Geranylgeranyl transferase type I beta subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-[[5-[[[(3S)-1-[(3-Chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	3400.0 [1]
	3-(3-Methoxyphenyl)-4-[alpha-(1-methyl-1H-imidazole-5-yl)-4-cyanobenzyloxymethyl]benzonitrile	IC50	3900.0 [1]
	4-[3-(4-Cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)prop-1-ynyl]-3-(3-ethoxyphenyl)benzonitrile	IC50	2400.0 [1]
	4-{5-[(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile	IC50	40000.0 [1]
	6-[[(4-Cyano-3-naphthalen-1-ylphenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridine-3-carbonitrile	IC50	24.0 [1]
	4-[[5-[2-[[(3S)-1-Benzyl-2-oxopyrrolidin-3-yl]amino]ethyl]imidazol-1-yl]methyl]benzonitrile	IC50	7400.0 [1]
	(S)-4-((5-((1-(3-Chlorobenzoyl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile	IC50	11000.0 [1]
	Tert-butyl N-[3-[[(3S)-1-benzyl-2-oxopyrrolidin-3-yl]-[[3-[(4-cyanophenyl)methyl]imidazol-4-yl]methyl]amino]propyl]carbamate	IC50	3600.0 [1]
	4-[[5-[2-[[(3R)-2-Oxo-1-phenylpyrrolidin-3-yl]amino]ethyl]imidazol-1-yl]methyl]benzonitrile	IC50	16000.0 [1]
	4-[[5-[[[(3S)-1-Benzyl-2-oxopyrrolidin-3-yl]-(pyridin-3-ylmethyl)amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	4-[[5-[2-[[(3R)-1-Benzyl-2-oxopyrrolidin-3-yl]amino]ethyl]imidazol-1-yl]methyl]benzonitrile	IC50	11000.0 [1]
	4-[[5-[2-[[(3R)-2-Oxo-1-(2-phenylethyl)pyrrolidin-3-yl]amino]ethyl]imidazol-1-yl]methyl]benzonitrile	IC50	1500.0 [1]
	4-[[5-[2-[[(3S)-2-Oxo-1-(2-phenylethyl)pyrrolidin-3-yl]amino]ethyl]imidazol-1-yl]methyl]benzonitrile	IC50	2800.0 [1]
	4-{5-[2-(2-Oxo-1-phenyl-pyrrolidin-3-ylamino)-ethyl]-imidazol-1-ylmethyl}-benzonitrile	IC50	14000.0 [1]
	4-[3-(4-Cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)prop-1-ynyl]-3-(3-methoxyphenyl)benzonitrile	IC50	4100.0 [1]
	4-[[5-[[[(3S)-1-Benzyl-2-oxopyrrolidin-3-yl]-(3-phenylpropyl)amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	12000.0 [1]
	4-[[5-[[3-Aminopropyl-[(3S)-1-benzyl-2-oxopyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	4-[5-[[(3S)-1-(4-Pyridyl)-2-oxo-3-pyrrolidinyl]aminomethyl]-1H-imidazole-1-ylmethyl]benzonitrile	IC50	20000.0 [1]
	4-{5-[(2-Oxo-1-quinolin-5-yl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile	IC50	20000.0 [1]
	4-{5-[(2-Oxo-1-phenyl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile	IC50	41000.0 [1]
	4-[[5-[[[(3S)-2-Oxo-1-phenylpyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	46000.0 [1]
	4-[[5-[[[(3S)-2-Oxo-1-(2-phenylethyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	48000.0 [1]
	4-[[5-[[[(3R)-1-Benzyl-2-oxopyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	46000.0 [1]
	5-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-6-(3,5-difluorophenyl)pyridine-2-carbonitrile	IC50	4800.0 [1]
	5-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-6-(2,2-difluoro-1,3-benzodioxol-5-yl)pyridine-2-carbonitrile	IC50	1100.0 [1]
	4-[[5-[[[(3S)-1-(2-Sulfanylidene-1H-pyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	Tert-butyl N-[3-[[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]-[[3-[(4-cyanophenyl)methyl]imidazol-4-yl]methyl]amino]propyl]carbamate	IC50	2700.0 [1]
	4-[[5-[[[(3S)-1-(2-Aminopyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	4-[[5-[[[(3S)-1-(2-Methylpyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	4-[[5-[[[(3S)-1-(5-Bromopyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	41000.0 [1]
	4-[[5-[[[(3S)-1-(2-Methylsulfanylpyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	28000.0 [1]
	4-[[5-[[[(3S)-1-(2-Methoxypyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	4-{5-[(1-Benzoyl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile	IC50	24000.0 [1]
	4-[[5-[[[(3S)-1-(4-Chlorobenzoyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	19000.0 [1]
	4-(5-{[1-(2-Chloro-benzoyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	IC50	19000.0 [1]
	4-(5-{[1-(3-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	IC50	6500.0 [1]
