Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(3S)-3-Amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one	IC50	23.0 [1]
	(3S)-3-Amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one	Ki	14.0 [1]
	(5S)-5-Amino-7-hydroxy-2-phenyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	24.3 [1]
	(5S)-5-Amino-7-hydroxy-2-phenyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	Ki	1.9 [1]
	(5S)-5-Amino-7-hydroxy-3-[(3-methoxyphenyl)methyl]-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	65.6 [1]
	(5S)-5-Amino-7-hydroxy-3-[(3-methoxyphenyl)methyl]-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	Ki	22.0 [1]
	(5S)-5-Amino-2-benzyl-7-hydroxy-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	59.4 [1]
	(5S)-5-Amino-2-benzyl-7-hydroxy-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	Ki	23.0 [1]
	(6S)-6-Amino-1-benzyl-4-hydroxy-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	IC50	22.5 [1]
	(6S)-6-Amino-1-benzyl-4-hydroxy-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	Ki	12.0 [1]
	(6S)-6-Amino-1-benzyl-4-hydroxy-3-(trifluoromethyl)-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	IC50	42.7 [1], 43.7 [2]
	(6S)-6-Amino-1-benzyl-4-hydroxy-3-(trifluoromethyl)-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	Ki	48.0 [1]
	(3S)-3-Amino-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2-one	IC50	22.0 [1]
	(5S)-5-Amino-7-hydroxy-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	329.0 [1]
	(5S)-5-Amino-3-benzyl-7-hydroxy-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	63.7 [1]
	(5S)-5-Amino-3-benzyl-7-hydroxy-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	Ki	32.0 [1]
	(6S)-6-Amino-4-hydroxy-2-phenyl-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	IC50	85.0 [1]
	(6S)-6-Amino-4-hydroxy-2-phenyl-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	Ki	41.0 [1]
	(5S)-5-Amino-7-hydroxy-3-[(4-methoxyphenyl)methyl]-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	440.0 [1]
	(5S)-5-Amino-7-hydroxy-2-[(4-methoxyphenyl)methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	28.3 [1]
	(6S)-6-Amino-2-benzyl-4-hydroxy-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	IC50	182.0 [1]
	(5S)-5-Amino-3-benzyl-2-ethyl-7-hydroxy-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	24.3 [1]
	(5S)-5-Amino-7-hydroxy-2-[2-(trifluoromethyl)phenyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	38.8 [1]
	(5S)-5-Amino-7-hydroxy-2-[4-(trifluoromethyl)phenyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	31.6 [1]
	(5S)-5-Amino-7-hydroxy-2-methyl-3-[[4-(trifluoromethyl)phenyl]methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	37.0 [1]
	(5S)-5-Amino-2-benzyl-7-hydroxy-3-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	81.6 [1]
	(5S)-5-Amino-7-hydroxy-2-[(3-methoxyphenyl)methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	8.93 [1]
	(5S)-5-Amino-7-hydroxy-2-[(2-methoxyphenyl)methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	50.2 [1]
	(5S)-5-Amino-7-hydroxy-2-(naphthalen-2-ylmethyl)-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	117.0 [1]
	(5S)-5-Amino-7-hydroxy-2-(naphthalen-1-ylmethyl)-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	36.0 [1]
	(5S)-5-Amino-2-cyclobutyl-7-hydroxy-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	81.3 [1]
