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Inositol-trisphosphate 3-kinase B Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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6-[4-[[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,4-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[4-[5-(Trifluoromethyl)pyridin-2-yl]-4,7-diazaspiro[2.5]octan-7-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
(2S)-1-[[5-(2-Oxo-3,4-dihydro-1,3-benzoxazin-6-yl)-1H-pyrazol-4-yl]methyl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-2-carboxylic acidIC50500.0 [1]
6-[4-[[(3R)-4-Cyclohexyl-3-methylpiperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3R)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3H-1,3-benzoxazol-2-oneIC50500.0 [1]
6-[4-[[(3R)-4-[(2-Fluorophenyl)methyl]-3-methylpiperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3S)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3H-1,3-benzoxazol-2-oneIC50500.0 [1]
6-[4-[[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-1,3-benzoxazine-2,4-dioneIC50500.0 [1]
6-[4-[[(3S)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-1,3-benzoxazine-2,4-dioneIC50500.0 [1]
6-[4-[[(3R)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-1,3-benzoxazine-2,4-dioneIC50500.0 [1]
6-[4-[[(3S)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[4-[5-(Trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
7-[4-[[(3R)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-2,4-dihydro-1H-isoquinolin-3-oneIC50500.0 [1]
7-[4-[[(3R)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-4H-isoquinoline-1,3-dioneIC50500.0 [1]
6-[4-[[4-[5-(Trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1H-quinazolin-2-oneIC50500.0 [1]
7-[4-[[4-[5-(Trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl]methyl]-1H-pyrazol-5-yl]-2,4-dihydro-1H-isoquinolin-3-oneIC50500.0 [1]
6-[4-[[3-(Trifluoromethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[3-[5-(Trifluoromethyl)pyridin-2-yl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[2-(Trifluoromethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[3-[5-(Trifluoromethyl)pyridin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[3-[5-(Trifluoromethyl)pyridin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-1H-pyrazol-5-yl]-1,3-benzoxazine-2,4-dioneIC50500.0 [1]
6-[4-[[4-(2,3-Dimethylphenyl)piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-1,3-benzoxazine-2,4-dioneIC50500.0 [1]
6-[4-[[4-(2,3-Dimethylphenyl)piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3H-1,3-benzoxazol-2-oneIC50500.0 [1]
6-[4-[[(3S)-3-(Trifluoromethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3R)-3-(Trifluoromethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3S)-3-(Hydroxymethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3R)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
4,4-Dimethyl-6-[4-[[(3R)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3H-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3S)-3-(Fluoromethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[(2R)-2-Methyl-4-[[5-(2-oxo-3,4-dihydro-1,3-benzoxazin-6-yl)-1H-pyrazol-4-yl]methyl]piperazin-1-yl]pyridine-3-carbonitrileIC50500.0 [1]
6-[5-[[(3R)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-2H-triazol-4-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3R)-3-Methyl-4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3R)-3-Methyl-4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(2S)-2-(Fluoromethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3R)-3-Methyl-4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
5-[4-[[(3R)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3H-1,3-benzoxazol-2-oneIC50500.0 [1]
6-[4-[[(3R)-4-(4-Chlorophenyl)-3-methylpiperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3R)-4-(5-Chloropyridin-2-yl)-3-methylpiperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
6-[4-[[(3R)-3-Methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1H-quinazolin-2-oneIC50500.0 [1]
6-[4-[[(2S)-2-(Hydroxymethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
2-[(2R)-2-Methyl-4-[[5-(2-oxo-3,4-dihydro-1,3-benzoxazin-6-yl)-1H-pyrazol-4-yl]methyl]piperazin-1-yl]pyridine-4-carbonitrileIC50500.0 [1]
6-[4-[[(3R)-3-Methyl-4-(5-methylpyridin-2-yl)piperazin-1-yl]methyl]-1H-pyrazol-5-yl]-3,4-dihydro-1,3-benzoxazin-2-oneIC50500.0 [1]
Items per page: 1 - 10 of 43
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References

This online tool may be cited as follows

MLA

"Quest Database™ Inositol-trisphosphate 3-kinase B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/inositol-trisphosphate-3-kinase-b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Inositol-trisphosphate 3-kinase B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inositol-trisphosphate-3-kinase-b-inhibitors-ic50-ki.
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