 | Foretinib | IC50 | 1.48 [1] |
 | Crizotinib | IC50 | 2.93 [1] |
| Crizotinib | Ki | 2.0 [1], 4.0 [2] |
 | Cabozantinib | IC50 | 3.2 [1] |
 | MK-2461 | IC50 | 2.0 [1] |
 | N-[4-[2-(Cyclopropanecarbonylamino)imidazo[1,2-a]pyridin-6-yl]oxy-3-fluorophenyl]-6-methyl-2-oxo-1-phenyl-3H-pyridin-1-ium-3-carboxamide;hydrochloride | IC50 | 1.8 [1] |
 | Staurosporine | IC50 | 130.0 [1] |
 | MGCD-265 analog | IC50 | 37.0 [1] |
 | MK-8033 | IC50 | 1.2 [1] |
 | Amg-458 | IC50 | 60.0 [1], 60.1 [2] |
| Amg-458 | Ki | 1.2 [1] |
 | 3-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-(2-phenylacetyl)thiourea | IC50 | 80.0 [1] |
| 3-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-(2-phenylacetyl)thiourea | Ki | 1.0 [1], 4.0 [2] |
 | Bms-777607 | IC50 | 3.9 [1] |
 | 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol | IC50 | 4.0 [1], 4.8 [2], 50.12 [3] |
| 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol | Ki | 5.0 [1], 3900.0 [2], 9400.0 [3] |
 | N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-2-oxo-3-phenylimidazolidine-1-carboxamide | IC50 | 23.0 [1] |
 | Met Kinase Inhibitor | IC50 | 20.0 [1] |
 | 7-Methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline | IC50 | 9.0 [1] |
 | N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamide | IC50 | 500.0 [1] |
 | N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide | IC50 | 1.0 [1] |
| N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide | Ki | 1.0 [1] |
 | Pha-665752 | IC50 | 9.0 [1] |
 | Jnj-38877605 | IC50 | 0.95 [1], 1.0 [2], 4.0 [3], 5.5 [4], 9.5 [5] |
 | Pyrimidone, 22 | IC50 | 8.9 [1], 10.0 [2], 17.0 [3] |
| Pyrimidone, 22 | Ki | 8.9 [1] |
 | 7-Methoxy-N-[[6-(3-methyl-1,2-thiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-1,5-naphthyridin-4-amine | IC50 | 3.0 [1], 5.0 [2], 6.0 [3] |
| 7-Methoxy-N-[[6-(3-methyl-1,2-thiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-1,5-naphthyridin-4-amine | Ki | 3.2 [1] |
 | Exelixis | IC50 | 21.0 [1] |
 | 7-Methoxy-4-[[6-(3,4,5-trifluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methoxy]quinoline | IC50 | 4.0 [1] |
 | 6-[[5-(1-Methylpyrazol-4-yl)triazolo[4,5-b]pyrazin-3-yl]methyl]quinoline | IC50 | 1.0 [1], 5.0 [2], 6.0 [3] |
| 6-[[5-(1-Methylpyrazol-4-yl)triazolo[4,5-b]pyrazin-3-yl]methyl]quinoline | Ki | 6.0 [1] |
 | N-(4-(6,7-Dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | IC50 | 30.0 [1], 53.0 [2], 80.0 [3], 90.0 [4] |
| N-(4-(6,7-Dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Ki | 1.7 [1] |
 | Sunitinib | IC50 | 2000.0 [1], 5000.0 [2], 10000.0 [3], 20000.0 [4] |
 | N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide | IC50 | 2.7 [1], 50.0 [2], 50.5 [3] |
| N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide | Ki | 2.7 [1] |
 | N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-3-methyl-5-oxo-1-phenyl-2-propylpyrazole-4-carboxamide | IC50 | 1.0 [1], 48.8 [2], 49.0 [3] |
| N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-3-methyl-5-oxo-1-phenyl-2-propylpyrazole-4-carboxamide | Ki | 1.0 [1] |
 | N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide | IC50 | 1.0 [1], 37.0 [2], 37.1 [3] |
| N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide | Ki | 1.0 [1], 1.1 [2] |
 | N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-5-methyl-1-(2-methylpropyl)-3-oxo-2-phenylpyrazole-4-carboxamide | IC50 | 8.0 [1], 204.0 [2], 205.0 [3] |
| N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-5-methyl-1-(2-methylpropyl)-3-oxo-2-phenylpyrazole-4-carboxamide | Ki | 7.9 [1], 8.0 [2] |
