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HMG-CoA reductase Inhibitors (IC50, Ki)

Structure
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Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
LovastatinIC5037.0 [1]
SimvastatinIC5039.81 [1]
SimvastatinKi2.6 [1], 68000.0 [2]
RosuvastatinIC503.1 [1], 4.0 [2], 5.0 [3], 5.4 [4]
RosuvastatinKi0.9 [1], 71000.0 [2]
AtorvastatinIC506.0 [1], 11.6 [2], 12.9 [3]
Unii-B99nwa524XIC501340.0 [1], 1600.0 [2], 3000.0 [3]
PravastatinIC5030.0 [1], 400.0 [2]
Pravastatin sodiumIC5030.0 [1], 1370.0 [2]
VorinostatIC5010000.0 [1]
MevastatinIC5023.0 [1], 28.4 [2]
alpha-AsaroneIC5036.31 [1], 5860.0 [2]
MeglutolIC504000.0 [1]
MeglutolKi23.5 [1]
1-[(3S,10R,13R,14S,17R)-3-Hydroxy-4,4,10,13-tetramethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-14-yl]ethanoneIC501000.0 [1], 20000.0 [2]
Methyl 2-(5-hydroxy-2-methoxy-4-propylphenoxy)acetateIC5039.81 [1], 6110.0 [2]
DfgyvaeIC50160.0 [1]
DfgyvaeKi51.0 [1]
4,5-Dimethoxy-2-propylphenolIC5022.91 [1], 4790.0 [2]
Methyl 2-(4-butanoyl-5-hydroxy-2-methoxyphenoxy)acetateIC5044.67 [1], 6430.0 [2]
(3S,10R,13R,14S,17R)-14-(1-Hydroxyethyl)-4,4,10,13-tetramethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-olIC503000.0 [1], 20000.0 [2]
2-[[2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[(2-Aminoacetyl)amino]-3-(4-fluorophenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetic acidIC504820.0 [1]
2-[[2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[(2-Aminoacetyl)amino]-3-(4-fluorophenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetic acidKi260.0 [1]
1-(2-Hydroxy-4,5-dimethoxyphenyl)propan-1-oneIC5024.55 [1], 4940.0 [2]
[(1S,3R,7S,8S,8Ar)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] N-[7-(hydroxyamino)-7-oxoheptyl]carbamateIC5054.1 [1]
[(1S,3R,7S,8S,8Ar)-8-[(3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoateIC5011.4 [1], 13.1 [2]
1-[(3R,5R)-3,5-Dihydroxy-7-(hydroxyamino)-7-oxoheptyl]-5-(4-fluorophenyl)-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamideIC509.2 [1], 12.3 [2]
(E,3R,5S)-7-[4-(4-Fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-N,3,5-trihydroxyhept-6-enamideIC5043.7 [1]
[(1S,3R,7S,8S,8Ar)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] N-[4-[1-[7-(hydroxyamino)-7-oxoheptyl]triazol-4-yl]phenyl]carbamateIC5036.5 [1]
[(1S,3R,7S,8S,8Ar)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] N-[[4-[1-[7-(hydroxyamino)-7-oxoheptyl]triazol-4-yl]phenyl]methyl]carbamateIC5053.8 [1]
CalciumIC508900.0 [1]
EpilovastatinIC502.2 [1]
(6E)-7-[3-(4-Fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acidIC5028.0 [1]
25-HydroxycholesterolIC50300.0 [1]
CerivastatinIC5010.0 [1]
9-Octadecynoic acidIC505000.0 [1]
GlenvastatinIC505.0 [1]
7-Oxo-ganoderic acid ZIC5022300.0 [1]
Ganoderic acid TRIC5021700.0 [1]
[(1S,3R,7S,8S)-8-[2-[(2R,4R)-4-Hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoateIC5012.1 [1]
(E,3R,5R)-7-[4,5-Bis(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC505.7 [1]
(2S)-3-[2-[(1S,2R,4Ar,8aR)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-2-hydroxy-2H-furan-5-oneIC5030200.0 [1]
(4S)-4-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3S)-2-Amino-3-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC50201120.0 [1]
(3S)-3-[[(2S)-1-[(2S)-2-[(2-Aminoacetyl)amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-4-[[2-(carboxymethylamino)-2-oxoethyl]amino]-4-oxobutanoic acidIC5022310.0 [1]
3,5-Dihydroxy-7-(4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl)-6-heptenoic acidIC506.15 [1]
[(1S,3R,7S,8S)-8-[2-[(2R,4R)-4-Hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoateIC5018.0 [1]
7-[4,5-Bis-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoic acidIC509.0 [1]
[(1S,3R,4Ar,7S,8S,8aS)-3-hydroxy-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2S)-2-methylbutanoateIC501400.0 [1]
Lovastatin sodium saltIC5029.0 [1]
Tenivastatin sodiumIC5012.0 [1]
Sodium;(E,3R,5S)-7-[5-(4-fluorophenyl)-3-propan-2-yl-1-pyridin-2-ylpyrazol-4-yl]-3,5-dihydroxyhept-6-enoateIC508.0 [1]
Sodium;(E,3R,5S)-7-[5-(4-fluorophenyl)-3-propan-2-yl-1-pyrazin-2-ylpyrazol-4-yl]-3,5-dihydroxyhept-6-enoateIC5066.0 [1]
Sodium;(E,3R,5S)-7-[5-(4-fluorophenyl)-1-phenyl-3-propan-2-ylpyrazol-4-yl]-3,5-dihydroxyhept-6-enoateIC507.0 [1]
Sodium;(3R,5R)-7-[3-(4-fluorophenyl)-4-phenyl-5-(phenylcarbamoyl)-1-propan-2-ylpyrrol-2-yl]-3,5-dihydroxyheptanoateIC501.8 [1]
GfpdggIC501520.0 [1]
GfpeggIC501780.0 [1]
L-Isoleucyl-L-alanyl-L-valyl-L-glutamic acidIC5075230.0 [1]
L-Tyrosyl-L-alanyl-L-valyl-L-glutamic acidIC5044810.0 [1]
L-Isoleucyl-L-valyl-L-alanyl-L-glutamic acidIC5052670.0 [1]
L-Tyrosyl-L-valyl-L-alanyl-L-glutamic acidIC5041210.0 [1]
GlptggIC5019430.0 [1]
GfptggIC5016940.0 [1]
(4R)-6-[[2-(4-Fluorophenyl)-4,6-di(propan-2-yl)phenoxy]methyl]-4-hydroxyoxan-2-oneIC501.8 [1]
(4R)-6-[2-[4-(4-Fluorophenyl)-6-phenyl-2-propan-2-ylpyridin-3-yl]ethyl]-4-hydroxyoxan-2-oneIC50370.0 [1]
(E,3R,5S)-7-[4-(4-Fluorophenyl)-1-phenyl-2-propan-2-ylpyrrol-3-yl]-3,5-dihydroxyhept-6-enoic acidIC500.01 [1]
(E,3R,5S)-7-[2,3-Bis(4-fluorophenyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC506.98 [1]
L-Leucyl-L-prolyl-L-tyrosyl-L-prolineIC50484720.0 [1]
(4S)-4-[[(2S)-1-[(2S)-2-[(2-Aminoacetyl)amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-[[2-(carboxymethylamino)-2-oxoethyl]amino]-5-oxopentanoic acidIC5027280.0 [1]
F(4-Fluoro)VAEIC503840.0 [1]
FPYVAE peptide [PMID: 20494585]IC501470.0 [1]
(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3S)-2-Amino-3-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoic acidIC50152190.0 [1]
CID 73348335IC504.8 [1]
4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanolIC5010000.0 [1]
(3R,5R)-7-[3,4-Bis(4-fluorophenyl)-5-(phenylcarbamoyl)-1-propan-2-ylpyrrol-2-yl]-3,5-dihydroxyheptanoic acidIC501.8 [1]
[(1R,2S,3S,7S,8S)-2-Hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoateIC5013.3 [1]
[(1R,2S,3S,7S,8S)-8-[2-[(2R,4R)-4-Hydroxy-6-oxooxan-2-yl]ethyl]-2-[(R)-hydroxy(phenyl)methyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoateIC5019.7 [1]
[(1R,2S,3S,7S,8S)-2-[(1S)-1-Hydroxyethyl]-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoateIC507.6 [1]
[(1R,2S,3S,7S,8S)-2-(Hydroxymethyl)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoateIC5010.8 [1]
[(1S,3R,4S,6S,7R,8S,8Ar)-4,6-dihydroxy-3,7-dimethyl-8-[2-[(2R)-6-oxo-2,3-dihydropyran-2-yl]ethyl]-1,2,3,4,6,7,8,8a-octahydronaphthalen-1-yl] (2S)-2-methylbutanoateIC50387000.0 [1]
(4R,6S)-6-[(E)-2-[4-(4-Fluorophenyl)-2,6-dimethylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-oneIC502000.0 [1]
(4R,6S)-6-[(Z)-2-[4-(4-Fluorophenyl)-2-methyl-6-phenylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-oneIC505000.0 [1]
(4R,6S)-6-[(E)-2-[4-(4-Fluorophenyl)-2-methyl-6-phenylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-oneIC5090.0 [1]
(E)-6-{2-[4-(4-Fluoro-phenyl)-2,6-diisopropyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-oneIC5020.0 [1]
(4R,6S)-6-[(E)-2-[6-Cyclohexyl-4-(4-fluorophenyl)-2-propan-2-ylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-oneIC509.5 [1]
(4R,6S)-6-[(E)-2-[2-Cyclohexyl-4-(4-fluorophenyl)-6-phenylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-oneIC505000.0 [1]
(4R,6S)-6-[(E)-2-[4-(4-Fluorophenyl)-2-phenyl-6-propan-2-ylpyrimidin-5-yl]ethenyl]-4-hydroxyoxan-2-oneIC505.0 [1]
Sodium;(E,3R,5S)-7-[1-(1,3-benzothiazol-2-yl)-5-(4-fluorophenyl)-3-propan-2-ylpyrazol-4-yl]-3,5-dihydroxyhept-6-enoateIC5059.0 [1]
Sodium;(3R,5R)-7-[1-(4-fluorophenyl)-4-oxo-5-phenyl-3-propan-2-ylpyrrolo[2,3-c]quinolin-2-yl]-3,5-dihydroxyheptanoateIC5016.7 [1]
Sodium;7-[4-(4-fluorophenyl)-1-phenyl-2-propan-2-ylpyrrol-3-yl]-3,5-dihydroxyheptanoateIC500.01 [1]
Sodium;(3R,5R)-7-[3-(4-fluorophenyl)-5-[(4-methoxyphenyl)methylcarbamoyl]-4-phenyl-1-propan-2-ylpyrrol-2-yl]-3,5-dihydroxyheptanoateIC500.8 [1]
Sodium;(3R,5R)-7-[5-(ethylcarbamoyl)-3-(4-fluorophenyl)-4-phenyl-1-propan-2-ylpyrrol-2-yl]-3,5-dihydroxyheptanoateIC5012.0 [1]
Sodium;(3R,5R)-7-[3-(4-fluorophenyl)-8-oxo-7-phenyl-1-propan-2-yl-5,6-dihydro-4H-pyrrolo[2,3-c]azepin-2-yl]-3,5-dihydroxyheptanoateIC500.3 [1]
(4R)-6-[[2-[Chloro(cyclohexyl)methyl]-4,6-dimethylphenoxy]methyl]-4-hydroxyoxan-2-oneIC506500.0 [1]
(E,3R,5S)-7-[5-(4-Fluoro-3,5-dimethylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC507.52 [1]
(E,3R,5S)-7-[5-(4-Fluoro-2-methylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC508.4 [1]
(E,3R,5S)-7-[4,5-Bis(4-fluorophenyl)-2-(trifluoromethyl)imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC507.89 [1]
(E,3R,5S)-7-[5-(3,5-Dimethylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC507.25 [1]
(E,3R,5S)-7-[5-(3,5-Dichlorophenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC507.66 [1]
(E,3R,5S)-7-[5-(3-Chlorophenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC508.1 [1]
(E,3R,5S)-7-[2,4-Bis(4-fluorophenyl)-5-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acidIC509.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ HMG-CoA reductase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/hmg-coa-reductase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ HMG-CoA reductase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hmg-coa-reductase-inhibitors-ic50-ki.
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