	4-[[5-[[[(3S)-1-(2-Ethylsulfanylpyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	5100.0 [1]
	4-(5-{[1-(Naphthalene-1-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	IC50	880.0 [1]
	4-[[5-[[Benzyl-[(3S)-1-benzyl-2-oxopyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	20000.0 [1]
	4-{5-[(2-Oxo-1-phenethyl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile	IC50	31000.0 [1]
	4-[[5-[[[(3S)-1-(Pyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	4-[[5-[[[(3S)-1-(2-Oxo-1H-pyridine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	4-[[5-[[[(3S)-2-Oxo-1-pyridin-2-ylpyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	36000.0 [1]
	4-[1-Hydroxy-1-(1-methyl-1H-imidazole-5-yl)-3-(3',5-dichloro-2-biphenylyl)-2-propynyl]benzonitrile	IC50	100.0 [1]
	4-[3-(4-Cyanophenyl)-1-hydroxy-1-(3-methylimidazol-4-yl)prop-2-ynyl]-2-naphthalen-1-ylbenzonitrile	IC50	10.0 [1]
	3-(1,3-Benzodioxol-5-yl)-4-[3-(4-cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)prop-1-ynyl]benzonitrile	IC50	5600.0 [1]
	4-[(4-Cyanophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-2-(2-methylphenyl)benzonitrile	IC50	1200.0 [1]
	4-[3-(4-Cyanophenyl)-1-hydroxy-1-(3-methylimidazol-4-yl)prop-2-ynyl]-2-(2-methylphenyl)benzonitrile	IC50	210.0 [1]
	4-[1-Hydroxy-1-(3-methylimidazol-4-yl)-3-phenylprop-2-ynyl]-2-(2-methylphenyl)benzonitrile	IC50	240.0 [1]
	4-[1-Hydroxy-1-(3-methylimidazol-4-yl)-3-phenylpropyl]-2-(2-methylphenyl)benzonitrile	IC50	1800.0 [1]
	Tert-butyl 4-[5-(3-chlorophenyl)-3-cyano-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridin-2-yl]piperazine-1-carboxylate	IC50	650.0 [1]
	2-Chloro-5-(3-chlorophenyl)-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridine-3-carbonitrile	IC50	2800.0 [1]
	5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile	IC50	4200.0 [1]
	6-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-2-naphthalen-2-ylpyridine-3-carbonitrile	IC50	2600.0 [1]
	2-(4-Acetylpiperazin-1-yl)-5-(3-chlorophenyl)-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridine-3-carbonitrile	IC50	2100.0 [1]
	2-(4-Chlorophenyl)-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridine-3-carbonitrile	IC50	3900.0 [1]
	5-(3-Chlorophenyl)-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-2-(4-methylpiperazin-1-yl)pyridine-3-carbonitrile	IC50	2400.0 [1]
	5-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-6-[4-(trifluoromethoxy)phenyl]pyridine-2-carbonitrile	IC50	1200.0 [1]
	5-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-6-[3-(trifluoromethoxy)phenyl]pyridine-2-carbonitrile	IC50	510.0 [1]
	6-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-2-(3,4-dichlorophenyl)pyridine-3-carbonitrile	IC50	1600.0 [1]
	5-(3-Chlorophenyl)-4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridine-2-carbonitrile	IC50	10.0 [1]
	3-(3-Methoxyphenyl)-4-[1-methyl-1H-imidazole-5-yl(6-cyano-3-pyridinyl)methoxymethyl]benzonitrile	IC50	10.0 [1]
	2-(3-Chlorophenyl)-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridine-3-carbonitrile	IC50	1100.0 [1]
	5-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-6-naphthalen-2-ylpyridine-2-carbonitrile	IC50	5500.0 [1]
	5-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-6-morpholin-4-ylpyridine-2-carbonitrile	IC50	10.0 [1]
	Tert-butyl 4-[6-cyano-3-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridin-2-yl]piperazine-1-carboxylate	IC50	42.0 [1]
	5-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-6-(3,5-dichlorophenyl)pyridine-2-carbonitrile	IC50	1400.0 [1]
	3-(1-Naphthyl)-4-[1-methyl-1H-imidazole-5-yl(6-cyano-3-pyridinyl)methoxymethyl]benzonitrile	IC50	10.0 [1]
	5-(3-Chlorophenyl)-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-2-(4-hydroxypiperidin-1-yl)pyridine-3-carbonitrile	IC50	830.0 [1]
	6-(3-Chlorophenyl)-5-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridine-2-carbonitrile	IC50	1700.0 [1]
