Inhibitor of nuclear factor kappa B kinase beta subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	490.0 [1]
	BMS-345541 free base	IC50	200.0 [1]
	BMS-345541 free base	Ki	300.0 [1]
	2-Amino-6-(2-hydroxyphenyl)-4-(piperidin-3-yl)nicotinonitrile	IC50	25.12 [1]
	N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide	IC50	87.0 [1], 150.0 [2], 186.0 [3], 250.0 [4]
	N-(2-Hydroxyethyl)-N-methyl-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide	IC50	15.0 [1], 39.81 [2], 794.33 [3]
	(5Z)-5-[(3-Chloro-4-morpholin-4-ylphenyl)methylidene]-3-[4-[3-[4-(cyclopropylmethyl)piperazin-1-yl]propoxy]phenyl]-1,3-thiazolidine-2,4-dione	IC50	250.61 [1], 252.35 [2], 287.74 [3], 372.39 [4], 700.0 [5]
	(5Z)-3-[4-[5-[4-(Cyclopropylmethyl)piperazin-1-yl]pentoxy]phenyl]-5-[[4-(4-fluorophenoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	240.44 [1], 298.54 [2], 340.41 [3], 400.0 [4], 1096.48 [5]
	Bms-345541	IC50	240.0 [1], 300.0 [2], 644.0 [3], 4000.0 [4]
	5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide	IC50	18.0 [1], 19.5 [2], 19.95 [3]
	1-(5-Methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino)-3-methyl-1H-pyrrole-2,5-dione	IC50	8.0 [1], 62.0 [2], 67.0 [3]
	N,12-Dimethyl-4-phenyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amine	IC50	6.0 [1], 6.03 [2]
	3,4-Dichloro-2-ethoxy-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzenesulfonamide	IC50	32700.0 [1], 35400.0 [2], 55800.0 [3], 56100.0 [4]
	N-[3-[2-Amino-3-cyano-6-(2-hydroxyphenyl)pyridin-4-yl]phenyl]-5-oxooxolane-2-carboxamide	IC50	1500.0 [1]
	3-Amino-5-(3-thiophenyl)-2-thiophenecarboxamide	IC50	1300.0 [1], 2000.0 [2], 11200.0 [3]
	CID 22291652	IC50	1.6 [1], 25.0 [2], 1000.0 [3]
	[3-[8-(2-Aminoethylamino)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]methanol	IC50	7.94 [1], 8.0 [2]
	Ikk-IN-3	IC50	19.0 [1], 21.88 [2], 22.0 [3]
	N,12-Dimethyl-4-phenyl-5-oxa-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amine	IC50	10.96 [1], 11.0 [2]
	2-Amino-5-phenylbenzamide	IC50	14500.0 [1], 15848.93 [2]
	3-(3-Methyl-ureido)-5-phenyl-thiophene-2-carboxylic acid amide	IC50	50.0 [1], 50.12 [2], 1600.0 [3]
	2-Amino-6-[2-(cyclobutylmethoxy)-6-hydroxyphenyl]-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	3.98 [1], 4.0 [2]
	2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	3.0 [1], 3.02 [2]
	2-Amino-6-(2-hydroxy-6-propoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	5.0 [1], 5.01 [2]
	2-Amino-4-(1-amino-2-phenyl-ethyl)-6-(2-hydroxy-phenyl)-nicotinonitrile	IC50	60.0 [1]
	2-Amino-6-(2-heptoxy-6-hydroxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrile	IC50	50.0 [1], 50.12 [2]
	2-Amino-6-(2-hydroxy-6-pentoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	6.0 [1], 6.03 [2]
	N-[[3-[12-Methyl-8-(methylamino)-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl]methyl]acetamide	IC50	21.88 [1], 22.0 [2]
	N-(2-Hydroxyethyl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide	IC50	19.95 [1]
	N'-[4-(Furan-3-yl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamine	IC50	28.84 [1], 29.0 [2]
	4-[3-(Aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-amine	IC50	8.0 [1], 8.5 [2], 8.51 [3]
	12-Methyl-8-(methylamino)-4-[3-[2-(sulfamoylamino)ethyl]phenyl]-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene	IC50	7.0 [1], 7.08 [2]
	2-Amino-N-methyl-3-[3-[12-methyl-8-(methylamino)-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]propanamide	IC50	36.0 [1], 36.31 [2]
	3-Amino-5-phenylthiophene-2-carboxamide	IC50	1100.0 [1], 3235.94 [2], 8000.0 [3]
