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Histone deacetylase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
VorinostatIC50122.0 [1]
VorinostatKi2470.0 [1]
Trichostatin AIC5015.0 [1]
Trichostatin AKi504.0 [1]
EntinostatIC503200.0 [1]
CID 71520717IC50360.0 [1]
N-[6-(Hydroxyamino)-6-oxohexoxy]-3-methylbenzamideIC501130.0 [1]
N-[6-(Hydroxyamino)-6-oxohexoxy]-3,4-dimethylbenzamideIC501100.0 [1]
ApicidinIC501.0 [1]
7-Mercapto-heptanoic acid phenylamideIC5058.0 [1], 210.0 [2]
SodiumIC50140000.0 [1], 800000.0 [2]
SodiumKi6340.0 [1]
RomidepsinIC503.6 [1], 15.0 [2], 107.2 [3], 250.0 [4]
DacinostatIC5032.0 [1], 50.0 [2]
Cudc-101IC504.4 [1], 464.0 [2], 602.0 [3]
N1-(2-Aminophenyl)-N8-phenyloctanediamideIC5087000.0 [1], 120000.0 [2]
4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamideIC50110.0 [1], 152.0 [2], 244.0 [3], 1866.0 [4]
Chlorogenic acidIC50200000.0 [1], 375000.0 [2]
BelinostatIC5026.4 [1], 27.0 [2], 28.0 [3]
Trapoxin BIC504.0 [1], 5.0 [2]
6-(2-Mercaptoacetylamino)-N-PhenylhexanamideIC50390.0 [1], 2440.0 [2]
1,1,1-Trifluoro-8-(4-biphenylyloxy)-2-octanoneIC502900.0 [1]
8-Mercapto-octanoic acid phenylamideIC501500.0 [1]
7-(Benzoylamino)heptanehydroxamic acidIC50568.0 [1], 1006.0 [2], 10000.0 [3]
N-Quinolin-3-yl-7-sulfanylheptanamideIC5072.0 [1]
S-(7-Anilino-7-oxoheptyl) ethanethioateIC507100.0 [1]
6-Mercapto-hexanoic acid phenylamideIC50370.0 [1]
(E)-N-Hydroxy-3-[4-[(3-phenylpropylamino)methyl]phenyl]prop-2-enamideIC5064.0 [1], 150.0 [2]
N-(6-Sulfanylhexyl)-1-benzofuran-2-carboxamideIC5079.0 [1]
6-(2-Hydroxyacetamido)-N-phenylhexanamideIC5040000.0 [1], 100000.0 [2]
Thioacetic acid S-[(5-phenylcarbamoyl-pentylcarbamoyl)-methyl] esterIC5020100.0 [1], 22000.0 [2]
7-Methylsulfanyl-heptanoic acid phenylamideIC50100000.0 [1]
5-Mercapto-pentanoic acid phenylamideIC506200.0 [1]
4-(6-Anilino-6-oxohexyl)semicarbazideIC50150000.0 [1]
6-[4-[(4-Chlorophenyl)sulfonylamino]phenyl]sulfanyl-N-hydroxyhexanamideIC50110.0 [1], 9400.0 [2]
7-(4-Chlorophenyl)sulfinyl-N-hydroxyheptanamideIC50380.0 [1], 1600.0 [2]
6-(4-Chlorophenyl)sulfinyl-N-hydroxyhexanamideIC50150.0 [1], 1300.0 [2]
6-[4-(Dimethylamino)phenyl]sulfinyl-N-hydroxyhexanamideIC50180.0 [1], 2200.0 [2], 2240.0 [3]
6-Benzenesulfonylhexanoic acid hydroxamideIC5040.0 [1], 15500.0 [2]
6-Phenylsulfanylhexanoic acid hydroxamideIC50120.0 [1], 9400.0 [2]
6-(Benzenesulfinyl)hexanoic acid hydroxyamideIC5060.0 [1], 7400.0 [2], 7700.0 [3]
Ethyl 2-(4-methoxyphenyl)-2-oxoethyl trithiocarbonateIC50375.0 [1], 501.19 [2], 4670.0 [3]
N-[4-(2-Ethylsulfanylcarbothioylsulfanylacetyl)phenyl]acetamideIC50318.0 [1], 398.11 [2], 857.0 [3]
N-[3-(2-Ethylsulfanylcarbothioylsulfanylacetyl)phenyl]acetamideIC50506.0 [1], 630.96 [2], 3280.0 [3]
N-[4-(2-Ethylsulfanylcarbothioylsulfanylacetyl)phenyl]methanesulfonamideIC501260.0 [1], 1995.26 [2], 8950.0 [3]
Ethyl 2-(4-methylphenyl)-2-oxoethyl trithiocarbonateIC50375.0 [1], 630.96 [2], 812.0 [3]
6-(4-Chlorophenyl)sulfanyl-N-hydroxyhexanamideIC50260.0 [1], 25000.0 [2]
N-[2-[[4-[(1-Benzylpiperidin-4-yl)amino]-7-methoxyquinazolin-2-yl]amino]ethyl]-N'-hydroxyoctanediamideIC5015330.0 [1], 27750.0 [2], 100000.0 [3]
N'-Hydroxy-N-[2-[[7-methoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-yl]amino]ethyl]octanediamideIC50100000.0 [1]
N-[2-[[4-[(1-Benzylpiperidin-4-yl)amino]-7-methoxyquinazolin-2-yl]amino]ethyl]-N'-hydroxyheptanediamideIC505735.0 [1], 13800.0 [2], 100000.0 [3]
Valproic acidIC50995000.0 [1], 7240000.0 [2]
ErlotinibIC5015800.0 [1], 32000.0 [2]
4-(Dimethylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]benzamideIC5046.0 [1], 1620.0 [2]
HarmineIC5010000.0 [1]
VandetanibIC5010000.0 [1]
PanobinostatIC500.83 [1], 30.0 [2]
3,5-Dicaffeoylquinic acidIC50143240.0 [1], 500000.0 [2]
Neochlorogenic acidIC50170400.0 [1], 200000.0 [2]
