Histone-lysine N-methyltransferase SMYD3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	6-Chloro-2-oxo-N-[(1S,5R)-8-[[1-(4,4,4-trifluorobutyl)piperidin-4-yl]methylsulfonyl]-8-azabicyclo[3.2.1]octan-3-yl]-1,3-dihydroindole-5-carboxamide	IC50	3.0 [1], 36.0 [2]
	6-Chloro-2-oxo-N-[(1S,5R)-8-[[1-(4,4,4-trifluorobutyl)piperidin-4-yl]methylsulfonyl]-8-azabicyclo[3.2.1]octan-3-yl]-1,3-dihydroindole-5-carboxamide	Ki	1.1 [1], 1.2 [2]
	N-[(1S,5R)-8-[4-(Benzylamino)piperidin-1-yl]sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-6-chloro-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	4.0 [1], 48.0 [2]
	N-[(1S,5R)-8-[4-(Benzylamino)piperidin-1-yl]sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-6-chloro-2-oxo-1,3-dihydroindole-5-carboxamide	Ki	1.3 [1], 4.7 [2]
	2-Oxo-N-[1-(piperidin-4-ylmethylsulfonyl)piperidin-4-yl]-1,3-dihydroindole-5-carboxamide	IC50	70.0 [1], 10000.0 [2]
	N-[(1R,5S)-8-(4-Aminopiperidin-1-yl)sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	1.0 [1], 850.0 [2]
	N-[(1S,5R)-8-(4-Aminopiperidin-1-yl)sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-6-chloro-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	1.0 [1], 1100.0 [2]
	N-[(1S,5R)-8-(4-Aminopiperidin-1-yl)sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-6-fluoro-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	5.0 [1], 530.0 [2]
	N-[(1S,5R)-8-(4-Aminopiperidin-1-yl)sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-6-methyl-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	16.0 [1], 410.0 [2]
	6-Chloro-2-oxo-N-[(1S,5R)-8-[[(3R)-piperidin-3-yl]methylsulfonyl]-8-azabicyclo[3.2.1]octan-3-yl]-1,3-dihydroindole-5-carboxamide	IC50	5.0 [1], 730.0 [2]
	N-[(1R,5S)-8-(4-Aminocyclohexyl)sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	4.0 [1], 2200.0 [2]
	6-Chloro-N-[(1S,5R)-8-[4-(methylamino)piperidin-1-yl]sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	2.0 [1], 420.0 [2]
	6-Chloro-N-[(1S,5R)-8-[4-(dimethylamino)piperidin-1-yl]sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	3.0 [1], 300.0 [2]
	N-[1-(3-Aminopropylsulfonyl)piperidin-4-yl]-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	160.0 [1], 10000.0 [2]
	N-[1-(3-Aminopropylsulfonyl)piperidin-4-yl]-6-chloro-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	80.0 [1], 6800.0 [2]
	1-Methyl-2-oxo-N-[(1R,5S)-8-(piperidin-4-ylmethylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl]-3H-indole-5-carboxamide	IC50	26.0 [1], 3900.0 [2]
	6-Chloro-N-[(1S,5R)-8-[[1-(3-hydroxypropyl)piperidin-4-yl]methylsulfonyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	2.0 [1], 760.0 [2]
	2-Oxo-N-[(1R,5S)-8-(piperidin-4-ylmethylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl]-1,3-dihydroindole-5-carboxamide	IC50	4.0 [1], 3400.0 [2]
	6-Chloro-2-oxo-N-[(1S,5R)-8-(piperidin-4-ylmethylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl]-1,3-dihydroindole-5-carboxamide	IC50	4.0 [1], 3200.0 [2]
	N-[(1R,5S)-8-[(1-Methylpiperidin-4-yl)methylsulfonyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1,3-dihydroindole-5-carboxamide	IC50	1.0 [1], 480.0 [2]
	6-Chloro-2-oxo-N-[(1S,5R)-8-[[(3S)-piperidin-3-yl]methylsulfonyl]-8-azabicyclo[3.2.1]octan-3-yl]-1,3-dihydroindole-5-carboxamide	IC50	4.0 [1], 1300.0 [2]
	2-Oxidanylidene-N-Piperidin-4-Yl-1,3-Dihydroindole-5-Carboxamide	IC50	10000.0 [1], 17000.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Histone-lysine N-methyltransferase SMYD3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-smyd3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Histone-lysine N-methyltransferase SMYD3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-smyd3-inhibitors-ic50-ki.
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