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Hydroxycarboxylic acid receptor 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
▲
▼
Nicotinic acidIC5067300.0 [1]
Nicotinic acidKi50.0 [1], 82.0 [2], 104.0 [3]
2-{3-[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanamido}benzoic acidIC504.0 [1], 6.0 [2]
2-{3-[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanamido}benzoic acidKi4.0 [1], 120.0 [2]
2-(3-(3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)propanamido)cyclohex-1-enecarboxylic acidIC503.0 [1], 4.0 [2]
2-(3-(3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)propanamido)cyclohex-1-enecarboxylic acidKi3.0 [1], 150.0 [2]
3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC501500.0 [1]
3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleKi505.0 [1]
2-{3-[4-(2-Chloro-4-hydroxyphenyl)phenyl]propanamido}benzoic acidIC504.0 [1], 34.0 [2]
MK-6892Ki4.0 [1], 595.0 [2]
2-[3-(4-Phenylphenyl)propanamido]benzoic acidIC5094.0 [1], 290.0 [2]
2-[3-(Naphthalen-2-yl)propanamido]benzoic acidIC50140.0 [1]
2-[[3-(4'-Hydroxy-4-biphenylyl)propanoyl]amino]benzoic acidIC5016.0 [1], 75.0 [2]
2-(3-(3-(4-Hydroxyphenyl)-1,2,4-oxadiazol-5-yl)propanamido)benzoic acidIC5010.0 [1]
2-{3-[1-(4-Hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl]propanamido}benzoic acidIC5024.0 [1]
2-(3-(6-Hydroxynaphthalen-2-yl)propanamido)benzoic acidIC5021.0 [1], 24.0 [2]
2-[3-[4-(2-Chlorophenyl)phenyl]propanoylamino]benzoic acidIC5019.0 [1], 94.0 [2]
3-(1H-Tetrazol-5-yl)-5-(2,3,5-trifluorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC5040.0 [1], 80.0 [2]
2-[3-[4-(4-Hydroxyphenyl)phenyl]propanoylamino]cyclohexene-1-carboxylic acidIC5021.0 [1], 108.0 [2]
2-{3-[2-(2-Chloro-4-hydroxyphenyl)-1,3-thiazol-5-yl]propanamido}benzoic acidIC501.0 [1]
2-{3-[1-(5-Hydroxypyridin-2-yl)-1H-pyrazol-3-yl]propanamido}benzoic acidIC5058.0 [1]
5-(2-Fluoropyridin-3-yl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid, hydrochlorideIC50600.0 [1], 850.0 [2]
Rac-2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)butanamido)cyclohex-1-enecarboxylic acidKi29.0 [1], 1100.0 [2]
2-[[3-[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2-methylpropanoyl]amino]cyclohexene-1-carboxylic acidKi4.0 [1], 230.0 [2]
2-[[2-Hydroxy-3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acidKi22.0 [1], 660.0 [2]
2-[[1-[[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]methyl]cyclopropanecarbonyl]amino]cyclohexene-1-carboxylic acidKi11.0 [1], 9130.0 [2]
2-[[1-[[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]methyl]cyclobutanecarbonyl]amino]cyclohexene-1-carboxylic acidKi360.0 [1], 1080.0 [2]
2-[[3-[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-3-methylbutanoyl]amino]cyclohexene-1-carboxylic acidKi130.0 [1], 24700.0 [2]
2-[[2,2,3,3-Tetrafluoro-3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acidKi1.4 [1], 840.0 [2]
5-(2-Fluoropyridin-3-yl)-3-(tetrazol-5-ylidene)-4,5,6,7-tetrahydroindazole;hydrobromideIC50150.0 [1]
5-(2-Fluoropyridin-3-yl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid;hydrobromideIC50200.0 [1], 370.0 [2]
5-(2,5-Difluorophenyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid;hydrobromideIC5090.0 [1], 400.0 [2]
Cinnamic acidKi4900.0 [1]
4-Hydroxycinnamic acidKi14000.0 [1]
5-Methyl-1H-pyrazole-3-carboxylic acidIC50434000.0 [1]
CipargaminIC5010000.0 [1]
Ethyl fumarateKi410.0 [1]
AcifranIC50500.0 [1]
Monomethyl fumarateKi180.0 [1]
3-(2-Furyl)acrylic acidKi8100.0 [1]
4,5,6,7-Tetrahydro-1H-indazole-3-carboxylic acidKi3500.0 [1]
5-Isopropyl-1H-pyrazole-3-carboxylic acidIC502600.0 [1]
1,4,5,6-Tetrahydrocyclopenta[c]pyrazole-3-carboxylic acidKi156.0 [1]
3-Methylisoxazole-5-carboxylic acidIC501300.0 [1]
2-[2-(4-Methoxyphenoxy)acetamido]benzoic acidIC502500.0 [1]
1H-Pyrazole-3-carboxylic acid, 5-[(3-chlorophenyl)methyl]-IC504200.0 [1]
5-Pentyl-1H-pyrazole-3-carboxylic acidKi72.0 [1]
2-(3-(6-Hydroxynaphthalen-2-yl)propanamido)cyclohex-1-enecarboxylic acidIC508.0 [1]
CID 25101223IC50170.0 [1]
3-(3-Furyl)acrylic acidKi14000.0 [1]
CID 11494579IC5013.0 [1]
3-(3-Bromobenzyl)-1H-pyrazole-5-carboxylic acidIC501700.0 [1]
3-(3-Fluorobenzyl)-1H-pyrazole-5-carboxylic acidIC502200.0 [1]
5-(2-Methylpyrazol-3-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acidIC50390.0 [1]
2-(1-(6-Hydroxyquinoxalin-2-yl)piperazine-4-carboxamido)benzoic acidIC50140.0 [1]
7-Methyl-N-(2-phenoxyethyl)-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamideIC501000.0 [1]
CID 53238781IC5012.0 [1]
3-(2-Thienyl)acrylic acidKi5500.0 [1]
2-[[(E)-5-Phenylpent-2-en-4-ynoyl]amino]cyclohexene-1-carboxylic acidIC50327.0 [1]
Pentyl FumarateKi700.0 [1]
5-Ethyl-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC504600.0 [1]
5-Cyclopentyl-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC502500.0 [1]
5-Propyl-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC50690.0 [1]
2-(3-(6-Methoxynaphthalen-2-yl)propanamido)benzoic acidIC5087.0 [1]
2-(3-(7-Hydroxy-[1,2,3]triazolo[1,5-a]quinolin-3-yl)propanamido)benzoic acidIC508.0 [1]
2-[3-[4-(4-Fluorophenyl)phenyl]propanoylamino]benzoic acidIC50323.0 [1]
2-(3-(7-Hydroxy-2H-benzo[g]indazol-3-yl)propanamido)benzoic acidIC505.0 [1]
2-[[3-[1-(4-Hydroxyphenyl)-5-methylpyrazol-4-yl]-2-methylpropanoyl]amino]benzoic acidIC5077.0 [1]
2-[3-[4-(2-Methylphenyl)phenyl]propanoylamino]benzoic acidIC50555.0 [1]
2-[3-[4-(3-Fluorophenyl)phenyl]propanoylamino]benzoic acidIC50283.0 [1]
2-{3-[4-(Pyridin-2-yl)phenyl]propanamido}benzoic acidIC50120.0 [1]
2-[3-[4-(2-Hydroxyphenyl)phenyl]propanoylamino]benzoic acidIC5086.0 [1]
2-{3-[5-(5-Hydroxypyridin-2-yl)-1,3-thiazol-2-yl]propanamido}benzoic acidIC5051.0 [1]
2-{3-[4-(5-Hydroxypyridin-2-yl)phenyl]propanamido}benzoic acidIC509.0 [1]
2-[3-(6-Hydroxyimidazo[2,1-b][1,3]benzothiazol-2-yl)propanoylamino]benzoic acidIC5011.0 [1]
2-[3-[4-(3-Hydroxyphenyl)phenyl]propanoylamino]benzoic acidIC50940.0 [1]
2-(3-(6-Aminonaphthalen-2-yl)propanamido)benzoic acidIC5034.0 [1]
2-(3-(3H-Benzo[e]indazol-7-yl)propanamido)benzoic acidIC5018.0 [1]
2-[3-[4-(3-Methoxyphenyl)phenyl]propanoylamino]benzoic acidIC50769.0 [1]
2-{3-[5-(2-Chloro-4-hydroxyphenyl)thiophen-2-yl]propanamido}benzoic acidIC508.0 [1]
2-[3-[4-(3-Methylphenyl)phenyl]propanoylamino]benzoic acidIC50800.0 [1]
5-Butyl-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC5080.0 [1]
5-Phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acidIC50200.0 [1]
5-(3-Fluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC50140.0 [1]
5-(3,5-Difluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC5070.0 [1]
5-(4-Fluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC502700.0 [1]
3-(1H-Tetrazol-5-yl)-5-o-tolyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC507700.0 [1]
5-(3-Chlorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC50290.0 [1]
5-(2-Chlorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC501900.0 [1]
5-(3,4-Difluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC50610.0 [1]
5-(2,3-Difluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC50140.0 [1]
5-(2,5-Difluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC50760.0 [1]
5-(2,4-Difluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazoleIC502400.0 [1]
5-(2,5-Difluorophenyl)-3-(2H-tetrazol-5-yl)-4,5,6,7-tetrahydro-1H-indazoleIC50150.0 [1]
5-(2-Fluoropyridin-3-yl)-3-(2H-tetrazol-5-yl)-4,5,6,7-tetrahydro-1H-indazoleIC50500.0 [1]
5-(2,3,5-Trifluorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acidIC5020.0 [1]
5-(Thiophen-2-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acidIC50240.0 [1]
5-(Thiophen-3-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acidIC5090.0 [1]
5-(1H-Pyrazol-1-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acidIC501900.0 [1]
5-(1H-1,2,3-Triazol-1-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acidIC504000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Hydroxycarboxylic acid receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/hydroxycarboxylic-acid-receptor-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Hydroxycarboxylic acid receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hydroxycarboxylic-acid-receptor-2-inhibitors-ic50-ki.
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