Heat shock protein 75 kDa, mitochondrial Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Luminespib	IC50	38.0 [1], 500.0 [2], 535.0 [3]
	Luminespib	Ki	16.0 [1]
	PU-H71	IC50	205.0 [1], 257.0 [2]
	6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine	IC50	90.0 [1], 535.0 [2]
	6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine	Ki	62.0 [1]
	Snx-2112	IC50	726.0 [1]
	Snx-2112	Ki	791.0 [1]
	Adenosine-5'-triphosphate	IC50	31303.0 [1]
	Adenosine-5'-diphosphate	IC50	55594.0 [1]
	Geldanamycin	IC50	661.0 [1]
	Tanespimycin	IC50	1496.0 [1]
	Ganetespib	IC50	51.0 [1]
	Nvp-hsp990(hsp990)	IC50	200.0 [1]
	Debio 0932	IC50	1586.0 [1]
	CID 67495834	Ki	1195.0 [1]
	5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]-2-methylpent-4-yn-2-ol	Ki	255.0 [1]
	8-((3,5-Dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine	IC50	7300.0 [1]
	9-(Pent-4-yn-1-yl)-8-((2,4,5-trichlorophenyl)thio)-9H-purin-6-amine	IC50	78400.0 [1]
	8-((2,4-Dimethylphenyl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine	IC50	13800.0 [1]
	8-((2,5-Dichlorophenyl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine	IC50	5100.0 [1]
	8-((3,5-Dimethylphenyl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine	IC50	157900.0 [1]
	8-((2,4-Dichlorophenyl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine	IC50	145400.0 [1]
	8-((3,5-Dichlorophenyl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine	IC50	83600.0 [1]
	8-((2,5-Dimethylphenyl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine	IC50	203700.0 [1]
	5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-(3-morpholin-4-ylpropanoylamino)-1,2-oxazole-3-carboxamide	IC50	20000.0 [1]
	5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[(4-methoxybenzoyl)amino]-1,2-oxazole-3-carboxamide	IC50	400.0 [1]
	8-(Mesitylthio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine	IC50	65500.0 [1]
	8-(2,4-Dichlorophenyl)sulfanyl-9-pentan-2-ylpurin-6-amine	IC50	50000.0 [1]
	9-Pent-4-ynyl-8-(2,3,4-trichlorophenyl)sulfanylpurin-6-amine	IC50	3600.0 [1]
	8-(3,5-Dichlorophenyl)sulfanyl-9-(2-phenylethyl)purin-6-amine	IC50	100000.0 [1]
	8-(2,6-Dichloropyridin-4-yl)sulfanyl-9-pent-4-ynylpurin-6-amine	IC50	9600.0 [1]
	(6-Amino-9-pent-4-ynylpurin-8-yl)-(2,4-dichlorophenyl)methanone	IC50	4980.0 [1]
	4-[6-Amino-8-(3,5-dichlorophenyl)sulfanylpurin-9-yl]butanenitrile	IC50	4580.0 [1]
	8-(2,4-Dichlorophenyl)sulfanyl-9-hex-5-yn-3-ylpurin-6-amine	IC50	50000.0 [1]
	2-(2,4-Dichlorophenyl)sulfanyl-1-[3-(propan-2-ylamino)propyl]imidazo[4,5-c]pyridin-4-amine	IC50	14100.0 [1]
	2-(3,5-Dichlorophenyl)sulfanyl-1-[3-(propan-2-ylamino)propyl]imidazo[4,5-c]pyridin-4-amine	IC50	7200.0 [1]
	9-But-3-ynyl-8-(2,4-dichlorophenyl)sulfanylpurin-6-amine	IC50	7230.0 [1]
	1-[(6-Bromo-1,3-benzodioxol-5-yl)methyl]-4-chloropyrazolo[3,4-d]pyrimidin-6-amine	IC50	79.0 [1]
	1-(1,3-Benzodioxol-5-ylmethyl)-4-chloropyrazolo[3,4-d]pyrimidin-6-amine	IC50	6335.0 [1]
	4-[6-Imino-8-(2,4,5-trichlorophenyl)sulfanyl-7H-purin-3-yl]butanenitrile	IC50	19500.0 [1]
	3-[8-(3,5-Dichlorophenyl)sulfanyl-6-imino-7H-purin-3-yl]-N-propan-2-ylpropan-1-amine	IC50	100000.0 [1]
	4-[8-(2,4-Dichlorophenyl)sulfanyl-6-imino-7H-purin-3-yl]butanenitrile	IC50	9600.0 [1]
	4-[8-(2,4-Dimethylphenyl)sulfanyl-6-imino-7H-purin-3-yl]butanenitrile	IC50	54100.0 [1]
	2-Amino-7-(1,3-benzodioxol-5-ylmethyl)-4-chloropyrrolo[2,3-d]pyrimidine-6-carboxylic acid	IC50	8434.0 [1]
	7-(1,3-Benzodioxol-5-ylmethyl)-4-chloroimidazo[5,1-f][1,2,4]triazin-2-amine	IC50	10000.0 [1]
	5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-(6-pyridin-1-ium-1-ylhexanoylamino)-1,2-oxazole-3-carboxamide;bromide	IC50	10000.0 [1]
	[6-[[5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-3-(ethylcarbamoyl)-1,2-oxazol-4-yl]amino]-6-oxohexyl]-triphenylphosphanium;bromide	IC50	25000.0 [1]
	N-[3-[2-(3-Aminopropylamino)ethylamino]propyl]-N'-[5-(2,4-dihydroxy-5-propan-2-ylphenyl)-3-(ethylcarbamoyl)-1,2-oxazol-4-yl]hexanediamide	IC50	5000.0 [1]
