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Integrin alpha-4/beta-7 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2S)-1-[(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylic acidIC50433.0 [1], 862.0 [2], 2000.0 [3]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonyl-2-methylazetidine-2-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC5014.0 [1], 14.2 [2]
(S)-2-(2-Chloro-6-methyl-benzoylamino)-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acidIC5043.0 [1]
(2S)-2-[[2-(Diethylamino)-5-[(4-fluorophenyl)sulfonyl-prop-2-ynylamino]pyrimidin-4-yl]amino]-3-[4-(pyrrolidine-1-carbonyloxy)phenyl]propanoic acidIC507240.0 [1], 10700.0 [2]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonyl-2-methylpyrrolidine-2-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC502.98 [1], 11.5 [2]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonyl-2-methylpyrrolidine-2-carbonyl]amino]-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acidIC50646.0 [1], 647.0 [2]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC503.0 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonylazetidine-2-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC5010.6 [1], 11.0 [2]
(S)-2-(2,6-Dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acidIC500.75 [1]
CID 53340771IC5010.0 [1]
(3S,6R,11R,14S)-6-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-(carboxymethyl)-2,5,13-trioxo-8,9-dithia-1,4,12-triazabicyclo[12.3.0]heptadecane-11-carboxylic acidIC5010.0 [1]
(3S)-4-[[(2S,3R)-1-Amino-3-hydroxy-1-oxobutan-2-yl]amino]-3-[[(2S)-2-(isoquinoline-3-carbonylamino)-4-methylpentanoyl]amino]-4-oxobutanoic acidIC50465000.0 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC50102.0 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoic acidIC50820.0 [1]
(2S)-2-[[(2S)-1-(Benzenesulfonyl)pyrrolidine-2-carbonyl]amino]-3-[4-(pyrrolidine-1-carbonyloxy)phenyl]propanoic acidIC502.83 [1]
(2S)-3-[4-(2,6-Dimethoxyphenyl)phenyl]-2-[[(2R)-2-methyloxolane-2-carbonyl]amino]propanoic acidIC507.09 [1]
(5Z)-5-(Furan-2-ylmethylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trioneIC501300.0 [1]
(2S)-3-[4-(2-Cyanophenyl)phenyl]-2-[[(2S)-1-(3,5-dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]propanoic acidIC5089.0 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-3-(4-methoxyphenyl)propanoic acidIC50362.0 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acidIC50116.0 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonylpyrrolidin-2-yl]methylamino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC508400.0 [1]
(2S)-2-[(2-Chlorobenzoyl)amino]-3-[4-[2-[[2-(4-hydroxyphenyl)ethylamino]methyl]phenyl]phenyl]propanoic acidIC5025.0 [1]
(2S)-3-[4-(2-Methoxyphenyl)phenyl]-2-[[1-(4-methylphenyl)sulfonylcyclohexanecarbonyl]amino]propanoic acidIC5091.0 [1]
(2S)-2-[[2-(Diethylamino)-5-(3,5-dimethyl-1,2-oxazol-4-yl)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acidIC50510.0 [1]
3-(4-{2-Oxo-3-[4-(3-o-tolyl-ureido)phenyl]-2H-pyridin-1-ylmethyl}phenyl)-propionic acidKi10000.0 [1]
(2S)-2-[[(4S)-3-Acetyl-1,3-thiazolidine-4-carbonyl]amino]-3-[4-[(2,6-dichlorophenyl)methoxy]phenyl]propanoic acidIC50190.0 [1]
(2S)-3-[4-(2-Methoxyphenyl)phenyl]-2-[[(2R)-2-methyloxolane-2-carbonyl]amino]propanoic acidIC5045.3 [1]
(S)-2-(2-Hydroxy-5-nitro-benzylamino)-3-phenyl-propionic acid benzyl esterIC507000.0 [1]
(2S)-3-[4-(2-Methoxyphenyl)phenyl]-2-[(1-pyridin-3-ylcyclopentanecarbonyl)amino]propanoic acidIC509.9 [1]
(S)-2-(2-Hydroxy-5-nitro-benzylamino)-N-(3-methyl-butyl)-3-phenyl-propionamideIC506000.0 [1]
(2S)-2-[[(2S)-2-(1,3-Benzoxazol-2-yl)oxolane-2-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC50376.9 [1]
(2S)-3-[2-(2,6-Dichlorophenyl)-1,3-benzoxazol-5-yl]-2-[(3,5-dichloropyridine-4-carbonyl)amino]propanoic acidIC504.3 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-3-[4-(pyrrolidine-1-carbonyloxy)phenyl]propanoic acidIC501.92 [1]
(2S)-2-[[C-[(2S)-1-(Benzenesulfonyl)azetidin-2-yl]-N-(2,2,2-trifluoroethyl)carbonimidoyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC5027.0 [1]
