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Hormone sensitive lipase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(S)-4-Isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC503.0 [1], 28.0 [2], 170.0 [3]
4-Hydroxy-piperidine-1-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl esterIC50270.0 [1], 500.0 [2]
N-Methyl-5-methylsulfanyl-N-phenyl-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazole-1-carboxamideIC50250.0 [1], 250000.0 [2]
N,N-Dimethyl-5-methylsulfanyl-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazole-1-carboxamideIC50100.0 [1], 100000.0 [2]
[2-[[4-[5-(Trifluoromethyl)pyridin-2-yl]oxybenzoyl]amino]phenyl]boronic acidIC5091.0 [1]
Hsl-IN-1IC502.0 [1]
4-Isopropyl-3-methyl-2-(morpholine-4-carbonyl)isoxazol-5(2H)-oneIC5052.0 [1], 1000.0 [2]
3-Methyl-4-(propan-2-yl)-2-(pyrrolidine-1-carbonyl)-1,2-oxazol-5(2H)-oneIC5015.0 [1], 28.0 [2]
4-(2-Ethoxyethyl)-3-methyl-2-(4-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC503.0 [1], 20.0 [2]
2-(4-Benzylpiperidine-1-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC50102.0 [1], 1000.0 [2]
1-(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carbonyl)-piperidine-3-carboxylic acid ethyl esterIC5028.0 [1], 170.0 [2]
4-Isobutyl-3-methyl-2-(4-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC503.0 [1], 18.0 [2]
3,4-Dimethyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC5013.0 [1], 655.0 [2]
4-Ethyl-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC5018.0 [1], 325.0 [2]
2-[3-(Hydroxymethyl)piperidine-1-carbonyl]-3-methyl-4-propan-2-yl-1,2-oxazol-5-oneIC50180.0 [1], 800.0 [2]
4-Butyl-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC507.0 [1], 61.0 [2]
4-(4-Chlorophenylthio)-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC506.0 [1], 135.0 [2]
4-Isopropyl-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC502.0 [1], 75.0 [2]
4-Isobutyl-3-methyl-2-(piperidine-1-carbonyl)-2H-isoxazol-5-oneIC505.0 [1], 32.0 [2]
4-Cyclohexyl-3-methyl-2-(4-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC504.0 [1], 20.0 [2]
3-Methyl-2-(4-methylpiperidine-1-carbonyl)-4-(tetrahydro-2H-thiopyran-4-yl)isoxazol-5(2H)-oneIC506.0 [1], 24.0 [2]
4-(4-Chlorophenylsulfonyl)-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC5035.0 [1], 1270.0 [2]
3-Methyl-4-(phenylthio)-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC506.0 [1], 190.0 [2]
4-Benzyl-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC505.0 [1], 90.0 [2]
4-Isopropyl-3-methyl-2-(4-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC506.0 [1], 40.0 [2]
4-Butyl-3-methyl-2-(4-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC501.0 [1], 10.0 [2]
N-[(2-Fluorophenyl)methyl]-N,3-dimethyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC504.0 [1], 10.0 [2]
N-[(3-Fluorophenyl)methyl]-N,3-dimethyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC505.0 [1], 12.0 [2]
N-[(4-Fluorophenyl)methyl]-N,3-dimethyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC50111.0 [1], 1000.0 [2]
N,N-Diethyl-3-methyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC50600.0 [1], 1400.0 [2]
4-Isobutyl-3-methyl-2-(4-phenylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC504.0 [1], 10.0 [2]
N,3-Dimethyl-5-oxo-N-phenyl-4-propan-2-yl-1,2-oxazole-2-carboxamideIC507.0 [1], 190.0 [2]
4-Tert-Butyl-3-methyl-2-(piperidine-1-carbonyl)-2H-isoxazol-5-oneIC5014.0 [1], 90.0 [2]
N-(4-Chlorophenyl)-N,3-dimethyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC5017.0 [1], 1000.0 [2]
3-Methyl-2-(piperidine-1-carbonyl)-4-(tetrahydro-thiopyran-4-yl)-2H-isoxazol-5-oneIC5011.0 [1], 98.0 [2]
4-(1,1-Dioxothian-4-yl)-3-methyl-2-(piperidine-1-carbonyl)-1,2-oxazol-5-oneIC5055.0 [1], 380.0 [2]
4-Cyclopentyl-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC506.0 [1], 22.0 [2]
4-Cyclohexyl-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC5011.0 [1], 27.0 [2]
4-Cyclopentyl-3-methyl-2-(4-phenylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC508.0 [1], 24.0 [2]
4-(2-Methoxyethyl)-3-methyl-2-(4-phenylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC505.0 [1], 11.0 [2]
4-(2-Methoxyethyl)-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC5010.0 [1], 180.0 [2]
2-(4-(3-Fluorophenyl)piperidine-1-carbonyl)-4-(2-methoxyethyl)-3-methylisoxazol-5(2H)-oneIC500.2 [1], 20.0 [2]
4-(2-Methoxyethyl)-3-methyl-2-(4-m-tolylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC504.0 [1], 23.0 [2]
3-Methyl-2-(piperidine-1-carbonyl)-4-(tetrahydro-2H-pyran-4-yl)isoxazol-5(2H)-oneIC5071.0 [1], 200.0 [2]
4-Isopropyl-3-methyl-2-(4-phenylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC5012.0 [1], 33.0 [2]
3-Methyl-4-(2-phenoxyethyl)-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC502.0 [1], 4.0 [2]
2-(4-(3-Fluorophenyl)piperidine-1-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC504.0 [1], 12.0 [2]
2-(2,5-Dihydro-pyrrole-1-carbonyl)-4-isopropyl-3-methyl-2H-isoxazol-5-oneIC5072.0 [1], 120.0 [2]
N-Cyclohexyl-N,3-dimethyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC509.0 [1], 1000.0 [2]
Ethyl 1-(3-methyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carbonyl)piperidine-4-carboxylateIC506.0 [1], 49.0 [2]
2-(4-Hydroxypiperidine-1-carbonyl)-3-methyl-4-propan-2-yl-1,2-oxazol-5-oneIC50166.0 [1], 450.0 [2]
1-(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carbonyl)-piperidin-4-oneIC50150.0 [1], 200.0 [2]
N-Benzyl-N,3-dimethyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC505.0 [1], 67.0 [2]
2-(4-Benzoylpiperidine-1-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC50250.0 [1], 1000.0 [2]
2-(3,4-Dihydro-2H-quinoline-1-carbonyl)-4-isopropyl-3-methyl-2H-isoxazol-5-oneIC5060.0 [1], 1000.0 [2]
3-Methyl-4-phenyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-oneIC5014.0 [1], 150.0 [2]
N,3-Dimethyl-N-[(4-methylphenyl)methyl]-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC50408.0 [1], 1000.0 [2]
N-(Furan-2-ylmethyl)-N,3-dimethyl-5-oxo-4-propan-2-yl-1,2-oxazole-2-carboxamideIC504.0 [1], 9.0 [2]
N,3-Dimethyl-5-oxo-N-(2-phenylethyl)-4-propan-2-yl-1,2-oxazole-2-carboxamideIC50180.0 [1], 300.0 [2]
N,3-Dimethyl-5-oxo-4-propan-2-yl-N-(thiophen-2-ylmethyl)-1,2-oxazole-2-carboxamideIC502.0 [1], 3.0 [2]
4-Isopropyl-3-methyl-2-(4-p-tolylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC5037.0 [1], 246.0 [2]
2-(2,5-Dimethylpiperidine-1-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC50460.0 [1], 1000.0 [2]
2-(3,3-Dimethylpiperidine-1-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC507.0 [1], 48.0 [2]
2-(3,5-Dimethylpiperidine-1-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC50140.0 [1], 326.0 [2]
2-(4-Hydroxy-4-phenylpiperidine-1-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC501000.0 [1]
4-Isopropyl-3-methyl-2-[(4-methyl-1-piperazinyl)carbonyl]-1,2-oxazol-5(2H)-oneIC50314.0 [1], 1000.0 [2]
2-(1-Benzylpiperazine-4-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC5056.0 [1], 65.0 [2]
4-Isopropyl-3-methyl-2-(1-phenylpiperazine-4-carbonyl)isoxazol-5(2H)-oneIC506.0 [1], 27.0 [2]
2-(1-(2-Chlorophenyl)piperazine-4-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-oneIC5030.0 [1], 31.0 [2]
2-(Azepane-1-carbonyl)-3-methyl-4-propan-2-yl-1,2-oxazol-5-oneIC5062.0 [1], 215.0 [2]
4-Isopropyl-3-methyl-2-(2-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC5093.0 [1], 400.0 [2]
(R)-4-Isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-oneIC5020.0 [1], 187.0 [2]
4-Isopropyl-3-methyl-2-(1-(pyrimidin-2-yl)piperazine-4-carbonyl)isoxazol-5(2H)-oneIC5051.0 [1], 67.0 [2]
4-Isopropyl-3-methyl-2-(thiomorpholine-4-carbonyl)isoxazol-5(2H)-oneIC508.0 [1], 290.0 [2]
Tert-butyl 6-(furan-2-yl)-1,4-dioxo-2-(4-phenylbutyl)-8a-(phenylmethoxymethyl)-3,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylateIC50200.0 [1], 210.0 [2]
Phenyl 6-(furan-2-yl)-8a-(hydroxymethyl)-1,4-dioxo-2-(4-phenylbutyl)-3,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylateIC505500.0 [1], 8300.0 [2]
Benzyl 6-(furan-2-yl)-1,4-dioxo-8a-(phenylmethoxymethyl)-2-prop-2-enyl-3,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylateIC506200.0 [1], 8500.0 [2]
2-Methoxyethyl 6-(furan-2-yl)-1,4-dioxo-2-(4-phenylbutyl)-8a-(phenylmethoxymethyl)-3,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylateIC50760.0 [1], 770.0 [2]
2-Cyanoethyl 6-(furan-2-yl)-1,4-dioxo-2-(4-phenylbutyl)-8a-(phenylmethoxymethyl)-3,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylateIC501300.0 [1], 1900.0 [2]
Methyl 6-(furan-2-yl)-1,4-dioxo-2-(4-phenylbutyl)-8a-(phenylmethoxymethyl)-3,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylateIC50210.0 [1], 260.0 [2]
3-Methyl-2-[4-(4-methyl-3H-1,2-oxazol-2-yl)piperidine-1-carbonyl]-4-propan-2-yl-1,2-oxazol-5-oneIC5028.0 [1], 73.0 [2]
4-[[1H-Indol-2-yl(methyl)amino]methyl]-3-methyl-2-(piperidine-1-carbonyl)-1,2-oxazol-5-oneIC5017.0 [1], 177.0 [2]
4-Isopropyl-2-[4-(3-methoxy-phenyl)-piperazine-1-carbonyl]-3-methyl-2H-isoxazol-5-oneIC501.0 [1], 13.0 [2]
2,2,2-Trifluoroethyl 2-[2-(cyclohexen-1-yl)ethyl]-6-(furan-2-yl)-1,4-dioxo-8a-(phenylmethoxymethyl)-3,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylateIC50120.0 [1], 180.0 [2]
3-(4-Chlorophenyl)-N,N-dimethyl-5-methylsulfanyl-1,2,4-triazole-1-carboxamideIC5020.0 [1]
3-(4-Chlorophenyl)-N-methyl-N-phenyl-5-(2,2,2-trifluoroethylsulfanyl)-1,2,4-triazole-1-carboxamideIC50170.0 [1]
4-Tert-Butyl-N-[4-(5-methoxy-2-oxo-[1,3,4]oxadiazol-3-yl)-phenyl]-benzamideIC5023.0 [1]
[4-[(4-Tert-butylcyclohexanecarbonyl)amino]phenyl] N-morpholin-4-ylcarbamateIC501.0 [1]
3-(4-Methoxyphenyl)-N,N-dimethyl-5-methylsulfanyl-1,2,4-triazole-1-carboxamideIC50900.0 [1]
[3-(4-Chlorophenyl)-5-(2,2,2-trifluoroethylsulfanyl)-1,2,4-triazol-1-yl]-piperidin-1-ylmethanoneIC50400.0 [1]
(5-(Methylthio)-3-p-tolyl-1H-1,2,4-triazol-1-yl)(morpholino)methanoneIC504000.0 [1]
3-(4-Chlorophenyl)-N-methyl-5-methylsulfanyl-N-phenyl-1,2,4-triazole-1-carboxamideIC50160.0 [1]
N,N-Dimethyl-5-methylsulfanyl-3-[4-(trifluoromethyl)phenyl]-1,2,4-triazole-1-carboxamideIC50100.0 [1]
N-Methyl-3-(4-methylphenyl)-5-methylsulfanyl-N-phenyl-1,2,4-triazole-1-carboxamideIC50100.0 [1]
(3-(4-Chlorophenyl)-5-(hexylthio)-1H-1,2,4-triazol-1-yl)(morpholino)methanoneIC5050000.0 [1]
N,N-Dimethyl-5-methylsulfanyl-3-[(E)-2-phenylethenyl]-1,2,4-triazole-1-carboxamideIC5050000.0 [1]
(3-(4-Chlorophenyl)-5-(methylthio)-1H-1,2,4-triazol-1-yl)(morpholino)methanoneIC502000.0 [1]
(3-(4-Chlorophenyl)-5-(cyclopropylmethylthio)-1H-1,2,4-triazol-1-yl)(piperidin-1-yl)methanoneIC50200.0 [1]
3-(4-Chlorophenyl)-5-hexylsulfanyl-N-methyl-N-phenyl-1,2,4-triazole-1-carboxamideIC50400.0 [1]
3-(4-Chlorophenyl)-5-ethylsulfanyl-N,N-dimethyl-1,2,4-triazole-1-carboxamideIC50210.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Hormone sensitive lipase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/hormone-sensitive-lipase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Hormone sensitive lipase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hormone-sensitive-lipase-inhibitors-ic50-ki.
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