Glyceraldehyde-3-phosphate dehydrogenase liver Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Adenosine	IC50	35000000.0 [1]
	Adenosine	Ki	2500000.0 [1]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolan-3-yl]-3-methoxybenzamide	IC50	25000.0 [1]
	Adenosine, 8-(2-thienyl)-	IC50	1300.0 [1]
	Adenosine, 8-(2-thienyl)-	Ki	300000.0 [1]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-methoxybenzamide	IC50	300000.0 [1]
	[(2R,3S,4R,5R)-3-Hydroxy-4-[(3-methoxybenzoyl)amino]-5-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate	IC50	2000.0 [1], 5000.0 [2], 7000.0 [3], 100000.0 [4]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-[(2-methylphenyl)methylamino]purin-9-yl]oxolan-3-yl]-3-methoxybenzamide	IC50	4000.0 [1], 30000.0 [2], 270000.0 [3]
	N-[(2R,3R,4S,5R)-2-[6-(Benzylamino)purin-9-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-methoxybenzamide	IC50	16000.0 [1], 159000.0 [2], 220000.0 [3], 530000.0 [4]
	[(2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl] [hydroxy-[[(2R,3S,4R,5R)-3-hydroxy-4-[(3-methoxybenzoyl)amino]-5-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolan-2-yl]methoxy]phosphoryl] phosphate	IC50	60.0 [1], 100.0 [2], 500000.0 [3]
	2-Methyladenosine	IC50	6000.0 [1], 8000.0 [2], 10000.0 [3]
	2-Methyladenine	IC50	6000000.0 [1], 8000000.0 [2], 10000000.0 [3]
	N-Naphthalen-1-ylmethyl-2'-[3,5-dimethoxybenzamido]-2'-deoxy-adenosine	IC50	7000.0 [1], 50000.0 [2]
	N-[[(2R,3S,4R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-2,2-diphenylacetamide	IC50	250000.0 [1]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]thiophene-2-carboxamide	IC50	2400.0 [1], 5000.0 [2], 10000.0 [3]
	N-[(2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-ylpurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]benzamide	IC50	500000.0 [1], 1200000.0 [2]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-4-phenylbenzamide	IC50	200000.0 [1], 400000.0 [2]
	N-[(1R,2R)-2-(6-Amino-purin-9-yl)-cyclopentyl]-3-bromo-benzamide	IC50	700000.0 [1], 1500000.0 [2]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-ethoxybenzamide	IC50	400000.0 [1], 500000.0 [2], 600000.0 [3]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3H-benzimidazole-5-carboxamide	IC50	3000000.0 [1], 10000000.0 [2]
	N-[(2R,3R,4S,5R)-2-(6-Amino-8-bromopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]benzamide	IC50	3000000.0 [1], 6300000.0 [2], 10000000.0 [3]
	3,5-Dichloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolan-3-yl]benzamide	IC50	50000.0 [1], 75000.0 [2], 100000.0 [3]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-chlorobenzamide	IC50	200000.0 [1], 500000.0 [2], 2000000.0 [3]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-[(4-methoxynaphthalen-1-yl)methylamino]purin-9-yl]oxolan-3-yl]-3-methoxybenzamide	IC50	26000.0 [1], 50000.0 [2]
	N-[(2R,3R,4S,5R)-2-(6-Amino-8-methoxypurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]benzamide	IC50	9000000.0 [1], 10000000.0 [2]
	(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-4-(benzylamino)-2-(hydroxymethyl)oxolan-3-ol	IC50	10000000.0 [1]
	N-[2-(6-Amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl]-benzamide	IC50	3300.0 [1], 6000.0 [2], 10000.0 [3]
	N-[(2R,3R,4S,5R)-2-(6-Amino-2-methylpurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-methoxybenzamide	IC50	10000000.0 [1]
	8-(Thiophen-2-yl)-9-(2-aminoethyl)-9H-purin-6-amine	IC50	1600000.0 [1], 1800000.0 [2]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]quinoline-7-carboxamide	IC50	500000.0 [1], 1000000.0 [2], 2000000.0 [3]
	3,5-Dihydroxy-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolan-3-yl]benzamide	IC50	14000.0 [1], 26000.0 [2], 50000.0 [3]