(2S)-3-[2-(2,6-Dichlorophenyl)-1,3-benzoxazol-5-yl]-2-[[(2S)-1-(3,5-dichlorophenyl)sulfonylazetidine-2-carbonyl]amino]propanoic acidIC50179.0 [1]
(2S)-2-[[1-(2-Methoxyethyl)cyclopentanecarbonyl]amino]-3-[4-(1,3,4-trimethyl-2,6-dioxopyrimidin-5-yl)phenyl]propanoic acidIC50324.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[3-methyl-4-(1,3,4-trimethyl-2,6-dioxopyrimidin-5-yl)phenyl]propanoic acidIC50168.0 [1]
(2S)-2-[[3-(Benzenesulfonyl)piperidine-3-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC50622.0 [1]
(2S)-2-[[3-(Benzenesulfonyl)-1-methylpiperidine-3-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC505790.0 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-3-(4-phenylmethoxyphenyl)propanoic acidIC50849.0 [1]
(2S)-2-[(2-Chloro-6-methylbenzoyl)amino]-3-[4-(1,4-dimethyl-2-oxopyridin-3-yl)phenyl]propanoic acidIC50363.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-(1,4-dimethyl-2-oxopyridin-3-yl)phenyl]propanoic acidIC50179.0 [1]
(2S)-3-[4-(1,3-Diethyl-4-methyl-2,6-dioxopyrimidin-5-yl)phenyl]-2-[[1-(2-methoxyethyl)cyclopentanecarbonyl]amino]propanoic acidIC50565.0 [1]
(2S)-2-[[4-(Benzenesulfonyl)-1-methylpiperidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC501998.0 [1]
(2S)-3-[4-(2,6-Dimethoxyphenyl)phenyl]-2-[[3-(1-methylimidazol-4-yl)sulfonylpiperidine-3-carbonyl]amino]propanoic acidIC5097.0 [1]
(2S)-2-[[4-(Benzenesulfonyl)-1-methylpiperidine-4-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC50466.0 [1]
(2S)-2-[(3-Benzylsulfonylpiperidine-3-carbonyl)amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC50436.0 [1]
(2S)-2-[[4-(Benzenesulfonyl)-1-tert-butylpiperidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC509220.0 [1]
(2S)-3-[4-(2,6-Dimethoxyphenyl)phenyl]-2-[[3-(2-morpholin-4-ylethylsulfonyl)piperidine-3-carbonyl]amino]propanoic acidIC50257.0 [1]
(2S)-3-[4-(2,6-Dimethoxyphenyl)phenyl]-2-[(3-methylsulfonylpiperidine-3-carbonyl)amino]propanoic acidIC5021.0 [1]
(2S)-2-[[4-(Benzenesulfonyl)-1-phenylpiperidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC501260.0 [1]
(2S)-2-[[3-(4-Bromophenyl)sulfonylpiperidine-3-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC5094.0 [1]
(2S)-2-[[4-(Benzenesulfonyl)piperidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC501900.0 [1]
(2S)-2-[[3-(Benzenesulfonyl)piperidine-3-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC50168.0 [1]
(2S)-2-[[4-(Benzenesulfonyl)-1-butylpiperidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC509180.0 [1]
(2S)-2-[[3-(2-Bromophenyl)sulfonylpiperidine-3-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC5096.0 [1]
3-Methylbutyl (2S)-2-[(2-hydroxy-5-nitrophenyl)methylamino]-3-phenylpropanoateIC507000.0 [1]
(2S)-2-[(2-Chloro-6-methylbenzoyl)amino]-3-[4-(1-methyl-2-oxopyridin-3-yl)phenyl]propanoic acidIC50687.0 [1]
(2S)-2-[[4-(Benzenesulfonyl)-1-ethylpiperidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC501230.0 [1]
(2S)-3-[4-(2,6-Dimethoxyphenyl)phenyl]-2-[[3-(3-methylimidazol-4-yl)sulfonylpiperidine-3-carbonyl]amino]propanoic acidIC5046.0 [1]
(2S)-2-[[3-(Benzenesulfonyl)piperidine-3-carbonyl]amino]-3-[4-[(2,6-dichlorobenzoyl)amino]phenyl]propanoic acidIC5022.0 [1]
(2S)-3-[4-(2,6-Dimethoxyphenyl)phenyl]-2-[[3-(4-pyrrolidin-1-ylphenyl)sulfonylpiperidine-3-carbonyl]amino]propanoic acidIC50536.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)-3-methylphenyl]propanoic acidIC50220.0 [1]
(2S)-2-[(2-Chloro-6-methylbenzoyl)amino]-3-[4-(1,3-diethyl-4-methyl-2,6-dioxopyrimidin-5-yl)phenyl]propanoic acidIC50164.0 [1]
(2S)-2-[[3-(3-Bromophenyl)sulfonylpiperidine-3-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC5083.0 [1]
(2S)-3-[4-(2-Methoxyphenyl)phenyl]-2-[(1-phenylcyclopentanecarbonyl)amino]propanoic acidIC50110.0 [1]
2,2-Dimethylpropyl (2S)-2-[(2-hydroxy-5-nitrophenyl)methylamino]-3-phenylpropanoateIC509000.0 [1]
(2S)-2-[[(4R)-3-Acetyl-1,3-thiazolidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acidIC5050.0 [1]
(2S)-2-[[(2S)-1-(3,5-Dichlorophenyl)sulfonyl-2-methylpyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acidIC503546.0 [1]
