Histone deacetylase (HDAC1 and HDAC2) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Vorinostat	IC50	130.0 [1]
	1,1,1-Trifluoro-8-(4-biphenylyloxy)-2-octanone	IC50	2.9 [1], 2900.0 [2]
	7-(Benzoylamino)heptanehydroxamic acid	IC50	1006.0 [1], 1010.0 [2]
	N-Methyl-2-oxo-N'-phenylnonanediamide	IC50	338.0 [1], 340.0 [2]
	7-(1H-Indole-2-ylcarbonylamino)heptanehydroximic acid	IC50	14.6 [1]
	Ubenimex	IC50	100000.0 [1]
	Entinostat	IC50	2000.0 [1]
	Belinostat	IC50	25.0 [1]
	Luotonin A	IC50	6400.0 [1]
	3,4-Bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide	IC50	1000000.0 [1]
	9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide	IC50	6700.0 [1]
	Heptanamide, 7-[(4'-cyano[1,1'-biphenyl]-4-yl)oxy]-N-hydroxy-	IC50	9.2 [1]
	N-Hydroxy-4-(3-phenylpropanoylamino)benzamide	IC50	1100.0 [1]
	5-Carboxy-2,1,3-benzoxadiazol-1-ium-1-olate	IC50	1000000.0 [1]
	N-Methyl-2-oxo-8-(4-phenylphenoxy)octanamide	IC50	0.11 [1]
	9,9,9-Trifluoro-8-oxo-N-(4-phenoxyphenyl)nonanamide	IC50	300.0 [1]
	CID 25023793	IC50	380.0 [1]
	N-Methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide	IC50	3.7 [1]
	7-[4-[4-[[[(2S,3R,4S,6R)-2-[[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadec-11-yl]oxy]-3-hydroxy-6-methyloxan-4-yl]-methylamino]methyl]phenyl]triazol-1-yl]-N-hydroxyheptanamide	IC50	13.9 [1]
	(2S)-N-Hydroxy-4-methyl-2-(phenylcarbamoylamino)pentanamide	IC50	100000.0 [1]
	7-[5-(4-Methoxyphenyl)-2-oxazolyl]heptanehydroximic acid	IC50	2.1 [1]
	N-[7-(Hydroxyamino)-7-oxoheptyl]pyridine-2-carboxamide	IC50	1680.0 [1]
	7-(1H-Pyrrole-2-ylcarbonylamino)heptanehydroximic acid	IC50	524.0 [1]
	8-Phenyl-octanoic acid hydroxyamide	IC50	560.0 [1]
	N-Hydroxy-7-(4-phenylphenoxy)heptanamide	IC50	0.02 [1]
	7-[4-[4-[[[(2S,3R,4S,6R)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-3-hydroxy-6-methyloxan-4-yl]-methylamino]methyl]phenyl]triazol-1-yl]-N-hydroxyheptanamide	IC50	4.1 [1]
	Azithromycin-N-benzyltriazolylhexahydroxamic Acid	IC50	91.6 [1]
	6-[4-[4-[[[(2S,3R,4S,6R)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-3-hydroxy-6-methyloxan-4-yl]-methylamino]methyl]phenyl]triazol-1-yl]-N-hydroxyhexanamide	IC50	37.0 [1]
	N-[7-(Hydroxyamino)-7-oxoheptyl]-1H-indole-7-carboxamide	IC50	41.0 [1]
	N-[7-(Hydroxyamino)-7-oxoheptyl]-1H-indole-6-carboxamide	IC50	56.5 [1]
	N-[7-(Hydroxyamino)-7-oxoheptyl]-1H-indole-4-carboxamide	IC50	80.3 [1]
	5-Chloro-N-[7-(hydroxyamino)-7-oxoheptyl]-1-benzofuran-2-carboxamide	IC50	15.0 [1]
	7-(1H-Indole-5-ylcarbonylamino)heptanehydroximic acid	IC50	31.4 [1]
	N-[7-(Hydroxyamino)-7-oxoheptyl]-5-methoxy-1-benzofuran-2-carboxamide	IC50	15.0 [1]
	7-(1H-Indole-3-ylcarbonylamino)heptanehydroximic acid	IC50	37.5 [1]
	N-[7-(Hydroxyamino)-7-oxoheptyl]-4,6-dimethoxy-1H-indole-2-carboxamide	IC50	3.1 [1]
