Glutamate (NMDA) receptor subunit zeta 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	5-[3-(4-Benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one	IC50	5.3 [1], 35000.0 [2], 100000.0 [3]
	5-[3-[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one	IC50	8.2 [1], 38000.0 [2], 100000.0 [3]
	5-(3-(4-Benzylpiperidin-1-yl)prop-1-ynyl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one	IC50	62000.0 [1], 89000.0 [2], 100000.0 [3]
	5-[3-[4-[(3-Fluorophenyl)methyl]piperidin-1-yl]prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one	IC50	6.1 [1], 100000.0 [2]
	5-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]-1,3-dihydroindol-2-one	IC50	320.0 [1], 52000.0 [2], 100000.0 [3]
	5-[3-(4-Benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydroindol-2-one	IC50	110.0 [1], 100000.0 [2]
	5-[3-(4-Benzyl-4-hydroxypiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one	IC50	19.0 [1], 100000.0 [2]
	5-[3-(4-Benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazole-2-thione	IC50	16.0 [1], 25000.0 [2], 100000.0 [3]
	5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-indole	IC50	15000.0 [1], 100000.0 [2]
	5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-benzotriazole	IC50	420.0 [1], 100000.0 [2]
	5-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-1H-indazole	IC50	250.0 [1], 95000.0 [2], 100000.0 [3]
	5-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-1H-benzotriazole	IC50	220.0 [1], 100000.0 [2]
	5-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]-1,3-dihydrobenzimidazole-2-thione	IC50	180.0 [1], 75000.0 [2], 100000.0 [3]
	5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-indazole	IC50	380.0 [1], 100000.0 [2]
	5-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-1,3-dihydro-benzoimidazol-2-one	IC50	89.0 [1], 39000.0 [2], 100000.0 [3]
	7-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]-4H-1,4-benzoxazin-3-one	IC50	1100.0 [1], 100000.0 [2]
	5-[3-[4-[(4-Methoxyphenyl)methyl]piperidin-1-yl]prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one	IC50	26.0 [1], 100000.0 [2]
	6-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]-3H-1,3-benzoxazol-2-one	IC50	120.0 [1], 39000.0 [2], 100000.0 [3]
	5-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-1H-indole-2,3-dione	IC50	1800.0 [1], 57000.0 [2]
	4,6-Dichloro-1H-indole-2-carboxylic acid	Ki	2900.0 [1]
	[(1S)-1-{[(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid	IC50	5.0 [1]
	[(1S)-1-[(7-Nitro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methylamino]ethyl]phosphonic acid	IC50	32.0 [1]
	[(1S)-1-[[2,3-Dioxo-7-(trifluoromethyl)-1,4-dihydroquinoxalin-5-yl]methylamino]ethyl]phosphonic acid	IC50	8.0 [1]
	CID 9863759	IC50	1.0 [1]
	4,6-Dichloro-3-[(2,4-dioxo-3-phenylimidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid	Ki	22.0 [1]
	[(1S)-1-[(7-Iodo-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methylamino]ethyl]phosphonic acid	IC50	8.0 [1]
	4,6-Dichloro-3-[(2,4-dioxo-3-phenyl-5-propan-2-ylimidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid	Ki	1100.0 [1]
	5-[3-[4-[(4-Chlorophenyl)methyl]piperidin-1-yl]prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one	IC50	19.0 [1]
	5-[3-[4-[(4-Methylphenyl)methyl]piperidin-1-yl]prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one	IC50	17.0 [1]
	5-[3-(4-Benzylpiperidin-1-yl)prop-1-ynyl]-3-methyl-1H-benzimidazol-2-one	IC50	100000.0 [1]
	6-[3-(4-Benzylpiperidin-1-yl)prop-1-ynyl]-3H-1,3-benzoxazol-2-one	IC50	49.0 [1]
	4,6-Dichloro-3-[[3-(3-methylphenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid	Ki	45.0 [1]
	4,6-Dichloro-3-[[3-(3,5-dichlorophenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid	Ki	80.0 [1]
	4,6-Dichloro-3-[(3-cyclohexyl-2,4-dioxoimidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid	Ki	130.0 [1]
	4,6-Dichloro-3-[[3-(4-methoxyphenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid	Ki	100.0 [1]
	3-(Benzenesulfonylamino-methyl)-4,6-dichloro-1H-indole-2-carboxylic acid	Ki	990.0 [1]
	3-[[3-(3-Acetylphenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-4,6-dichloro-1H-indole-2-carboxylic acid	Ki	57.0 [1]
	4,6-Dichloro-3-[[3-(4-methylphenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid	Ki	36.0 [1]
	4,6-Dichloro-3-[(4-oxo-3-phenyl-2-sulfanylideneimidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid	Ki	580.0 [1]
	4,6-Dichloro-3-[[3-(4-chlorophenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid	Ki	120.0 [1]
