Glutamate [NMDA] receptor subunit epsilon 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Eliprodil	Ki	13.0 [1]
	4-(Trifluoromethoxy)-N'-[[2-(trifluoromethyl)phenyl]methyl]benzenecarboximidamide	IC50	47.0 [1]
	4-(Trifluoromethoxy)-N'-[[2-(trifluoromethyl)phenyl]methyl]benzenecarboximidamide	Ki	72.0 [1]
	Ifenprodil	IC50	20.0 [1]
	Ifenprodil	Ki	10.0 [1]
	3-Methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine	Ki	10.0 [1], 11.0 [2]
	4-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol	Ki	10.0 [1]
	N-Benzylbenzamidine	Ki	10000.0 [1], 15000.0 [2]
	(E)-N-Benzyl-3-phenyl-acrylamidine	Ki	9.0 [1]
	N-(4-(Benzyloxy)phenethyl)pyridin-4-amine	IC50	102.0 [1]
	N-(4-(Benzyloxy)phenethyl)pyridin-4-amine	Ki	93.0 [1]
	N-(2-Methoxy-benzyl)-4-trifluoromethoxy-benzamidine	IC50	4.1 [1]
	N-(2-Methoxy-benzyl)-4-trifluoromethoxy-benzamidine	Ki	5.7 [1]
	N-(4-Phenylcyclohexyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine	Ki	2.3 [1], 5.7 [2]
	3,4-Dichloro-N-(3-chloro-benzyl)-benzamidine	IC50	110.0 [1]
	3,4-Dichloro-N-(3-chloro-benzyl)-benzamidine	Ki	16.0 [1]
	3-Chloro-N-(3-chloro-benzyl)-benzamidine	IC50	420.0 [1]
	3-Chloro-N-(3-chloro-benzyl)-benzamidine	Ki	800.0 [1]
	4-Chloro-N-(3-chloro-benzyl)-benzamidine	IC50	160.0 [1]
	4-Chloro-N-(3-chloro-benzyl)-benzamidine	Ki	63.0 [1]
	N-(3-Chloro-benzyl)-4-fluoro-benzamidine	IC50	450.0 [1]
	N-(3-Chloro-benzyl)-4-fluoro-benzamidine	Ki	600.0 [1]
	2-(3-Chloro-benzyl)-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine	IC50	49.0 [1]
	2-(3-Chloro-benzyl)-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine	Ki	8.0 [1]
	N-Benzyl-4-chloro-benzamidine	IC50	720.0 [1]
	N-Benzyl-4-chloro-benzamidine	Ki	970.0 [1]
	N-(3,5-Dimethyl-benzyl)-4-trifluoromethyl-benzamidine	IC50	8.7 [1]
	N-(3,5-Dimethyl-benzyl)-4-trifluoromethyl-benzamidine	Ki	3.9 [1]
	4-Trifluoromethyl-N-(3-trifluoromethyl-benzyl)-benzamidine	IC50	660.0 [1]
	4-Trifluoromethyl-N-(3-trifluoromethyl-benzyl)-benzamidine	Ki	700.0 [1]
	N-(3-Chloro-benzyl)-4-trifluoromethyl-benzamidine	IC50	32.0 [1]
	N-(3-Chloro-benzyl)-4-trifluoromethyl-benzamidine	Ki	20.0 [1]
	N-(2-Chloro-benzyl)-4-trifluoromethyl-benzamidine	IC50	48.0 [1]
	N-(2-Chloro-benzyl)-4-trifluoromethyl-benzamidine	Ki	56.0 [1]
	N-Benzyl-4-trifluoromethyl-benzamidine	IC50	360.0 [1]
	N-Benzyl-4-trifluoromethyl-benzamidine	Ki	480.0 [1]
	5-(3-Chlorophenyl)-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydro-1H-imidazole	IC50	1976.0 [1]
	5-(3-Chlorophenyl)-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydro-1H-imidazole	Ki	296.0 [1]
	5-(3-Chlorophenyl)-2-[3-chloro-4-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-imidazole	IC50	266.0 [1]
	5-(3-Chlorophenyl)-2-[3-chloro-4-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-imidazole	Ki	66.0 [1]
	2-[3-Chloro-4-(trifluoromethoxy)phenyl]-5-(3,5-dichlorophenyl)-4,5-dihydro-1H-imidazole	IC50	3670.0 [1]
	2-[3-Chloro-4-(trifluoromethoxy)phenyl]-5-(3,5-dichlorophenyl)-4,5-dihydro-1H-imidazole	Ki	223.0 [1]
	2-[3-Chloro-4-(trifluoromethoxy)phenyl]-5-(2-methoxyphenyl)-4,5-dihydro-1H-imidazole	IC50	108.0 [1]
	2-[3-Chloro-4-(trifluoromethoxy)phenyl]-5-(2-methoxyphenyl)-4,5-dihydro-1H-imidazole	Ki	75.0 [1]
	2-[3-Chloro-4-(trifluoromethoxy)phenyl]-5-[2-(trifluoromethyl)phenyl]-4,5-dihydro-1H-imidazole	IC50	1270.0 [1]
	2-[3-Chloro-4-(trifluoromethoxy)phenyl]-5-[2-(trifluoromethyl)phenyl]-4,5-dihydro-1H-imidazole	Ki	353.0 [1]
	2-[3-Chloro-4-(trifluoromethoxy)phenyl]-5-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-imidazole	IC50	3480.0 [1]
	2-[3-Chloro-4-(trifluoromethoxy)phenyl]-5-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-imidazole	Ki	505.0 [1]
	2-Benzofuran-7-ylmethyl-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine	IC50	12.0 [1]
	2-Benzofuran-7-ylmethyl-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine	Ki	2.2 [1]
	(3R)-3-[(3S,4S)-3-Fluoro-4-(4-hydroxyphenyl)piperidin-1-yl]-1-[(4-methylphenyl)methyl]pyrrolidin-2-one	IC50	24.0 [1]
	(3R)-3-[(3S,4S)-3-Fluoro-4-(4-hydroxyphenyl)piperidin-1-yl]-1-[(4-methylphenyl)methyl]pyrrolidin-2-one	Ki	6.3 [1]
	3,4-Dichloro-N-(2-trifluoromethoxy-benzyl)-benzamidine	IC50	57.0 [1]
	3,4-Dichloro-N-(2-trifluoromethoxy-benzyl)-benzamidine	Ki	12.0 [1]
	N-(3-Methoxy-benzyl)-4-trifluoromethoxy-benzamidine	IC50	9.7 [1]
	N-(3-Methoxy-benzyl)-4-trifluoromethoxy-benzamidine	Ki	23.0 [1]
	2-(2-Methoxy-benzyl)-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine	IC50	5.9 [1]
	2-(2-Methoxy-benzyl)-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine	Ki	3.6 [1]
	N-Benzyl-4-trifluoromethoxy-benzamidine	IC50	46.0 [1]
	N-Benzyl-4-trifluoromethoxy-benzamidine	Ki	120.0 [1]
	N-(3,5-Dimethyl-benzyl)-4-trifluoromethoxy-benzamidine	IC50	4.2 [1]
	N-(3,5-Dimethyl-benzyl)-4-trifluoromethoxy-benzamidine	Ki	1.2 [1]
	2-(3,5-Dimethyl-benzyl)-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine	IC50	39.0 [1]
	2-(3,5-Dimethyl-benzyl)-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine	Ki	2.0 [1]
	N-(3,5-Dichloro-benzyl)-4-trifluoromethoxy-benzamidine	IC50	24.0 [1]
	N-(3,5-Dichloro-benzyl)-4-trifluoromethoxy-benzamidine	Ki	0.6 [1]
	(5S,7S)-2-Methoxy-7-(3-phenylpropylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol	IC50	12.0 [1]
	(5S,7S)-2-Methoxy-7-(3-phenylpropylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol	Ki	16.0 [1]
	2-Methyl-6-(phenylethynyl)pyridine	IC50	18000.0 [1]
	2-Methyl-4-(pyridin-3-ylethynyl)thiazole	IC50	300000.0 [1]
	4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol	Ki	173.0 [1]