 | N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-[(2R)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide | IC50 | 1.0 [1], 23.9 [2], 24.0 [3] |
| N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-[(2R)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide | Ki | 1.0 [1] |
 | N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-[(2S)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide | IC50 | 1.1 [1], 23.0 [2] |
| N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-[(2S)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide | Ki | 1.1 [1], 1.2 [2] |
 | N-[4-[2-(1-Ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2-oxoimidazolidine-1-carboxamide | IC50 | 27.0 [1], 50.0 [2], 80.0 [3], 240.0 [4] |
 | 14-(Dimethylsulfamoylamino)-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene | IC50 | 4.0 [1], 80.0 [2], 2300.0 [3] |
 | 4,4,4-Trifluoro-3-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]-N-phenylbutanamide | IC50 | 120.0 [1], 600.0 [2], 2000.0 [3] |
 | 6-[6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl]-quinoline | IC50 | 44.0 [1], 69.0 [2], 210.0 [3] |
| 6-[6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl]-quinoline | Ki | 9.1 [1], 74.0 [2] |
 | 4-[6-Amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamide | IC50 | 26.0 [1], 42.0 [2], 72.0 [3], 110.0 [4], 600.0 [5] |
 | Ceritinib | IC50 | 1000.0 [1], 1339.0 [2], 3170.0 [3] |
 | Sgx-523 | IC50 | 3.1 [1], 4.0 [2], 10.0 [3] |
 | Tepotinib | IC50 | 1.0 [1], 3.0 [2], 12.0 [3], 100.0 [4] |
 | 2-Anilino-5-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-methylpyrimidin-4-one | IC50 | 63.0 [1], 204.0 [2] |
| 2-Anilino-5-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-methylpyrimidin-4-one | Ki | 14.0 [1], 63.0 [2] |
 | 4-[[6-(3,4-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methoxy]-7-methoxyquinoline | IC50 | 9.0 [1], 26.0 [2] |
 | 4-[[6-(3,5-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methoxy]-7-methoxyquinoline | IC50 | 7.0 [1], 14.0 [2] |
 | 4-((6-Phenyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)phenol | IC50 | 2100.0 [1] |
| 4-((6-Phenyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)phenol | Ki | 1231.2 [1] |
 | N'-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-N-phenylpropanediamide | IC50 | 28.0 [1], 30.0 [2], 310.0 [3] |
 | N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-N'-methyl-N'-phenylpropanediamide | IC50 | 40.0 [1], 43.0 [2], 160.0 [3] |
 | CID 50942314 | IC50 | 10.0 [1], 44.0 [2] |
 | 5-[8-Fluoro-3-[(1S)-1-[3-(2-methoxyethoxy)quinolin-6-yl]ethyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-3-methyl-1,2-oxazole | IC50 | 1.0 [1], 5.0 [2] |
 | 4-((6-(3-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline | IC50 | 7.0 [1], 20.0 [2] |
| 4-((6-(3-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline | Ki | 7.0 [1] |
 | 4-[6-(1-Piperidin-4-ylpyrazol-4-yl)pyrrolo[3,2-b]pyridin-1-yl]sulfonyl-2,1,3-benzoxadiazole | IC50 | 9.0 [1], 130.0 [2], 200.0 [3] |
 | 3-[(1S)-1-[3-(2-Methoxyethoxy)quinolin-6-yl]ethyl]-5-(3-methyl-1,2-thiazol-5-yl)triazolo[4,5-c]pyridin-4-one | IC50 | 0.6 [1], 1.0 [2], 2.0 [3] |
 | 1-(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-ol | IC50 | 15.0 [1], 35.0 [2], 2810.0 [3], 3600.0 [4] |
 | 1-(2,1,3-Benzoxadiazol-4-ylsulfonyl)pyrrolo[3,2-b]pyridin-6-amine | IC50 | 16.0 [1], 1300.0 [2], 2200.0 [3] |
 | Tert-butyl 4-[4-[1-(2,1,3-benzoxadiazol-4-ylmethyl)pyrrolo[3,2-b]pyridin-6-yl]pyrazol-1-yl]piperidine-1-carboxylate | IC50 | 33.0 [1], 3080.0 [2], 3280.0 [3] |
 | 1-[4-[1-(2,1,3-Benzoxadiazol-4-ylsulfonyl)pyrrolo[3,2-b]pyridin-6-yl]piperazin-1-yl]ethanone | IC50 | 12.0 [1], 370.0 [2], 500.0 [3] |
