Glutamate NMDA receptor; GRIN1/GRIN2B Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Ifenprodil	IC50	177.4 [1]
	Ifenprodil	Ki	10.0 [1]
	N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-yl]-methanesulfonamide	IC50	1.4 [1], 1.9 [2], 50.29 [3]
	N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-yl]-methanesulfonamide	Ki	0.99 [1]
	2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-ol	IC50	8.2 [1], 209.2 [2]
	2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-ol	Ki	1.5 [1]
	2-[[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	IC50	12.0 [1], 47.27 [2]
	2-[[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	Ki	1.1 [1]
	Memantine	IC50	1020.0 [1], 5200.0 [2], 5500.0 [3], 9520.0 [4]
	Radiprodil	IC50	4.0 [1], 6.0 [2], 69.91 [3]
	3-(4-Phenylbutyl)-1,2,4,5-tetrahydro-3-benzazepine-5,8-diol	IC50	18.5 [1]
	3-(4-Phenylbutyl)-1,2,4,5-tetrahydro-3-benzazepine-5,8-diol	Ki	14.0 [1], 84.0 [2]
	4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol	IC50	57.0 [1]
	4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol	Ki	10.0 [1]
	4-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol	IC50	13.3 [1]
	4-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol	Ki	10.0 [1]
	N-(2-Methoxybenzyl)cinnamamidine	IC50	26000.0 [1], 28600.0 [2]
	N-(2-Methoxybenzyl)cinnamamidine	Ki	0.7 [1]
	7-Methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol	IC50	360.0 [1]
	7-Methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol	Ki	5.4 [1], 706.0 [2]
	2-Phenyl-4-(piperidin-1-ylmethyl)-1H-benzimidazol-5-ol	IC50	100.0 [1], 50118.72 [2]
	3-(4-Phenylcyclohexyl)-1,2,4,5-tetrahydro-3-benzazepine-5,8-diol	IC50	12100.0 [1]
	3-(4-Phenylcyclohexyl)-1,2,4,5-tetrahydro-3-benzazepine-5,8-diol	Ki	3.3 [1], 9.0 [2]
	Tacrine	IC50	44000.0 [1]
	Traxoprodil	IC50	30.0 [1]
	Traxoprodil	Ki	11.0 [1]
	Besonprodil	IC50	8.0 [1]
	2-(4-Benzylpiperidinocarbonyl)-1H-indole-5-ol	IC50	40.0 [1], 42.0 [2]
	2-[[4-[(2-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	IC50	9.7 [1]
	2-[[4-[(2-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	Ki	0.85 [1]
	(E)-N-Benzyl-3-phenyl-acrylamidine	IC50	70.0 [1]
	(E)-N-Benzyl-3-phenyl-acrylamidine	Ki	9.0 [1]
	2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-benzooxazol-6-yl)-acetamide	IC50	3.0 [1], 4.0 [2]
	2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-acetamide	IC50	2.0 [1], 5.0 [2]
	2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-acetamide	IC50	6.0 [1], 8.0 [2]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]methanesulfonamide	IC50	0.72 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]methanesulfonamide	Ki	0.68 [1]
	2-[[4-[(3-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	IC50	44.0 [1]
	2-[[4-[(3-Fluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	Ki	4.2 [1]
	2-[[4-[(2,6-Difluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	IC50	21.0 [1]
	2-[[4-[(2,6-Difluorophenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	Ki	0.82 [1]
	2-[[4-[(4-Methylphenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	IC50	5.7 [1]
	2-[[4-[(4-Methylphenyl)methyl]piperidin-1-yl]methyl]-3H-benzimidazol-5-ol	Ki	0.4 [1]
	2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazole-5-carbonitrile	IC50	800.0 [1]
	2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazole-5-carbonitrile	Ki	790.0 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]propane-2-sulfonamide	IC50	14.0 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]propane-2-sulfonamide	Ki	15.0 [1]
	N-Methyl-N-[2-[(4-phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]methanesulfonamide	IC50	25.0 [1]
	N-Methyl-N-[2-[(4-phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]methanesulfonamide	Ki	470.0 [1]
	N-[2-[(4-Benzylpiperidin-1-yl)methyl]-3H-benzimidazol-5-yl]propane-2-sulfonamide	IC50	300.0 [1]
	N-[2-[(4-Benzylpiperidin-1-yl)methyl]-3H-benzimidazol-5-yl]propane-2-sulfonamide	Ki	240.0 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]acetamide	IC50	42.0 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]acetamide	Ki	93.0 [1]