(2S)-2-[[(2S)-2-(4-Chlorophenyl)oxolane-2-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC5052.2 [1]
(2S)-2-[[Amino-[(2S)-1-(benzenesulfonyl)azetidin-2-yl]methylidene]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acidIC5019.0 [1]
(S)-2-(4-Methoxy-benzylamino)-3-phenyl-propionic acid tert-butyl esterIC50122000.0 [1]
(S)-2-Benzylamino-3-phenyl-propionic acid tert-butyl esterIC50100000.0 [1]
(2S)-2-[(3,5-Dimethyl-1,2-oxazole-4-carbonyl)amino]-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC50250.0 [1]
(2S)-2-[(2-Chloro-4-methylsulfonylbenzoyl)amino]-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC504.0 [1]
(2S)-3-[4-(2-Cyclohexyl-5-methoxy-3-oxopyridazin-4-yl)phenyl]-2-[(2,6-dichlorobenzoyl)amino]propanoic acidIC50330.0 [1]
(2S)-2-[[2-Hydroxyethyl(methyl)carbamoyl]amino]-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC5094.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-[2-methyl-5-(4-methylsulfonylphenyl)-3-oxopyridazin-4-yl]phenyl]propanoic acidIC502.0 [1]
(2S)-3-[4-(5-Methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]-2-[[methyl(phenyl)carbamoyl]amino]propanoic acidIC5063.0 [1]
(2S)-3-[4-(5-Methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]-2-[[phenyl(propyl)carbamoyl]amino]propanoic acidIC50350.0 [1]
a4 Integrin receptor antagonist 1IC50110.0 [1]
(2S)-3-[4-[5-(4-Carbamoylphenyl)-2-methyl-3-oxopyridazin-4-yl]phenyl]-2-[(2,6-dichlorobenzoyl)amino]propanoic acidIC503.0 [1]
(2S)-3-[4-(5-Methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]-2-[[methyl(2-methylpropyl)carbamoyl]amino]propanoic acidIC5017.0 [1]
(2S)-3-[4-(5-Methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]-2-[[phenyl(propan-2-yl)carbamoyl]amino]propanoic acidIC5092.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-[2-(2-hydroxyethyl)-5-methoxy-3-oxopyridazin-4-yl]phenyl]propanoic acidIC502.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-(2-methyl-5-morpholin-4-yl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC503.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-[5-methoxy-2-(2-morpholin-4-ylethyl)-3-oxopyridazin-4-yl]phenyl]propanoic acidIC502.0 [1]
2,6-Dichloro-N-[(2S)-1-(hydroxyamino)-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]-1-oxopropan-2-yl]benzamideIC50610.0 [1]
(2S)-2-(Dimethylcarbamoylamino)-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC501500.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-[5-(2-hydroxyethoxy)-2-methyl-3-oxopyridazin-4-yl]phenyl]propanoic acidIC502.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-[2-methyl-5-(2-methylimidazol-1-yl)-3-oxopyridazin-4-yl]phenyl]propanoic acidIC507.0 [1]
(2S)-3-[4-[5-(1,3-Benzodioxol-5-yl)-2-methyl-3-oxopyridazin-4-yl]phenyl]-2-[(2,6-dichlorobenzoyl)amino]propanoic acidIC505.0 [1]
(2S)-2-[(2-Chloro-5-fluorobenzoyl)amino]-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC5019.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-[2-methyl-5-(2-morpholin-4-ylethoxy)-3-oxopyridazin-4-yl]phenyl]propanoic acidIC503.0 [1]
(2S)-2-[(3-Chlorothiophene-2-carbonyl)amino]-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC501400.0 [1]
(2S)-3-[4-(5-Methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acidIC50810.0 [1]
(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-(2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC50360.0 [1]
(2S)-2-(Methoxycarbonylamino)-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC50710.0 [1]
(2S)-2-[(2,6-Dichlorobenzenecarbothioyl)amino]-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]propanoic acidIC50230.0 [1]
2,6-Dichloro-N-[(2S)-1-(methanesulfonamido)-3-[4-(5-methoxy-2-methyl-3-oxopyridazin-4-yl)phenyl]-1-oxopropan-2-yl]benzamideIC501000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Integrin alpha-4/beta-7 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/integrin-alpha-4-beta-7-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Integrin alpha-4/beta-7 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/integrin-alpha-4-beta-7-inhibitors-ic50-ki.
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