	Traxoprodil	IC50	74.0 [1]
	Besonprodil	Ki	30.0 [1]
	4-[4-(4-Benzylpiperidino)-1-butynyl]phenol	IC50	100.0 [1]
	N-(2-Methoxybenzyl)cinnamamidine	Ki	0.7 [1]
	7-(3-Phenylpropylamino)-6,7,8,9-tetrahydro-5H-benzocycloheptene	Ki	16.0 [1]
	7-Methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol	Ki	5.4 [1]
	2-(4-Benzylpiperidin-1-yl)-1-(1H-indol-3-yl)ethanone	IC50	769.0 [1]
	2-Methoxy-7-(3-phenylpropylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol	Ki	16.0 [1]
	2-Methyl-5-[3-(4-benzylpiperidino)propylthio]-1,3,4-thiadiazole	IC50	6400.0 [1]
	2-Hydroxy-5-phenyl-7-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaene-12-carbonitrile	IC50	9.0 [1]
	Benzyl 4-[(1,3-thiazol-2-ylamino)methyl]piperidine-1-carboxylate	Ki	122.0 [1]
	7-(Phenethylamino)-6,7,8,9-tetrahydro-5H-benzocycloheptene	Ki	20.0 [1]
	7-(4-Phenylbutylamino)-6,7,8,9-tetrahydro-5H-benzocycloheptene	Ki	17.0 [1]
	7-(4-Phenylpiperazine-1-yl)-6,7,8,9-tetrahydro-5H-benzocycloheptene	Ki	12.0 [1]
	7-(4-Benzylpiperidine-1-yl)-6,7,8,9-tetrahydro-5H-benzocycloheptene	Ki	2.9 [1]
	Benzyl 4-[(pyridin-2-ylamino)methyl]piperidine-1-carboxylate	Ki	37.0 [1]
	Benzyl 4-[(pyrimidin-4-ylamino)methyl]piperidine-1-carboxylate	Ki	75.0 [1]
	4-Fluorobenzyl 4-[(2-pyrimidinylamino)methyl]-1-piperidinecarboxylate	Ki	18.0 [1]
	2-Hydroxy-5-piperidin-1-yl-7-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaene-12-carbonitrile	IC50	27.0 [1]
	5-[2-(4-Benzylpiperidino)ethylthio]-1H-1,2,4-triazole-3-amine	IC50	35.0 [1]
	(3R)-1-[(4-Fluorophenyl)methyl]-3-[4-(4-hydroxyphenyl)piperidin-1-yl]pyrrolidin-2-one	IC50	4.2 [1]
	4-[4-Chloro-3-(difluoromethoxy)phenyl]-1-[(5-ethyl-1H-pyrazol-4-yl)methyl]pyrazole	IC50	3700.0 [1]
	3-[[4-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazol-1-yl]methyl]-1-methylpyrazole	IC50	2460.0 [1]
	4-[4-Chloro-3-(difluoromethyl)phenyl]-1-(1H-pyrazol-5-ylmethyl)pyrazole	IC50	890.0 [1]
	4-[3-(Difluoromethoxy)-4-fluorophenyl]-1-(1H-pyrazol-5-ylmethyl)pyrazole	IC50	370.0 [1]
	4-[4-Chloro-3-(difluoromethoxy)phenyl]-1-(1H-pyrazol-5-ylmethyl)pyrazole	IC50	230.0 [1]
	4-[4-Chloro-3-(difluoromethoxy)phenyl]-1-[(1-methylpyrazol-4-yl)methyl]pyrazole	IC50	1750.0 [1]
	4-[4-Chloro-3-(difluoromethoxy)phenyl]-1-(1H-pyrazol-4-ylmethyl)pyrazole	IC50	350.0 [1]
	1-[3-(Phenylthio)propyl]-4-benzylpiperidine	IC50	4300.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate [NMDA] receptor subunit epsilon 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/glutamate-nmda-receptor-subunit-epsilon-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Glutamate [NMDA] receptor subunit epsilon 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-nmda-receptor-subunit-epsilon-2-inhibitors-ic50-ki.
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