Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine	IC50	1900.0 [1]
	Unc-0638	IC50	55.0 [1]
	Unc-0638	Ki	3.7 [1]
	CID 44251522	IC50	43.0 [1]
	CID 44251522	Ki	2.6 [1]
	CID 53315878	IC50	40.0 [1]
	CID 53315878	Ki	3.7 [1]
	CID 53315868	IC50	25.0 [1]
	CID 53315882	IC50	12.0 [1]
	Chaetocin	IC50	2500.0 [1]
	CID 44604812	IC50	230.0 [1]
	N2,N2-Diethyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine	IC50	910.0 [1]
	6,7-Dimethoxy-N2,N2-dimethyl-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine	IC50	900.0 [1]
	6,7-Dimethoxy-N-(1-methylpiperidin-4-yl)-2-(piperidin-1-yl)quinazolin-4-amine	IC50	31.0 [1], 510.0 [2], 550.0 [3], 591.0 [4], 510000.0 [5]
	6,7-Dimethoxy-2-(4-methylpiperazin-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	200.0 [1], 680.0 [2], 200000.0 [3]
	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine	IC50	20.0 [1], 25.0 [2], 910.0 [3], 20000.0 [4]
	6,7-Dimethoxy-N-(1-Methylpiperidin-4-Yl)-2-(Morpholin-4-Yl)quinazolin-4-Amine	IC50	440.0 [1], 810.0 [2], 1600.0 [3], 810000.0 [4], 1600000.0 [5]
	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	8.0 [1], 2200.0 [2], 8000.0 [3], 11000.0 [4]
	CID 46901937	IC50	9.0 [1], 6000.0 [2], 9000.0 [3], 11000.0 [4]
	CID 76285486	IC50	3.0 [1], 3.3 [2]
	(1R,4R,7R,9R)-4-(Hydroxymethyl)-9-[(1R,4R,7R,9R)-4-(hydroxymethyl)-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-trien-9-yl]-5-methyl-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dione	IC50	50000.0 [1], 100000.0 [2]
	6-Methoxy-2-piperidin-1-yl-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	2.5 [1], 16.0 [2], 150.0 [3]
	2-(Azepan-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	2.5 [1], 20.0 [2], 100.0 [3]
	7-[2-(Dimethylamino)ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	110.0 [1], 120.0 [2], 110000.0 [3], 120000.0 [4]
	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(4-methylpentoxy)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	3400.0 [1], 5200.0 [2], 3400000.0 [3], 5200000.0 [4]
	Ent-Chaetocin	IC50	1700.0 [1], 6400.0 [2]
	N-Cyclohexyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine	IC50	3877.0 [1], 10000.0 [2], 10000000.0 [3]
	2-Cyclohexyl-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine	IC50	0.5 [1], 0.7 [2]
	1-[2-[4-(4-Methoxybenzoyl)oxyphenyl]ethyl]-2-[[4-(trifluoromethyl)benzoyl]amino]benzimidazole-5-carboxylic acid	IC50	106.0 [1], 4700.0 [2], 5000.0 [3]
	Sodium	IC50	9200.0 [1], 100000.0 [2]
	S-Adenosyl-L-homocysteine	IC50	2000.0 [1]
	S-Adenosyl-L-homocysteine	Ki	570.0 [1]
	Gliotoxin	IC50	530.0 [1], 6400.0 [2]
	Sinefungin	IC50	100.0 [1], 509000.0 [2]
	N-(4-((2-Amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide	IC50	10000.0 [1], 59000.0 [2]
	6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine	IC50	8.0 [1]
	N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methylpiperazin-1-yl)quinazolin-4-amine	IC50	101.0 [1]
	2-(5-Ethylfuran-2-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine	IC50	2.0 [1]
	6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(piperidin-4-yl)quinazolin-4-amine	IC50	10000.0 [1], 10000000.0 [2]
	6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(oxan-4-yl)quinazolin-4-amine	IC50	10000.0 [1], 10000000.0 [2]
	N-Cyclopropyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine	IC50	5100.0 [1], 5100000.0 [2]
	N-Isopropyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine	IC50	5800.0 [1], 5800000.0 [2]
	2-Chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	9100.0 [1], 9100000.0 [2]
	(1S,4S,7S,9S)-4-(Hydroxymethyl)-9-[(1S,4S,7S,9S)-4-(hydroxymethyl)-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-trien-9-yl]-5-methyl-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dione	IC50	50000.0 [1], 100000.0 [2]
	N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinolin-4-amine	IC50	13.0 [1]
	N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methylpiperazin-1-yl)quinolin-4-amine	IC50	21.0 [1], 31.0 [2]
	(1S,4S)-5,7-Dibenzyl-2,3-dithia-5,7-diazabicyclo[2.2.2]octane-6,8-dione	IC50	4900.0 [1], 5105.05 [2]
	CID 46899643	IC50	910000.0 [1], 1900000.0 [2]
	7-[4-(Dimethylamino)butoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	110000.0 [1], 140000.0 [2]
