Inhibitor of nuclear factor kappa B kinase alpha subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	BMS-345541 free base	IC50	4000.0 [1], 7000.0 [2], 7400.0 [3]
	N,12-Dimethyl-4-phenyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amine	IC50	3500.0 [1]
	Staurosporine	IC50	39.0 [1], 233.0 [2]
	N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide	IC50	100.0 [1], 100000.0 [2]
	IKK-3 Inhibitor	IC50	15848.93 [1]
	2-Amino-6-(2-hydroxyphenyl)-4-(piperidin-3-yl)nicotinonitrile	IC50	25.0 [1], 640.0 [2]
	N-(2-Hydroxyethyl)-N-methyl-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide	IC50	3162.28 [1]
	Ikk-IN-3	IC50	400.0 [1], 910.0 [2]
	N,12-Dimethyl-4-phenyl-5-oxa-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amine	IC50	270.0 [1]
	N-[[3-[12-Methyl-8-(methylamino)-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl]methyl]acetamide	IC50	1900.0 [1]
	N-(2-Hydroxyethyl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide	IC50	316.23 [1]
	N-(1,1-Dioxothian-4-yl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide	IC50	12.59 [1]
	N,5,12-Trimethyl-4-phenyl-3,5,7,10,12-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amine	IC50	4280.0 [1], 4300.0 [2]
	N-(5-(4-(Cyclopropylamino)-1-methyl-1H-pyrazolo[5,1-b]purin-7-yl)-2-fluorobenzyl)acetamide	IC50	9700.0 [1]
	9H-Pyrido[3,4-B]indole	IC50	15000.0 [1]
	Wedelolactone	IC50	10000.0 [1]
	N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide	IC50	100000.0 [1]
	Bms-345541	IC50	4000.0 [1]
	CID 46215815	IC50	25118.0 [1]
	1-(5-Methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino)-3-methyl-1H-pyrrole-2,5-dione	IC50	1300.0 [1]
	CID 22291652	IC50	14000.0 [1]
	3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	591.0 [1]
	A-770041	IC50	25000.0 [1]
	CID 44219749	IC50	50000.0 [1]
	2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrile	IC50	250.0 [1]
	JNK Inhibitor VIII	Ki	1500.0 [1]
	IKK Inhibitor VII	IC50	200.0 [1]
	CID 59604787	IC50	10000.0 [1]
	2-Amino-3-phenyl-5-(pyridin-4-yl)benzamide	IC50	3162.28 [1]
	3-Methyl-4-phenyl-1H-pyrazol-5-amine	IC50	100000.0 [1]
	Unii-BL7xsd8R7B	IC50	4960.0 [1]
	4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-amine	IC50	100000.0 [1]
	N-[3-[2-Amino-3-cyano-6-(2-hydroxyphenyl)pyridin-4-yl]phenyl]-5-oxooxolane-2-carboxamide	IC50	20000.0 [1]
	2-Amino-3-(4-methanesulfonamidophenyl)-5-phenylbenzamide	IC50	12589.25 [1]
	2-Amino-5-(4-fluorophenyl)-3-(pyridin-4-yl)benzamide	IC50	5011.87 [1]
	[3-[8-(2-Aminoethylamino)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]methanol	IC50	450.0 [1]
	2-Amino-5-(4-fluorophenyl)-N-methyl-3-[4-(pyrrolidine-1-sulfonyl)phenyl]benzamide	IC50	15848.93 [1]
	2-Methoxy-5-(pyridin-4-yl)benzamide	IC50	15848.93 [1]
	5-(4-Chlorophenyl)-2-methoxy-3-(4-sulfamoylphenyl)benzamide	IC50	15848.93 [1]
	3-(7-Phenylmethoxyisoquinolin-6-yl)benzenesulfonamide	IC50	25118.86 [1]
	4-(7-Phenylmethoxyisoquinolin-6-yl)benzenesulfonamide	IC50	25118.86 [1]
	3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide	IC50	2800.0 [1]
	Unii-8FX9DP2Y1W	IC50	10000.0 [1]
	2-Amino-5-phenylbenzamide	IC50	15848.93 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	1500.0 [1]
	2-Amino-4-[4-(hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Ki	650.0 [1]
	N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-phenyl}-3-piperidin-1-yl-propionamide	IC50	20000.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	3800.0 [1]
	Eudistomin N	IC50	600.0 [1]
	4-Phenyl-1H-pyrrolo[2,3-b]pyridine	IC50	3981.07 [1]
	4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide	IC50	100000.0 [1]
	N'-[4-(Furan-3-yl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamine	IC50	940.0 [1]
	4-[3-(Aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-amine	IC50	220.0 [1]
	12-Methyl-8-(methylamino)-4-[3-[2-(sulfamoylamino)ethyl]phenyl]-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene	IC50	440.0 [1]
	2-Amino-N-methyl-3-[3-[12-methyl-8-(methylamino)-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]propanamide	IC50	330.0 [1]
	3-Amino-5-phenylthiophene-2-carboxamide	IC50	30000.0 [1]
	3-Methoxy-N-[[3-[3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-11-yl]phenyl]methyl]propanamide	IC50	12.0 [1]
