Integrin alpha-V/beta-3 and alpha-IIb/beta 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(2S)-3-[[(5S,8S)-8-[(1H-Imidazol-2-ylamino)methyl]-7-(pyridin-3-ylmethoxycarbonyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	5600.0 [1]
	(2S)-3-[[(5S,8S)-7-Phenylmethoxycarbonyl-8-[(pyridin-2-ylamino)methyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	100000.0 [1]
	(2S)-3-[[(5S,8S)-8-[(1H-Imidazol-2-ylamino)methyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	1400.0 [1]
	(2S)-3-[[(5S,8S)-8-[(1H-Imidazol-2-ylamino)methyl]-7-phenylmethoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	34000.0 [1]
	(2S)-3-[[(5S,8S)-8-[(1H-Imidazol-2-ylamino)methyl]-7-methoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	7300.0 [1]
	(2S)-3-[[(5S,8S)-7-Butoxycarbonyl-8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	11000.0 [1]
	(2S)-3-[[(5S,8S)-8-[(1H-Benzimidazol-2-ylamino)methyl]-7-methoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	100000.0 [1]
	(2S)-2-(2,6-Dichlorophenyl)sulfonyl-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acid	IC50	490.0 [1]
	(2S)-3-[[(5S,8S)-8-[(1H-Benzimidazol-2-ylamino)methyl]-7-phenylmethoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	100000.0 [1]
	(2S)-3-[[8-(1H-Imidazol-2-ylcarbamoyl)-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]-2-(2,4,6-trimethylphenyl)sulfonylpropanoic acid	IC50	33000.0 [1]
	(2S)-3-[[8-[(1H-Imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]-2-(2,4,6-trimethylphenyl)sulfonylpropanoic acid	IC50	1000.0 [1]
	(2S)-2-(2,6-Dimethyl-4-phenylphenyl)sulfonyl-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acid	IC50	8300.0 [1]
	(2S)-2-(Benzenesulfonyl)-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acid	IC50	830.0 [1]
	(2S)-2-(2,6-Dichloro-4-phenylphenyl)sulfonyl-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acid	IC50	8300.0 [1]
	(2S)-3-[[(5S,8S)-8-[(2H-Imidazol-2-ylamino)methyl]-7-phenylmethoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	7300.0 [1]
	(2S)-2-(2,6-Dimethylphenyl)sulfonyl-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acid	IC50	310.0 [1]
	(2S)-3-[[8-[(1H-Benzimidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]-2-(2,4,6-trimethylphenyl)sulfonylpropanoic acid	IC50	7100.0 [1]
	(2S)-3-[[8-[(1,4,5,6-Tetrahydropyrimidin-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]-2-(2,4,6-trimethylphenyl)sulfonylpropanoic acid	IC50	800.0 [1]
	(2S)-3-[[(5R,8S)-8-[(2H-Imidazol-2-ylamino)methyl]-7-phenylmethoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid	IC50	9200.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 19 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Integrin alpha-V/beta-3 and alpha-IIb/beta 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/integrin-alpha-v-beta-3-and-alpha-iib-beta-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Integrin alpha-V/beta-3 and alpha-IIb/beta 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/integrin-alpha-v-beta-3-and-alpha-iib-beta-3-inhibitors-ic50-ki.
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