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Interleukin-1 receptor-associated kinase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
N-[7-(4-Hydroxycyclohexyl)oxyquinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamideIC5070.0 [1], 123.0 [2], 168.0 [3]
2-[2-Aminoethyl(methyl)amino]-N-(7-methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC50982.5 [1], 983.0 [2]
N-[2-[4-(Aminomethyl)piperidin-1-yl]-5-chlorophenyl]-6-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamideIC5055.0 [1]
N-[5-Chloro-2-(4-hydroxycyclohexyl)oxyphenyl]thieno[3,2-d]pyrimidine-7-carboxamideIC50126.0 [1], 600.0 [2]
DoramapimodIC5030000.0 [1]
LY-3009120IC50390.0 [1]
IRAK-1/4 InhibitorIC50300.0 [1]
CID 11634725Ki10000.0 [1]
CID 59604787IC5010000.0 [1]
N-(Azetidin-3-yl)-6-(6-chloroimidazo[1,2-a]pyridin-3-yl)pyridin-2-amineIC50195000.0 [1]
IRAK4 inhibitor rac-45 [PMID: 18501603]IC5023000.0 [1]
JH-VIII-157-02IC5014.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi3011.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
N-{4-[(7-Hydroxy-6-Methoxyquinazolin-4-Yl)amino]phenyl}benzamideIC5030000.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
N-[1-[4-(Hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamideKi72.0 [1]
3-Nitro-N-[1-Phenyl-5-(Piperidin-1-Ylmethyl)-1h-Benzimidazol-2-Yl]benzamideKi374.0 [1]
N-[1-(4-Hydroxycyclohexyl)-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-nitrobenzamideKi18.0 [1]
N-[1-Phenyl-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamideKi608.0 [1]
N-[1-[4-(Hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-nitrobenzamideKi48.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi4000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2200.0 [1]
N-[4-[[7-(2-Amino-2-oxoethoxy)-6-methoxyquinazolin-4-yl]amino]phenyl]benzamideIC5030000.0 [1]
N-[4-[(4-Hydroxy-3-methoxybenzoyl)amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
N-(4-Benzamidophenyl)-4-hydroxy-3-methoxybenzamideIC5030000.0 [1]
2-Amino-N-(4-benzamidophenyl)-4-hydroxy-5-methoxybenzamideIC5030000.0 [1]
2-[4-[(4-Benzamidophenyl)carbamoyl]-2-methoxyphenoxy]acetic acidIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)benzoyl]amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)-4-methoxybenzoyl]amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1,3-diazinan-1-yl)-5-methoxybenzoyl]amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)-5-methoxybenzoyl]amino]phenyl]piperidine-2-carboxamideIC5030000.0 [1]
3-(2,4-Dioxo-1H-pyrimidin-5-yl)-N-[4-(ethylcarbamoylamino)phenyl]-5-methoxybenzamideIC5030000.0 [1]
[1-[4-(3-Hydroxypropyl)phenyl]-2-[(3-nitrobenzoyl)amino]benzimidazol-5-yl] 2,2-dimethylpropanoateIC50900.0 [1]
8-[1-[3-(Dimethylamino)propyl]pyrazol-4-yl]-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC5015.0 [1]
N-(4-Morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amineIC5023.0 [1]
4,5,8,15,17,25,29-Heptazahexacyclo[23.3.1.12,5.119,23.08,16.09,14]hentriaconta-1(29),2(31),3,9,11,13,15,19,21,23(30),27-undecaene-18,26-dioneIC50100.0 [1]
5-Hydroxy-8,15,17,25,29-pentazahexacyclo[23.3.1.12,6.119,23.08,16.09,14]hentriaconta-1(29),2(31),3,5,9,11,13,15,19,21,23(30),27-dodecaene-18,26-dioneIC50100.0 [1]
N-[4-[(7-Hydroxy-6-methoxy-2-methylquinazolin-4-yl)amino]phenyl]benzamideIC5030000.0 [1]
N-[4-[(2-Amino-7-hydroxy-6-methoxyquinazolin-4-yl)amino]phenyl]benzamideIC5030000.0 [1]
N-[4-[[7-Hydroxy-6-methoxy-2-(2-pyridin-2-ylethylamino)quinazolin-4-yl]amino]phenyl]benzamideIC5030000.0 [1]
2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-olIC50100000.0 [1]
1-[4-[4-[[5-(Oxan-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]cyclohexyl]piperazin-1-yl]ethanoneIC5072.0 [1]
1-[4-[4-[(5-Propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]piperazin-1-yl]ethanoneIC5021.0 [1]
N-[1-[4-(2-Hydroxyethyl)phenyl]-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamideKi12.0 [1]
4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-iumIC5010000.0 [1]
6-(6-Methoxyimidazo[1,2-a]pyridin-3-yl)-N-piperidin-4-ylpyridin-2-amineIC50293000.0 [1]
3-[6-(Piperidin-4-ylamino)pyridin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrileIC5096000.0 [1]
6-(6-Chloroimidazo[1,2-a]pyridin-3-yl)-N-piperidin-3-ylpyridin-2-amineIC50175000.0 [1]