	5-Fluoro-N-[7-(hydroxyamino)-7-oxoheptyl]-1H-indole-2-carboxamide	IC50	5.4 [1]
	7-(1-Methyl-2-indanylcarbonylamino)heptanehydroximic acid	IC50	732.0 [1]
	7-(5-Bromo-1H-indole-2-ylcarbonylamino)heptanehydroximic acid	IC50	3.5 [1]
	7-(5-Methoxy-1H-indole-2-ylcarbonylamino)heptanehydroximic acid	IC50	6.5 [1]
	7-(4-Methoxy-1H-indole-2-ylcarbonylamino)heptanehydroximic acid	IC50	3.1 [1]
	2-Oxo-8-(4-phenylphenoxy)octanamide	IC50	50.0 [1]
	N-Ethyl-2-oxo-8-(4-phenylphenoxy)octanamide	IC50	4.9 [1]
	N-[2-(Dimethylamino)ethyl]-2-oxo-8-(4-phenylphenoxy)octanamide	IC50	50.0 [1]
	N,N-Dimethyl-2-oxo-8-(4-phenylphenoxy)octanamide	IC50	5.0 [1]
	Methyl 2-oxo-9-(4-phenylphenoxy)nonanoate	IC50	0.11 [1]
	Methyl 2-oxo-8-(4-phenylphenoxy)octanoate	IC50	0.06 [1]
	8-[([1,1'-Biphenyl]-4-yl)oxy]-2-oxooctanoic acid	IC50	3.7 [1]
	2-[[2-Oxo-8-(4-phenylphenoxy)octanoyl]amino]acetic acid	IC50	50.0 [1]
	Methyl 2-oxo-7-(4-phenylphenoxy)heptanoate	IC50	0.08 [1]
	N'-[4-[4-[2-(Dimethylamino)ethyl]phenyl]-1,3-thiazol-2-yl]-N-methyl-2-oxononanediamide	IC50	3.1 [1]
	1,1,1-Trifluoro-7-(4-biphenylyloxy)-2-heptanone	IC50	2600.0 [1]
	1,1,1-Trifluoro-8-(4-biphenylyloxy)-3-octyne-2-one	IC50	8600.0 [1]
	9,9,9-Trifluoro-8-oxo-N-(2-phenylphenyl)nonanamide	IC50	16000.0 [1]
	9,9,9-Trifluoro-8-oxo-N-(4-phenylphenyl)nonanamide	IC50	3000.0 [1]
	N-Phenyl-2-[4-[(E)-4,4,4-trifluoro-3-oxobut-1-enyl]phenoxy]acetamide	IC50	2200.0 [1]
	N-Phenyl-3-[4-(2,2,2-trifluoroacetyl)phenyl]propanamide	IC50	50000.0 [1]
	9,9,9-Trifluoro-8-oxo-N-(3-phenoxyphenyl)nonanamide	IC50	3200.0 [1]
	8-(4-Biphenylyloxy)-2-octanone	IC50	50000.0 [1]
	2,2,2-Trifluoro-1-[2-[4-(4-phenylphenoxy)butyl]cyclopropyl]ethanone	IC50	2900.0 [1]
	7-[5-(4-Bromophenyl)-2-oxazolyl]heptanehydroximic acid	IC50	2.7 [1]
	7-[2-(4-Bromophenyl)-5-oxazolyl]heptanehydroximic acid	IC50	4.4 [1]
	7-[4-(3-Bromophenyl)-2-thiazolyl]heptanehydroximic acid	IC50	5.8 [1]
	7-[4-[4-(Trifluoromethoxy)phenyl]-2-thiazolyl]heptanehydroximic acid	IC50	74.0 [1]
	7-(5-Phenyl-2-oxazolyl)heptanehydroximic acid	IC50	9.8 [1]
	7-[4-(2-Naphthyl)-2-thiazolyl]heptanehydroximic acid	IC50	4.3 [1]
	7-[4-(2,6-Dimethoxyphenyl)-2-thiazolyl]heptanehydroximic acid	IC50	4.3 [1]
	7-[4-[4-(Trifluoromethyl)phenyl]-2-thiazolyl]heptanehydroximic acid	IC50	42.0 [1]
	7-[4-(4-Biphenylyl)-2-thiazolyl]heptanehydroximic acid	IC50	11.0 [1]
	7-[4-(4-Bromophenyl)-2-thiazolyl]heptanehydroximic acid	IC50	8.5 [1]
	7-[4-(4-Methoxyphenyl)-2-thiazolyl]heptanehydroximic acid	IC50	2.5 [1]
	7-[2-(4-Fluorophenyl)-5-oxazolyl]heptanehydroximic acid	IC50	23.0 [1]
	7-[2-(4-Biphenylyl)-5-oxazolyl]heptanehydroximic acid	IC50	12.0 [1]
	7-(4-Phenyl-2-thiazolyl)heptanehydroximic acid	IC50	19.0 [1]