	1-(4-Hydroxyphenyl)-2-[4-[(4-isothiocyanatophenyl)methyl]piperidin-1-yl]ethanone	IC50	16000.0 [1], 570000.0 [2]
	N-[4-[2-(4-Benzylpiperidin-1-yl)propanoyl]phenyl]-2-chloroacetamide	IC50	14000.0 [1], 230000.0 [2]
	2-Methyl-9-[9-(2-methylpyrido[3,4-b]indol-2-ium-9-yl)nonyl]pyrido[3,4-b]indol-2-ium	IC50	2900.0 [1]
	cis-7-(Benzyloxy)-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol	Ki	139.0 [1], 388.0 [2]
	2-(4-Benzyl-piperidin-1-ylmethyl)-1H-benzimidazole	IC50	710.0 [1]
	2-(4-Benzyl-piperidin-1-ylmethyl)-1H-benzimidazole	Ki	420.0 [1]
	2-[(4-Phenoxyphenyl)methyl]-1H-benzimidazol-4-ol	IC50	150.0 [1]
	2-[(4-Phenoxyphenyl)methyl]-1H-benzimidazol-4-ol	Ki	140.0 [1]
	6-Methoxy-2-[(4-phenoxyphenyl)methyl]-1H-benzimidazole	IC50	9200.0 [1]
	6-Methoxy-2-[(4-phenoxyphenyl)methyl]-1H-benzimidazole	Ki	8400.0 [1]
	2-[(4-Phenoxyphenyl)methyl]-1H-benzimidazole	IC50	200.0 [1]
	2-[(4-Phenoxyphenyl)methyl]-1H-benzimidazole	Ki	260.0 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]benzenesulfonamide	IC50	49.0 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]benzenesulfonamide	Ki	17.0 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]propane-1-sulfonamide	IC50	19.0 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]propane-1-sulfonamide	Ki	21.0 [1]
	2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-ol	IC50	9.2 [1]
	2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-ol	Ki	3.2 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]ethanesulfonamide	IC50	2.1 [1]
	N-[2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]ethanesulfonamide	Ki	3.0 [1]
	2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-amine	IC50	78.0 [1]
	2-[(4-Phenoxyphenyl)methyl]-3H-benzimidazol-5-amine	Ki	180.0 [1]
	6-Nitro-2-[(4-phenoxyphenyl)methyl]-1H-benzimidazole	IC50	6600.0 [1]
	6-Nitro-2-[(4-phenoxyphenyl)methyl]-1H-benzimidazole	Ki	5400.0 [1]
	2-[6-(9H-Pyrido[3,4-b]indol-2-ium-2-yl)hexyl]-9H-pyrido[3,4-b]indol-2-ium	IC50	6500.0 [1]
	2-[6-(9H-Pyrido[3,4-b]indol-2-ium-2-yl)hexyl]-9H-pyrido[3,4-b]indol-2-ium	Ki	20000.0 [1]
	Ketamine	IC50	3200.0 [1]
	Dizocilpine	IC50	9.0 [1]
	Dextrorphan	IC50	246.0 [1]
	Eliprodil	Ki	13.0 [1]
	N-(4-(2-Benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonamide	IC50	100.0 [1]
	1-(2-(4-Hydroxyphenoxy)ethyl)-4-((4-methylphenyl)methyl)-4-piperidinol	IC50	5.0 [1]
	1-(4-Benzylpiperidin-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one	IC50	104.0 [1]
	2-(4-Benzylpiperidinocarbonyl)-1H-indole-6-ol	IC50	20.0 [1]
	6-(3-(4-((4-Fluorophenyl)methyl)-1-piperidinyl)-1-oxopropyl)-2(3H)-benzoxazolone	IC50	48.0 [1]
	Peaqx	IC50	29600.0 [1]
	3-(4-Phenylbutyl)-1,2,4,5-tetrahydro-3-benzazepin-5-ol	Ki	73.0 [1]
	7-(3-Phenylpropylamino)-6,7,8,9-tetrahydro-5H-benzocycloheptene	Ki	16.0 [1]
	N-Benzylbenzamidine	Ki	10000.0 [1]
	3-Methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine	Ki	10.0 [1]
	2-[4-(Benzyloxy)piperidinocarbonyl]-1H-indole-6-ol	IC50	46.0 [1]
	2-[4-[(4-Methylphenyl)methyl]piperidin-1-yl]-2-oxo-N-(2-oxo-1,3-dihydroindol-5-yl)acetamide	IC50	15.0 [1]
	2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-acetamide	IC50	9.0 [1]
	2-Methoxy-7-(3-phenylpropylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol	Ki	16.0 [1]
	2-(4-Phenylpiperidinocarbonyl)-1H-indole-6-ol	IC50	8000.0 [1]
	2-(4-Phenethylpiperidinocarbonyl)-1H-indole-6-ol	IC50	24.0 [1]
	2-(4-Benzylpiperidinocarbonyl)-1H-indole-7-ol	IC50	77.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate NMDA receptor; GRIN1/GRIN2B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/glutamate-nmda-receptor-grin1-grin2b-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Glutamate NMDA receptor; GRIN1/GRIN2B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-nmda-receptor-grin1-grin2b-inhibitors-ic50-ki.
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