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GTPase KRas Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-29-[(2S)-butan-2-yl]-26-(hydroxymethyl)-23,32-bis[(4-hydroxyphenyl)methyl]-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC501.6 [1], 18.0 [2], 42.0 [3], 87.0 [4]
2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-29-[(2S)-butan-2-yl]-26-(hydroxymethyl)-23,32-bis[(4-hydroxyphenyl)methyl]-35-methyl-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC501630.0 [1], 1790.0 [2], 100000.0 [3]
(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]-29-[(2S)-butan-2-yl]-26-(hydroxymethyl)-23,32-bis[(4-hydroxyphenyl)methyl]-20-methyl-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontane-8-carboxamideIC50975.0 [1], 15400.0 [2], 65000.0 [3], 100000.0 [4]
2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-26-(hydroxymethyl)-23,32-bis[(4-hydroxyphenyl)methyl]-29-methyl-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC505190.0 [1], 20600.0 [2], 39300.0 [3], 73500.0 [4]
2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-29-[(2S)-butan-2-yl]-26-(hydroxymethyl)-23-[(4-hydroxyphenyl)methyl]-32-methyl-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC5050.0 [1], 53.0 [2], 192.0 [3], 1730.0 [4]
2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-29-[(2S)-butan-2-yl]-26-(hydroxymethyl)-32-[(4-hydroxyphenyl)methyl]-23-methyl-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC5064.0 [1], 244.0 [2], 358.0 [3], 4190.0 [4]
2-[(5R,11S,14S,17S,20S,23S,26S,29S,35S,38S,41R)-5-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-41-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-20-[(2S)-butan-2-yl]-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-14-(2-methylpropyl)-6,12,15,18,21,24,27,30,36,39-decaoxo-38-propan-2-yl-3,43-dithia-7,13,16,19,22,25,28,31,37,40-decazatetracyclo[43.4.0.07,11.031,35]nonatetraconta-1(49),45,47-trien-29-yl]acetic acidIC501190.0 [1], 2580.0 [2], 24600.0 [3], 31000.0 [4]
2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-29-[(2S)-butan-2-yl]-26-(hydroxymethyl)-23,32-bis[(4-hydroxyphenyl)methyl]-11-methyl-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC507.5 [1], 35.8 [2], 44.0 [3], 105.0 [4]
2-[(3R,13R,16S,19S,25S,28S,31S,34S,37S,40S,43S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-13-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-34-[(2S)-butan-2-yl]-31-(hydroxymethyl)-28,37-bis[(4-hydroxyphenyl)methyl]-40-(2-methylpropyl)-2,7,9,15,18,24,27,30,33,36,39,42-dodecaoxo-16-propan-2-yl-5,11-dithia-1,8,14,17,23,26,29,32,35,38,41-undecazatetracyclo[41.3.0.06,10.019,23]hexatetracont-6(10)-en-25-yl]acetic acidIC5059.0 [1], 90.0 [2], 197.0 [3], 3920.0 [4]
2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-29-[(2S)-butan-2-yl]-26-(hydroxymethyl)-23,32-bis[(4-hydroxyphenyl)methyl]-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC506.1 [1], 35.0 [2], 82.0 [3]
2-[(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S,35S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-26-[(2S)-butan-2-yl]-23-(hydroxymethyl)-20,29-bis[(4-hydroxyphenyl)methyl]-14-methyl-32-(2-methylpropyl)-2,10,13,16,19,22,25,28,31,34-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,15,18,21,24,27,30,33-decazabicyclo[33.3.0]octatriacontan-17-yl]acetic acidIC502.7 [1], 7.4 [2], 12.0 [3], 216.0 [4]
2-[(3R,10R,13S,16S,22S,25S,28S,31S,34S,37S,40S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-10-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-31-[(2S)-butan-2-yl]-28-(hydroxymethyl)-25,34-bis[(4-hydroxyphenyl)methyl]-37-(2-methylpropyl)-2,12,15,21,24,27,30,33,36,39-decaoxo-13-propan-2-yl-5,8-dithia-1,11,14,20,23,26,29,32,35,38-decazatricyclo[38.3.0.016,20]tritetracontan-22-yl]acetic acidIC5061.0 [1], 63.0 [2], 426.0 [3], 655.0 [4]
2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-8-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-29-[(2S)-butan-2-yl]-23,32-bis[(4-hydroxyphenyl)methyl]-26-methyl-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC506.3 [1], 22.0 [2], 36.0 [3], 764.0 [4]
2-[(3S,6S,9S,12S,15S,18S,21S,24R,29R,32S,35S)-24-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-29-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-12-[(2S)-butan-2-yl]-9-(hydroxymethyl)-6,15-bis[(4-hydroxyphenyl)methyl]-21-methyl-18-(2-methylpropyl)-2,5,8,11,14,17,20,23,31,34-decaoxo-32-propan-2-yl-26,27-dithia-1,4,7,10,13,16,19,22,30,33-decazabicyclo[33.3.0]octatriacontan-3-yl]acetic acidIC5019.0 [1], 113.0 [2], 172.0 [3], 763.0 [4]
2-[(3R,9R,12S,15S,21S,24S,27S,30S,33S,36S,39S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-9-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-30-[(2S)-butan-2-yl]-27-(hydroxymethyl)-24,33-bis[(4-hydroxyphenyl)methyl]-36-(2-methylpropyl)-2,11,14,20,23,26,29,32,35,38-decaoxo-12-propan-2-yl-5,7-dithia-1,10,13,19,22,25,28,31,34,37-decazatricyclo[37.3.0.015,19]dotetracontan-21-yl]acetic acidIC5012.0 [1], 18.0 [2], 243.0 [3], 439.0 [4]
2-[(3R,11R,14S,17S,23S,26S,29S,32S,35S,38S,41S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-11-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-32-[(2S)-butan-2-yl]-29-(hydroxymethyl)-26,35-bis[(4-hydroxyphenyl)methyl]-38-(2-methylpropyl)-2,13,16,22,25,28,31,34,37,40-decaoxo-14-propan-2-yl-5,9-dithia-1,12,15,21,24,27,30,33,36,39-decazatricyclo[39.3.0.017,21]tetratetracontan-23-yl]acetic acidIC5083.0 [1], 110.0 [2], 848.0 [3], 2010.0 [4]
2-[(3R,8R,11S,14S,20S,23S,26S,29S,32S,35S,38S)-3-Acetamido-29-[(2S)-butan-2-yl]-8-carbamoyl-26-(hydroxymethyl)-23,32-bis[(4-hydroxyphenyl)methyl]-35-(2-methylpropyl)-2,10,13,19,22,25,28,31,34,37-decaoxo-11-propan-2-yl-5,6-dithia-1,9,12,18,21,24,27,30,33,36-decazatricyclo[36.3.0.014,18]hentetracontan-20-yl]acetic acidIC5011.0 [1], 82.0 [2], 142.0 [3], 9770.0 [4]
2-(4,6-Dichloro-2-methyl-1H-indol-3-yl)ethanamineIC50155000.0 [1], 342000.0 [2]
VemurafenibIC5016600.0 [1]
DabrafenibIC505880.0 [1]
LY-3009120IC50150.0 [1]
[[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] 2-[(2-chloroacetyl)amino]ethyl hydrogen phosphateKi9.0 [1]
CID 137003167Ki64000.0 [1]
1-(3-Tert-butyl-1,2-oxazol-5-yl)-3-[2-fluoro-5-[7-(methylamino)-2-oxo-1-[(3S)-oxolan-3-yl]-1,6-naphthyridin-3-yl]phenyl]ureaIC5057.0 [1]
1-(3,3-Dimethylbutyl)-3-[5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluoro-4-methylphenyl]ureaIC50120.0 [1]
[[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] 2-(prop-2-enoylamino)ethyl hydrogen phosphateKi280.0 [1]
2-[(2-Chloroacetyl)amino]ethyl N-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxysulfonyl]carbamateKi5000.0 [1]