	3-Methoxy-N-[[3-[3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-11-yl]phenyl]methyl]propanamide	IC50	12.02 [1], 13.0 [2], 2620.0 [3]
	4-{4-[4-(Piperazine-1-sulfonyl)-phenyl]-pyrimidin-2-ylamino}-benzonitrile	IC50	43.65 [1], 44.0 [2]
	N-(1,1-Dioxothian-4-yl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide	IC50	19.95 [1]
	N-[[3-[3-Methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-11-yl]phenyl]methyl]acetamide	IC50	14.0 [1], 14.13 [2], 633.0 [3]
	12-Methyl-N-(2-piperidin-1-ylethyl)-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-amine	IC50	45.71 [1], 46.0 [2], 600.0 [3]
	8-[[5-Chloro-2-[4-(2-methoxyethyl)piperazin-1-yl]pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide	IC50	1.9 [1], 59.0 [2], 1000.0 [3]
	5-Phenyl-3-[1-(propylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide	IC50	12.59 [1], 158.49 [2]
	N,12-Dimethyl-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-amine	IC50	18.0 [1], 18.2 [2], 340.0 [3]
	N,12-Dimethyl-14,15,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,11,13,16-octaen-16-amine	IC50	10.96 [1], 11.0 [2], 8300.0 [3]
	N-Methyl-N'-(12-methyl-14,15,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,11,13,16-octaen-16-yl)ethane-1,2-diamine	IC50	34.67 [1], 35.0 [2], 1500.0 [3]
	2-[(12-Methyl-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-yl)amino]ethanol	IC50	18.0 [1], 18.2 [2], 1400.0 [3]
	Doramapimod	IC50	20000.0 [1], 30000.0 [2]
	N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide	IC50	218.0 [1], 100000.0 [2]
	2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one	IC50	10000.0 [1]
	IKK-3 Inhibitor	IC50	15848.93 [1]
	IKK Inhibitor VII	IC50	39.81 [1], 40.0 [2]
	(4R,4As,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-4-[(Z)-2-methylbut-2-enoyl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid	IC50	2620.0 [1]
	2-Amino-3-phenyl-5-(pyridin-4-yl)benzamide	IC50	3981.07 [1]
	3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide	IC50	2200.0 [1], 2700.0 [2]
	N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-phenyl}-3-piperidin-1-yl-propionamide	IC50	600.0 [1]
	4-Phenyl-1H-pyrrolo[2,3-b]pyridine	IC50	3162.28 [1]
	4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide	IC50	200.0 [1]
	4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide	IC50	55.0 [1]
	5-(4-Chlorophenyl)thiophene-2-carboxamide	IC50	50000.0 [1]
	5-Phenyl-2-Ureidothiophene-3-Carboxamide	IC50	12.88 [1], 13.0 [2]
	Reduced Lantadene B	IC50	4240.0 [1]
	4-{3-[3-Adamantan-1-yl-4-(2-methoxy-ethoxymethoxy)-phenyl]-3-oxo-propenyl}-benzoic acid	IC50	7000.0 [1], 11830.0 [2]
	3-Amino-6-(4-hydroxypiperidin-1-yl)-4-methylthieno[2,3-b]pyridine-2-carboxamide	IC50	750.0 [1], 1000.0 [2]
	N'-(12-Methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)ethane-1,2-diamine	IC50	170.0 [1]
	3-(Carbamoylamino)-5-Phenylthiophene-2-Carboxamide	IC50	25.12 [1], 10300.0 [2]
	5-Pyrimidin-5-yl-1H-indole-7-carboxamide	IC50	5011.87 [1]
	5-Phenyl-3-(1-propan-2-ylsulfonylpiperidin-4-yl)-1H-indole-7-carboxamide	IC50	19.95 [1]
	3-[1-(Ethanesulfonyl)-4-piperidinyl]-5-phenyl-1H-indole-7-carboxamide	IC50	25.12 [1]
	3-Dimethylamino-5-(4-fluoro-phenyl)-thiophene-2-carboxylic acid amide	IC50	23500.0 [1]
	5-Amino-2-(4-methoxy-phenyl)-oxazole-4-carboxylic acid amide	IC50	17700.0 [1], 18000.0 [2]
	5-Amino-2-(1-benzothiophen-2-yl)-1,3-oxazole-4-carboxamide	IC50	4600.0 [1]
	3-Amino-4-hydroxymethyl-6-methyl-thieno[2,3-b]pyridine-2-carboxamide	IC50	12700.0 [1], 13500.0 [2]
