Glucokinase/Glucokinase regulatory protein Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-[6-[4-(6-Aminopyridin-3-yl)sulfonylphenyl]-5-methoxypyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol	IC50	4506.0 [1]
	2-[4-(6-Aminopyridin-3-yl)sulfonylphenyl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridine-3-carbonitrile	IC50	796.0 [1]
	(2S)-4-[2-[4-(6-Aminopyridin-3-yl)sulfonylphenyl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]but-3-yn-2-ol	IC50	42.0 [1]
	4-[2-[4-(6-Aminopyridin-3-yl)sulfonylphenyl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2-methylbut-3-yn-2-ol	IC50	211.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(methylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	140.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(ethylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	152.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(propan-2-ylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	288.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(cyclopropylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	238.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(cyclohexylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	99.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-anilinopyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	7.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(benzylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	233.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-phenoxypyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	6021.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(pyridin-4-ylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	15.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(pyridin-3-ylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	38.0 [1]
	2-[6-[6-(6-Aminopyridin-3-yl)sulfonyl-2-(pyridin-2-ylamino)pyridin-3-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	120.0 [1]
	2-[2-[5-(6-Aminopyridin-3-yl)sulfonylthiophen-2-yl]pyrimidin-5-yl]-1,1,1-trifluoropropan-2-ol	IC50	480.0 [1]
	2-[4-[5-(6-Aminopyridin-3-yl)sulfonylthiophen-2-yl]phenyl]-1,1,1-trifluoropropan-2-ol	IC50	1930.0 [1]
	2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol	IC50	534.0 [1]
	2-[4-[4-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol	IC50	33000.0 [1]
	2-[4-[4-(6-Aminopyridin-3-yl)sulfonyl-1-methylimidazol-2-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol	IC50	33000.0 [1]
	2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1-methylimidazol-2-yl]phenyl]-1,1,1-trifluoropropan-2-ol	IC50	33000.0 [1]
	2-[6-[5-(6-Aminopyridin-3-yl)sulfonylthiophen-2-yl]-5-chloropyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	129.0 [1]
	2-[6-[5-(6-Aminopyridin-3-yl)sulfonylthiophen-2-yl]-5-prop-1-ynylpyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	51.0 [1]
	2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]-3-chlorophenyl]-1,1,1-trifluoropropan-2-ol	IC50	23.0 [1]
	(2R)-2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]-3-chlorophenyl]-1,1,1-trifluoropropan-2-ol	IC50	37.0 [1]
	(2S)-2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]-3-chlorophenyl]-1,1,1-trifluoropropan-2-ol	IC50	18.0 [1]
	2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]-3-chlorophenyl]propan-2-ol	IC50	15.0 [1]
	4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]-3-chlorobenzenesulfonamide	IC50	257.0 [1]
	2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]-3-chlorophenyl]propane-1,2-diol	IC50	10.0 [1]
	(2R)-2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]-3-chlorophenyl]propane-1,2-diol	IC50	6.0 [1]
	(2S)-2-[4-[5-(6-Aminopyridin-3-yl)sulfonyl-1,3-thiazol-2-yl]-3-chlorophenyl]propane-1,2-diol	IC50	61.0 [1]
	2-(6-(4-((6-Amino-3-pyridinyl)sulfonyl)phenyl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol	IC50	358.0 [1]
	2-(4-(4-((6-Amino-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol	IC50	454.0 [1]
	2-(4'-((6-Amino-3-pyridinyl)sulfonyl)-4-biphenylyl)-1,1,1-trifluoro-2-propanol	IC50	1010.0 [1]
	2-[6-[4-(6-Aminopyridin-3-yl)sulfonylphenyl]-5-chloropyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol	IC50	1885.0 [1]
	2-[6-[4-(6-Aminopyridin-3-yl)sulfonylphenyl]-5-prop-1-ynylpyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol	IC50	84.0 [1]
	2-[6-[4-(6-Aminopyridin-3-yl)sulfonylphenyl]-5-(3-methoxyprop-1-ynyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol	IC50	21.0 [1]
	2-[6-[4-(6-Aminopyridin-3-yl)sulfonylphenyl]-5-(3-hydroxyprop-1-ynyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol	IC50	65.0 [1]
	2-[6-[5-(6-Aminopyridin-3-yl)sulfonylpyridin-2-yl]pyridin-3-yl]-1,1,1-trifluoropropan-2-ol	IC50	434.0 [1]
	2-(2-(4-((6-Amino-3-pyridinyl)sulfonyl)phenyl)-5-pyrimidinyl)-1,1,1,3,3,3-hexafluoro-2-propanol	IC50	104.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 40 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glucokinase/Glucokinase regulatory protein Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/glucokinase-glucokinase-regulatory-protein-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Glucokinase/Glucokinase regulatory protein Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glucokinase-glucokinase-regulatory-protein-inhibitors-ic50-ki.
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