N-[3-[[2-[[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]-3,4-dioxocyclobuten-1-yl]amino]propyl]-2-chloroacetamideKi25000.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[3-[(2-chloroacetyl)amino]propoxy-hydroxyphosphoryl]-difluoromethyl]phosphinic acidKi382.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[3-[(2-chloroacetyl)amino]propoxy-hydroxyphosphoryl]methyl]phosphinic acidKi374.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(1R,3S)-3-[(2-chloroacetyl)amino]cyclopentyl]oxy-hydroxyphosphoryl]methyl]phosphinic acidKi50000.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[2-[(2-chloroacetyl)amino]ethoxy-hydroxyphosphoryl]-fluoromethyl]phosphinic acidKi8000.0 [1]
[2-[[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-2-oxoethyl]-[2-[(2-chloroacetyl)amino]ethoxy]phosphinic acidKi2200.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[2-[2-[(2-chloroacetyl)amino]ethoxy]-2-oxoethyl]phosphinic acidKi15200.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-[2-[(2-chloroacetyl)amino]ethylsulfamoyl]acetateKi10000.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[1-(2-chloroacetyl)pyrrolidin-3-yl]oxy-hydroxyphosphoryl]methyl]phosphinic acidKi920.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(1R,3R)-3-[(2-chloroacetyl)amino]cyclopentyl]oxy-hydroxyphosphoryl]methyl]phosphinic acidKi36000.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[3-[(2-chloroacetyl)amino]-2,2-dimethylpropoxy]-hydroxyphosphoryl]methyl]phosphinic acidKi5000.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[2-[(2-chloroacetyl)amino]ethoxy-hydroxyphosphoryl]-difluoromethyl]phosphinic acidKi380.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[(E)-6-methoxy-6-oxohex-4-enoxy]phosphoryl]methyl]phosphinic acidKi20000.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[2-[(2-chloroacetyl)amino]ethoxy-hydroxyphosphoryl]methyl]phosphinic acidKi2700.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[2-[(2-chloroacetyl)amino]ethylsulfamoylmethyl]phosphinic acidKi1600.0 [1]
[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[1-(2-chloroacetyl)piperidin-3-yl]oxy-hydroxyphosphoryl]methyl]phosphinic acidKi3500.0 [1]
1-(3-Tert-butyl-1,2-oxazol-5-yl)-3-[5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]ureaIC5091.0 [1]
3-[(8S,11S,14S,17S,20S,23S,26S,30R,33S)-11,14,23-Tris[3-(diaminomethylideneamino)propyl]-20-[(4-fluorophenyl)methyl]-17-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-8-(2-methylpropyl)-2,3,7,10,13,16,19,22,25,28,32-undecaoxo-30-(2-phenylethyl)-6-oxa-1,9,12,15,18,21,24,27,31-nonazabicyclo[31.4.0]heptatriacontan-26-yl]propanamideIC50200.0 [1]
1-(3,3-Dimethylbutyl)-3-[2-fluoro-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]ureaIC5048.0 [1]
1-(3,3-Dimethylbutyl)-3-[2-fluoro-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]ureaIC5046.0 [1]
1-(3,3-Dimethylbutyl)-3-[4-methyl-3-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]ureaIC50270.0 [1]
1-(3,3-Dimethylbutyl)-3-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]ureaIC50120.0 [1]
1-(3,3-Dimethylbutyl)-3-[2-fluoro-4-methyl-5-[2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]ureaIC5016.0 [1]
1-[2-Fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[(2S)-2-hydroxy-3,3-dimethylbutyl]ureaIC50160.0 [1]