 | 4-[6-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]pyrrolo[3,2-b]pyridin-1-yl]sulfonyl-2,1,3-benzoxadiazole | IC50 | 15.0 [1], 820.0 [2], 1310.0 [3] |
 | [4-[1-(2,1,3-Benzoxadiazol-4-ylsulfonyl)pyrrolo[3,2-b]pyridin-6-yl]piperazin-1-yl]-pyridin-3-ylmethanone | IC50 | 11.0 [1], 430.0 [2], 480.0 [3] |
 | 6-Chloro-5-[6-(1-piperidin-4-ylpyrazol-4-yl)pyrrolo[3,2-b]pyridin-1-yl]sulfonylimidazo[2,1-b][1,3]thiazole | IC50 | 9.0 [1], 90.0 [2], 110.0 [3] |
 | Tert-butyl 4-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-yl]piperazine-1-carboxylate | IC50 | 15.0 [1], 27.0 [2], 110.0 [3], 1946.0 [4] |
 | 4-[[6-(1-Piperidin-4-ylpyrazol-4-yl)pyrrolo[3,2-b]pyridin-1-yl]methyl]-2,1,3-benzoxadiazole | IC50 | 19.0 [1], 1800.0 [2], 1880.0 [3] |
 | 1-[4-[1-(2,1,3-Benzoxadiazol-4-ylsulfonyl)pyrrolo[3,2-b]pyridin-6-yl]piperazin-1-yl]-2-(methylamino)ethanone | IC50 | 14.0 [1], 570.0 [2] |
 | 1-(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-amine | IC50 | 10.0 [1], 490.0 [2], 580.0 [3] |
 | Tert-butyl 4-[4-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-yl]pyrazol-1-yl]piperidine-1-carboxylate | IC50 | 19.0 [1], 27.0 [2], 147.0 [3], 450.0 [4] |
 | 2-[[5-Chloro-2-[(2-oxo-1,3,4,5-tetrahydro-1-benzazepin-8-yl)amino]pyrimidin-4-yl]amino]-3-fluoro-N-methylbenzamide | IC50 | 30.0 [1], 99.0 [2] |
 | 2-[[5-Chloro-2-[(5,5-dimethyl-2-oxo-3,4-dihydro-1H-1-benzazepin-8-yl)amino]pyrimidin-4-yl]amino]-3-fluoro-N-methylbenzamide | IC50 | 10.0 [1], 54.0 [2] |
 | 3-(Quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-amine | IC50 | 34.0 [1] |
| 3-(Quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-amine | Ki | 15.0 [1] |
 | N-(2-Oxo-5-phenyl-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl)methanesulfonamide | IC50 | 31.0 [1], 220.0 [2], 2500.0 [3] |
 | 4,4,4-Trifluoro-3-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]-N-(4-fluorophenyl)butanamide | IC50 | 90.0 [1], 370.0 [2], 400.0 [3] |
 | 4,4,4-Trifluoro-3-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]-N-(2-methoxyphenyl)butanamide | IC50 | 840.0 [1], 1800.0 [2], 2000.0 [3], 10000.0 [4] |
 | 4,4,4-Trifluoro-N-(4-fluorophenyl)-3-[4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]butanamide | IC50 | 180.0 [1], 880.0 [2], 2000.0 [3] |
 | Golvatinib | IC50 | 14.0 [1], 20.0 [2] |
 | CID 21081761 | IC50 | 1.8 [1] |
 | N'-[3-Fluoro-4-(5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)oxyphenyl]-N-(4-fluorophenyl)propanediamide | IC50 | 780.0 [1] |
 | 2-(4-Fluorophenyl)-N-[[3-fluoro-4-[(3-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]carbamoyl]acetamide | IC50 | 2.0 [1] |
 | 1-(4-(2-(Thiazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea | IC50 | 28.0 [1], 65.0 [2] |
 | N-[[3-Fluoro-4-[2-(1-methylimidazol-2-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]carbamothioyl]-2-phenylacetamide | IC50 | 2.0 [1], 51.0 [2] |
 | N-[4-[2-(1-Ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-2-oxo-3-phenylimidazolidine-1-carboxamide | IC50 | 25.0 [1], 40.0 [2] |
 | N-[4-[2-(1-Ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-3-(2-fluorophenyl)-2-oxoimidazolidine-1-carboxamide | IC50 | 21.0 [1], 100.0 [2] |
 | N-[4-[2-(1-Ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-3-(2-methoxyphenyl)-2-oxoimidazolidine-1-carboxamide | IC50 | 26.0 [1], 60.0 [2] |
 | N-[4-[2-[1-[2-(Dimethylamino)ethyl]imidazol-4-yl]thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-2-oxo-3-phenylimidazolidine-1-carboxamide | IC50 | 34.0 [1], 60.0 [2] |
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