyl)phosphonic acid	IC50	79432.82 [1]
	[({4-[4-(Propan-2-Yloxy)phenyl]pyridin-2-Yl}amino)methanediyl]bis(Phosphonic Acid)	IC50	100000.0 [1]
	3-[[(3E)-4,8-Dimethylnona-3,7-dienyl]-methylamino]propyl phosphono hydrogen phosphate	IC50	310.0 [1]
	[(2E,6E,10E)-14-(Dimethylamino)-3,7,11-trimethyltetradeca-2,6,10-trienyl] phosphono hydrogen phosphate	IC50	100000.0 [1]
	Tetrasodium;[2-[1-[(4Z)-5,9-dimethyldeca-4,8-dienyl]triazol-4-yl]-1-phosphonatoethyl]-dioxido-oxo-lambda5-phosphane	IC50	1300.0 [1]
	Tetrasodium;[1-[1-(3,7-dimethylocta-2,6-dienyl)triazol-4-yl]-2-phosphonatobutan-2-yl]-dioxido-oxo-lambda5-phosphane	IC50	5850.0 [1]
	(9-Phosphonoheptadecan-9-yl)phosphonic acid	IC50	2511.89 [1]
	[2-[3-Decoxy-5-(3,5-difluorophenyl)pyridin-1-ium-1-yl]-1-phosphonoethyl]-hydroxyphosphinate	IC50	794.33 [1]
	Hydroxy-[2-(3-oct-1-ynylpyridin-1-ium-1-yl)-1-phosphonoethyl]phosphinate	IC50	1584.89 [1]
	(6e,11e)-Heptadeca-6,11-Diene-9,9-Diylbis(Phosphonic Acid)	IC50	1995.26 [1]
	{1-[3-(Decyloxy)phenyl]-2-phosphonodecan-2-yl}phosphonic acid	IC50	2511.89 [1]
	[2-[3-(3-Butoxyphenyl)pyridin-1-ium-1-yl]-1-phosphonoethyl]-hydroxyphosphinate	IC50	2511.89 [1]
	{2-[5-(Dodecyloxy)pyridin-3-yl]-1-phosphonoethyl}phosphonic acid	IC50	5011.87 [1]
	[2-(3-Hexylpyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate	IC50	6309.57 [1]
	2-[[(2E,6E)-2,6-Dimethyl-9,9-diphosphononona-2,6-dienyl]amino]benzoic acid	IC50	100000.0 [1]
	[(3Z)-4,8-Dimethyl-1-phosphononona-3,7-dienyl]phosphonic acid	IC50	100000.0 [1]
	[(3Z,7E)-4,8,12-Trimethyl-1-phosphonotrideca-3,7,11-trienyl]phosphonic acid	IC50	40000.0 [1]
	[(3Z,7Z)-4,8,12-Trimethyl-1-phosphonotrideca-3,7,11-trienyl]phosphonic acid	IC50	70000.0 [1]
	[(3E,7Z)-4,8,12-Trimethyl-1-phosphonotrideca-3,7,11-trienyl]phosphonic acid	IC50	600.0 [1]
	[(6Z,11E)-2,6,12,16-Tetramethyl-9-phosphonoheptadeca-2,6,11,15-tetraen-9-yl]phosphonic acid	IC50	7000.0 [1]
	[(6Z,11Z)-2,6,12,16-Tetramethyl-9-phosphonoheptadeca-2,6,11,15-tetraen-9-yl]phosphonic acid	IC50	6000.0 [1]
	[(7E)-2,8,12-Trimethyl-5-phosphonotrideca-2,7,11-trien-5-yl]phosphonic acid	IC50	3000.0 [1]
	[(6E,11Z,15E)-2,6,12,16,20-Pentamethyl-9-phosphonohenicosa-2,6,11,15,19-pentaen-9-yl]phosphonic acid	IC50	300.0 [1]
	Tetrasodium;[(3Z)-4,8-dimethyl-1-phosphonatonona-3,7-dienyl]-dioxido-oxo-lambda5-phosphane	IC50	100000.0 [1]
	Tetrasodium;dioxido-oxo-[(3Z,7Z)-4,8,12-trimethyl-1-phosphonatotrideca-3,7,11-trienyl]-lambda5-phosphane	IC50	70000.0 [1]
	Tetrasodium;dioxido-oxo-[(3E,7Z)-4,8,12-trimethyl-1-phosphonatotrideca-3,7,11-trienyl]-lambda5-phosphane	IC50	40000.0 [1]
	Tetrasodium;[(3E)-4,8-dimethyl-1-phosphonatonona-3,7-dienyl]-dioxido-oxo-lambda5-phosphane	IC50	10000.0 [1]
	2-[[(2E,7E)-9-(2-Carboxyanilino)-2,8-dimethyl-5,5-diphosphononona-2,7-dienyl]amino]benzoic acid	IC50	100000.0 [1]
	Tetrasodium;dioxido-oxo-[(6Z,11E)-2,6,12,16-tetramethyl-9-phosphonatoheptadeca-2,6,11,15-tetraen-9-yl]-lambda5-phosphane	IC50	7000.0 [1]
	Tetrasodium;dioxido-oxo-[(7Z)-2,8,12-trimethyl-5-phosphonatotrideca-2,7,11-trien-5-yl]-lambda5-phosphane	IC50	60000.0 [1]
	[(7Z,11E)-2,8,12,16-Tetramethyl-5-phosphonoheptadeca-2,7,11,15-tetraen-5-yl]phosphonic acid	IC50	1000.0 [1]
	2-[[(2Z,7E)-2,8,12-Trimethyl-5,5-diphosphonotrideca-2,7,11-trienyl]amino]benzoic acid	IC50	900.0 [1]
	2-[[(2E,6Z,11E)-2,6,12,16-Tetramethyl-9,9-diphosphonoheptadeca-2,6,11,15-tetraenyl]amino]benzoic acid	IC50	900.0 [1]
	2-[Methyl-(4-methyl-pent-3-enyl)-amino]-ethyl-diphosphate	IC50	240000.0 [1]
	[2-[Decyl(methyl)amino]-1-phosphonoethyl]phosphonic acid	IC50	120000.0 [1]
	[2-[Methyl(octyl)amino]-1-phosphonoethyl]phosphonic acid	IC50	440000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Geranylgeranyl pyrophosphate synthetase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/geranylgeranyl-pyrophosphate-synthetase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Geranylgeranyl pyrophosphate synthetase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/geranylgeranyl-pyrophosphate-synthetase-inhibitors-ic50-ki.
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