3-[(8S,11R,14S,17S,20S,23S,26S,30R,33S)-11-(2-Amino-2-oxoethyl)-14,17-bis[3-(diaminomethylideneamino)propyl]-20-[(4-fluorophenyl)methyl]-23-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2,3,7,10,13,16,19,22,25,28,32-undecaoxo-30-(2-phenylethyl)-8-propan-2-yl-6-oxa-1,9,12,15,18,21,24,27,31-nonazabicyclo[31.4.0]heptatriacontan-26-yl]propanamideIC501200.0 [1]
3-[(8R,11R,14R,17R,20S,23S,26S,30R,33S)-17-(4-Aminobutyl)-8-butyl-20-(3-carbamimidamidopropyl)-23-[(4-fluorophenyl)methyl]-4,4-dimethyl-11,14-bis(naphthalen-2-ylmethyl)-2,3,7,10,13,16,19,22,25,28,32-undecaoxo-30-(2-phenylethyl)-6-oxa-1,9,12,15,18,21,24,27,31-nonazabicyclo[31.4.0]heptatriacontan-26-yl]propanamideIC5010000.0 [1]
3-[(8S,11S,17S,20R,23S,26S,30R,33S)-23-(3-Aminopropyl)-8-benzyl-11-[3-(diaminomethylideneamino)propyl]-17-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-20-(naphthalen-2-ylmethyl)-2,3,7,10,13,16,19,22,25,28,32-undecaoxo-30-(2-phenylethyl)-6-oxa-1,9,12,15,18,21,24,27,31-nonazabicyclo[31.4.0]heptatriacontan-26-yl]propanamideIC501800.0 [1]
3-[(1S,4R,8S,11R,14S,20S,23S,26S,29S)-11,29-Dibenzyl-26-(3-carbamimidamidopropyl)-14,23-bis[(4-hydroxyphenyl)methyl]-33,33-dimethyl-2,6,9,12,15,21,24,27,30,34,35-undecaoxo-4-(2-phenylethyl)-31-oxa-3,7,10,13,16,22,25,28,36-nonazatricyclo[34.4.0.016,20]tetracontan-8-yl]propanamideIC5010000.0 [1]
3-[(1S,4R,8S,14S,17S,20R,23S,26S,29S)-8-(3-Amino-3-oxopropyl)-17-(3-aminopropyl)-20-benzyl-33,33-dimethyl-29-(2-methylpropyl)-2,6,9,15,18,21,24,27,30,34,35-undecaoxo-23-phenyl-4-(2-phenylethyl)-31-oxa-3,7,10,16,19,22,25,28,36-nonazatricyclo[34.4.0.010,14]tetracontan-26-yl]propanoic acidIC5010000.0 [1]
3-[(8R,11S,14S,17R,20S,23S,26S,30R,33S)-8-Butyl-14,20,23-tris[3-(diaminomethylideneamino)propyl]-11-[(4-fluorophenyl)methyl]-4,4-dimethyl-17-(naphthalen-2-ylmethyl)-2,3,7,10,13,16,19,22,25,28,32-undecaoxo-30-(2-phenylethyl)-6-oxa-1,9,12,15,18,21,24,27,31-nonazabicyclo[31.4.0]heptatriacontan-26-yl]propanamideIC50700.0 [1]
3-[(8S,11S,14R,17S,20R,23S,26S,30R,33S)-8,20-Dibenzyl-11,17-bis(3-carbamimidamidopropyl)-23-[3-(diaminomethylideneamino)propyl]-4,4-dimethyl-14-(naphthalen-2-ylmethyl)-2,3,7,10,13,16,19,22,25,28,32-undecaoxo-30-(2-phenylethyl)-6-oxa-1,9,12,15,18,21,24,27,31-nonazabicyclo[31.4.0]heptatriacontan-26-yl]propanamideIC501100.0 [1]
3-[(8S,11R,14S,17R,20S,23S,26S,30R,33S)-14,20-Bis[3-(diaminomethylideneamino)propyl]-4,4,23-trimethyl-8-(2-methylpropyl)-11-(naphthalen-2-ylmethyl)-2,3,7,10,13,16,19,22,25,28,32-undecaoxo-30-(2-phenylethyl)-17-propan-2-yl-6-oxa-1,9,12,15,18,21,24,27,31-nonazabicyclo[31.4.0]heptatriacontan-26-yl]propanamideIC502000.0 [1]
3-[(8S,11S,14S,17S,20R,26S,30R,33S)-8-Benzyl-17-[3-(diaminomethylideneamino)propyl]-20-[(1S)-1-hydroxyethyl]-14-[(4-hydroxyphenyl)methyl]-4,4,11-trimethyl-2,3,7,10,13,16,19,22,25,28,32-undecaoxo-30-(2-phenylethyl)-6-oxa-1,9,12,15,18,21,24,27,31-nonazabicyclo[31.4.0]heptatriacontan-26-yl]propanamideIC502300.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ GTPase KRas Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/gtpase-kras-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ GTPase KRas Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/gtpase-kras-inhibitors-ic50-ki.
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