Histone-lysine N-methyltransferase EZH2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	S-Adenosyl-L-homocysteine	IC50	4800.0 [1]
	CID 68210102	IC50	1.0 [1], 2.0 [2], 280.0 [3]
	CID 68210102	Ki	0.5 [1]
	5-Chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-ethylbenzamide	IC50	2.9 [1]
	5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-(pyrrolidine-1-carbonyl)cyclohexyl]amino]-2-methylbenzamide	IC50	21.4 [1]
	Ethyl 4-[5-chloro-3-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methylcarbamoyl]-N-ethyl-2-methylanilino]cyclohexane-1-carboxylate	IC50	3.2 [1]
	4-[5-Chloro-3-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methylcarbamoyl]-N-ethyl-2-methylanilino]cyclohexane-1-carboxylic acid	IC50	42.0 [1]
	Tazemetostat	IC50	11.07 [1]
	Tazemetostat	Ki	2.5 [1]
	CID 60160561	IC50	75.0 [1]
	CID 60160561	Ki	24.0 [1]
	Ezh2-in-3	IC50	190.0 [1]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl)phenyl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide	IC50	184.6 [1]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-pyrazin-2-ylbenzamide	IC50	2.9 [1]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(1-methylpyrazol-4-yl)benzamide	IC50	1.9 [1]
	2-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide	IC50	5.1 [1]
	N-[(5-Bromo-4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide	IC50	3287.59 [1]
	3-[Ethyl(oxan-4-yl)amino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide	IC50	10.35 [1]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[4-(3-hydroxypropylcarbamoyl)phenyl]-2-methylbenzamide	IC50	2.9 [1]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(6-piperazin-1-ylpyridin-3-yl)benzamide	IC50	10.1 [1]
	3-[Ethyl(oxan-4-yl)amino]-N-[(5-fluoro-4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide	IC50	183.5 [1]
	3-[Ethyl(oxan-4-yl)amino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-5-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]benzamide	IC50	3.9 [1]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(5-methylpyrazin-2-yl)benzamide	IC50	9.55 [1]
	5,8-Dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one	IC50	15.0 [1], 17.0 [2]
	5,8-Dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one	Ki	0.7 [1], 1.15 [2], 3.0 [3]
	5-Chloro-N-[(6-ethyl-4-methyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide	IC50	2.2 [1], 5.1 [2], 18.2 [3], 20.0 [4], 22.3 [5]
	2-Amino-4-[[(3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-[2-[2-(4-chlorophenyl)ethylamino]ethyl]amino]butanoic acid	IC50	2500.0 [1], 4100.0 [2], 7180.0 [3], 7560.0 [4], 8950.0 [5]
	CID 67469117	IC50	2.3 [1], 5.5 [2], 9.2 [3], 33.3 [4]
	3-[Cyclopentyl(methyl)amino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(2,2,6,6-tetramethyl-1,3-dihydropyridin-4-yl)benzamide	IC50	19.0 [1], 27.7 [2], 230.0 [3], 311.0 [4]
	5-Chloro-3-[(4,4-dimethylcyclohexyl)-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	9.4 [1], 19.3 [2], 29.3 [3], 34.8 [4]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)-1-propan-2-ylindole-4-carboxamide	IC50	9.3 [1], 10.6 [2], 19.1 [3], 38.4 [4]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-(2,2,6,6-tetramethylpiperidin-4-yl)pyrazolo[3,4-b]pyridine-4-carboxamide	IC50	31.6 [1], 59.9 [2], 292.3 [3], 357.9 [4]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-(methylamino)-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide	IC50	213.0 [1], 318.9 [2], 1578.1 [3], 2375.5 [4]
	3-[(4-Aminocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[6-(morpholin-4-ylmethyl)pyridin-3-yl]benzamide	IC50	46.24 [1], 48.4 [2], 54.68 [3], 67.5 [4]
	3-[(4-Aminocyclohexyl)-methylamino]-5-[6-[(dimethylamino)methyl]pyridin-3-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	30.53 [1], 56.02 [2], 58.05 [3], 58.37 [4]
	3-[Ethyl(oxan-4-yl)amino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-5-(6-piperazin-1-ylpyridin-3-yl)benzamide	IC50	0.8 [1], 0.9 [2], 0.92 [3], 1.1 [4]