	4,6-Dichloro-3-[(5-methyl-2,4-dioxo-3-phenylimidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid	Ki	310.0 [1]
	4,6-Dichloro-3-[(3-phenyl-ureido)-methyl]-1H-indole-2-carboxylic acid	Ki	14.0 [1]
	4,6-Dichloro-3-[[3-(3-chlorophenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid	Ki	85.0 [1]
	3-(Benzylamino-methyl)-4,6-dichloro-1H-indole-2-carboxylic acid	Ki	92000.0 [1]
	3-(Benzoylamino-methyl)-4,6-dichloro-1H-indole-2-carboxylic acid	Ki	120.0 [1]
	4,6-Dichloro-3-[(3-ethyl-2,4-dioxoimidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid	Ki	1000.0 [1]
	4,6-Dichloro-3-(2-oxo-3-phenyl-imidazolidin-1-ylmethyl)-1H-indole-2-carboxylic acid	Ki	58.0 [1]
	3-[(Benzenesulfonylcarbamoylamino)methyl]-4,6-dichloro-1H-indole-2-carboxylic acid	Ki	72.0 [1]
	4,6-Dichloro-3-[[3-(4-fluorophenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid	Ki	53.0 [1]
	4,6-Dichloro-3-[(2,4-dioxo-3-propan-2-ylimidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid	Ki	1050.0 [1]
	3-[[3-(4-Acetylphenyl)-2,4-dioxoimidazolidin-1-yl]methyl]-4,6-dichloro-1H-indole-2-carboxylic acid	Ki	150.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-(2-hydroxypropyl)methanesulfonamide	IC50	40.0 [1]
	2-[(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-methylsulfonylamino]acetic acid	IC50	2.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(3,3,3-trifluoropropyl)ethanesulfonamide	IC50	27.0 [1]
	[(1S)-1-[(7-Cyano-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methylamino]ethyl]phosphonic acid	IC50	76.0 [1]
	[(1S)-1-[(7-Fluoro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methylamino]ethyl]phosphonic acid	IC50	9.0 [1]
	[(1S)-1-[(7-Chloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methylamino]ethyl]phosphonic acid	IC50	6.0 [1]
	N-(7-Chloro-6-methyl-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-hydroxyethyl)methanesulfonamide	IC50	14.0 [1]
	N-(6-Chloro-7-methyl-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-hydroxyethyl)methanesulfonamide	IC50	4.0 [1]
	N-(7-Chloro-6-ethyl-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-hydroxyethyl)methanesulfonamide	IC50	58.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(3-hydroxypropyl)methanesulfonamide	IC50	41.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-[(3-methoxyphenyl)methyl]methanesulfonamide	IC50	12.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-[(3-fluorophenyl)methyl]methanesulfonamide	IC50	45.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(oxan-2-ylmethyl)methanesulfonamide	IC50	39.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(oxolan-2-ylmethyl)methanesulfonamide	IC50	59.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-[2-(2-ethoxyethoxy)ethyl]methanesulfonamide	IC50	166.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-methoxyethyl)methanesulfonamide	IC50	38.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(3-methoxypropyl)methanesulfonamide	IC50	24.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-ethoxyethyl)methanesulfonamide	IC50	209.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(3-ethoxypropyl)methanesulfonamide	IC50	19.0 [1]
	N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(3,3,3-trifluoropropyl)methanesulfonamide	IC50	18.0 [1]
	N-(7-Chloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(3-methoxypropyl)methanesulfonamide	IC50	728.0 [1]
	N-(6-Chloro-7-methyl-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-methoxyethyl)methanesulfonamide	IC50	77.0 [1]
	N-(7-Chloro-6-methyl-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-methoxyethyl)methanesulfonamide	IC50	74.0 [1]
	N-(6-Chloro-7-ethyl-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(3-methoxypropyl)methanesulfonamide	IC50	49.0 [1]
	2-[(7-Chloro-6-methyl-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-methylsulfonylamino]acetic acid	IC50	2.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 76 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glutamate (NMDA) receptor subunit zeta 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/glutamate-nmda-receptor-subunit-zeta-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Glutamate (NMDA) receptor subunit zeta 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glutamate-nmda-receptor-subunit-zeta-1-inhibitors-ic50-ki.
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