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Kelch-like ECH-associated protein 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N,N'-Naphthalene-1,4-Diylbis(4-Methoxybenzenesulfonamide)IC501600.0 [1], 1700.0 [2], 2700.0 [3]
2,2'-(Naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acidIC5020.0 [1], 230.0 [2]
(3R)-1-[4-[(2,3,5,6-Tetramethylphenyl)sulfonylamino]naphthalen-1-yl]pyrrolidine-3-carboxylic acidIC50100.0 [1], 140.0 [2]
(1S,2R)-2-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC501100.0 [1]
(3s)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}naphthalen-1-Yl)pyrrolidine-3-Carboxylic AcidIC50140.0 [1]
(1S,2R)-2-[(1S)-5-Methyl-1-[(3-oxo-1H-isoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC50750.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acidIC5042.6 [1]
2-[[5-(2,4-Dimethylphenyl)sulfonyl-6-oxo-1H-pyrimidin-2-yl]sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamideIC50118000.0 [1]
2-[[(1S)-2-[(1R,2S)-2-(2H-Tetrazol-5-yl)cyclohexanecarbonyl]-3,4-dihydro-1H-isoquinolin-1-yl]methyl]isoindole-1,3-dioneIC507400.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acidIC5033.0 [1]
(4S)-4-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-5-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acidIC50194.0 [1]
N-[(4-Methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}naphthalen-1-yl)glycineIC50110.0 [1]
2,2'-(Naphthalene-1,4-Diylbis(((4-Methoxyphenyl)sulfonyl)azanediyl))diacetamideIC5044.0 [1]
3-[4-Chloro-3-[[methyl(methylsulfonyl)amino]methyl]phenyl]-3-(1-methylbenzotriazol-5-yl)propanoic acidIC503400.0 [1]
(3S)-3-[3-[[Benzenesulfonyl(methyl)amino]methyl]-4-chlorophenyl]-3-(1-methylbenzotriazol-5-yl)propanoic acidIC50270.0 [1]
(3R)-1-[5-[(2,3,5,6-Tetramethylphenyl)sulfonylamino]quinolin-8-yl]pyrrolidine-3-carboxylic acidIC50700.0 [1]
(3R)-1-[4-[(4-Methyl-2-phenyl-1,3-thiazol-5-yl)sulfonylamino]naphthalen-1-yl]pyrrolidine-3-carboxylic acidIC50400.0 [1]
1-[4-[(2,3,5,6-Tetramethylphenyl)sulfonylamino]naphthalen-1-yl]pyrrolidine-3-carboxylic acidIC50200.0 [1]
(3R)-1-[4-[(5-Chloro-3-methyl-1-benzothiophen-2-yl)sulfonylamino]naphthalen-1-yl]pyrrolidine-3-carboxylic acidIC50200.0 [1]
(3R)-1-[4-[(2-Methoxy-4-methylphenyl)sulfonylamino]naphthalen-1-yl]pyrrolidine-3-carboxylic acidIC505400.0 [1]
3-Methoxy-N-[4-[(3-methoxyphenyl)sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC502300.0 [1]
Ethyl 2-[[4-[(2-ethoxy-2-oxoethyl)-(4-methoxyphenyl)sulfonylamino]naphthalen-1-yl]-(4-methoxyphenyl)sulfonylamino]acetateIC50250000.0 [1]
Ethyl 2-[(4-methoxyphenyl)sulfonyl-[4-[(4-methoxyphenyl)sulfonylamino]naphthalen-1-yl]amino]acetateIC50400.0 [1]
3-(4-Chlorophenyl)propanoic acidIC501000000.0 [1]
3-(4-Chlorophenyl)-3-(1-methylbenzotriazol-5-yl)propanoic acidIC5061000.0 [1]
(4S)-4-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-Acetamido-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acidIC50248.0 [1]
(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-Acetamido-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoic acidIC50115.0 [1]
(3S,6S,9R,14R,17S,20S,23S,29S,32S,35S)-9-Acetamido-23,32-bis(2-carboxyethyl)-3-(carboxymethyl)-29-[(1R)-1-hydroxyethyl]-20-[(4-hydroxyphenyl)methyl]-6,17-bis(2-methylpropyl)-2,5,8,16,19,22,25,28,31,34-decaoxo-11,12-dithia-1,4,7,15,18,21,24,27,30,33-decazabicyclo[33.3.0]octatriacontane-14-carboxylic acidIC509.45 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acidIC505390.0 [1]
(4S)-5-[[(2S)-1-[[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-5-oxopentanoic acidIC503570.0 [1]
(4S)-4-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acidIC50730.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoic acidIC5029.6 [1]
4-Methoxy-N-[1-(4-methoxyphenyl)sulfonyl-2-methyl-3-(methylaminocarbamoyl)benzo[g]indol-5-yl]benzenesulfonamideIC50290.0 [1]
4-Methoxy-N-[1-(4-methoxyphenyl)sulfonyl-2-methyl-3-[(4-nitroanilino)carbamoyl]benzo[g]indol-5-yl]benzenesulfonamideIC50260.0 [1]