	3-[(4-Aminocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide	IC50	22.06 [1], 25.48 [2], 30.09 [3], 43.22 [4]
	3-[(4-Aminocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]benzamide	IC50	74.26 [1], 96.73 [2], 125.2 [3], 139.9 [4]
	3-[(4-Aminocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(1-methylpyrazol-4-yl)benzamide	IC50	62.19 [1], 70.98 [2], 75.46 [3], 99.9 [4]
	3-[(4-Acetamidocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[6-(morpholin-4-ylmethyl)pyridin-3-yl]benzamide	IC50	13.67 [1], 15.27 [2], 23.33 [3], 32.26 [4]
	3-[(4-Acetamidocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]benzamide	IC50	27.01 [1], 54.92 [2], 66.99 [3], 82.1 [4]
	5-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylpyridine-3-carboxamide	IC50	10.4 [1], 12.5 [2], 17.1 [3], 19.2 [4]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(1-methylazetidin-3-yl)oxybenzamide	IC50	0.8 [1], 1.4 [2], 1.5 [3], 8.7 [4]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-propan-2-ylbenzamide	IC50	6.5 [1], 7.3 [2], 15.8 [3], 16.9 [4]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethylsulfonyl-2-methylbenzamide	IC50	4.8 [1], 5.1 [2], 10.8 [3], 11.4 [4]
	5-Chloro-3-[ethyl-(1-methylpiperidin-4-yl)amino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]benzamide	IC50	14.6 [1], 17.8 [2], 35.1 [3], 65.7 [4]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-(3-hydroxy-3-methylbut-1-ynyl)-2-methylbenzamide	IC50	1.6 [1], 3.6 [2], 4.6 [3], 12.4 [4]
	3-[[4-(Azetidin-1-yl)cyclohexyl]-ethylamino]-5-chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	2.5 [1], 5.8 [2], 6.7 [3], 7.9 [4]
	5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[methyl(oxetan-3-yl)amino]cyclohexyl]amino]-2-methylbenzamide	IC50	1.6 [1], 1.7 [2], 6.1 [3], 6.7 [4]
	3-[(4-Tert-butylcyclohexyl)-ethylamino]-5-chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	63.8 [1], 118.8 [2], 167.8 [3], 333.3 [4]
	5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-(hydroxymethyl)cyclohexyl]amino]-2-methylbenzamide	IC50	1.6 [1], 2.1 [2], 2.7 [3]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-methoxy-2-methylbenzamide	IC50	10.0 [1], 10.3 [2], 11.6 [3], 11.7 [4]
	5-Bromo-2-chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]benzamide	IC50	2.9 [1], 3.2 [2], 3.4 [3], 3.5 [4]
	5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-(4-propan-2-ylcyclohexyl)amino]-2-methylbenzamide	IC50	11.1 [1], 12.0 [2], 22.7 [3], 30.0 [4]
	5-Chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-2-methyl-N-[(1,4,6-trimethyl-2-oxopyridin-3-yl)methyl]benzamide	IC50	6.5 [1], 6.8 [2], 7.4 [3], 8.6 [4]
	5-Chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-N,2-dimethylbenzamide	IC50	12.2 [1], 12.8 [2], 14.3 [3], 20.7 [4]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(trifluoromethyl)benzamide	IC50	8.2 [1], 9.2 [2], 9.4 [3], 9.6 [4]
	5-Chloro-3-[[4-[cyclobutyl(methyl)amino]cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	4.2 [1], 7.1 [2], 8.8 [3], 11.4 [4]
	5-(2-Cyclopropylethynyl)-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	1.5 [1], 1.8 [2], 2.5 [3], 4.3 [4]
	5-(Azetidine-1-carbonyl)-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	1.4 [1], 2.9 [2], 9.1 [3]
	5-Chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]benzamide	IC50	2.8 [1], 3.8 [2], 4.6 [3], 7.9 [4]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-5-(3,3-dimethylbut-1-ynyl)-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	4.0 [1], 7.6 [2], 10.4 [3], 15.4 [4]
	5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-(1-propan-2-ylpiperidin-4-yl)amino]-2-methylbenzamide	IC50	12.1 [1], 20.5 [2], 27.5 [3], 71.5 [4]
	5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-(1-methylazetidin-3-yl)amino]-2-methylbenzamide	IC50	5.7 [1], 22.2 [2], 25.5 [3], 76.5 [4]
	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethynyl-2-methylbenzamide	IC50	3.4 [1], 4.0 [2], 8.8 [3], 18.1 [4]
	3-Bromo-5-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2,6-dimethylbenzamide	IC50	4.5 [1], 5.5 [2], 7.3 [3], 9.6 [4]
