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JAK2/JAK1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
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▼
TofacitinibIC50170.0 [1]
FilgotinibIC501045.0 [1], 3364.0 [2]
N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamideIC50163.0 [1], 271.0 [2]
Jak-IN-1IC50290.0 [1], 291.0 [2]
RuxolitinibIC5031.0 [1]
[2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanoneIC502100.0 [1]
N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC502540.0 [1]
2-Cyclopropyl-N-[(2s)-3-Hydroxy-3-Methylbutan-2-Yl]-5h-Pyrrolo[2,3-B]pyrazine-7-CarboxamideIC5013200.0 [1]
N-[(1R)-2-(3-Cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC50141.0 [1]
N-[(1R)-2-[(3S)-3-Cyanopyrrolidin-1-yl]-1-cyclopropyl-2-oxoethyl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC50102.0 [1]
2-Cyclopropyl-N-[(2s)-3,3-Dimethylbutan-2-Yl]-5h-Pyrrolo[2,3-B]pyrazine-7-CarboxamideIC503380.0 [1]
N-[(2S)-3-Cyano-3-methylbutan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC502570.0 [1]
N-[(2R)-1-(3-Cyanopyrrolidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC502260.0 [1]
N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC50490.0 [1]
2-[[(3R)-3-Acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1R)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5030000.0 [1]
CID 67008828IC5014400.0 [1]
N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC501350.0 [1]
2-(6-Chloro-4-fluoro-1-methylindazol-3-yl)-N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5030000.0 [1]
N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(6-methoxy-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC502610.0 [1]
2-(6-Chloro-1-methylindazol-3-yl)-N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5030000.0 [1]
N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(6,8-difluoroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5012900.0 [1]
2-(6-Chloro-1-methylindol-3-yl)-N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC50230.0 [1]
N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(6-fluoroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC502860.0 [1]
2-[[(3R)-3-Acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5030000.0 [1]
Items per page: 1 - 10 of 24
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References

This online tool may be cited as follows

MLA

"Quest Database™ JAK2/JAK1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/jak2-jak1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ JAK2/JAK1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/jak2-jak1-inhibitors-ic50-ki.
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