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Heat shock protein HSP 90-beta Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
LuminespibIC507.0 [1]
LuminespibKi0.06 [1], 0.07 [2], 2.0 [3], 8.2 [4]
TanespimycinIC507.0 [1], 12.0 [2], 15.0 [3], 26500.0 [4]
TanespimycinKi9.0 [1], 530.0 [2]
6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amineIC507.0 [1], 17.0 [2], 30.0 [3], 38.0 [4], 140.0 [5]
6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amineKi1.7 [1], 4.0 [2], 13.0 [3], 26.0 [4]
Snx-2112IC507.0 [1], 22.0 [2], 25.0 [3]
Snx-2112Ki1.1 [1], 2.8 [2], 6.0 [3]
GeldanamycinIC5010.0 [1], 20.0 [2], 22.0 [3], 348.0 [4]
17-AminogeldanamycinIC507.0 [1], 12.0 [2]
17-AminogeldanamycinKi3.0 [1], 21.0 [2]
AlvespimycinIC5024.0 [1], 90.0 [2], 930.0 [3], 1410.0 [4]
1-(2-Amino-4-methyl-quinazolin-7-yl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-indol-4-oneIC504.0 [1], 5.0 [2], 11.0 [3], 36.0 [4]
PU-H71IC5042.0 [1], 50.0 [2]
8-Cyclopentyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC506.0 [1], 24.0 [2]
8-Cyclopentyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi5.0 [1]
RadicicolIC5019.0 [1], 20.0 [2]
OnalespibIC5030.0 [1], 350.0 [2]
CID 67495834IC5030.0 [1]
CID 67495834Ki4.0 [1]
8-((6-Bromobenzo[d][1,3]dioxol-5-yl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amineIC50300.0 [1], 365.0 [2]
2-Fluoro-8-[(6-Iodo-1,3-Benzodioxol-5-Yl)methyl]-9-[3-(Isopropylamino)propyl]-9h-Purin-6-AmineIC5080.0 [1], 90.0 [2]
4-N-[5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-3-(ethylcarbamoyl)-1,2-oxazol-4-yl]cyclohexane-1,4-dicarboxamideIC505.0 [1]
5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[(4-hydroxycyclohexanecarbonyl)amino]-1,2-oxazole-3-carboxamideIC505.0 [1]
5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[[4-(hydroxymethyl)cyclohexanecarbonyl]amino]-1,2-oxazole-3-carboxamideIC505.0 [1], 15.0 [2]
6-Hydroxy-N-[[4-(methanesulfonamidomethyl)phenyl]methyl]-N-methyl-3-[(3-methylphenyl)methyl]-1H-indazole-5-carboxamideIC50150.0 [1], 1100.0 [2]
3-[(3-Chlorophenyl)methyl]-6-hydroxy-N-[[4-(methanesulfonamidomethyl)phenyl]methyl]-N-methyl-1H-indazole-5-carboxamideIC5060.0 [1], 1000.0 [2]
N,N-Dimethyl-4-[[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methyl]anilineIC5046130.0 [1], 100000.0 [2]
6-[(4-Chlorophenyl)methyl]-2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidineIC5047880.0 [1], 100000.0 [2]
6-[(4-Fluorophenyl)methyl]-2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidineIC5040240.0 [1], 100000.0 [2]
2-[[2-Amino-5-(1,3-benzodioxol-5-ylmethyl)-[1,2,4]triazolo[1,5-c]quinazolin-10-yl]amino]ethanolKi5000.0 [1], 13200.0 [2]
5-(1,3-Benzodioxol-5-Ylmethyl)[1,2,4]triazolo[1,5-C]quinazolin-2-AmineKi35.0 [1], 170.0 [2]
8-(2-Methylpropyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC50222.0 [1]
8-(2-Methylpropyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi26.0 [1]
(5-Chloro-2,4-dihydroxyphenyl)-(2-methyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)methanoneIC50100.0 [1], 420.0 [2]
8-Cyclohexyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC5036.0 [1]
8-Cyclohexyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi5.0 [1]
8-(Oxan-4-yl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC5019.0 [1]
8-(Oxan-4-yl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi3.0 [1]
8-Cyclobutyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC50195.0 [1]
8-Cyclobutyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi39.0 [1]
8-Butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC501000.0 [1]
8-Butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi56.0 [1]
8-Tert-butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC501700.0 [1]
8-Tert-butyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi140.0 [1]
8-Benzyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC50480.0 [1]
8-Benzyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi120.0 [1]
8-Phenyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC50230.0 [1]
8-Phenyl-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi15.0 [1]
8-(4-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC5080.0 [1]
8-(4-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi10.0 [1]
8-(3-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC5081.0 [1]
8-(3-Fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi20.0 [1]
8-(4-Methoxyphenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneIC50280.0 [1]
8-(4-Methoxyphenyl)-6-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)-3,4-dihydro-2H-isoquinolin-1-oneKi40.0 [1]
2-Fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50120.0 [1]
