Glucose-dependent insulinotropic receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Isopropyl 4-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)piperidine-1-carboxylate	Ki	23.0 [1]
	4-[[2-[(2R)-2-Methyl-4-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)piperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile	IC50	3.0 [1]
	Propan-2-yl 4-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate	Ki	53.0 [1]
	Tert-butyl 4-(5-(4-(methylsulfonyl)-benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate	IC50	351.0 [1]
	(R)-Tert-butyl 3-methyl-4-(5-(4-(methylsulfonyl)benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate	IC50	17.0 [1]
	Tert-butyl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)piperazine-1-carboxylate	IC50	10.0 [1]
	Tert-butyl (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate	IC50	1.0 [1]
	2,2,2-Trifluoroethyl (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate	IC50	31.0 [1]
	Propan-2-yl 8-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]oxy-6-oxa-3-azabicyclo[3.2.1]octane-3-carboxylate	Ki	1599.0 [1]
	Propan-2-yl 9-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate	Ki	20.0 [1]
	Ethyl 1-(6-(4-bromophenoxy)-5-nitropyrimidin-4-yl)piperidine-4-carboxylate	IC50	50.0 [1]
	Ethyl 1-[6-[4-(2-methoxyethoxy)phenoxy]-5-nitropyrimidin-4-yl]piperidine-4-carboxylate	IC50	500.0 [1]
	Ethyl 1-[6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]oxy-5-nitropyrimidin-4-yl]piperidine-4-carboxylate	IC50	84.0 [1]
	Propan-2-yl (1S,5R)-9-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate	Ki	20.0 [1]
	4-((2-(4-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile	IC50	12.0 [1]
	2,2,2-Trifluoroethyl 4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate	IC50	18.0 [1]
	Propan-2-yl (1R,5R,8R)-8-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]oxy-6-oxa-3-azabicyclo[3.2.1]octane-3-carboxylate	Ki	1176.0 [1]
	Propan-2-yl (1S,5S,8S)-8-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]oxy-6-oxa-3-azabicyclo[3.2.1]octane-3-carboxylate	Ki	2270.0 [1]
	(1-Methylcyclopropyl) 4-[5-cyano-4-[[2-fluoro-4-(1-methyltetrazol-5-yl)phenoxy]methyl]pyrazol-1-yl]piperidine-1-carboxylate	Ki	99.0 [1]
	(1-Methylcyclopropyl) 4-[5-cyano-4-[(4-cyano-2-fluorophenoxy)methyl]pyrazol-1-yl]piperidine-1-carboxylate	Ki	36.5 [1]
	(1-Methylcyclopropyl) 4-[5-cyano-4-[[4-(tetrazol-1-yl)phenoxy]methyl]pyrazol-1-yl]piperidine-1-carboxylate	Ki	29.8 [1]
	4-[(4-Cyano-2-fluorophenoxy)methyl]-2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]pyrazole-3-carbonitrile	Ki	9.25 [1]
	2-[1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]pyrazole-3-carbonitrile	Ki	14.9 [1]
	Propan-2-yl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	2233.0 [1]
	Ethyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	1970.0 [1]
	(1-Methylcyclopropyl) 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	586.0 [1]
	Cyclobutyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	682.0 [1]
	Tert-butyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	486.0 [1]
	2-Methylpropyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	231.0 [1]
	[(2R)-Butan-2-yl] 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	290.0 [1]
	[(2S)-Butan-2-yl] 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	493.0 [1]
	(1-Methylcyclobutyl) 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	136.0 [1]
	Tert-butyl 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	41.0 [1]
	Propan-2-yl 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	141.0 [1]
	(1-Methylcyclopropyl) 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	131.0 [1]
	(1-Methylcyclopropyl) 6-[6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	8148.0 [1]
	Tert-butyl 6-[6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	8148.0 [1]
	Propan-2-yl 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	197.0 [1]
	(1-Methylcyclopropyl) 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	123.0 [1]
	Tert-butyl 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	18.0 [1]
	(1-Methylcyclopropyl) 6-[5-fluoro-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	7318.0 [1]
	Tert-butyl 6-[5-fluoro-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	814.0 [1]
	Propan-2-yl 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	1496.0 [1]
	(1-Methylcyclopropyl) 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	3123.0 [1]
	Tert-butyl 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	163.0 [1]
	Propan-2-yl 6-[6-(4-cyano-2-fluorophenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	912.0 [1]
	Tert-butyl 6-[6-(4-cyano-2-fluorophenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	133.0 [1]
	Propan-2-yl 6-[5-methyl-6-[4-(triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	294.0 [1]
	Propan-2-yl 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	94.0 [1]
	(1-Methylcyclopropyl) 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	48.0 [1]
	Tert-butyl 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	21.0 [1]
	Propan-2-yl 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	18.0 [1]
	(1-Methylcyclopropyl) 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	15.0 [1]
	Tert-butyl 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	7.0 [1]
	Propan-2-yl 6-[6-[4-(dimethylcarbamoyl)-2-fluorophenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	1148.0 [1]
	Tert-butyl 6-[6-[2-fluoro-4-(1,2,4-triazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	33.0 [1]
	Tert-butyl 6-[5-methyl-6-[4-(1,2,4-triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	125.0 [1]
	Tert-butyl 6-[6-[2-fluoro-4-(3-methyl-1,2,4-triazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	507.0 [1]
	Tert-butyl 6-[5-methyl-6-[4-(3-methyl-1,2,4-triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate	Ki	948.0 [1]
	(2,2,3,3-Tetrafluorocyclobutyl) 4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate	IC50	25.0 [1]
	(2,2,3,3-Tetrafluorocyclobutyl) 3-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octane-8-carboxylate	IC50	9.0 [1]
	Tert-butyl 3-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octane-8-carboxylate	IC50	1.0 [1]
	4-[[2-[8-(5-Propan-2-yl-1,2,4-oxadiazol-3-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile	IC50	4.0 [1]
	(2,2,3,3-Tetrafluorocyclobutyl) (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate	IC50	6.0 [1]
	2,2,2-Trifluoroethyl 3-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octane-8-carboxylate	IC50	8.0 [1]
	Tert-butyl 8-[5-[(4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octane-3-carboxylate	IC50	92.0 [1]
	Tert-butyl 3-[5-[(4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octane-8-carboxylate	IC50	3.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 67 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glucose-dependent insulinotropic receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/glucose-dependent-insulinotropic-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Glucose-dependent insulinotropic receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glucose-dependent-insulinotropic-receptor-inhibitors-ic50-ki.
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