	4-(4-(5-Methylthiophen-2-yl)pyrimidin-2-ylamino)benzenesulfonamide	IC50	19.0 [1], 1710.0 [2]
	4-(4-(4-Methoxyphenyl)pyrimidin-2-ylamino)benzenesulfonamide	IC50	40.0 [1], 640.0 [2]
	5-Amino-2-(4-chloro-phenyl)-oxazole-4-carboxylic acid amide	IC50	13600.0 [1], 14000.0 [2]
	5-Amino-2-phenyloxazole-4-carboxylic acid amide	IC50	11000.0 [1]
	N,3-Dimethyl-11-phenyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-7-amine	IC50	39.81 [1], 1670.0 [2]
	2-Amino-6-[2-(cyclobutylmethoxy)-6-hydroxyphenyl]-4-piperidin-4-ylpyridine-3-carbonitrile	IC50	12.0 [1], 12.02 [2]
	2-Amino-4-(4-dimethylamino-phenyl)-6-(2-hydroxy-phenyl)-nicotinonitrile	IC50	19952.62 [1], 20000.0 [2]
	2-Amino-6-(2-hydroxy-6-phenylmethoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	9.0 [1], 9.12 [2]
	2-Amino-6-(2-hexoxy-6-hydroxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrile	IC50	25.0 [1], 25.12 [2]
	2-Amino-6-(2-hydroxy-phenyl)-4-(4-nitro-phenyl)-nicotinonitrile	IC50	19952.62 [1], 20000.0 [2]
	2-Amino-4-[1-amino-2-(4-fluorophenyl)ethyl]-6-(2-hydroxyphenyl)-3-pyridinecarbonitrile	IC50	39.81 [1], 40.0 [2]
	2-Amino-4-(1-amino-ethyl)-6-(2-hydroxy-phenyl)-nicotinonitrile	IC50	150.0 [1]
	2-Amino-4-(2-amino-ethyl)-6-(2-hydroxy-phenyl)-nicotinonitrile	IC50	70.0 [1]
	2-Amino-6-(2,6-dihydroxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	15.0 [1], 15.14 [2]
	2-Amino-6-(2-butoxy-6-hydroxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrile	IC50	15.0 [1], 15.14 [2]
	2-Amino-6-[2-(cyclohexylmethoxy)-6-hydroxyphenyl]-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	26.0 [1], 26.3 [2]
	2-Amino-6-(2-ethoxy-6-hydroxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	14.0 [1], 14.13 [2]
	2-Amino-6-(2-heptoxy-6-hydroxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	14.0 [1], 14.13 [2]
	2-Amino-6-[2-hydroxy-6-(2-methylpropoxy)phenyl]-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	5.0 [1], 5.01 [2]
	2-Amino-6-[2-hydroxy-6-(2-methylpropoxy)phenyl]-4-piperidin-4-ylpyridine-3-carbonitrile	IC50	15.0 [1], 15.14 [2]
	2-Amino-6-(2-hydroxy-6-methoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	33.88 [1], 34.0 [2]
	2-Amino-6-(2-hydroxy-6-pentoxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrile	IC50	19.95 [1], 20.0 [2]
	2-Amino-6-(2-hydroxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrile	IC50	300.0 [1]
	3-[3-(12-Methyl-8-methylimino-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,11-trien-4-yl)phenyl]propanoic acid	IC50	9.0 [1], 9.12 [2]
	N,12-Dimethyl-4-phenyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,11-trien-8-imine	IC50	21.88 [1], 27.0 [2]
	2-Amino-6-(2-hydroxy-4-methoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrile	IC50	560.0 [1]
	2-Amino-4-[3-[2-amino-3-cyano-6-(2-hydroxyphenyl)pyridin-4-yl]anilino]-4-oxobutanoic acid	IC50	600.0 [1]
	3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-N-(2-piperidin-1-yl-ethyl)-benzamide	IC50	1800.0 [1], 1819.7 [2]
	2-[3-(12-Methyl-8-methylimino-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,11-trien-4-yl)phenyl]acetamide	IC50	7.94 [1], 8.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Inhibitor of nuclear factor kappa B kinase beta subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-beta-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Inhibitor of nuclear factor kappa B kinase beta subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-beta-subunit-inhibitors-ic50-ki.
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