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Hepatic lipase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
2-[(3S)-3-(Pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC509500.0 [1]
(S)-4-Isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC5050000.0 [1]
N-Methyl-5-methylsulfanyl-N-phenyl-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazole-1-carboxamideIC5050000.0 [1]
3-(4-Chlorophenyl)-N-methyl-N-phenyl-5-(2,2,2-trifluoroethylsulfanyl)-1,2,4-triazole-1-carboxamideIC5050000.0 [1]
4-Tert-Butyl-N-[4-(5-methoxy-2-oxo-[1,3,4]oxadiazol-3-yl)-phenyl]-benzamideIC501800.0 [1]
3-(3-(Benzyloxy)phenyl)-5-ethoxy-1,3,4-oxadiazol-2(3H)-oneIC5015000.0 [1]
N-[3-(3,4-Dichlorophenyl)propyl]-4-hydroxy-1-methyl-5-oxo-2H-pyrrole-3-carboxamideIC5076.0 [1]
2-(Cyclopropylmethylamino)-5-(trifluoromethyl)benzoic acidIC506400.0 [1]
S-[(2-Fluorophenyl)methyl] N-(6-phenylhexyl)carbamothioateIC501360.0 [1]
2-[(3S)-3-(4-Fluorophenoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC507600.0 [1]
2-[(3S)-3-Butoxypyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC5024110.0 [1]
2-[(3S)-3-[(5-Fluoropyridin-2-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC5016920.0 [1]
2-[(3S)-3-[(3-Fluoropyridin-2-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC5019500.0 [1]
2-[(3S)-3-[(5-Fluoropyridin-3-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC5023300.0 [1]
2-[(3S)-3-[2-(2-Methoxyethoxy)ethoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acidIC5088310.0 [1]
N-[3-(3,4-Dichlorophenyl)propyl]-3-hydroxy-1-methyl-2-oxopyridine-4-carboxamideIC5016.0 [1]
2-[6-(6-Fluoro-5-methylpyridin-3-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5022.0 [1]
2-Methylsulfonyl-2-(5-pyrimidin-2-yl-1,3-benzothiazol-2-yl)-N-(2-sulfamoylethyl)acetamideIC5023.7 [1]
2-[6-[1-(2-Methylpropyl)pyrazol-4-yl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5041.0 [1]
2-[5-[4-(Methoxymethyl)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC506.7 [1]
2-Methylsulfonyl-2-[5-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC501800.0 [1]
2-[6-[3-(4-Hydroxy-4-methylpiperidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)-2-(3,3,3-trifluoropropylsulfonyl)acetamideIC50111.8 [1]
2-[6-(4-Acetamidophenyl)-1,3-benzothiazol-2-yl]-2-benzylsulfonyl-N-(2-sulfamoylethyl)acetamideIC50148.0 [1]
2-[5-Methyl-6-[4-(morpholine-4-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-2-methylsulfonylacetamideIC50196.0 [1]
2-[5-Fluoro-6-[3-fluoro-4-(pyrrolidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-2-(2-methoxyethylsulfonyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]acetamideIC50764.6 [1]
2-[6-[4-(2-Hydroxyethylsulfamoyl)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC50144.0 [1]
2-Methylsulfonyl-2-[6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50313.0 [1]
2-[5-Fluoro-6-[4-(3-hydroxy-3-methylazetidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-2-(2-methoxyethylsulfonyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]acetamideIC501345.0 [1]
2-(5-Fluoro-6-phenyl-1,3-benzothiazol-2-yl)-2-(2-methoxyethylsulfonyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]acetamideIC5010.0 [1]
2-[6-(6-Fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-2-(2-morpholin-4-ylethylsulfonyl)-N-(2-sulfamoylethyl)acetamideIC50106.5 [1]
2-[5-[1-(2-Hydroxy-2-methylpropyl)-2-oxopyridin-4-yl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC506304.0 [1]
2-[5-Methyl-6-[4-(morpholine-4-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5090.5 [1]
2-Benzylsulfonyl-2-[6-[3-(dimethylamino)phenyl]-1,3-benzothiazol-2-yl]-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]acetamideIC5043.5 [1]
2-Benzylsulfonyl-2-[6-(3-chloropyridin-4-yl)-1,3-benzothiazol-2-yl]-N-[(3-sulfamoylphenyl)methyl]acetamideIC50355.1 [1]
2-Benzylsulfonyl-2-[6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50631.0 [1]