	N-Hydroxy-7-[2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-5-yl]heptanamide	IC50	89.0 [1]
	7-(2-Phenyl-5-oxazolyl)heptanehydroximic acid	IC50	13.0 [1]
	N-Hydroxy-4-[3-[3-methoxy-4-(thiophen-2-ylmethoxy)phenyl]propanoylamino]benzamide	IC50	300.0 [1]
	2-[[2-(5'-Bromo-2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)acetyl]amino]-N-hydroxyacetamide	IC50	50000.0 [1]
	6-[[4-(Benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]hexan-1-ol	IC50	1000000.0 [1]
	N-(2-Aminophenyl)-4-[[2-(5'-bromo-2'-oxospiro[1,3-dioxane-2,3'-indole]-1'-yl)acetyl]amino]benzamide	IC50	310.0 [1]
	N'-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-N-methyl-2-oxononanediamide	IC50	9.1 [1]
	7-[5-[4-(4-Chlorophenyl)phenyl]-1,3-oxazol-2-yl]-N-hydroxyheptanamide	IC50	6.8 [1]
	9,9,9-Trifluoro-8-oxo-N-(4-phenyl-1,3-thiazol-2-yl)nonanamide	IC50	310.0 [1]
	1-Butyl-3-[4-[(Z)-N'-hydroxycarbamimidoyl]phenyl]urea	IC50	591.0 [1]
	N-Hydroxy-3-(phenylsulfamoyl)benzamide	IC50	20000.0 [1]
	N'-Hydroxy-N-[5-(4-morpholin-4-ylphenyl)-1,3,4-thiadiazol-2-yl]heptanediamide	IC50	5000.0 [1]
	N-[5-[4-(Dimethylamino)phenyl]-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamide	IC50	5000.0 [1]
	N'-Hydroxy-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]heptanediamide	IC50	437.0 [1]
	N-[5-(3,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamide	IC50	487.0 [1]
	N'-Hydroxy-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]heptanediamide	IC50	422.0 [1]
	N'-Hydroxy-N-[5-(4-phenylphenyl)-1,3,4-thiadiazol-2-yl]heptanediamide	IC50	5000.0 [1]
	N-[5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamide	IC50	741.0 [1]
	N-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamide	IC50	988.0 [1]
	N-[5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamide	IC50	847.0 [1]
	N-[5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamide	IC50	507.0 [1]
	N-[5-(4-Bromophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamide	IC50	1285.0 [1]
	N'-Hydroxy-N-[5-(4-iodophenyl)-1,3,4-thiadiazol-2-yl]heptanediamide	IC50	875.0 [1]
	N'-Hydroxy-N-[5-(4-methylsulfonylphenyl)-1,3,4-thiadiazol-2-yl]heptanediamide	IC50	721.0 [1]
	N'-Hydroxy-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]heptanediamide	IC50	709.0 [1]
	N'-Hydroxy-N-[5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl]heptanediamide	IC50	1154.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Histone deacetylase (HDAC1 and HDAC2) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/histone-deacetylase-hdac1-and-hdac2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Histone deacetylase (HDAC1 and HDAC2) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-hdac1-and-hdac2-inhibitors-ic50-ki.
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