Hematopoietic prostaglandin D synthase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-Phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole	IC50	21.0 [1], 23.0 [2], 700.0 [3], 97700.0 [4]
	4-(Benzhydryloxy)-1-[3-(1H-tetraazol-5-YL)propyl]piperidine	IC50	1800.0 [1], 3800.0 [2], 73900.0 [3]
	2-Benzoylthiophene	IC50	9200.0 [1], 12800.0 [2], 83500.0 [3]
	4-{[4-(4-Fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid	IC50	138.0 [1], 1400.0 [2], 94600.0 [3]
	N-Cyclopentyl-3-(5-cyclopropyl-1H-pyrazol-4-yl)-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamide	IC50	10.0 [1], 40.0 [2], 317.0 [3]
	3-(5-Cyclopropyl-1H-pyrazol-4-yl)-N-ethyl-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamide	IC50	40.0 [1], 501.0 [2], 4000.0 [3]
	CID 46899922	IC50	700.0 [1], 79200.0 [2]
	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-6-thiophen-2-ylpyridine-3-carboxamide	IC50	1200.0 [1], 97000.0 [2]
	3-(Dimethylamino)-N-[5-(1H-indol-4-yl)pyridin-3-yl]propanamide	IC50	300.0 [1], 460.0 [2]
	3-(1H-Indol-4-yl)-N-(3-methoxypropyl)-1,2,4-oxadiazole-5-carboxamide	IC50	170.0 [1], 2900.0 [2]
	CID 46899923	IC50	1900.0 [1], 76400.0 [2]
	N-Benzhydryl-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide	IC50	10800.0 [1], 71200.0 [2]
	CID 46900088	IC50	8000.0 [1], 73900.0 [2]
	N-(1-Amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide	IC50	7100.0 [1], 66900.0 [2]
	N-[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide	IC50	2100.0 [1], 72500.0 [2]
	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-4-(3-hydroxyphenyl)benzamide	IC50	4600.0 [1], 88500.0 [2]
	N-[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-(3-hydroxyphenyl)benzamide	IC50	1000.0 [1], 91000.0 [2]
	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-2-hydroxy-4-(3-hydroxyphenyl)benzamide	IC50	24800.0 [1], 61300.0 [2]
	N-[(1-Amino-1-oxo-3-phenylpropan-2-yl)carbamoyl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide	IC50	3700.0 [1], 89500.0 [2]
	N-[[1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide	IC50	1300.0 [1], 91300.0 [2]
	6-(3-Methoxyphenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide	IC50	60.0 [1], 210.0 [2]
	4-(Dimethylamino)-N-[5-(1h-Indol-4-Yl)pyridin-3-Yl]butanamide	IC50	180.0 [1], 820.0 [2]
	N-(6-Bromo-1,3-benzothiazol-2-yl)-4-(3-fluorobenzoyl)piperazine-1-carboxamide	IC50	106.0 [1]
	2-Phenyl-5-(2-phenyl-1H-imidazol-5-yl)pyrimidine	IC50	12.0 [1], 250.0 [2]
	2-Phenyl-5-(2-phenyl-1H-imidazol-5-yl)pyridine	IC50	97.0 [1], 480.0 [2]
	5-(3-Methyl-2-phenylimidazol-4-yl)-2-phenylpyrimidine	IC50	250.0 [1], 625.0 [2]
	5-(5-Methyl-2-phenyl-1H-imidazol-4-yl)-2-phenylpyrimidine	IC50	82.0 [1], 450.0 [2]
	2-Phenyl-5-(2-pyridin-3-yl-1H-imidazol-5-yl)pyrimidine	IC50	21.0 [1], 79.0 [2]
	2-Phenyl-5-(2-(pyridin-4-yl)-1H-imidazol-5-yl)pyrimidine	IC50	75.0 [1], 125.0 [2]
	5-[2-(1-Benzylpiperidin-4-yl)-1H-imidazol-5-yl]-2-phenylpyrimidine	IC50	6.0 [1], 80.0 [2]
	4-(3-Fluorobenzoyl)-N-(6-methyl-1,3-benzothiazol-2-yl)piperazine-1-carboxamide	IC50	260.0 [1]