2-Fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi31.0 [1]
2-[[(3S)-Oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50120.0 [1]
2-[[(3S)-Oxolan-3-yl]amino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi35.0 [1]
2-(Cyclopentylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50110.0 [1]
2-(Cyclopentylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi12.0 [1]
2-(Cyclopropylmethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50190.0 [1]
2-(Cyclopropylmethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi19.0 [1]
2-(2-Methoxyethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50720.0 [1]
2-(2-Methoxyethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi60.0 [1]
2-(Thian-4-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC5090.0 [1]
2-(Thian-4-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi25.0 [1]
2-(Propylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50190.0 [1]
2-(Propylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi21.0 [1]
2-(Cyclopropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50420.0 [1]
2-(Cyclopropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi48.0 [1]
2-(2,2-Difluoroethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50220.0 [1]
2-(2,2-Difluoroethylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi29.0 [1]
2-[(3-Methyloxetan-3-yl)methylamino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50450.0 [1]
2-[(3-Methyloxetan-3-yl)methylamino]-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi22.0 [1]
2-(Propan-2-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50140.0 [1]
2-(Propan-2-ylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi25.0 [1]
2-(2,2-Dimethylpropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC50930.0 [1]
2-(2,2-Dimethylpropylamino)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi22.0 [1]
2,7,7-Trimethyl-9-[1-oxo-8-(propan-2-ylamino)-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneIC5073.0 [1]
2,7,7-Trimethyl-9-[1-oxo-8-(propan-2-ylamino)-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneKi30.0 [1]
2,7,7-Trimethyl-9-(1-oxo-2,3-dihydroisoindol-5-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneIC5010000.0 [1]
2,7,7-Trimethyl-9-(1-oxo-2,3-dihydroisoindol-5-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneKi10000.0 [1]
2,7,7-Trimethyl-9-(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneIC508500.0 [1]
2,7,7-Trimethyl-9-(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneKi590.0 [1]
2,7,7-Trimethyl-9-(1-oxo-2,3,4,5-tetrahydro-2-benzazepin-7-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneIC5010000.0 [1]
2,7,7-Trimethyl-9-(1-oxo-2,3,4,5-tetrahydro-2-benzazepin-7-yl)-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneKi10000.0 [1]
2-(2-Cyclopropylethyl)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideIC503600.0 [1]
2-(2-Cyclopropylethyl)-4-(2,7,7-trimethyl-5-oxo-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-9-yl)benzamideKi420.0 [1]
2,7,7-Trimethyl-9-[8-(2-methylpropyl)-1-oxo-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneIC50143.0 [1]
2,7,7-Trimethyl-9-[8-(2-methylpropyl)-1-oxo-3,4-dihydro-2H-isoquinolin-6-yl]-3,4,6,8-tetrahydro-1H-pyrido[3,4-b]indol-5-oneKi37.0 [1]
4-(7,7-Dimethyl-5-oxo-1,2,3,4,6,8-hexahydrocarbazol-9-yl)-2-[[(3S)-oxolan-3-yl]amino]benzamideIC50530.0 [1]
4-(7,7-Dimethyl-5-oxo-1,2,3,4,6,8-hexahydrocarbazol-9-yl)-2-[[(3S)-oxolan-3-yl]amino]benzamideKi40.0 [1]
(2,5-Dimethoxyphenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanoneIC5016440.0 [1], 40360.0 [2]
(4-Fluorophenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanoneIC5027210.0 [1], 100000.0 [2]
(4-Chlorophenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanoneIC5024480.0 [1], 100000.0 [2]
(2,4-Dimethoxyphenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanoneIC507880.0 [1], 30540.0 [2]
(2,4-Dihydroxyphenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanoneIC503230.0 [1], 10230.0 [2]
(5-Chloro-2,4-dihydroxyphenyl)-[2-(4-pyrimidin-2-ylpiperazin-1-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]methanoneIC50930.0 [1], 1670.0 [2]
(2-Amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-(5-chloro-2,4-dihydroxyphenyl)methanoneIC50310.0 [1], 510.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Heat shock protein HSP 90-beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/heat-shock-protein-hsp-90-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Heat shock protein HSP 90-beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/heat-shock-protein-hsp-90-beta-inhibitors-ic50-ki.
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