2-[5-(4-Acetamidophenyl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5096.3 [1]
2-[6-(1,3-Benzodioxol-5-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5010.0 [1]
2-(2-Aminoethylsulfonyl)-2-(6-phenyl-1,3-benzothiazol-2-yl)-N-(2-sulfamoylethyl)acetamideIC5022.0 [1]
2-Benzylsulfonyl-2-[6-[4-(piperidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC5014.9 [1]
2-[6-(6-Methoxypyridin-2-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5010.0 [1]
2-[6-[4-(3-Hydroxy-3-methylazetidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-2-methylsulfonylacetamideIC5010000.0 [1]
2-[6-[1-(2-Hydroxy-2-methylpropyl)-2-oxopyridin-4-yl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC504444.0 [1]
2-[6-(4-Chlorophenyl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC502.8 [1]
2-[6-[4-(Methoxymethyl)phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)-2-(3,3,3-trifluoropropylsulfonyl)acetamideIC507.3 [1]
2-(Cyclopropylmethylsulfonyl)-2-[6-[4-(morpholine-4-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50364.6 [1]
2-(Cyclopropylmethylsulfonyl)-2-[6-[4-[(2S)-2-methylmorpholine-4-carbonyl]phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50362.7 [1]
2-[6-(3,5-Difluoro-4-methoxyphenyl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC505.2 [1]
2-Methylsulfonyl-N-(2-sulfamoylethyl)-2-[6-[4-(trifluoromethoxy)phenyl]-1,3-benzothiazol-2-yl]acetamideIC5010.0 [1]
2-[6-[4-(2-Hydroxyethyl)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5035.0 [1]
2-Benzylsulfonyl-2-[6-(2-fluoropyridin-4-yl)-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC5051.0 [1]
2-(6-Phenyl-1,3-benzothiazol-2-yl)-2-propylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5010.0 [1]
2-[6-(5-Fluoro-2-methoxypyridin-4-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5077.0 [1]
2-Methylsulfonyl-2-[5-(6-oxo-1H-pyridin-3-yl)-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50105.0 [1]
2-[6-[3-(Morpholine-4-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)-2-(3,3,3-trifluoropropylsulfonyl)acetamideIC50119.3 [1]
2-[(4-Fluorophenyl)methylsulfonyl]-2-[6-[1-(2-hydroxy-2-methylpropyl)-2-oxopyridin-4-yl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC5010000.0 [1]
2-[(4-Fluorophenyl)methylsulfonyl]-2-[5-(6-fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC5051.4 [1]
2-Methylsulfonyl-2-[6-(2-oxo-1H-pyridin-4-yl)-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC5013.0 [1]
2-[6-(6-Fluoropyridin-3-yl)-5-methyl-1,3-benzothiazol-2-yl]-2-propan-2-ylsulfonyl-N-(2-sulfamoylethyl)acetamideIC50411.0 [1]
N-[(5-Methyl-1,3,4-oxadiazol-2-yl)methyl]-2-[5-methyl-6-(2-oxo-3,4-dihydro-1H-quinolin-6-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonylacetamideIC50124.0 [1]
2-[5-[4-(3-Hydroxy-3-methylazetidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC501001.0 [1]
2-[5-(3-Acetamidophenyl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5083.7 [1]
Tert-butyl 4-[2-[1-methylsulfonyl-2-oxo-2-(2-sulfamoylethylamino)ethyl]-1,3-benzothiazol-6-yl]benzoateIC5010.0 [1]
N-(2-Methoxyethyl)-3-[2-[2-oxo-2-(2-sulfamoylethylamino)-1-(3,3,3-trifluoropropylsulfonyl)ethyl]-1,3-benzothiazol-6-yl]benzamideIC50170.0 [1]
2-[6-(2-Fluorophenyl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC501.0 [1]
2-(2-Methylpropylsulfonyl)-2-[6-[4-(morpholine-4-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50191.0 [1]
2-Benzylsulfonyl-2-[6-[4-(3-hydroxy-3-methylazetidine-1-carbonyl)phenyl]-5-methyl-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50579.6 [1]
2-[5-(2-Methoxypyridin-4-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC502.2 [1]
2-[6-[4-(Hydroxymethyl)phenyl]-1,3-benzothiazol-2-yl]-2-(2-morpholin-4-ylethylsulfonyl)-N-(2-sulfamoylethyl)acetamideIC5035.1 [1]
2-[6-(3-Acetamidophenyl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5066.0 [1]
2-[5-[1-(2-Methoxyethyl)pyrazol-4-yl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC50100.0 [1]