	5-(2-Benzyl-1H-imidazol-5-yl)-2-phenylpyrimidine	IC50	59.0 [1], 625.0 [2]
	2-Phenyl-5-(5-phenyl-4H-1,2,4-triazol-3-yl)pyrimidine	IC50	84.0 [1], 1000.0 [2]
	2-Phenoxy-5-(2-pyridin-3-yl-1H-imidazol-5-yl)pyrimidine	IC50	370.0 [1], 625.0 [2]
	2-Phenyl-5-(2-(pyridin-2-yl)-1H-imidazol-5-yl)pyrimidine	IC50	53.0 [1], 125.0 [2]
	2-(3,4-Dimethoxyphenyl)-5-(2-phenyl-1H-imidazol-5-yl)pyrimidine	IC50	3500.0 [1], 8000.0 [2]
	5-[2-(3-Fluorophenyl)-1H-imidazol-5-yl]-2-phenylpyrimidine	IC50	4.0 [1], 188.0 [2]
	(E)-2-Phenyl-5-(2-(2-(pyridin-3-yl)vinyl)-1H-imidazol-5-yl)pyrimidine	IC50	23.0 [1], 150.0 [2]
	Ethyl 5-(2-phenoxypyrimidin-5-yl)-1H-pyrazole-3-carboxylate	IC50	130.0 [1], 1300.0 [2]
	(4-Methylpiperazin-1-yl)(5-(2-phenoxypyrimidin-5-yl)-1H-pyrazol-3-yl)methanone	IC50	420.0 [1], 650.0 [2]
	4-(2-Phenylpyrimidin-5-yl)-2-pyridin-3-yl-1,3-thiazole	IC50	150.0 [1], 1000.0 [2]
	2-(3-Fluorophenyl)-5-(2-phenyl-1H-imidazol-5-yl)pyrimidine	IC50	47.0 [1], 280.0 [2]
	2-(3-Fluorophenyl)-5-(2-(pyridin-3-yl)-1H-imidazol-5-yl)pyrimidine	IC50	41.0 [1], 156.0 [2]
	N-(5,6-Dimethyl-1,3-benzothiazol-2-yl)-4-(3-fluorobenzoyl)piperazine-1-carboxamide	IC50	222.0 [1]
	4-(3-Fluorobenzoyl)-N-(6-methoxy-1,3-benzothiazol-2-yl)piperazine-1-carboxamide	IC50	318.0 [1]
	N-(6-Chloro-1,3-benzothiazol-2-yl)-4-(3-fluorobenzoyl)piperazine-1-carboxamide	IC50	204.0 [1]
	4,5,6,7-Tetrabromo-3',3''-disulfophenolphthalein	IC50	27000.0 [1]
	Ethacrynic acid	IC50	122300.0 [1]
	Cibacron Blue	IC50	200.0 [1]
	Tranilast	IC50	11600.0 [1]
	Oxfendazole	IC50	300000.0 [1]
	3-(4-Methylphenyl)-5H-indeno[1,2-c]pyridazin-5-one	IC50	3800.0 [1]
	3-(4-Hydroxyphenyl)-5H-indeno[1,2-c]pyridazin-5-one	IC50	3800.0 [1]
	4-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-5-amine	IC50	33000.0 [1]
	4-Methyl-2-phenyl-N-(4-sulfamoylphenyl)-1,3-thiazole-5-carboxamide	IC50	1.0 [1]
	1-Phenyl-1H-pyrazole-4-carboxylic acid	IC50	890000.0 [1]
	6-(3-Fluorophenyl)-N-[1-(2,2,2-Trifluoroethyl)piperidin-4-Yl]pyridine-3-Carboxamide	IC50	200.0 [1]
	Ethyl 5-hydroxy-6-phenyl-3-pyridazinecarboxylate	IC50	45000.0 [1]
	3-(3,5-Dimethyl-1H-pyrrol-2-yl)-1H-pyrazole	IC50	26400.0 [1]
	1-(5-Chloro-1,3-benzoxazol-2-yl)-N-[(1S,2S)-2-phenylmethoxycyclopentyl]piperidine-4-carboxamide	IC50	10000.0 [1]
	2-(4-Methoxybenzoyl)thiophene	IC50	105000.0 [1]
	N-[[4-[5-(2-Hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-2-pyridin-2-ylpyrimidine-5-carboxamide	IC50	70.0 [1]
	N-[5-(1H-Indol-4-yl)pyridin-3-yl]-3-pyridin-3-ylpropanamide	IC50	26.0 [1]
	N-[5-(1H-Indol-4-yl)pyridin-3-yl]propanamide	IC50	32.0 [1]
	(2S)-N-[5-(1H-Indol-4-yl)pyridin-3-yl]-5-oxopyrrolidine-2-carboxamide	IC50	35.0 [1]
	N-[5-(1H-Indol-4-yl)pyridin-3-yl]-2-(tetrazol-1-yl)acetamide	IC50	43.0 [1]
	N-[5-(1H-Indol-4-yl)pyridin-3-yl]-3-piperidin-1-ylpropanamide	IC50	130.0 [1]
	N-[5-(1H-Indol-4-yl)pyridin-3-yl]-2-(3-methylimidazol-4-yl)acetamide	IC50	1200.0 [1]
	6-Phenoxy-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide	IC50	31.0 [1]
	6-Piperidin-1-yl-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide	IC50	48.0 [1]