	5-[[(4-Cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-6-phenylpyridine-2-carbonitrile	IC50	10.0 [1]
	1-[5-(3-Chlorophenyl)-3-cyano-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]pyridin-2-yl]piperidine-4-carboxamide	IC50	2100.0 [1]
	4-[alpha-(1-Methyl-1H-imidazole-5-yl)-3-(8-quinolinyl)-4-cyanobenzyloxymethyl]benzonitrile	IC50	103.0 [1]
	5-(3-Chlorophenyl)-6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-2-morpholin-4-ylpyridine-3-carbonitrile	IC50	1800.0 [1]
	5-[[4-Cyano-2-[3-(trifluoromethoxy)phenyl]phenyl]methoxy-(3-methylimidazol-4-yl)methyl]pyridine-2-carbonitrile	IC50	990.0 [1]
	3-(3-Chlorophenyl)-4-[1-methyl-1H-imidazole-5-yl(6-cyano-3-pyridinyl)methoxymethyl]benzonitrile	IC50	8620.0 [1]
	5-[[2-(1,3-Benzodioxol-5-yl)-4-cyanophenyl]methoxy-(3-methylimidazol-4-yl)methyl]pyridine-2-carbonitrile	IC50	10.0 [1]
	3-(3,5-Dichlorophenyl)-4-[1-methyl-1H-imidazole-5-yl(6-cyano-3-pyridinyl)methoxymethyl]benzonitrile	IC50	960.0 [1]
	3-(3,5-Difluorophenyl)-4-[1-methyl-1H-imidazole-5-yl(6-cyano-3-pyridinyl)methoxymethyl]benzonitrile	IC50	10.0 [1]
	5-[[2-(3-Chloro-4-fluorophenyl)-4-cyanophenyl]methoxy-(3-methylimidazol-4-yl)methyl]pyridine-2-carbonitrile	IC50	8600.0 [1]
	4-[3-(4-Ethylphenyl)-1-hydroxy-1-(3-methylimidazol-4-yl)prop-2-ynyl]-2-naphthalen-1-ylbenzonitrile	IC50	18.0 [1]
	4-[1-Hydroxy-1-(3-methylimidazol-4-yl)-3-(6-methylpyridin-3-yl)prop-2-ynyl]-2-naphthalen-1-ylbenzonitrile	IC50	40.0 [1]
	4-[3-[4-Chloro-2-(3-methoxyphenyl)phenyl]-1-hydroxy-1-(3-methylimidazol-4-yl)prop-2-ynyl]benzonitrile	IC50	740.0 [1]
	4-[3-(4-Cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)prop-1-ynyl]-3-[3-(trifluoromethoxy)phenyl]benzonitrile	IC50	430.0 [1]
	4-[3-(4-Cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)propyl]-3-(3-methoxyphenyl)benzonitrile	IC50	870.0 [1]
	2-(1-Naphthyl)-4-[1-hydroxy-1-(1-methyl-1H-imidazole-5-yl)-3-phenyl-2-propynyl]benzonitrile	IC50	3.1 [1]
	4-[1-Hydroxy-1-(3-methylimidazol-4-yl)-3-(4-pentylphenyl)prop-2-ynyl]-2-naphthalen-1-ylbenzonitrile	IC50	360.0 [1]
	4-[3-(4-Cyanophenyl)-1-hydroxy-1-(3-methylimidazol-4-yl)prop-2-ynyl]-2-quinolin-8-ylbenzonitrile	IC50	83000.0 [1]
	4-[3-(4-Chlorophenyl)-1-hydroxy-1-(3-methylimidazol-4-yl)prop-2-ynyl]-2-naphthalen-1-ylbenzonitrile	IC50	9.5 [1]
	4-[3-(4-Ethynylphenyl)-1-hydroxy-1-(3-methylimidazol-4-yl)prop-2-ynyl]-2-naphthalen-1-ylbenzonitrile	IC50	16.0 [1]
	4-[3-(3-Aminophenyl)-1-hydroxy-1-(3-methylimidazol-4-yl)prop-2-ynyl]-2-naphthalen-1-ylbenzonitrile	IC50	92.0 [1]
	4-[1-Hydroxy-3-[2-(3-methoxyphenyl)-4-pentanoylphenyl]-1-(3-methylimidazol-4-yl)prop-2-ynyl]benzonitrile	IC50	10000.0 [1]
	4-[[5-[[[(3S)-2-Oxo-1-pyridin-3-ylpyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	20000.0 [1]
	4-[[5-[[[(3S)-1-[(3-Chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]-(2-piperazin-1-ylethyl)amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]
	4-(5-{[1-(4-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	IC50	11000.0 [1]
	4-(5-{[1-(2-Chloro-benzyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	IC50	11000.0 [1]
	4-(5-{[1-(4-Chloro-benzyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	IC50	15000.0 [1]
	4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	IC50	15000.0 [1]
	4-[[5-[[[(3S)-1-[(3-Chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]-(2-morpholin-4-ylethyl)amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	12000.0 [1]
	4-[[5-[[3-Aminopropyl-[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile	IC50	50000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Geranylgeranyl transferase type I beta subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/geranylgeranyl-transferase-type-i-beta-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Geranylgeranyl transferase type I beta subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/geranylgeranyl-transferase-type-i-beta-subunit-inhibitors-ic50-ki.
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