Ethyl 2-(2-(3-nitrobenzamido)-1H-benzo[d]imidazol-1-yl)acetateIC50750.0 [1]
N-[(4-Methoxyphenyl)methyl]-[1]benzofuro[2,3-b]pyridin-4-amineKi1000000.0 [1]
2-{3-[3-(Piperidin-4-Yl)propoxy]phenyl}-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamideIC5010000.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC5010000.0 [1]
N-[4-[[7-(2-Hydroxyethoxy)-6-methoxyquinazolin-4-yl]amino]phenyl]benzamideIC5030000.0 [1]
N-[6-(Hydroxymethyl)-1H-benzimidazol-2-yl]-3-[(6-oxo-3-pyridin-3-ylpyridazin-1-yl)methyl]benzamideIC50100.0 [1]
N-[6-[2-(Dimethylamino)-2-oxoethyl]-1H-benzimidazol-2-yl]-3-[(6-oxo-3-pyridin-3-ylpyridazin-1-yl)methyl]benzamideIC50100.0 [1]
[(4-{[4-(Benzoylamino)phenyl]amino}-6-Methoxyquinazolin-7-Yl)oxy]acetic AcidIC5030000.0 [1]
N-{4-[(4-Hydroxy-3-Nitrobenzoyl)amino]phenyl}pyridine-2-CarboxamideIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)-5-methoxybenzoyl]amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
(2S)-1-({4-[3-(4-Fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}amino)propan-2-olIC5030000.0 [1]
N-(5-Chloro-2-piperidin-1-ylphenyl)-3-oxo-4H-pyrazolo[1,5-b][1,2,4]triazine-8-carboxamideIC50644.0 [1]
N-[5-Chloro-2-[4-[(dimethylamino)methyl]piperidin-1-yl]phenyl]-6-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamideIC50307.0 [1]
2-(Cyclopropylamino)-N-(7-methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC50575.0 [1]
N-[3-(4-Hydroxycyclohexyl)oxynaphthalen-2-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC50817.0 [1]
2-(2-Aminoethylamino)-N-(7-methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC50712.0 [1]
2-[2-Hydroxyethyl(methyl)amino]-N-(7-methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC50300.0 [1]
N-[2-[4-(Aminomethyl)piperidin-1-yl]-5-chlorophenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC50463.0 [1]
N-[5-Chloro-2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]-6-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamideIC50836.0 [1]
N-[7-(3-Aminopropoxy)quinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamideIC50529.0 [1]
N-[5-Chloro-2-[3-(1-hydroxyethyl)pyrrolidin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC50897.0 [1]
N-[5-Chloro-2-[4-(1-hydroxyethyl)piperidin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC50970.0 [1]
N-[2-[4-(Aminomethyl)piperidin-1-yl]-5-chlorophenyl]thieno[3,2-d]pyrimidine-7-carboxamideIC50800.0 [1]
N-[7-[(1R,3R)-3-Hydroxycyclopentyl]oxyquinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamideIC50246.0 [1]
N-[7-[4-(Aminomethyl)piperidin-1-yl]quinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamideIC50850.0 [1]
6-Hydroxy-N-(7-methoxyquinolin-6-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamideIC50200.0 [1]
2-(2,3-Dihydroxypropylamino)-N-(7-methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC50608.0 [1]
N-[5-Chloro-2-(4-hydroxycyclohexyl)oxyphenyl]-6-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamideIC50163.0 [1]
N-[7-(4-Hydroxy-2-methylbutan-2-yl)oxyquinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamideIC50364.0 [1]
N-[5-Chloro-2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]thieno[3,2-d]pyrimidine-7-carboxamideIC50700.0 [1]
N-[7-(4-Hydroxypentan-2-yloxy)quinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamideIC50760.0 [1]
N-[2-(2-Hydroxyethylamino)-7-methoxyquinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamideIC50200.0 [1]
2-(2-Aminoethylamino)-N-(5-chloro-2-methoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamideIC50813.0 [1]
N-[2-[4-(Aminomethyl)piperidin-1-yl]-4-(phenylcarbamoyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC50450.0 [1]
N-(5-Chloro-2-piperidin-4-yloxyphenyl)thieno[3,2-b]pyridine-3-carboxamideIC50930.0 [1]
Items per page: 1 - 10 of 87
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References

This online tool may be cited as follows

MLA

"Quest Database™ Interleukin-1 receptor-associated kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/interleukin-1-receptor-associated-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Interleukin-1 receptor-associated kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/interleukin-1-receptor-associated-kinase-1-inhibitors-ic50-ki.
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