	6-Pyrrolidin-1-yl-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide	IC50	230.0 [1]
	6-Morpholin-4-yl-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide	IC50	320.0 [1]
	6-(3-Oxopiperazin-1-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide	IC50	590.0 [1]
	6-(2-Oxo-1H-pyridin-4-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide	IC50	70.0 [1]
	6-(6-Oxo-1H-pyridin-2-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide	IC50	71.0 [1]
	4-Methyl-2-pyrimidin-2-yl-N-[4-(trifluoromethyl)indol-1-yl]pyrimidine-5-carboxamide	IC50	8.0 [1]
	4-Methyl-2-pyridin-2-yl-N-[4-(trifluoromethyl)indol-1-yl]pyrimidine-5-carboxamide	IC50	10.0 [1]
	2-(3-Fluorophenyl)-N-[[3-[(1-hydroxy-2-methylpropan-2-yl)sulfamoyl]phenyl]methyl]pyrimidine-5-carboxamide	IC50	23.0 [1]
	2-(3-Fluorophenyl)-4-methyl-N-[[3-(methylsulfamoyl)phenyl]methyl]pyrimidine-5-carboxamide	IC50	9.5 [1]
	2-Bromo-1-(4-methoxynaphthalen-1-yl)ethanone	IC50	12400.0 [1]
	3-Phenyl-5-(1H-pyrazol-3-YL)isoxazole	IC50	920.0 [1]
	4-{[4-(2-Methoxyphenyl)-1,3-thiazol-2-yl]amino}benzoic acid	IC50	994.0 [1]
	N-[4-Methyl-3-[[3-[(4-methylpiperazin-1-yl)methyl]benzoyl]amino]phenyl]-3-phenyl-1,2-thiazole-5-carboxamide	IC50	75.0 [1]
	Methyl 6-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)pyridine-3-carboxylate	IC50	1500.0 [1]
	N-(5-Fluoro-3-methyl-1H-indol-1-yl)-4-methyl-2-(pyridin-2-yl)pyrimidine-5-carboxamide	IC50	7.0 [1]
	2-Methyl-5-(1H-pyrazol-5-yl)pyridine	IC50	34700.0 [1]
	2,4-Dichloro-6-(1H-pyrazol-5-yl)phenol	IC50	17400.0 [1]
	N-Benzhydryl-5-phenylthiophene-2-carboxamide	IC50	19900.0 [1]
	N-Benzhydryl-2-phenyl-1,3-thiazole-4-carboxamide	IC50	10800.0 [1]
	N-Benzhydryl-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide	IC50	43800.0 [1]
	N-Benzhydryl-5-(3-cyanophenyl)thiophene-2-carboxamide	IC50	1800.0 [1]
	N-Benzhydryl-5-(1H-indol-4-yl)thiophene-2-carboxamide	IC50	57900.0 [1]
	N-(1-Amino-3-cyclohexyl-1-oxopropan-2-yl)-5-(1H-indol-4-yl)thiophene-2-carboxamide	IC50	5070.0 [1]
	N-(1-Amino-4-methyl-1-oxopentan-2-yl)-4-(3-hydroxyphenyl)benzamide	IC50	57600.0 [1]
	N-(1-Amino-3-methyl-1-oxobutan-2-yl)-4-(3-hydroxyphenyl)benzamide	IC50	53300.0 [1]
	N-(1,6-Diamino-1-oxohexan-2-yl)-4-(3-hydroxyphenyl)benzamide	IC50	24600.0 [1]
	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-4-(1H-indol-4-yl)benzamide	IC50	14700.0 [1]
	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-3-hydroxy-4-(3-hydroxyphenyl)benzamide	IC50	20500.0 [1]
	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-3-(3-hydroxyphenyl)benzamide	IC50	38000.0 [1]
	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-4-thiophen-2-ylbenzamide	IC50	54000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Hematopoietic prostaglandin D synthase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/hematopoietic-prostaglandin-d-synthase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Hematopoietic prostaglandin D synthase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hematopoietic-prostaglandin-d-synthase-inhibitors-ic50-ki.
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