	3,5-Dichloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-[(3-hydroxynaphthalen-1-yl)methylamino]purin-9-yl]oxolan-3-yl]benzamide	IC50	40000.0 [1], 50000.0 [2], 55000.0 [3]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolan-3-yl]-3,4-dimethoxybenzamide	IC50	7000.0 [1], 47000.0 [2], 50000.0 [3]
	[3-Acetyloxy-5-[[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolan-3-yl]carbamoyl]phenyl] acetate	IC50	12000.0 [1], 14000.0 [2], 50000.0 [3]
	3,5-Dichloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-[(3-methoxynaphthalen-1-yl)methylamino]purin-9-yl]oxolan-3-yl]benzamide	IC50	40000.0 [1], 45000.0 [2], 50000.0 [3]
	3-Chloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-[(3-hydroxynaphthalen-1-yl)methylamino]purin-9-yl]oxolan-3-yl]benzamide	IC50	12000.0 [1], 25000.0 [2], 50000.0 [3]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-[(3-methoxynaphthalen-1-yl)methylamino]purin-9-yl]oxolan-3-yl]-3-methoxybenzamide	IC50	12000.0 [1], 50000.0 [2]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-[(3-hydroxynaphthalen-1-yl)methylamino]purin-9-yl]oxolan-3-yl]-3-methoxybenzamide	IC50	12000.0 [1], 25000.0 [2], 50000.0 [3]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-[(3-methoxynaphthalen-1-yl)methylamino]purin-9-yl]oxolan-3-yl]-3,5-dimethoxybenzamide	IC50	5000.0 [1], 7000.0 [2], 50000.0 [3]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-[(3-hydroxynaphthalen-1-yl)methylamino]purin-9-yl]oxolan-3-yl]-3,5-dimethoxybenzamide	IC50	8000.0 [1], 10000.0 [2], 50000.0 [3]
	N-[(3S,4R)-4-Hydroxy-5-(hydroxymethyl)-2-[[6-(naphthalen-2-ylmethylamino)purin-9-yl]methyl]oxolan-3-yl]-3,5-dimethoxybenzamide	IC50	5000.0 [1], 10000.0 [2], 50000.0 [3]
	N-[(3S,4R)-4-Hydroxy-5-(hydroxymethyl)-2-[[6-(naphthalen-2-ylmethylamino)purin-9-yl]methyl]oxolan-3-yl]-3-methoxybenzamide	IC50	10000.0 [1], 24000.0 [2], 50000.0 [3]
	3,5-Dichloro-N-[(3S,4R)-4-hydroxy-5-(hydroxymethyl)-2-[[6-(naphthalen-2-ylmethylamino)purin-9-yl]methyl]oxolan-3-yl]benzamide	IC50	30000.0 [1], 50000.0 [2]
	(3R,4S,5R)-2-(6-Amino-8-cyclohexylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol	IC50	1000000.0 [1], 2000000.0 [2]
	N-[[(2R,3S,4R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-4-(4-ethylphenyl)benzamide	IC50	750000.0 [1], 1000000.0 [2], 2000000.0 [3]
	(3R,4S,5R)-2-(6-Amino-8-pyrimidin-2-ylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol	IC50	2000000.0 [1], 4000000.0 [2], 8000000.0 [3]
	9-(2-Benzylamino-ethyl)-8-thiophen-2-yl-9H-purin-6-ylamine	IC50	400000.0 [1], 500000.0 [2], 600000.0 [3]
	2-Methylpropyl N-[(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]carbamate	IC50	10000000.0 [1]
	beta-Nicotinamide ribose monophosphate	IC50	500000.0 [1]
	N6-Benzyladenosine	IC50	4200000.0 [1]
	N6-Benzyladenosine	Ki	2800000.0 [1]
	8-Phenyladenosine	IC50	10000.0 [1]
	N-[(1R,2R)-2-(6-Amino-purin-9-yl)-cyclopentyl]-benzamide	IC50	4000000.0 [1]
	N-[2-(6-Amino-purin-9-yl)-ethyl]-3-fluoro-benzamide	IC50	4000000.0 [1]
	N-[(1R,2R)-2-(6-Amino-purin-9-yl)-cyclopentyl]-3-chloro-benzamide	IC50	2000000.0 [1], 4000000.0 [2]
	N-[2-(6-Amino-purin-9-yl)-ethyl]-3-chloro-benzamide	IC50	4000000.0 [1]
	N-[(1R,2R)-2-(6-Amino-purin-9-yl)-cyclopentyl]-3-methoxy-benzamide	IC50	4000000.0 [1], 5000000.0 [2]
	N-[2-(6-Amino-purin-9-yl)-ethyl]-4-methyl-benzamide	IC50	2000000.0 [1], 4000000.0 [2]
	(2R,3S,4R)-2-(Hydroxymethyl)-5-[6-(3-methylbut-2-enylamino)-8-thiophen-2-ylpurin-9-yl]oxolane-3,4-diol	Ki	9000.0 [1], 18000.0 [2]
	6-Hydroxydopamine	IC50	8000.0 [1]
	Coumarin	IC50	691830.97 [1]
	Pentamidine	IC50	50000.0 [1]