	5-Chloro-3-[[4-[2,2-difluoroethyl(methyl)amino]cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide	IC50	2.2 [1], 2.8 [2], 6.9 [3], 9.4 [4]
	CID 72551585	IC50	10.0 [1], 124.0 [2]
	CID 72551585	Ki	4.6 [1]
	6-Cyclopropyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide	IC50	10632.0 [1]
	6-Cyclopropyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide	Ki	700.0 [1]
	CID 72199293	IC50	13.0 [1], 15.0 [2]
	CID 72199293	Ki	13.0 [1]
	CID 118572065	IC50	4.0 [1]
	CID 118572065	Ki	0.1 [1]
	CPI-169 R-enantiomer	IC50	2.0 [1], 3.0 [2], 80.0 [3]
	CID 73442743	IC50	2.0 [1], 4.0 [2], 75.0 [3]
	1-[(1R)-1-(1-Ethylsulfonylpiperidin-4-yl)ethyl]-2-methyl-N-[[6-methyl-2-oxo-4-(2,2,2-trifluoroethoxy)-1H-pyridin-3-yl]methyl]indole-3-carboxamide	IC50	40.0 [1], 485.0 [2], 1080.0 [3]
	1-[(1R)-1-(1-Ethylsulfonylpiperidin-4-yl)ethyl]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]indole-3-carboxamide	IC50	5.0 [1], 40.0 [2], 266.0 [3]
	5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(3,5-dimethyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one	IC50	16.0 [1], 82.0 [2], 502.0 [3]
	5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(1,3,5-trimethylpyrazol-4-yl)-3,4-dihydroisoquinolin-1-one	IC50	1500.0 [1], 6000.0 [2], 15308.0 [3]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-phenylethyl]indole-3-carboxamide	IC50	7.0 [1], 34.0 [2], 484.0 [3]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(2R)-1-methoxypropan-2-yl]-2-methylindole-3-carboxamide	IC50	5.0 [1], 43.0 [2], 703.0 [3]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-(oxan-4-yl)ethyl]indole-3-carboxamide	IC50	1.0 [1], 4.0 [2], 98.0 [3]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-(1-methylpiperidin-4-yl)ethyl]indole-3-carboxamide	IC50	2.0 [1], 7.0 [2], 568.0 [3]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(1R)-1-(1-ethylsulfonylpiperidin-4-yl)ethyl]-2-methylindole-3-carboxamide	IC50	1.0 [1], 3.0 [2], 59.0 [3]
	5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one	IC50	51.0 [1], 270.0 [2], 1726.0 [3]
	8-Chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one	IC50	105.0 [1]
	8-Chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one	Ki	2.0 [1], 6.3 [2]
	5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(5-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one	IC50	24.0 [1], 110.0 [2], 873.0 [3]
	1-Butan-2-yl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylindole-3-carboxamide	IC50	14.0 [1], 118.0 [2], 929.0 [3]
	5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one	IC50	5.6 [1], 18.0 [2], 170.0 [3]
	8-Chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-methyl-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one	IC50	18.0 [1], 61.0 [2], 290.0 [3]
	8-Chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one	IC50	28.0 [1], 110.0 [2], 796.0 [3]
	8-Chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-fluoro-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one	IC50	56.0 [1], 260.0 [2], 994.0 [3]
	8-Chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-propan-2-yloxy-3,4-dihydroisoquinolin-1-one	IC50	41.0 [1], 160.0 [2], 1187.0 [3]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(3-methoxypropyl)amino]-2-methylbenzamide	IC50	12.7 [1], 88.2 [2], 132.0 [3]
	6-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide	IC50	500.0 [1], 620.0 [2]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)indole-3-carboxamide	IC50	1760.0 [1], 10000.0 [2]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-(1-phenylethyl)indole-3-carboxamide	IC50	1640.0 [1], 10000.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Histone-lysine N-methyltransferase EZH2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-ezh2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Histone-lysine N-methyltransferase EZH2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-ezh2-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan