Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Furospongolide	IC50	30000.0 [1]
	(1S,4As,4bR,6aS,10aR,10bS,12aS)-2-acetyl-10a-(hydroxymethyl)-4b,7,7,12a-tetramethyl-12-oxo-4,4a,5,6,6a,8,9,10,10b,11-decahydro-1H-chrysene-1-carbaldehyde	IC50	900.0 [1]
	(1R,4As,4bR,6aS,10aR,10bS,12S,12aS)-2-acetyl-12-hydroxy-10a-(hydroxymethyl)-4b,7,7,12a-tetramethyl-1,4,4a,5,6,6a,8,9,10,10b,11,12-dodecahydrochrysene-1-carbaldehyde	IC50	500.0 [1]
	Methyl (4aR,4bS,6aS,7S,10aS,10bS,12aS)-8-acetyl-7-formyl-1,1,6a,10b-tetramethyl-6-oxo-3,4,4b,5,7,10,10a,11,12,12a-decahydro-2H-chrysene-4a-carboxylate	IC50	7700.0 [1]
	Lificiguat	IC50	1200.0 [1], 13800.0 [2], 14800.0 [3], 48400.0 [4]
	Alvespimycin	IC50	3.6 [1], 36.0 [2], 61.0 [3], 30000.0 [4]
	Mammea E/BB	IC50	890.0 [1], 960.0 [2], 2000.0 [3], 6500.0 [4]
	(4Ar)-5-[2-[(5aS,6S,7S,9aS)-7-hydroxy-2,2,5a,7-tetramethyl-3-oxo-4,5,6,8,9,9a-hexahydrobenzo[b]oxepin-6-yl]ethyl]-8-hydroxy-1,1,4a,6-tetramethyl-3,4-dihydronaphthalene-2,7-dione	IC50	20000.0 [1], 30000.0 [2]
	[(3R,5As,6R,9aS)-6-[2-[(5aR,6S,7S,9aS)-6-hydroxy-2,2,5a,7-tetramethyl-3-oxo-4,5,7,8,9,9a-hexahydrobenzo[b]oxepin-6-yl]ethyl]-2,2,5a-trimethyl-7-methylidene-4,5,6,8,9,9a-hexahydro-3H-benzo[b]oxepin-3-yl] acetate	IC50	20000.0 [1], 30000.0 [2]
	Sodwanone T	IC50	20000.0 [1], 30000.0 [2]
	Sodwanone U	IC50	30000.0 [1]
	3-Epi-sodwanone K	IC50	25000.0 [1], 30000.0 [2]
	(4Ar)-5-[2-[(5aS,9aS)-2,2,5a,7-tetramethyl-3-oxo-5,8,9,9a-tetrahydro-4H-1-benzoxepin-6-yl]ethyl]-8-hydroxy-1,1,4a,6-tetramethyl-3,4-dihydronaphthalene-2,7-dione	IC50	20000.0 [1], 30000.0 [2]
	Sodwanone V	IC50	15000.0 [1]
	12R-Hydroxyyardenone	IC50	30000.0 [1]
	(4Ar)-5-[2-[(5aS,6R,7R,9aS)-2,2,5a,7-tetramethyl-3-oxo-5,6,7,8,9,9a-hexahydro-4H-benzo[b]oxepin-6-yl]ethyl]-8-hydroxy-1,1,4a,6-tetramethyl-3,4-dihydronaphthalene-2,7-dione	IC50	30000.0 [1]
	Carbonyl cyanide p-trifluoromethoxyphenylhydrazone	IC50	310.0 [1], 510.0 [2]
	Tanshinone IIA	IC50	6180.0 [1], 7530.0 [2]
	Tanshinone I	IC50	8510.0 [1], 12500.0 [2]
	Latrunculin a	IC50	6700.0 [1], 25000.0 [2]
	Cryptotanshinone	IC50	1360.0 [1], 1580.0 [2]
	Dihydrotanshinone I	IC50	2050.0 [1], 2290.0 [2]
	2-[(1R,2R)-1-(3,4-Dimethoxyphenyl)-1-hydroxypropan-2-yl]oxy-5-[(2S,3R,4R,5S)-5-[4-[(1R,2R)-1-(3,4-dimethoxyphenyl)-1-hydroxypropan-2-yl]oxy-3-methoxyphenyl]-3,4-dimethyloxolan-2-yl]phenol	IC50	3.0 [1], 11.0 [2]
	Xestoquinone	IC50	7300.0 [1], 12300.0 [2]
	2-Methyl-4-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]oxolan-2-yl]tridecyl]-2H-furan-5-one	IC50	13.0 [1], 1000.0 [2]
	Mammeisin	IC50	3710.0 [1], 4440.0 [2]
	Danshenxinkun A	IC50	20000.0 [1]
	(1S)-1-Methyl-7,7-dioxo-18-oxa-7lambda6-thia-10-azahexacyclo[15.6.1.02,15.04,13.06,11.020,24]tetracosa-2(15),3,6(11),13,17(24),19-hexaene-5,12,16-trione	IC50	200.0 [1], 4600.0 [2]
	Mammea A/BA	IC50	3230.0 [1], 3730.0 [2]
	Methyl tanshinonate	IC50	7340.0 [1], 7480.0 [2]
	(1S)-1-Methyl-10,10-dioxo-18-oxa-10lambda6-thia-7-azahexacyclo[15.6.1.02,15.04,13.06,11.020,24]tetracosa-2(15),3,6(11),13,17(24),19-hexaene-5,12,16-trione	IC50	200.0 [1], 6400.0 [2]
	(4Ar,4bS,6aS,7S,10aS,10bS,12aS)-8-acetyl-7-formyl-1,1,6a,10b-tetramethyl-6-oxo-3,4,4b,5,7,10,10a,11,12,12a-decahydro-2H-chrysene-4a-carboxylic acid	IC50	500.0 [1], 640.0 [2]
	5-(5,6-Dihydroxy-2-methoxynaphthalen-1-yl)-6-methoxynaphthalene-1,2-diol	IC50	4300.0 [1], 5100.0 [2]
	Mammea B/BA	IC50	1280.0 [1], 2200.0 [2]
	1,4-Phenanthrenedione, 7,8-dihydro-8,8-dimethyl-2-(1-methylethyl)-	IC50	280.0 [1], 340.0 [2]
	8-Methyl-2-propan-2-ylphenanthrene-1,4-dione	IC50	10600.0 [1], 15100.0 [2]
	Xestoquinol Sulfate	IC50	30000.0 [1]
	Dihydroisotanshinone II	IC50	20000.0 [1]
	1-Hydroxy-2-[(2S)-1-hydroxypropan-2-yl]-8,8-dimethyl-6,7-dihydro-5H-phenanthrene-3,4-dione	IC50	12700.0 [1], 20000.0 [2]
	Isotanshinone II	IC50	20000.0 [1]
	(1S,5S,10S,11S,13R,16S,17S,18S,20S)-17-Acetyl-18-hydroxy-10-(hydroxymethyl)-6,6,20-trimethyl-14-oxapentacyclo[11.6.1.02,11.05,10.016,20]icosan-15-one	IC50	4500.0 [1], 6900.0 [2]
	(3As,4S,5aS,5bR,7aS,11aS,11bR,13R,13aS,13bS)-4,13-dihydroxy-3,5b,8,8,11a,13a-hexamethyl-3a,4,5,5a,6,7,7a,9,10,11,11b,12,13,13b-tetradecahydro-3H-phenanthro[1,2-g][2]benzofuran-1-one	IC50	2400.0 [1], 3500.0 [2]
	10-Hydroxyglaucanetin	IC50	12.0 [1], 1000.0 [2]
	Mammea F/BB, (-)-	IC50	2230.0 [1], 2300.0 [2]
	Mammea F/BA, (-)-	IC50	1720.0 [1], 1810.0 [2]
	Mammea C/AA	IC50	4120.0 [1], 4190.0 [2]
	[4-[(1S)-1-Acetyloxypentyl]-5-hydroxy-8-[(2S)-2-methylbutanoyl]-6-(3-methylbut-2-enyl)-2-oxochromen-7-yl] acetate	IC50	5110.0 [1], 5470.0 [2]
	[7-Acetyloxy-4-[(1S)-1-acetyloxypentyl]-8-[(2S)-2-methylbutanoyl]-6-(3-methylbut-2-enyl)-2-oxochromen-5-yl] acetate	IC50	830.0 [1], 1060.0 [2]
	[4-[(1S)-1-Acetyloxypentyl]-7-hydroxy-8-[(2S)-2-methylbutanoyl]-6-(3-methylbut-2-enyl)-2-oxochromen-5-yl] acetate	IC50	1680.0 [1], 2060.0 [2]
	5,7-Dimethoxy-4-[(1S)-1-methoxypentyl]-8-[(2S)-2-methylbutanoyl]-6-(3-methylbut-2-enyl)chromen-2-one	IC50	13200.0 [1], 18400.0 [2]
	5,7-Dimethoxy-4-[(1S)-1-methoxypentyl]-6-(3-methylbut-2-enyl)-8-[(3S)-3-methyl-2-oxopentyl]chromen-2-one	IC50	5910.0 [1], 15700.0 [2]
	4-[(1S)-1-Hydroxypentyl]-5,7-dimethoxy-8-[(2S)-2-methylbutanoyl]-6-(3-methylbut-2-enyl)chromen-2-one	IC50	6310.0 [1], 6500.0 [2]
	4-[(1S)-1-Hydroxypentyl]-5,7-dimethoxy-6-(3-methylbut-2-enyl)-8-[(3S)-3-methyl-2-oxopentyl]chromen-2-one	IC50	7420.0 [1], 11300.0 [2]
	5,7-Dihydroxy-6-(3-methylbut-2-enyl)-8-(3-methylbutanoyl)-4-pentyl-2H-chromen-2-one	IC50	2710.0 [1], 2760.0 [2]
	Mammea B/BB, (-)-	IC50	3250.0 [1], 5040.0 [2]
	Mammea A/AB, (-)-	IC50	4630.0 [1], 4820.0 [2]
	Mammea A/BB, (-)-	IC50	5960.0 [1], 6760.0 [2]
	Mammea C/BB, (-)-	IC50	3400.0 [1], 3730.0 [2]
	5,7-Dihydroxy-6-[(2R)-2-methylbutanoyl]-8-(3-methylbut-2-enyl)-4-pentylchromen-2-one	IC50	5310.0 [1], 5700.0 [2]
	5,7-Dihydroxy-6-[(2R)-2-methylbutanoyl]-8-(3-methylbut-2-enyl)-4-propylchromen-2-one	IC50	8210.0 [1], 9960.0 [2]
	[(1S,2R,3R,5R,7R,10S,11R,14R,15R)-15-[(3S,5R)-5-[(2S)-3,3-Dimethyloxiran-2-yl]-2-hydroxyoxolan-3-yl]-3-hydroxy-2,6,6,10-tetramethyl-7-pentacyclo[12.3.1.01,14.02,11.05,10]octadecanyl] 3-methylbutanoate	IC50	63.0 [1], 10000.0 [2]
	[(1S,2R,3R,5R,7R,10S,11R,14R,15R)-15-[(3S,5R)-5-[(2S)-3,3-Dimethyloxiran-2-yl]-2-hydroxyoxolan-3-yl]-3-hydroxy-2,6,6,10-tetramethyl-7-pentacyclo[12.3.1.01,14.02,11.05,10]octadecanyl] 3-methylbut-2-enoate	IC50	68.0 [1], 5600.0 [2]
	Isomammein	IC50	9400.0 [1], 9560.0 [2]
	(1S)-6-(Hydroxymethyl)-1-methyl-14-oxapentacyclo[11.6.1.02,11.04,9.016,20]icosa-2(11),3,6,9,13(20),15-hexaene-5,8,12-trione	IC50	1500.0 [1], 2300.0 [2]
	(1S)-7-(Hydroxymethyl)-1-methyl-14-oxapentacyclo[11.6.1.02,11.04,9.016,20]icosa-2(11),3,6,9,13(20),15-hexaene-5,8,12-trione	IC50	1200.0 [1], 1700.0 [2]
	(1S)-1-Methyl-14-oxapentacyclo[11.6.1.02,11.04,9.016,20]icosa-2(11),3,9,13(20),15-pentaene-5,8,12-trione	IC50	4200.0 [1], 10600.0 [2]
	Sibiriquinone B	IC50	3180.0 [1], 3360.0 [2]
	Cycloheximide	IC50	36.0 [1]
	Emetine	IC50	83.0 [1]
	Phenethyl isothiocyanate	IC50	7500.0 [1]
	Bakuchiol	IC50	6100.0 [1]
	Cryptopleurine	IC50	8.7 [1]
	Moracin M	IC50	30000.0 [1]
	Manassantin B	IC50	3.0 [1]
	Sanggenon C	IC50	8260.0 [1]
	N-[(2,2-Dimethylchromen-6-yl)methyl]-3,4-dimethoxy-N-phenylbenzenesulfonamide	IC50	593.0 [1]
	Mulberrofuran G	IC50	30000.0 [1]
	5-[(6R)-6-Hydroxy-7,7-dimethyl-5,6-dihydrofuro[3,2-g]chromen-2-yl]benzene-1,3-diol	IC50	30000.0 [1]
	Moracin O	IC50	30000.0 [1]
	CID 16124726	IC50	2600.0 [1]
	4H-Naphtho[2,3-b]pyran-4-one, 5,8-dihydroxy-6-methoxy-2-methyl-	IC50	3400.0 [1]
	4-[(1E,3S)-3-[2-(3,3-Dimethyloxiran-2-yl)ethyl]-3-methylpenta-1,4-dienyl]phenol	IC50	50000.0 [1]
	1-((E)-(S)-3,7-Dimethyl-3-vinyl-octa-1,6-dienyl)-4-methoxy-benzene	IC50	8700.0 [1]
	Klugine	IC50	200.0 [1]
	Emetan-6'-ol, 7',10,11-trimethoxy-, (1'beta)-	IC50	1100.0 [1]
	3-[[2-(4-Tert-butylphenoxy)acetyl]amino]benzoic Acid	IC50	29000.0 [1]
	Sanggenon O	IC50	8750.0 [1]
	Comaparvin	IC50	3000.0 [1]
	Mulberrofuran W	IC50	6070.0 [1]
	(E)-1-[3-[(1S,5S,6R)-6-[3,5-Dihydroxy-4-(3-methylbut-2-enyl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2,4-dihydroxyphenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one	IC50	8550.0 [1]
	Mulberrofuran D	IC50	8760.0 [1]
	(1R,2R)-1-(3,4-Dimethoxyphenyl)-2-[4-[(2S,3R,4R,5S)-5-(3,4-dimethoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenoxy]propan-1-ol	IC50	320.0 [1]
	4-[(1R,2R)-2-[4-[(2S,3R,4R,5S)-5-[4-[(1R,2R)-1-(1,3-Benzodioxol-5-yl)-1-hydroxypropan-2-yl]oxy-3-methoxyphenyl]-3,4-dimethyloxolan-2-yl]-2-methoxyphenoxy]-1-hydroxypropyl]-2-methoxyphenol	IC50	30.0 [1]
	5,8-Dihydroxy-6-methoxy-2-propyl-4H-benzo[g]chromen-4-one	IC50	1700.0 [1]
	(E,6S)-6-Ethenyl-8-(4-hydroxyphenyl)-2,6-dimethyloct-7-ene-2,3-diol	IC50	50000.0 [1]
	3-[2-(4-Adamant-1-yl-phenoxy)-acetylamino]-benzoic acid methyl ester	IC50	9900.0 [1]
	Acetylbakuchiol	IC50	5700.0 [1]
	(E)-1-[3-[(1S,5S,6R)-6-[3,5-Dihydroxy-4-(3-methylbut-2-enyl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one	IC50	6420.0 [1]
	(E)-1-[3-[(1S,5S,6R)-6-[3,5-Dihydroxy-4-(3-methylbut-2-enyl)benzoyl]-5-(4-hydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one	IC50	9540.0 [1]
	Albafuran A	IC50	6270.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/hypoxia-inducible-factors-hif-1-alpha-hif-2-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hypoxia-inducible-factors-hif-1-alpha-hif-2-alpha-inhibitors-ic50-ki.
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