	Benznidazole	IC50	50000.0 [1]
	N6-Cyclopentyladenosine	IC50	5000000.0 [1]
	Umbelliferone	IC50	616595.0 [1]
	Scopoletin	IC50	257039.58 [1]
	Osthole	IC50	208929.61 [1]
	Riboprine	IC50	5000000.0 [1]
	Xanthyletin	IC50	194984.46 [1]
	Seselin	IC50	123026.88 [1]
	Metrifudil	IC50	700000.0 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolane-3,4-diol	IC50	150000.0 [1]
	3-(4-Hydroxyphenyl)-2H-chromen-2-one	IC50	38904.51 [1]
	2-Phenoxynaphthalene-1,4-dione	IC50	590.0 [1]
	(2R,3R,4S,5R)-2-[6-(Cycloheptylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	IC50	1800000.0 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(m-tolylmethylamino)purin-9-yl]tetrahydrofuran-3,4-diol	IC50	700000.0 [1]
	N-[(4-Aminophenyl)methyl]adenosine	IC50	3100000.0 [1]
	Acetic acid 7-acetoxy-3-(3,4-diacetoxy-phenyl)-2-oxo-2H-chromen-6-yl ester	IC50	17782.79 [1]
	(3R,4S,5R)-2-[6-(Benzhydrylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	IC50	240000.0 [1]
	N-Isopentyladenosine	IC50	3700000.0 [1]
	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(1,2,3,4-tetrahydronaphthalen-1-ylamino)purin-9-yl]oxolane-3,4-diol	IC50	360000.0 [1]
	6-(1,1-Dimethylallyl)-2-(1-hydroxy-1-methylethyl)-2,3-dihydro-7H-furo[3,2-G]chromen-7-one	IC50	54954.09 [1]
	7-Hydroxy-3-(1,1-dimethylprop-2-enyl)coumarin	IC50	162181.01 [1]
	Ethyl 6-chloro-1-[(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-(benzoyloxymethyl)oxolan-2-yl]-4-oxoquinoline-3-carboxylate	IC50	29000.0 [1]
	[3-(3-Acetyloxyphenyl)-2-oxochromen-6-yl] acetate	IC50	16982.44 [1]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-(2-methylpropanoylamino)purin-9-yl]oxolan-3-yl]-3-methoxybenzamide	IC50	1200000.0 [1]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-2-hydroxy-3-methoxybenzamide	IC50	600000.0 [1]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-hydroxybenzamide	IC50	850000.0 [1]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3,5-dihydroxybenzamide	IC50	650000.0 [1]
	N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-[(2-methoxyphenyl)methylamino]purin-9-yl]oxolan-3-yl]-3-methoxybenzamide	IC50	25000.0 [1]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3,4,5-trihydroxybenzamide	IC50	250000.0 [1]
	N-[(2R,3R,4S,5R)-2-[6-[(2,5-Dimethylphenyl)methylamino]purin-9-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-methoxybenzamide	IC50	25000.0 [1]
	N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-4-hydroxy-3-methoxybenzamide	IC50	500000.0 [1]
	N-[(2R,3R,4S,5R)-2-[6-[(2,3-Dimethylphenyl)methylamino]purin-9-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-methoxybenzamide	IC50	5500.0 [1]
	[[(2R,5R)-5-(4-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,5R)-3-hydroxy-4-[(3-methoxybenzoyl)amino]-5-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolan-2-yl]methyl phosphate	IC50	100.0 [1]
	2-(4-Fluorophenoxy)-8-methoxynaphthalene-1,4-dione	IC50	1340.0 [1]
	2-(4-Methoxyphenoxy)anthracene-1,4-dione	IC50	1410.0 [1]
	5-Hydroxy-2-phenoxynaphthalene-1,4-dione	IC50	2410.0 [1]
	3-(1,3-Benzodioxol-5-yl)-6-(1H-pyrrol-2-ylmethylideneamino)chromen-2-one	IC50	56234.13 [1]
	4-Methoxy-2,3-dihydrofuro[3,2-g]chromen-7-one	IC50	346736.85 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Glyceraldehyde-3-phosphate dehydrogenase liver Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/glyceraldehyde-3-phosphate-dehydrogenase-liver-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Glyceraldehyde-3-phosphate dehydrogenase liver Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/glyceraldehyde-3-phosphate-dehydrogenase-liver-inhibitors-ic50-ki.
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