	4-{4-[4-(Piperazine-1-sulfonyl)-phenyl]-pyrimidin-2-ylamino}-benzonitrile	IC50	3802.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	3750.0 [1]
	N-[[3-[3-Methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-11-yl]phenyl]methyl]acetamide	IC50	14.0 [1]
	4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide	IC50	40000.0 [1]
	6-Methoxy-9H-pyrido[3,4-b]indole	IC50	4000.0 [1]
	12-Methyl-N-(2-piperidin-1-ylethyl)-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-amine	IC50	1700.0 [1]
	N'-(12-Methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)ethane-1,2-diamine	IC50	12100.0 [1]
	6,8-Dichloro-9h-pyrido[3,4-b]indole	IC50	200.0 [1]
	5-Pyrimidin-5-yl-1H-indole-7-carboxamide	IC50	15848.93 [1]
	7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrile	Ki	10000.0 [1]
	5-Phenyl-3-(1-propan-2-ylsulfonylpiperidin-4-yl)-1H-indole-7-carboxamide	IC50	3162.28 [1]
	3-[1-(Ethanesulfonyl)-4-piperidinyl]-5-phenyl-1H-indole-7-carboxamide	IC50	1995.26 [1]
	7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrile	Ki	10000.0 [1]
	N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamide	Ki	10000.0 [1]
	5-Bromo-6-methoxy-beta-carboline	IC50	1000.0 [1]
	5-Phenyl-3-[1-(propylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide	IC50	1995.26 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamide	Ki	1500.0 [1]
	N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	1500.0 [1]
	N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	1500.0 [1]
	N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamide	Ki	970.0 [1]
	5-Amino-2-phenyloxazole-4-carboxylic acid amide	IC50	30000.0 [1]
	N,3-Dimethyl-11-phenyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-7-amine	IC50	40.0 [1]
	1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone	IC50	100000.0 [1]
	3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione	IC50	50000.0 [1]
	(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione	IC50	1000.0 [1]
	2-Amino-5-phenyl-3-[4-(sulfamoylmethyl)phenyl]benzamide	IC50	7943.28 [1]
	N,12-Dimethyl-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-amine	IC50	230.0 [1]
	N,12-Dimethyl-14,15,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,11,13,16-octaen-16-amine	IC50	670.0 [1]
	2-[(12-Methyl-4-phenyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)amino]acetamide	IC50	25000.0 [1]
	8-Methoxy-12-methyl-4-phenyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene	IC50	100000.0 [1]
	4-(4-Fluorophenyl)-N,12-dimethyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amine	IC50	3100.0 [1]
	N-[[3-[12-Methyl-8-(methylamino)-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl]methyl]methanesulfonamide	IC50	1000.0 [1]
	N-Ethyl-4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amine	IC50	3400.0 [1]
	N-(2-Aminoethyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide	IC50	251.19 [1]
	4-(4-Pyrrolidin-1-ylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	1258.93 [1]
	2-[2-[3-[12-Methyl-8-(methylamino)-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]ethylamino]acetamide	IC50	390.0 [1]
	N-(2-Aminoethyl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide	IC50	125.89 [1]
	2-[4-[4-(2-Aminoethylsulfamoyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-2-yl]acetamide	IC50	158.49 [1]
	N'-[12-Methyl-4-(1H-pyrrol-2-yl)-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamine	IC50	1260.0 [1]
	N'-(12-Methyl-4-pyridin-2-yl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)ethane-1,2-diamine	IC50	1240.0 [1]
	N'-[4-(2-Methoxyphenyl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamine	IC50	13000.0 [1]
	N'-[4-(3-Methoxyphenyl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamine	IC50	690.0 [1]
	N'-[4-(4-Methoxyphenyl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamine	IC50	2800.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Inhibitor of nuclear factor kappa B kinase alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-alpha-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Inhibitor of nuclear factor kappa B kinase alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-alpha-subunit-inhibitors-ic50-ki.
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