TacedinalineIC502590.0 [1], 6000.0 [2]
Methyl 3,5-di-O-caffeoyl quinateIC504990.0 [1], 7590.0 [2]
5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thioneIC50450.0 [1]
PyroxamideIC50200.0 [1], 10000.0 [2]
4-(Dimethylamino)-N-[[4-[(E)-3-(hydroxyamino)-3-oxoprop-1-enyl]phenyl]methyl]benzamideIC50172.0 [1], 172.02 [2]
4-Acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideIC50204.0 [1], 300.0 [2]
(E)-5-[4-(Benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamideIC50233.15 [1], 2000.0 [2]
9,9,9-Trifluoro-8-Oxo-N-PhenylnonanamideIC506700.0 [1]
N-Hydroxy-2,2-diphenylacetamideIC504600.0 [1], 50000.0 [2]
N-Hydroxy-4-(4-phenylbutanoylamino)benzamideIC5044.0 [1]
N-Hydroxy-3-[6-oxo-1-(2-phenylethyl)-2,3-dihydropyridin-5-yl]propanamideIC50350.0 [1]
CID 11427204IC50170.0 [1]
N1-(4-(3-Aminophenyl)thiazol-2-yl)-N8-hydroxyoctanediamideIC503.9 [1], 8.0 [2]
8-[4-(Dimethylamino)benzoylamino]octanehydroxamic acidIC50145.0 [1], 2180.0 [2]
N-Methyl-2-oxo-8-(4-phenylphenoxy)octanamideIC50110.0 [1]
N-[[4-[(E)-3-(Hydroxyamino)-3-oxoprop-1-enyl]phenyl]methyl]-4-pyrrolidin-1-ylbenzamideIC50205.0 [1], 205.27 [2]
6-(4-Phenylbenzoylamino)hexanehydroxamic acidIC5038.0 [1], 265.0 [2]
N1-Hydroxy-N8-(4-phenylthiazol-2-yl)octanediamideIC506.6 [1], 15.0 [2]
3-(1-Benzyl-6-oxo-2,3-dihydropyridin-5-yl)-N-hydroxypropanamideIC50670.0 [1]
6-Phenoxyhexane-1-thiolIC5011000.0 [1]
N-(3-Phenylphenyl)-7-sulfanylheptanamideIC5075.0 [1]
TucidinostatIC507160.0 [1], 7200.0 [2]
(E)-N-Hydroxy-3-[4-(4-methoxyphenyl)phenyl]prop-2-enamideIC508700.0 [1], 32600.0 [2]
N-Hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanamideIC501.0 [1], 3.0 [2]
6-[(2S,5S,8S,11S)-2-Methyl-11-(2-methylpropyl)-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanoic acidIC50205.0 [1], 377.0 [2]
N-Hydroxy-9H-xanthene-9-carboxamideIC503000.0 [1], 50000.0 [2]
N-Hydroxy-6-(naphthalen-1-ylcarbamoylamino)oxyhexanamideIC50900.0 [1], 1060.0 [2]
1-(4-Tert-butylphenyl)-3-[6-(hydroxyamino)-6-oxo-hexoxy]ureaIC501320.0 [1], 1410.0 [2]
Octanedioic acid phenylamide pyridin-2-ylamideIC5099000.0 [1], 100000.0 [2]
(E)-N-Hydroxy-3-(4-{[2-(1H-indol-3-yl)-ethylamino]-methyl}-phenyl)-acrylamideIC5063.0 [1]
Pyridin-3-ylmethyl N-[[4-[(2-amino-5-methoxyphenyl)carbamoyl]phenyl]methyl]carbamateIC504600.0 [1]
7-[(2-Bromoacetyl)amino]-N-phenylheptanamideIC5014000.0 [1]
Pyridin-3-ylmethyl N-[[4-[(2-hydroxyphenyl)carbamoyl]phenyl]methyl]carbamateIC502200.0 [1]
N-Hydroxy-6-[[(2S)-2-[(3R,4R)-3-(2-methylpropyl)-2,5-dioxo-4-propylpyrrolidin-1-yl]-3-phenylpropanoyl]amino]hexanamideIC5051.0 [1]
Pyridin-3-ylmethyl N-[[4-[(2-acetamidophenyl)carbamoyl]phenyl]methyl]carbamateIC50100000.0 [1]
Pyridin-3-ylmethyl N-[[4-[(2-amino-4-methylphenyl)carbamoyl]phenyl]methyl]carbamateIC50100000.0 [1]
Pyridin-3-ylmethyl N-[[4-[(2-amino-4-chlorophenyl)carbamoyl]phenyl]methyl]carbamateIC5040000.0 [1]
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-(1-methoxy-4-oxoquinolin-3-yl)-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneIC5086.0 [1]
Pyridin-3-ylmethyl N-[[4-[(4-aminophenyl)carbamoyl]phenyl]methyl]carbamateIC50100000.0 [1]
Pyridin-3-ylmethyl N-[[4-[(2-amino-4-methoxyphenyl)carbamoyl]phenyl]methyl]carbamateIC5044000.0 [1]
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-(1-ethyl-4-oxoquinolin-3-yl)-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneIC50330.0 [1]
Pyridin-3-ylmethyl N-[[4-[(3-aminophenyl)carbamoyl]phenyl]methyl]carbamateIC50100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone deacetylase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/histone-deacetylase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Histone deacetylase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-inhibitors-ic50-ki.
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