4-Ethoxy-N-[1-(4-ethoxyphenyl)sulfonyl-3-(hydrazinecarbonyl)-2-methylbenzo[g]indol-5-yl]benzenesulfonamideIC50160.0 [1]
1-(4-Ethoxyphenyl)sulfonyl-5-[(4-ethoxyphenyl)sulfonylamino]-N-hydroxy-2-methylbenzo[g]indole-3-carboxamideIC50200.0 [1]
N-[3-(Anilinocarbamoyl)-1-(4-methoxyphenyl)sulfonyl-2-methylbenzo[g]indol-5-yl]-4-methoxybenzenesulfonamideIC50180.0 [1]
4-Methoxy-N-[3-[(4-methoxyanilino)carbamoyl]-1-(4-methoxyphenyl)sulfonyl-2-methylbenzo[g]indol-5-yl]benzenesulfonamideIC50170.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-Acetamidoacetyl)amino]-5-amino-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acidIC5063.15 [1]
3-[(3S,6S,9S,15S,18S,21S,27S,30S,33S)-9-(3-Amino-3-oxopropyl)-18-benzyl-30-(2-carboxyethyl)-3-(carboxymethyl)-27-[(1R)-1-hydroxyethyl]-6,15-bis(2-methylpropyl)-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecazabicyclo[31.3.0]hexatriacontan-21-yl]propanoic acidIC5018.31 [1]
1-[3-[3-[(2R)-2-Butylpyrrolidine-1-carbonyl]phenyl]phenyl]-5-cyclopropylpyrazole-4-carboxylic acidIC5010.0 [1]
3-[(4R,7S,13S,16S,19S,22S,25R)-25-Amino-4-carbamoyl-16,19-bis(2-carboxyethyl)-22-(carboxymethyl)-13-[(1R)-1-hydroxyethyl]-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacos-7-yl]propanoic acidKi274.9 [1]
3-[(4R,7S,10S,16S,19S,22S,28S,31S,34R)-4-Acetamido-31-benzyl-34-carbamoyl-19-(2-carboxyethyl)-10-(carboxymethyl)-38,39,40,41-tetrafluoro-22-[(1R)-1-hydroxyethyl]-7-(2-methylpropyl)-5,8,11,17,20,23,26,29,32-nonaoxo-2,36-dithia-6,9,12,18,21,24,27,30,33-nonazatricyclo[35.2.2.012,16]hentetraconta-1(40),37(41),38-trien-28-yl]propanoic acidKi61.9 [1]
3-[(4R,7S,10S,16S,19S,22S,25S,28S,31R)-31-Acetamido-7-benzyl-4-carbamoyl-19,22-bis(2-carboxyethyl)-25-(carboxymethyl)-16-[(1R)-1-hydroxyethyl]-28-(2-methylpropyl)-6,9,12,15,18,21,24,27,30-nonaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacont-10-yl]propanoic acidKi47.9 [1]
3-[(4R,7S,13S,16S,19S,25S,28R)-4-Acetamido-28-carbamoyl-16-(2-carboxyethyl)-7-(carboxymethyl)-32,33,34,35-tetrafluoro-19-[(1R)-1-hydroxyethyl]-5,8,14,17,20,23,26-heptaoxo-2,30-dithia-6,9,15,18,21,24,27-heptazatricyclo[29.2.2.09,13]pentatriaconta-1(34),31(35),32-trien-25-yl]propanoic acidKi6.1 [1]
3-[(4R,7S,13S,16S,19S,22S,25R)-25-Acetamido-4-carbamoyl-16,19-bis(2-carboxyethyl)-22-(carboxymethyl)-13-[(1R)-1-hydroxyethyl]-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacos-7-yl]propanoic acidKi95.0 [1]
3-[(4R,10S,13S,16S,19R)-19-Acetamido-4-carbamoyl-13-(2-carboxyethyl)-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]propanoic acidKi151500.0 [1]
(4R,7S,13S,16S,19S,22S,25R)-25-Acetamido-7,16,19-tris(2-carboxyethyl)-22-(carboxymethyl)-13-[(1R)-1-hydroxyethyl]-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carboxylic acidKi47.7 [1]
(1S,2R)-2-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclopropane-1-carboxylic acidIC5020800.0 [1]
(1S,2R)-2-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclobutane-1-carboxylic acidIC508000.0 [1]
(1S,2R)-2-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-5-methyl-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC50750.0 [1]
(3S,4S)-3-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]piperidine-4-carboxylic acidIC5069700.0 [1]
(1S,2R)-2-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclopentane-1-carboxylic acidIC502200.0 [1]
(1S,2R)-2-[(1S)-1-[(2,5-Dioxopyrrolidin-1-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC501200.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Kelch-like ECH-associated protein 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/kelch-like-ech-associated-protein-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Kelch-like ECH-associated protein 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/kelch-like-ech-associated-protein-1-inhibitors-ic50-ki.
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