	(5S)-5-Amino-7-hydroxy-2-propan-2-yl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	153.0 [1]
	(6S)-6-Amino-4-hydroxy-3-methyl-2-phenyl-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	IC50	2010.0 [1]
	(5S)-5-Amino-3-benzyl-7-hydroxy-2-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	11.5 [1]
	(5S)-5-Amino-7-hydroxy-2-methyl-3-[[3-(trifluoromethyl)phenyl]methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	42.2 [1]
	(5S)-5-Amino-7-hydroxy-2-methyl-3-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	40.7 [1]
	(5S)-5-Amino-3-benzyl-7-hydroxy-2-propan-2-yl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	63.0 [1]
	(5S)-5-Amino-7-hydroxy-2-[3-(trifluoromethyl)phenyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	74.7 [1]
	(5S)-5-Amino-7-hydroxy-2-[[4-(trifluoromethoxy)phenyl]methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	43.6 [1]
	(2S)-6-(4-Aminopiperazin-1-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	IC50	1000.0 [1]
	(3S)-3-Amino-1-hydroxy-6-phenoxy-3,4-dihydroquinolin-2-one	IC50	23.0 [1]
	(3S)-3-Amino-3,4-dihydro-1H-quinolin-2-one	IC50	10000.0 [1]
	3-Amino-1-hydroxy-3-methyl-4H-quinolin-2-one	IC50	10000.0 [1]
	(3S,4S)-3-Amino-1-hydroxy-4-methyl-3,4-dihydroquinolin-2-one	IC50	3280.0 [1]
	(3S)-3-Amino-1-methoxy-3,4-dihydroquinolin-2-one	IC50	10000.0 [1]
	(3S)-3-Amino-7-chloro-1-hydroxy-3,4-dihydroquinolin-2-one	IC50	29.0 [1]
	(2R)-6-(4-Aminopiperazin-1-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	IC50	1500.0 [1]
	(3S)-3-Amino-1-hydroxy-6-(trifluoromethyl)-3,4-dihydroquinolin-2-one	IC50	29.0 [1]
	(3S)-3-Amino-1-hydroxy-8-(trifluoromethyl)-3,4-dihydroquinolin-2-one	IC50	174.0 [1]
	(3S)-1-Hydroxy-3-amino-5-methyl-3,4-dihydroquinoline-2(1H)-one	IC50	319.0 [1]
	(3S)-3-Amino-5-fluoro-1-hydroxy-3,4-dihydroquinolin-2-one	IC50	45.0 [1]
	(3S)-3-Amino-1-hydroxy-6-methyl-3,4-dihydroquinolin-2-one	IC50	30.0 [1]
	(3S)-3-Amino-6-chloro-1-hydroxy-3,4-dihydroquinolin-2-one	IC50	36.0 [1]
	(3S)-3-Amino-1-hydroxy-7-methyl-3,4-dihydroquinolin-2-one	IC50	37.0 [1]
	(3S)-3-Amino-1-hydroxy-8-methoxy-3,4-dihydroquinolin-2-one	IC50	572.0 [1]
	(3S)-3-Amino-1-hydroxy-8-methyl-3,4-dihydroquinolin-2-one	IC50	1050.0 [1]
	(3S)-3-Amino-8-chloro-1-hydroxy-3,4-dihydroquinolin-2-one	IC50	252.0 [1]
	(3S)-3-Amino-6-benzyl-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2-one	Ki	1.6 [1]
	(3S)-3-Amino-8-fluoro-1-hydroxy-3,4-dihydroquinolin-2-one	IC50	40.0 [1]
	(3S)-3-Amino-1-hydroxy-5-methoxy-3,4-dihydroquinolin-2-one	IC50	179.0 [1]
	(3S)-3-Amino-5-chloro-1-hydroxy-3,4-dihydroquinolin-2-one	IC50	349.0 [1]
	(3R)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2-one	IC50	219.0 [1]
	(3S)-3-Amino-1-hydroxy-5-(trifluoromethyl)-3,4-dihydroquinolin-2-one	IC50	10000.0 [1]
	(3S)-3-Amino-1-hydroxy-7-methoxy-6-phenoxy-3,4-dihydroquinolin-2-one	IC50	37.0 [1]
	6-Amino-4-hydroxy-2-phenyl-6,7-dihydropyrazolo[4,3-b]pyridin-5-one	IC50	85.0 [1]
	(5R)-5-Amino-3-benzyl-7-hydroxy-2-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-one	IC50	63.7 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 66 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/kynurenine-alpha-aminoadipate-aminotransferase-mitochondrial-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/kynurenine-alpha-aminoadipate-aminotransferase-mitochondrial-inhibitors-ic50-ki.
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