	7-[5-(Dimethylamino)pentoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	49000.0 [1], 95000.0 [2]
	7-[6-(Dimethylamino)hexoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	3200000.0 [1], 15100000.0 [2]
	6-Methoxy-7-[3-(methylamino)propoxy]-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	41000.0 [1], 120000.0 [2]
	7-[3-(Diethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	52000.0 [1], 65000.0 [2]
	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-[3-[methyl(propyl)amino]propoxy]quinazolin-4-amine	IC50	45000.0 [1], 51000.0 [2]
	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine	IC50	780000.0 [1], 880000.0 [2]
	CID 46901785	IC50	10000.0 [1], 10000000.0 [2]
	7-(5-Aminopentoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	IC50	110000.0 [1], 235000.0 [2]
	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-[2-(2-pyrrolidin-1-ylethoxy)ethoxy]quinazolin-4-amine	IC50	57000.0 [1], 110000.0 [2]
	N'-[2-[6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-[(1-methylpiperidin-4-yl)amino]quinazolin-7-yl]oxyethyl]-N,N,N'-trimethylethane-1,2-diamine	IC50	173000.0 [1], 345000.0 [2]
	CID 46901936	IC50	1500000.0 [1], 5100000.0 [2]
	N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-piperidin-1-ylquinazolin-4-amine	IC50	472.0 [1]
	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	10.0 [1], 520.0 [2]
	6-Methoxy-7-(3-piperidin-1-ylpropoxy)-2-(4-propan-2-yl-1,4-diazepan-1-yl)-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amine	IC50	8.0 [1], 54.0 [2]
	2-(Azepan-1-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amine	IC50	31.0 [1], 240.0 [2]
	6-Methoxy-2-(4-propan-2-yl-1,4-diazepan-1-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	2.0 [1], 340.0 [2]
	2-(4-Cyclohexyl-1,4-diazepan-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	22.0 [1], 100.0 [2]
	2-[4-(Cyclohexylmethyl)-1,4-diazepan-1-yl]-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	7.0 [1], 93.0 [2]
	2-(4-Ethyl-1,4-diazepan-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	5.0 [1], 470.0 [2]
	2-(4-Benzyl-1,4-diazepan-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	9.0 [1], 58.0 [2]
	2-Cyclohexyl-7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amine	IC50	21.0 [1], 180.0 [2]
	2-Cyclohexyl-6-methoxy-7-(3-piperidin-1-ylpropoxy)-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amine	IC50	110.0 [1], 260.0 [2]
	6-Methoxy-2-(4-phenyl-1,4-diazepan-1-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	10.0 [1], 220.0 [2]
	N-(1-Cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine	IC50	11.0 [1], 56.0 [2]
	N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-pyridin-2-ylpiperazin-1-yl)quinazolin-4-amine	IC50	3190.0 [1]
	6-Methoxy-2-morpholin-4-yl-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	2.5 [1], 180.0 [2]
	N-(1-Cyclopropylpiperidin-4-yl)-2-(4,4-difluoropiperidin-1-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	3.0 [1], 310.0 [2]
	N-(1-Cyclopropylpiperidin-4-yl)-2-(1,1-dioxo-1,4-thiazinan-4-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	4.0 [1], 590.0 [2]
	6-Methoxy-2-(oxan-4-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine	IC50	9.0 [1], 310.0 [2]
	Glutathione	IC50	100000.0 [1]
	Azacitidine	IC50	10000.0 [1]
	Decitabine	IC50	10000.0 [1]
	Oxiglutatione	IC50	100000.0 [1]
	Cysteamine	IC50	100000.0 [1]
	Disulfiram	IC50	600.0 [1]
	Anthraquinone	IC50	100000.0 [1]
	Cystamine dihydrochloride	IC50	15000.0 [1]
	Ninhydrin	IC50	54000.0 [1]
	1,4-Naphthoquinone	IC50	2000.0 [1]
	Ebselen	IC50	400.0 [1]
	Thiram	IC50	550.0 [1]
	Diphenyl diselenide	IC50	550.0 [1]
	2,2'-Dithiodipyridine	IC50	650.0 [1]
	Azodicarbonamide	IC50	500.0 [1]
	Chetomin	IC50	170.0 [1]
	CID 71268957	IC50	100000.0 [1]
	Bisdethiobis(methylthio)gliotoxin	IC50	100000.0 [1]
	Verticillin	IC50	630.0 [1]
	Benzeneseleninic acid	IC50	4400.0 [1]
	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acid	Ki	20000.0 [1]
	6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	IC50	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-h3-lysine-9-specific-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-h3-lysine-9-specific-3-inhibitors-ic50-ki.
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