2-Methylsulfonyl-2-[6-(6-oxo-1H-pyridin-2-yl)-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50398.0 [1]
2-[5-(2-Fluorophenyl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5013.7 [1]
2-[6-(6-Fluoropyridin-3-yl)-5-methyl-1,3-benzothiazol-2-yl]-2-(2-methylpropylsulfonyl)-N-(2-sulfamoylethyl)acetamideIC5012.0 [1]
2-[5-(2-Fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5013.0 [1]
2-Methylsulfonyl-2-[6-[1-[2-(oxan-4-yl)ethyl]pyrazol-4-yl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC50391.3 [1]
2-[(4-Fluorophenyl)methylsulfonyl]-2-[6-[4-(3-methoxyazetidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)acetamideIC5052.0 [1]
2-[6-(2-Methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5065.0 [1]
2-Methylsulfonyl-2-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)-N-(2-sulfamoylethyl)acetamideIC50916.0 [1]
2-Benzylsulfonyl-2-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)-N-(2-sulfamoylethyl)acetamideIC508789.0 [1]
2-[6-(4-Acetamidophenyl)-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)-2-(3,3,3-trifluoropropylsulfonyl)acetamideIC5055.3 [1]
2-[5-(6-Methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC502.6 [1]
2-[6-(6-Fluoropyridin-3-yl)-5-methyl-1,3-benzothiazol-2-yl]-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-2-methylsulfonylacetamideIC5010.0 [1]
2-[6-(4-Methyl-2,3-dihydro-1,4-benzoxazin-7-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5050.0 [1]
2-[6-(3-Chloro-4-propan-2-yloxyphenyl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC503.6 [1]
2-[6-[3-Chloro-4-(morpholine-4-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC50923.0 [1]
4-[5-Fluoro-2-[1-(2-methoxyethylsulfonyl)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)methylamino]-2-oxoethyl]-1,3-benzothiazol-6-yl]-N-(2-methoxyethyl)benzamideIC50888.7 [1]
2-[6-[3-(3,3-Difluoropiperidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)-2-(3,3,3-trifluoropropylsulfonyl)acetamideIC5014.7 [1]
2-[6-[3-(2-Hydroxyethyl)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5036.0 [1]
2-[6-[4-[(3S)-3-Methoxypyrrolidine-1-carbonyl]phenyl]-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)-2-(3,3,3-trifluoropropylsulfonyl)acetamideIC5016.6 [1]
2-[5-(6-Fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-N-(2-sulfamoylethyl)-2-(3,3,3-trifluoropropylsulfonyl)acetamideIC5024.2 [1]
2-[5-(6-Fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC50124.2 [1]
2-[6-(3-Fluoro-2-methoxypyridin-4-yl)-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5064.0 [1]
Tert-butyl 4-[2-[1-benzylsulfonyl-2-oxo-2-[[(3R)-2-oxopyrrolidin-3-yl]amino]ethyl]-1,3-benzothiazol-6-yl]benzoateIC5014.3 [1]
2-[6-[4-(3-Fluoroazetidine-1-carbonyl)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5046.7 [1]
2-[6-[1-(4-Fluorophenyl)pyrazol-4-yl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC5010.0 [1]
2-[6-[1-(2-Methoxyethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC50199.0 [1]
4-[2-[1-(Cyclopropylmethylsulfonyl)-2-oxo-2-(2-sulfamoylethylamino)ethyl]-1,3-benzothiazol-6-yl]-N-(2-methoxyethyl)-N-methylbenzamideIC5035.2 [1]
N-[(5-Methyl-1,3,4-oxadiazol-2-yl)methyl]-2-(5-methyl-6-phenyl-1,3-benzothiazol-2-yl)-2-methylsulfonylacetamideIC50177.0 [1]
Tert-butyl 4-[4-[2-[1-methylsulfonyl-2-oxo-2-(2-sulfamoylethylamino)ethyl]-1,3-benzothiazol-6-yl]pyrazol-1-yl]piperidine-1-carboxylateIC5021.0 [1]
2-[6-[3-(Difluoromethoxy)phenyl]-1,3-benzothiazol-2-yl]-2-methylsulfonyl-N-(2-sulfamoylethyl)acetamideIC503.0 [1]
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References

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MLA

"Quest Database™ Hepatic lipase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/hepatic-lipase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Hepatic lipase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hepatic-lipase-inhibitors-ic50-ki.
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