	4-N-(Diaminomethylidene)-1-N-[5-(2,4-dihydroxy-5-propan-2-ylphenyl)-3-(ethylcarbamoyl)-1,2-oxazol-4-yl]benzene-1,4-dicarboxamide	IC50	500.0 [1]
	4-[7-[4-(Diaminomethylidenecarbamoyl)phenyl]heptanoylamino]-5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-1,2-oxazole-3-carboxamide	IC50	3000.0 [1]
	4-Chloro-1-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrazolo[3,4-d]pyrimidin-6-amine	IC50	138.0 [1]
	[(4E,6Z,8R,9S,10E,12S,13R,14S,16R)-19-[2-(Dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate	Ki	326.0 [1]
	8-(2-Methylpropyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-Cyclopentyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-Cyclohexyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-(Oxan-4-yl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-Cyclobutyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-Butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-Tert-butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-Benzyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-Phenyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-(4-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-(3-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	8-(4-Methoxyphenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	Ki	10000.0 [1]
	2-Fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	8500.0 [1]
	2-[[(3S)-Oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	5000.0 [1]
	2-(Cyclopentylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	1700.0 [1]
	2-(Cyclopropylmethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	4500.0 [1]
	2-(2-Methoxyethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	8800.0 [1]
	2-(Thian-4-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	1200.0 [1]
	2-(Propylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	5800.0 [1]
	2-(Cyclopropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	10000.0 [1]
	2-(2,2-Difluoroethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	7400.0 [1]
	2-[(3-Methyloxetan-3-yl)methylamino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	1200.0 [1]
	2-(Propan-2-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	10000.0 [1]
	2-(2,2-Dimethylpropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	1400.0 [1]
	2,7,7-Trimethyl-9-[1-oxo-8-(propan-2-ylamino)-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	10000.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-2,3-dihydroisoindol-5-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	10000.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	10000.0 [1]
	2,7,7-Trimethyl-9-(1-oxo-2,3,4,5-tetrahydro-2-benzazepin-7-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	10000.0 [1]
	2-(2-Cyclopropylethyl)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamide	Ki	10000.0 [1]
	2,7,7-Trimethyl-9-[8-(2-methylpropyl)-1-oxo-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-one	Ki	10000.0 [1]
	4-(2,8,8-Trimethyl-6-oxo-1,3,4,5,5a,7,9,10a-octahydroazepino[3,4-b]indol-10-yl)benzamide	Ki	10000.0 [1]
	4-(7,7-Dimethyl-5-oxo-1,2,3,4,6,8-hexahydropyrido[3,4-b]indol-9-yl)benzamide	Ki	10000.0 [1]
	4-(7,7-Dimethyl-9-oxo-6,8-dihydropyrido[3,2-b]indol-5-yl)benzamide	Ki	10000.0 [1]
	4-(7,7-Dimethyl-5-oxo-6,8-dihydropyrido[3,4-b]indol-9-yl)benzamide	Ki	10000.0 [1]
	4-(7,7-Dimethyl-5-oxo-6,8-dihydropyrido[2,3-b]indol-9-yl)benzamide	Ki	10000.0 [1]
	4-(7,7-Dimethyl-5-oxo-1,2,3,4,6,8-hexahydrocarbazol-9-yl)benzamide	Ki	10000.0 [1]
	4-(2,7,7-Trimethyl-5-Oxo-1,2,3,4,5,6,7,8-Octahydro-9h-beta-Carbolin-9-Yl)benzamide	Ki	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 89 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Heat shock protein 75 kDa, mitochondrial Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/heat-shock-protein-75-kda-mitochondrial-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Heat shock protein 75 kDa, mitochondrial Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/heat-shock-protein-75-kda-mitochondrial-inhibitors-ic50-ki.
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