HLA-DR antigens-associated invariant chain Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-[1-[2-Hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	410.0 [1]
	4-[1-[3-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	950.0 [1]
	1-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]-3,4-dihydroquinolin-2-one	IC50	2000.0 [1]
	5-Methyl-4-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	2000.0 [1]
	6-Chloro-4-[1-[2-hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	1300.0 [1]
	4-[1-[2-Hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]pyrido[3,2-b][1,4]oxazin-3-one	IC50	1300.0 [1]
	4-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-5-methyl-1,4-benzoxazin-3-one	IC50	1600.0 [1]
	6-Chloro-1-[1-[2-hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-3,4-dihydroquinazolin-2-one	IC50	1900.0 [1]
	1-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]-6-chloro-3,4-dihydroquinolin-2-one	IC50	750.0 [1]
	1-[4-(6-Chloro-2,2-dioxo-3,4-dihydro-2lambda6,1,3-benzothiadiazin-1-yl)piperidin-1-yl]-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propan-2-ol	IC50	1300.0 [1]
	4-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	1800.0 [1]
	4-[1-[3-[5-Acetyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	810.0 [1]
	4-[1-[3-[5-Acetyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	1100.0 [1]
	4-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	1600.0 [1]
	1-[1-[2-Hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-3,4-dihydroquinolin-2-one	IC50	1800.0 [1]
	4-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-6-chloro-1,4-benzoxazin-3-one	IC50	2600.0 [1]
	1-[1-[2-Hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one	IC50	1400.0 [1]
	4-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]pyrido[3,2-b][1,4]oxazin-3-one	IC50	900.0 [1]
	1-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]-3,4-dihydroquinazolin-2-one	IC50	1100.0 [1]
	1-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]-6-chloro-3,4-dihydroquinazolin-2-one	IC50	1500.0 [1]
	1-[1-[2-Hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-5H-4,1-benzoxazepin-2-one	IC50	930.0 [1]
	4-[1-[3-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]-6-chloro-1,4-benzoxazin-3-one	IC50	4400.0 [1]
	1-[1-[2-Hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-3,4-dihydroquinazolin-2-one	IC50	1400.0 [1]
	1-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(6-chloro-2,2-dioxo-3,4-dihydro-2lambda6,1,3-benzothiadiazin-1-yl)piperidin-1-yl]propan-2-ol	IC50	2700.0 [1]
	6-Chloro-1-[1-[2-hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-3,4-dihydroquinolin-2-one	IC50	980.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 25 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ HLA-DR antigens-associated invariant chain Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/hla-dr-antigens-associated-invariant-chain-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ HLA-DR antigens-associated invariant chain Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hla-dr-antigens-associated-invariant-chain-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan