Hypoxia-inducible factor prolyl hydroxylase 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-Oxalylglycine	IC50	842.0 [1], 2100.0 [2]
	Pyridine-2,4-dicarboxylic acid	IC50	1500.0 [1], 624800.0 [2]
	Pyridine-2,4-dicarboxylic acid	Ki	7000.0 [1]
	3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	IC50	0.2 [1]
	Molidustat	IC50	480.0 [1], 490.0 [2]
	3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acid	IC50	100000.0 [1]
	3-[[1-Cyano-4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino]-3-methylbutanoic acid	IC50	240.0 [1]
	Salicyluric acid	IC50	1000000.0 [1]
	2,5-Pyridinedicarboxylic acid	Ki	300000.0 [1]
	N,3-Dihydroxybenzamide	IC50	18370.0 [1]
	Picolinoylglycine	IC50	1000000.0 [1]
	4-Oxo-4-[4-[4-(1-naphthylcarbamoyloxymethyl)benzylamino]butylhydroxyamino]-2-butenoic acid	IC50	54000.0 [1]
	N-[(3-Hydroxypyridin-2-Yl)carbonyl]glycine	IC50	91090.0 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-[4-(1H-pyrazol-5-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	0.2 [1]
	(1-Hydroxy-2,5-dioxo-pyrrolidin-3-yl)-acetic acid	IC50	1000000.0 [1]
	5-Phenyl-[1,2,4]triazolo[1,5-a]pyridine	IC50	30000.0 [1]
	4-(2-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	570.0 [1]
	1-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)piperidine-4-carbonitrile	IC50	280.0 [1]
	3-Amino-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	57.0 [1]
	2,6-Difluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	34.0 [1]
	2,3-Difluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	67.0 [1]
	4-(6-Amino-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	770.0 [1]
	PHD-1 Inhibitor C53	IC50	90.0 [1]
	4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)piperazine-1-carbonitrile	IC50	1800.0 [1]
	3-Chloro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	140.0 [1]
	3-Fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	50.0 [1]
	4-(7-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	39.0 [1]
	3-Methoxy-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	140.0 [1]
	4-(7-Amino-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	13.0 [1]
	5-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyrazine-2-carbonitrile	IC50	1280.0 [1]
	3-Fluoro-5-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	220.0 [1]
	2-Chloro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	3900.0 [1]
	6-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyridazine-3-carbonitrile	IC50	1370.0 [1]
	2-Fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	10.0 [1]
	5-(2,4-Dichlorophenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	670.0 [1]
	N-[5-(4-Cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]acetamide	IC50	8.0 [1]
	5-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyrimidine-2-carbonitrile	IC50	84.0 [1]
	5-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyridine-2-carbonitrile	IC50	170.0 [1]
	3-Ethyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	6100.0 [1]
	4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)-2-(trifluoromethyl)benzonitrile	IC50	1870.0 [1]
	5-(4-Chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	550.0 [1]
	PHD-1 Inhibitor C39	IC50	74.0 [1]
	2-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	830.0 [1]
	2-Fluoro-3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	52.0 [1]
	2-Fluoro-5-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	140.0 [1]
	4-(6-Fluoro-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	460.0 [1]
	4-[7-(Ethylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile	IC50	25.0 [1]
	PHD-1 Inhibitor C17	IC50	34.0 [1]
	3,5-Dimethyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	200.0 [1]
	3,5-Difluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	160.0 [1]
	4-(6-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	460.0 [1]
	PHD-1 Inhibitor C54	IC50	70.0 [1]
	6-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyridine-3-carbonitrile	IC50	270.0 [1]
	2-(3-Hydroxyphenyl)-2-oxo-ethanoic acid	IC50	1000000.0 [1]
	3-[4-(1,3-Benzothiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	0.2 [1]
	3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid	IC50	0.5 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	1.3 [1]
	3-(4-Cyclohexylphenyl)-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	1.9 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(2-oxoazetidin-1-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	17.0 [1]
	3-[4-[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	11.0 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-pyrazol-1-ylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	38.0 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	4.5 [1]
	3-[4-(2,4-Dimethyl-1,3-thiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	0.4 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-pyrimidin-5-ylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	5.6 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	2.0 [1]
	4-[4-[8-[(3-Methylpyridin-2-yl)methyl]-2,4-dioxo-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	IC50	1.1 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(4-morpholin-4-ylphenyl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	0.5 [1]
	7-(2,4-Dichlorophenyl)pyrazolo[1,5-a]pyrimidine	IC50	100000.0 [1]
	5-(4-Methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	5600.0 [1]
	5-(3-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	55000.0 [1]
	5-(2-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	100000.0 [1]
	N-[5-(4-Cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	IC50	2500.0 [1]
	4-(8-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	80000.0 [1]
	4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)-3-(trifluoromethyl)benzonitrile	IC50	10000.0 [1]
	4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)thiophene-2-carbonitrile	IC50	10000.0 [1]
	5-(3-Methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	100000.0 [1]
	5-(2-Fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	24000.0 [1]
	5-(2-Chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	48000.0 [1]
	5-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	26000.0 [1]
	N-[5-(4-Cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]acetamide	IC50	10000.0 [1]
	1-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)imidazole-4-carbonitrile	IC50	10000.0 [1]
	5-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)furan-2-carbonitrile	IC50	10000.0 [1]
	1-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyrrolidine-3-carbonitrile	IC50	10000.0 [1]
	4-(8-Fluoro-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	9600.0 [1]
	N-[5-Cyano-2-([1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl]acetamide	IC50	10000.0 [1]
	1-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyrazole-4-carbonitrile	IC50	10000.0 [1]
	2-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)-2-azaspiro[3.3]heptane-6-carbonitrile	IC50	10000.0 [1]
	5-(4-Fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	1300.0 [1]
	4-[6-(Dimethylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile	IC50	10000.0 [1]
	4-[2-(Dimethylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile	IC50	18000.0 [1]
	5-(3-Fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	28000.0 [1]
	3-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)benzonitrile	IC50	61000.0 [1]
	5-(3-Chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridine	IC50	26000.0 [1]
	5-(2,4-Dichlorophenyl)imidazo[1,2-a]pyrimidine	IC50	24000.0 [1]
	3-[Acetyl(hydroxy)amino]propanoic acid	IC50	100000.0 [1]
	N-[(1,3-Dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine	IC50	3.5 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-2-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	1.8 [1]
	3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-1-(2-methylpyrimidin-4-yl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	IC50	0.3 [1]
	4-[5-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid	IC50	1.1 [1]
	8-[(3-Methylpyridin-2-yl)methyl]-1-(2-oxo-1H-pyrimidin-6-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	1.4 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Hypoxia-inducible factor prolyl hydroxylase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/hypoxia-inducible-factor-prolyl-hydroxylase-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Hypoxia-inducible factor prolyl hydroxylase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hypoxia-inducible-factor-prolyl-hydroxylase-1-inhibitors-ic50-ki.
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